Opioid drugs and timeout from avoidance.

abstract：:Cannabis is the most popular illicit drug used by adolescents. Yet, there are only a few studies that have examined the effects of cannabis use on learning and memory during this sensitive and important neurodevelopmental stage. Male adolescent Sprague-Dawley rats were treated with Δ(9)-tetrahydrocannabinol (THC, 6 mg...

journal_title：Behavioural pharmacology

authors： Steel RW,Miller JH,Sim DA,Day DJ

更新日期：2011-12-01 00:00:00

abstract：:Drug addiction is a progressive, relapsing disease comprised of interlocking stages of disordered motivation. Numerous animal models describing various stages of the addiction process have been developed over the past few decades, providing considerable advantages for the modeling of drug addiction compared with other...

journal_title：Behavioural pharmacology

authors： Edwards S,Koob GF

更新日期：2013-09-01 00:00:00

abstract：:In previous studies, it was shown that apomorphine-induced stereotyped behaviour could be conditioned when apomorphine was repeatedly paired with sensory stimuli (CS). Since in these experiments, the sum of various sensory stimuli were applied, it seemed of interest to use each sensory stimulus separately in order to ...

journal_title：Behavioural pharmacology

authors： Ferger B,Kuschinsky K

更新日期：1995-01-01 00:00:00

abstract：:The interactions of -adrenoceptors and acute restraint stress with morphine state-dependent memory of passive avoidance were examined in mice. Memory acquired following pre-training morphine administration (5 mg/kg, i.p.) was dose- and time-dependently retrieved by pre-test morphine; this effect was reversible by yohi...

journal_title：Behavioural pharmacology

authors： Homayoun H,Khavandgar S,Zarrindast MR

更新日期：2003-02-01 00:00:00

abstract：:The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...

journal_title：Behavioural pharmacology

authors： Hughes CE,Picker MJ,Dykstra LA

更新日期：1995-12-01 00:00:00

abstract：:Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than ...

journal_title：Behavioural pharmacology

authors： Rosas M,Porru S,Giugliano V,Antinori S,Scheggi S,Fadda P,Fratta W,Acquas E,Fattore L

更新日期：2018-09-01 00:00:00

abstract：:Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

journal_title：Behavioural pharmacology

authors： Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

更新日期：2014-08-01 00:00:00

abstract：:This study examined associations between drinking and smoking prior to treatment (biochemically measured at baseline), alcohol and tobacco craving, and biochemical alcohol and tobacco use during the analog trial period. We conducted a secondary data analysis of a randomized clinical analog trial where participants wit...

journal_title：Behavioural pharmacology

authors： Smith CL,Jenkins G,Burduli E,Tham P,Miguel A,Roll J,Mcpherson S

更新日期：2020-10-01 00:00:00

abstract：:A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...

journal_title：Behavioural pharmacology

authors： Willner P,Papp M,Cheeta S,Muscat R

更新日期：1992-02-01 00:00:00

abstract：:It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and substitution tests were carried out with phenc...

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1993-10-01 00:00:00

abstract：:Rats in one group were trained to discriminate alprazolam (1.0mg/kg, i.p.) and in another group diazepam (3.0mg/kg, i.p.) from saline in a two-lever drug discrimination procedure. Food presentation occurred after 10 consecutive responses on the lever associated either with the training drug or with saline. Alprazolam,...

journal_title：Behavioural pharmacology

authors： Wettstein JG,Gauthier B

更新日期：1992-06-01 00:00:00

abstract：:Early-life administration of risperidone, the most widely used antipsychotic drug in children, leads to persistently elevated locomotor activity in adult rats. This study determined whether and when elevated locomotor activity emerges during developmental risperidone administration. Developing and adult rats were admi...

journal_title：Behavioural pharmacology

authors： Stevens RM,Gannon MA,Griffith MS,Bardgett ME

更新日期：2016-08-01 00:00:00

abstract：:Methoxetamine (MXE) is a chemical analogue of ketamine. Originally proposed as a ketamine-like fast-acting antidepressant, owing to similar N-methyl-D-aspartate blocker properties, it is now scheduled for reports of hallucinations and psychosis similar to ketamine and lysergic acid. As little is known about the addict...

journal_title：Behavioural pharmacology

authors： Chiamulera C,Armani F,Mutti A,Fattore L

更新日期：2016-04-01 00:00:00

abstract：:Nitrous oxide (N2O) effects were evaluated, as a behavioural model of inert gas narcosis, in rats performing a vigilance task in which they were required to respond to a slight luminous increment of the house-light. A dose-related decrease of correct responses was produced by the tested range of concentrations of N2O ...

journal_title：Behavioural pharmacology

authors： Courtière A,Hardouin J

更新日期：1997-10-01 00:00:00

abstract：:Evidence of observational learning (social learning) is present in many species. One such task is the one-trial taste-avoidance task, in which Actor chicks peck a bead coated with an aversant substance. Observer chicks learn to avoid beads that are similar in appearance to the one presented to the Actors. It has been ...

journal_title：Behavioural pharmacology

authors： Barber TA,Kimbrough TN

更新日期：2015-06-01 00:00:00

abstract：:Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

journal_title：Behavioural pharmacology

authors： Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

更新日期：2000-06-01 00:00:00

abstract：:Dopamine receptors are implicated in the reinforcing effects of food and drug reinforcement. The purpose of this study was to evaluate whether blocking D2 dopamine receptors during extinction (secondary reinforcement) would affect reacquisition of responding for food pellets (primary reinforcement). Food-restricted ra...

journal_title：Behavioural pharmacology

authors： Koerber J,Goodman D,Barnes JL,Grimm JW

更新日期：2013-12-01 00:00:00

abstract：:Recently, we have described a new model of chronic social stress in rats, based on the resident-intruder paradigm. In this model, rats show behavioural changes that may be considered correlates of depressive symptoms, such as anhedonia and motivational deficits. The present study was designed for pharmacological valid...

journal_title：Behavioural pharmacology

authors： Rygula R,Abumaria N,Flügge G,Hiemke C,Fuchs E,Rüther E,Havemann-Reinecke U

更新日期：2006-02-01 00:00:00

abstract：:In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...

journal_title：Behavioural pharmacology

authors： Carta AR,Pinna A,Morelli M

更新日期：2006-09-01 00:00:00

abstract：:Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...

journal_title：Behavioural pharmacology

authors： Brigman JL,Mathur P,Lu L,Williams RW,Holmes A

更新日期：2009-03-01 00:00:00

abstract：:In the present study, we focused on γ-aminobutyric acid (GABA) signaling through the γ-aminobutyric acid transporter (GAT) in the developing rat cerebral cortex. Tiagabine was used as a GAT inhibitor. The offspring received injections from birth until postnatal day 21 intraperitoneally. Physical development and neurol...

journal_title：Behavioural pharmacology

authors： Shahrokhi A,Hassanzadeh G,Vousooghi N,Joghataei MT,Eftekhari S,Zarrindast MR

更新日期：2013-10-01 00:00:00

abstract：:This study evaluated the effect of intermittent administration in the development of dependence to diazepam in chronic use of the drug. Gabapentin was used to provide an anxiolytic effect on drug-free days. During a 28-day treatment schedule, rats were given diazepam (15 mg/kg) once daily continuously, or intermittent...

journal_title：Behavioural pharmacology

authors： Açikmeşe B,Haznedar S,Hatipoğlu I,Enginar N

更新日期：2012-04-01 00:00:00

abstract：:Inhibitors of phosphodiesterase 10A (PDE10A) represent a novel class of potential antipsychotic compounds. These principles increase the level of cAMP and cGMP in the medium spiny neurons of the striatum and resemble the neurochemical consequences of dopamine D2 receptor inhibition and dopamine D1 receptor stimulation...

journal_title：Behavioural pharmacology

authors： Nikiforuk A,Potasiewicz A,Rafa D,Drescher K,Bespalov A,Popik P

更新日期：2016-06-01 00:00:00

abstract：:The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

journal_title：Behavioural pharmacology

authors： Baron SP,Wenger GR

更新日期：2001-07-01 00:00:00

abstract：:Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

journal_title：Behavioural pharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-03-01 00:00:00

abstract：:Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) mo...

journal_title：Behavioural pharmacology

authors： Li X,Liu C,Jiang B,Chen K,Li W,Wang H

更新日期：2018-06-01 00:00:00

abstract：:The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...

journal_title：Behavioural pharmacology

authors： Bickerdike MJ,Wright IK,Marsden CA

更新日期：1993-06-01 00:00:00

abstract：:The Tinkertoy test (TTT) has often been used to assess executive function. Despite its clinical importance, there are few published normative data for it. Thus, the primary aim of this study was to fill this gap. Moreover, as there exists a sex difference in many cognitive abilities and neuropsychological tests, a sec...

journal_title：Behavioural pharmacology

authors： Lambert M,Stenger J,Bielajew C

更新日期：2018-12-01 00:00:00

abstract：:Animals neonatally depleted of dopamine show decreases in exploratory behaviour. As latent learning may depend on exploratory behaviour the present study was undertaken to examine the effects of neonatal dopamine depletion on latent learning. In two experiments dopamine was depleted neonatally, using 6-hydroxydopamine...

journal_title：Behavioural pharmacology

authors： Archer T,Beninger RJ,Järbe TU,Seiden LS

更新日期：1989-01-01 00:00:00

abstract：:The pathophysiological role of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) in neuropsychiatric disorders has been highlighted in several recent investigations. For instance, allopregnanolone levels are decreased in the CSF of patients with post-traumatic stress disorder (PTSD) and major un...

journal_title：Behavioural pharmacology

authors： Pinna G

更新日期：2010-09-01 00:00:00