Clonidine and yohimbine in opioid-dependent humans responding under a naloxone novel-response discrimination procedure.

abstract：:Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than ...

journal_title：Behavioural pharmacology

authors： Rosas M,Porru S,Giugliano V,Antinori S,Scheggi S,Fadda P,Fratta W,Acquas E,Fattore L

更新日期：2018-09-01 00:00:00

abstract：:We investigated relationships between drinking, other drug use, and drug craving, using ecological momentary assessment (EMA), in a sample of polydrug users who were not heavy drinkers. In a prospective longitudinal cohort study, 114 heroin and cocaine users on methadone-maintenance treatment carried handheld electron...

journal_title：Behavioural pharmacology

authors： Preston KL,Jobes ML,Phillips KA,Epstein DH

更新日期：2016-10-01 00:00:00

abstract：:A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

journal_title：Behavioural pharmacology

authors： Nogueira RL,Graeff FG

更新日期：1991-02-01 00:00:00

abstract：:Individuals with attention-deficit/hyperactivity disorder tend to make risker choices during probabilistic-discounting procedures. Thus, how common attention-deficit/hyperactivity disorder medications affect probabilistic discounting is of interest. In general, d-amphetamine increases risk-taking while atomoxetine has...

journal_title：Behavioural pharmacology

authors： Ozga-Hess JE,Anderson KG

更新日期：2019-10-01 00:00:00

abstract：:It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and substitution tests were carried out with phenc...

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1993-10-01 00:00:00

abstract：:Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel dr...

journal_title：Behavioural pharmacology

authors： Wu Z,Yang Z,Zhang M,Bao X,Han F,Li L

更新日期：2018-02-01 00:00:00

abstract：:Synthetic cathinone derivatives are commonly considered quasi-legal alternatives for stimulant drugs, such as cocaine and methamphetamine, but some derivatives are increasingly being detected in club drug formulations of Ecstasy or 'Molly' as substitutes for methylenedioxymethamphetamine (±-MDMA). Although several stu...

journal_title：Behavioural pharmacology

authors： Gatch MB,Dolan SB,Forster MJ

更新日期：2020-06-01 00:00:00

abstract：:Acute (10mg/kg, i.p.) and chronic (10mg/kg/day, i.p. for 10 days) diazepam treatments decreased hippocampal dialysate 5-HT (but not 5-HIAA) concentrations in freely moving rats, suggesting decreased availability of 5-HT to receptors. Twenty-four hours after the last chronic diazepam injection, hippocampal dialysate 5-...

journal_title：Behavioural pharmacology

authors： Gibson EL,Barnfield AM,Curzon G

更新日期：1996-03-01 00:00:00

abstract：:The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

journal_title：Behavioural pharmacology

authors： Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

更新日期：2009-03-01 00:00:00

abstract：:The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

更新日期：1997-11-01 00:00:00

abstract：:A core symptom of human depressive disorder is anhedonia, the loss of interest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimul...

journal_title：Behavioural pharmacology

authors： Moreau JL,Scherschlicht R,Jenck F,Martin JR

更新日期：1995-11-01 00:00:00

abstract：:Over the last 15 years, genetically modified mice have added important data to our knowledge on psychiatric diseases including anxiety. This has produced many behavioural publications, partially by non-behaviourists, in which differences between mutants and normal wild-type animals were described. The popularity of th...

journal_title：Behavioural pharmacology

authors： Bouwknecht JA,Paylor R

更新日期：2008-09-01 00:00:00

abstract：:Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

journal_title：Behavioural pharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-03-01 00:00:00

abstract：:This study assessed whether access to a sweet solution in the home cage could change sensitivity to cocaine, using a drug discrimination procedure. Rats were trained to discriminate 10 mg/kg cocaine from saline. After acquisition, rats were tested with a cumulative dose-response procedure (0-18 mg/kg) for 12 consecuti...

journal_title：Behavioural pharmacology

authors： Kohut SJ,Riley AL

更新日期：2010-05-01 00:00:00

abstract：:Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

journal_title：Behavioural pharmacology

authors： Darrah JM,Stefani MR,Moghaddam B

更新日期：2008-05-01 00:00:00

abstract：:In the present study, we focused on γ-aminobutyric acid (GABA) signaling through the γ-aminobutyric acid transporter (GAT) in the developing rat cerebral cortex. Tiagabine was used as a GAT inhibitor. The offspring received injections from birth until postnatal day 21 intraperitoneally. Physical development and neurol...

journal_title：Behavioural pharmacology

authors： Shahrokhi A,Hassanzadeh G,Vousooghi N,Joghataei MT,Eftekhari S,Zarrindast MR

更新日期：2013-10-01 00:00:00

abstract：:Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular hist...

journal_title：Behavioural pharmacology

authors： Riveros ME,Forray MI,Torrealba F

更新日期：2015-06-01 00:00:00

abstract：:This study examined associations between drinking and smoking prior to treatment (biochemically measured at baseline), alcohol and tobacco craving, and biochemical alcohol and tobacco use during the analog trial period. We conducted a secondary data analysis of a randomized clinical analog trial where participants wit...

journal_title：Behavioural pharmacology

authors： Smith CL,Jenkins G,Burduli E,Tham P,Miguel A,Roll J,Mcpherson S

更新日期：2020-10-01 00:00:00

abstract：:The purpose of this study was to examine, in healthy volunteers without histories of extensive sedative use, the acute behavioral effects of doses of alprazolam used in clinical applications. Subjects participated in daily sessions over 12 study days. They consumed a standard breakfast, received an oral drug dose (0, ...

journal_title：Behavioural pharmacology

authors： Kelly TH,Foltin RW,Serpick E,Fischman MW

更新日期：1997-02-01 00:00:00

abstract：:The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

journal_title：Behavioural pharmacology

authors： Lile JA,Wesley MJ,Kelly TH,Hays LR

更新日期：2016-04-01 00:00:00

abstract：:Different approaches to measuring stimulus generalization in drug discrimination experiments are compared. The main issue, with implications for interpreting partial generalization, has been whether it is preferable to use graded or quantal indices. The first step is to determine whether discriminative drug effects ar...

journal_title：Behavioural pharmacology

authors： Stoleman IP

更新日期：1991-11-01 00:00:00

abstract：:Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...

journal_title：Behavioural pharmacology

authors： Sugimachi K,Izawa K,Nakamura K,Kimura-Iwasaki K,Yamaguchi M,Nakagawa H,Oshino N

更新日期：1992-08-01 00:00:00

abstract：:Recently, we have described a new model of chronic social stress in rats, based on the resident-intruder paradigm. In this model, rats show behavioural changes that may be considered correlates of depressive symptoms, such as anhedonia and motivational deficits. The present study was designed for pharmacological valid...

journal_title：Behavioural pharmacology

authors： Rygula R,Abumaria N,Flügge G,Hiemke C,Fuchs E,Rüther E,Havemann-Reinecke U

更新日期：2006-02-01 00:00:00

abstract：:Insufficient research has been carried out on the effects of repeated treatments with psychostimulants on agonistic behaviour. These effects were studied in mice using different schedules of administration and employing a low dose of amphetamine (1.5 mg/kg) which did not produce significant motor disruptions. After tw...

journal_title：Behavioural pharmacology

authors： Moro M,Salvador A,Simón VM

更新日期：1997-08-01 00:00:00

abstract：:Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

journal_title：Behavioural pharmacology

authors： Kos T,Popik P

更新日期：2005-05-01 00:00:00

abstract：:Serotonin-selective reuptake inhibitors (SSRIs) have been shown to enhance the locomotor stimulatory, discriminative-stimulus, and convulsive effects of cocaine in rodents. A pharmacokinetic mechanism for the interaction is supported by increases in the brain levels of cocaine by fluoxetine treatment. Furthermore, the...

journal_title：Behavioural pharmacology

authors： Soto PL,Hiranita T,Katz JL

更新日期：2009-12-01 00:00:00

abstract：:Obesity and cigarette smoking are often cited separately as the top two preventable causes of death in the United States; however, little research has explored the factors associated with being both obese and a smoker. Delay discounting is a behavioral characteristic that may underlie both of these conditions/behavior...

journal_title：Behavioural pharmacology

authors： Fields SA,Sabet M,Peal A,Reynolds B

更新日期：2011-06-01 00:00:00

abstract：:The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...

journal_title：Behavioural pharmacology

authors： Picker MJ,Cook CD

更新日期：1998-07-01 00:00:00

abstract：:There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher suscepti...

journal_title：Behavioural pharmacology

authors： Morais LH,Felice D,Golubeva AV,Moloney G,Dinan TG,Cryan JF

更新日期：2018-04-01 00:00:00

abstract：:Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Haidari H,Jafari MR,Djahanguiri B

更新日期：2004-07-01 00:00:00