Abstract:
:The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour). The number of reinforcers obtained was decreased by the non-competitive NMDA antagonists phencyclidine, dizocilpine and memantine, by the competitive NMDA antagonist CGS 19755, by the antitussive drug dextromethorphan, but not by the polyamine site antagonist eliprodil (SL 82.0715). Small increases in response rates were produced by phencyclidine and memantine, and dizocilpine gave rise to very marked increases in rates. CGS 19755, eliprodil and dextromethorphan only decreased rates of responding at high doses. Analysis of drug action in terms of inter-response times (IRT) showed that, except for eliprodil, all compounds shifted the peaks of the IRT distributions to the left. The percentage of short IRTs (response bursts) showed statistically significant increases after administration of dizocilpine, phencyclidine, memantine and CGS 19755. These results show that timing behaviour in rats is disturbed by several NMDA antagonists, although eliprodil, while decreasing responding at high doses, did not disrupt efficient timing.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Sanger DJsubject
Has Abstractpub_date
1992-12-01 00:00:00pages
593-600issue
6eissn
0955-8810issn
1473-5849journal_volume
3pub_type
杂志文章abstract::Drug-related stimuli seem to contribute to the persistence of drug seeking and relapse. Behavioral momentum theory is a framework for understanding how the discriminative-stimulus context in which operant behavior occurs governs the persistence of that behavior. The theory suggests that both resistance to change and r...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328341e9fb
更新日期:2011-02-01 00:00:00
abstract::We studied the effects of cannabinoids on contextual conditioned fear responses. CB1 knockout and wild-type (CD1) mice were exposed to a brief session of electric shocks, and their behavior was studied in the same context 24 h later. In wild-type mice, shock exposure increased freezing and resting, and decreased locom...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200605000-00003
更新日期:2006-05-01 00:00:00
abstract::Glutamate, an excitatory neurotransmitter in the brain, produces excitotoxicity through its agonistic action on postsynaptic N-methyl-D-aspartate receptor, resulting in neurodegeneration. We hypothesized that the administration of low doses of glutamate in cerebral ischemia could attenuate the excitotoxicity in neuron...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000256
更新日期:2016-10-01 00:00:00
abstract::In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/00008877-200609000-00005
更新日期:2006-09-01 00:00:00
abstract::Phencyclidine (PCP) can induce a model psychosis in humans that mimics the positive and negative symptoms of schizophrenia. The purpose of the present study was to determine whether PCP can induce similar behavioural effects in rats and whether these effects can be alleviated by neuroleptic drug treatment. Rats were t...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000038
更新日期:2014-06-01 00:00:00
abstract::Bipolar disorder (BD) is thought to be associated with abnormalities within discrete brain regions associated with emotional regulation, particularly in fronto-limbic-subcortical circuits. Several reviews have addressed the involvement of the prefrontal cortex in the pathophysiology of BD, whereas little attention has...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3282df3cde
更新日期:2007-09-01 00:00:00
abstract::Rats were placed in a circular swimming pool for two 3-min swims separated by 3 days. In the first swim control rats swam initially around the perimeter of the pool and later spent more time in the central region and swam more slowly. The time spent in the centre during min 1 was much higher in the second swim than in...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Parkinson's disease psychosis (PDP) is a condition for which a safe, tolerated, and effective therapy is lacking. Treatment with typical or atypical antipsychotics may be contraindicated in patients with PDP because of the potential for aggravating motor symptoms. This study used a novel animal model with features of ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834aff98
更新日期:2011-10-01 00:00:00
abstract::The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Alcohol consumption acutely increases smoking behavior, but the reverse relationship, the acute effects of smoking on alcohol intake, largely has been ignored. We examined whether smoking acutely increases the reinforcing value of alcohol, first in the absence of recent alcohol intake and then following an alcohol pre...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00008877-200002000-00007
更新日期:2000-02-01 00:00:00
abstract::To investigate the role of the nucleus accumbens core (NAc) in the development of quinpirole-induced compulsive checking, rats received an excitotoxic lesion of NAc or sham lesion and were injected with quinpirole (0.5 mg/kg) or saline; development of checking behavior was monitored for 10 biweekly tests. The results ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000112
更新日期:2015-02-01 00:00:00
abstract::Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000407
更新日期:2019-02-01 00:00:00
abstract::Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200104000-00001
更新日期:2001-04-01 00:00:00
abstract::The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participa...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000524
更新日期:2020-08-01 00:00:00
abstract::Human and animal studies provide evidence for vulnerable periods of brain development for deleterious effects of cannabinoids. We have recently shown that pubertal chronic cannabinoid treatment leads to long-lasting behavioral deficits, whereas a comparable treatment in adult rats did not affect the animals' behavior....
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200509000-00018
更新日期:2005-09-01 00:00:00
abstract::Cocaine addicts very often use different combinations of cocaine and other drugs of abuse such as gamma-hydroxybutyric acid. The objective of the present work was to evaluate the impact of gamma-hydroxybutyric acid administration on the rewarding actions of cocaine, using the conditioned place preference procedure. Co...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/01.fbp.0000190685.84984.ec
更新日期:2006-03-01 00:00:00
abstract::Inhibitors of phosphodiesterase 10A (PDE10A) represent a novel class of potential antipsychotic compounds. These principles increase the level of cAMP and cGMP in the medium spiny neurons of the striatum and resemble the neurochemical consequences of dopamine D2 receptor inhibition and dopamine D1 receptor stimulation...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000201
更新日期:2016-06-01 00:00:00
abstract::Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000384
更新日期:2018-04-01 00:00:00
abstract::The effects of topiramate, a potential treatment for drug dependence, were evaluated in two groups of rats trained to discriminate the administration of either 0.4 mg/kg nicotine or 10 mg/kg cocaine from that of saline, under a fixed-ratio 10 schedule of food delivery. Topiramate (1-60 mg/kg, intraperitoneal) did not ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282f3cf84
更新日期:2008-02-01 00:00:00
abstract::The effects of lithium in models of depression are often inconsistent. We aimed to replicate a regimen that induces robust antidepressant effects in the forced-swim test. Mice were treated with three different doses of lithium chloride (LiCl) 0.25, 0.4 or 0.5% in food and the forced-swim test or open field test was pe...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32801416ed
更新日期:2007-02-01 00:00:00
abstract::Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833fa7c7
更新日期:2010-12-01 00:00:00
abstract::In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200403000-00002
更新日期:2004-03-01 00:00:00
abstract::It has been known for years that systemic administration of the stress hormones, adrenocorticotrophin (ACTH), lysine-vasopressin, adrenaline, or beta-endorphin, enhances retrieval of aversive behaviours acquired one or a few days before. Here we show that the pre-test i.p. injection of the hormones in rats can also en...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200205000-00003
更新日期:2002-05-01 00:00:00
abstract::There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....
journal_title:Behavioural pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1097/FBP.0b013e328349fc02
更新日期:2011-09-01 00:00:00
abstract::Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. Once recovered from surgery, animals were submitted to one session of step-down inhibitory avoidance training (3.0 s, 0.4 mA footshock). Animals received a 0.5-microl infusion of saline, or of LY2940...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200112000-00007
更新日期:2001-12-01 00:00:00
abstract::Although microdialysis is commonly understood as a method of sampling low molecular weight compounds in the extracellular compartment of tissues, this definition appears insufficient to specifically describe brain microdialysis of neurotransmitters. In fact, transmitter overflow from the brain into dialysates is criti...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor. We have hypothesized that reduction of apoptosis in the limbic system can attenuate the depressive behaviour occurring post-MI. The p...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32834d1385
更新日期:2011-12-01 00:00:00
abstract::The brain endocannabinoid system is a potential target for the treatment of psychiatric and metabolic conditions. Here, a novel CB1 receptor antagonist (ABD459) was synthesized and assayed for pharmacological efficacy in vitro and for modulation of food consumption, vigilance staging and cortical electroencephalograph...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000108
更新日期:2015-04-01 00:00:00