Relationship between weight status and delay discounting in a sample of adolescent cigarette smokers.


:Obesity and cigarette smoking are often cited separately as the top two preventable causes of death in the United States; however, little research has explored the factors associated with being both obese and a smoker. Delay discounting is a behavioral characteristic that may underlie both of these conditions/behaviors. Delay discounting describes the extent to which an individual discounts the value of an outcome because of a delay in its occurrence. Higher rates of discounting are often considered as an index of impulsivity and have been linked with obesity and cigarette smoking. No research to date has explored delay discounting in a sample of obese smokers. For this study, adolescent smokers classified as obese (body mass index >95th percentile) and healthy weight (body mass index between the 5th and 85th percentiles) were compared on a laboratory assessment of delay discounting. Obese smokers discounted significantly more by delay than healthy weight smokers. This difference remained statistically significant even after controlling for demographic variables that differed across groups. These findings suggest that the relationships between delay discounting and obesity and cigarette smoking may be additive, such that extreme discounting might proportionally increase the risk of becoming an obese smoker. However, future prospective study is needed to fully determine the veracity of this hypothesis.


Behav Pharmacol


Behavioural pharmacology


Fields SA,Sabet M,Peal A,Reynolds B




Has Abstract


2011-06-01 00:00:00












  • Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression.

    abstract::Ketamine is the prototype of a new generation of antidepressant drugs, which is reported in clinical studies to be effective in treatment-resistant patients, with an effect that appears within hours and lasts for a few days. Chronic mild stress (CMS) is a well-established and widely used animal model of depression, in...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Papp M,Gruca P,Lason-Tyburkiewicz M,Willner P

    更新日期:2017-02-01 00:00:00

  • Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test.

    abstract::Some reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Olivares-Nazario M,Fernández-Guasti A,Martínez-Mota L

    更新日期:2016-02-01 00:00:00

  • Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models.

    abstract::Drug-addicted individuals show high levels of impulsive choice, characterized by preference for small immediate over larger but delayed rewards. Although the causal relationship between chronic drug use and elevated impulsive choice in humans has been unclear, a small but growing body of literature over the past decad...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Setlow B,Mendez IA,Mitchell MR,Simon NW

    更新日期:2009-09-01 00:00:00

  • Celecoxib potentiates the antianxiety and anticompulsive-like activity of fluoxetine against chronic unpredictable mild stress in experimental animals.

    abstract::Obsessive-compulsive disorder (OCD) is considered a heterogeneous anxiety disorder that includes compulsions. Celecoxib is considered an adjuvant to fluoxetine in the management of OCD in a clinical study. However, the experimental evidence is yet to be established. Therefore, the antianxiety and anticompulsive-like a...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Garabadu D,Kumar V

    更新日期:2019-04-01 00:00:00

  • Dopamine effects on stress-induced working memory deficits.

    abstract::The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling fol...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Bahari Z,Meftahi GH,Meftahi MA

    更新日期:2018-10-01 00:00:00

  • Environment modifies the expression of behavioral sensitization produced by methamphetamine: behavioral and neurochemical studies.

    abstract::Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ohmori T,Abekawa T,Koyama T

    更新日期:1995-03-01 00:00:00

  • First evidence that drugs of abuse produce behavioral sensitization and cross sensitization in planarians.

    abstract::Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Rawls SM,Patil T,Yuvasheva E,Raffa RB

    更新日期:2010-07-01 00:00:00

  • Self-reported smoking effects and comparative value between cigarettes and high dose e-cigarettes in nicotine-dependent cigarette smokers.

    abstract::The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: McPherson S,Howell D,Lewis J,Barbosa-Leiker C,Bertotti Metoyer P,Roll J

    更新日期:2016-04-01 00:00:00

  • Selective breeding for intravenous drug self-administration in rats: a pilot study.

    abstract::Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: He S,Yang Y,Mathur D,Grasing K

    更新日期:2008-12-01 00:00:00

  • LY294002, an inhibitor of phosphoinositide 3-kinase given into rat hippocampus impairs acquisition, consolidation and retrieval of memory for one-trial step-down inhibitory avoidance.

    abstract::Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the CA1 region of the dorsal hippocampus. Once recovered from surgery, animals were submitted to one session of step-down inhibitory avoidance training (3.0 s, 0.4 mA footshock). Animals received a 0.5-microl infusion of saline, or of LY2940...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Barros DM,Mello e Souza T,de Souza MM,Choi H,DeDavid e Silva T,Lenz G,Medina JH,Izquierdo I

    更新日期:2001-12-01 00:00:00

  • Infralimbic cortex activation and motivated arousal induce histamine release.

    abstract::Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular hist...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Riveros ME,Forray MI,Torrealba F

    更新日期:2015-06-01 00:00:00

  • Discriminative stimulus effects of alprazolam and diazepam: generalization to benzodiazepines, antidepressants and buspirone.

    abstract::Rats in one group were trained to discriminate alprazolam (1.0mg/kg, i.p.) and in another group diazepam (3.0mg/kg, i.p.) from saline in a two-lever drug discrimination procedure. Food presentation occurred after 10 consecutive responses on the lever associated either with the training drug or with saline. Alprazolam,...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Wettstein JG,Gauthier B

    更新日期:1992-06-01 00:00:00

  • Alzheimer's disease in the zebrafish: where can we take it?

    abstract::With the ever-growing geriatric population, research on brain diseases such as dementia is more imperative now than ever. The most prevalent of all dementias is Alzheimer's disease, a progressive neurodegenerative disease that presents with deficits in memory, cognition, motor skills, and a general decline in the qual...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章,评审


    authors: Caramillo EM,Echevarria DJ

    更新日期:2017-04-01 00:00:00

  • Changes in gut microbiota during development of compulsive checking and locomotor sensitization induced by chronic treatment with the dopamine agonist quinpirole.

    abstract::Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

    更新日期:2018-04-01 00:00:00

  • Genetic relationship between anxiety-related and fear-related behaviors in BXD recombinant inbred mice.

    abstract::Mood and anxiety disorders, and rodent phenotypic measures modeling these disorders, have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related and anxiety-related behaviors, phenotype genetically modified mice, and elucidate pharmacological modulation of these behavior...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Brigman JL,Mathur P,Lu L,Williams RW,Holmes A

    更新日期:2009-03-01 00:00:00

  • SR 141716A differentially attenuates the behavioral effects of delta9-THC in rhesus monkeys.

    abstract::The prototypic cannabinoid CB1 antagonist SR 141716A is one important pharmacologic tool for examining CB1 receptors that mediate the behavioral and physiologic effects of delta9-tetrahydrocannabinol (delta9-THC). This study examined the effects of SR 141716A on the rate-decreasing, hypothermic and discriminative stim...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: McMahon LR,Amin MR,France CP

    更新日期:2005-09-01 00:00:00

  • Strain differences in the susceptibility to the gut-brain axis and neurobehavioural alterations induced by maternal immune activation in mice.

    abstract::There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher suscepti...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Morais LH,Felice D,Golubeva AV,Moloney G,Dinan TG,Cryan JF

    更新日期:2018-04-01 00:00:00

  • A comparison of different sensory stimuli in producing conditioned apomorphine effects.

    abstract::In previous studies, it was shown that apomorphine-induced stereotyped behaviour could be conditioned when apomorphine was repeatedly paired with sensory stimuli (CS). Since in these experiments, the sum of various sensory stimuli were applied, it seemed of interest to use each sensory stimulus separately in order to ...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Ferger B,Kuschinsky K

    更新日期:1995-01-01 00:00:00

  • Estimation of in-vivo neurotransmitter release by brain microdialysis: the issue of validity.

    abstract::Although microdialysis is commonly understood as a method of sampling low molecular weight compounds in the extracellular compartment of tissues, this definition appears insufficient to specifically describe brain microdialysis of neurotransmitters. In fact, transmitter overflow from the brain into dialysates is criti...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Di Chiara G,Tanda G,Carboni E

    更新日期:1996-11-01 00:00:00

  • The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice.

    abstract::We studied the effects of cannabinoids on contextual conditioned fear responses. CB1 knockout and wild-type (CD1) mice were exposed to a brief session of electric shocks, and their behavior was studied in the same context 24 h later. In wild-type mice, shock exposure increased freezing and resting, and decreased locom...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Mikics E,Dombi T,Barsvári B,Varga B,Ledent C,Freund TF,Haller J

    更新日期:2006-05-01 00:00:00

  • Conditioned hyperkinesia induced by cocaine in mice is dose-dependent but not correlated with the unconditioned response or the contextually-sensitized response.

    abstract::The aims of the study were to test whether drug dose is positively related to the magnitude of the conditioned response following sensitization to the behavioural effects of cocaine and to investigate the relationship between the conditioned response and cocaine-induced sensitization. Male mice (C57BL/6J) were first i...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Michel A,Tirelli E

    更新日期:2002-02-01 00:00:00

  • Drug discrimination in pigeons trained to discriminate among morphine, U50488, a combination of these drugs, and saline.

    abstract::This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Wessinger WD,Li M,McMillan DE

    更新日期:2011-09-01 00:00:00

  • Motivation for alcohol assessed by multiple variable interval schedule behaviour: effects of reward size and alcohol cues.

    abstract::Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Glautier S,Rigney U,Willner P

    更新日期:2001-04-01 00:00:00

  • Ethanol-induced conditioned place aversion in mice.

    abstract::Previous studies have shown that ethanol produces conditioned place preference (CPP) in mice when injections are given immediately before exposure to the conditioned stimulus (CS). Paradoxically, however, injection of ethanol immediately after the CS produces conditioned place aversion (CPA). Four experiments were con...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Cunningham CL,Henderson CM

    更新日期:2000-11-01 00:00:00

  • Adolescent silymarin treatment increases anxiety-like behaviors in adult mice.

    abstract::Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

    更新日期:2014-08-01 00:00:00

  • The effects of PDE10 inhibition on attentional set-shifting do not depend on the activation of dopamine D1 receptors.

    abstract::Inhibitors of phosphodiesterase 10A (PDE10A) represent a novel class of potential antipsychotic compounds. These principles increase the level of cAMP and cGMP in the medium spiny neurons of the striatum and resemble the neurochemical consequences of dopamine D2 receptor inhibition and dopamine D1 receptor stimulation...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Nikiforuk A,Potasiewicz A,Rafa D,Drescher K,Bespalov A,Popik P

    更新日期:2016-06-01 00:00:00

  • Antagonism of cocaine self-administration by selective dopamine D(1) and D(2) antagonists.

    abstract::Effects of the dopamine D(1) antagonist SCH 39166 were compared with those of the D(2) antagonist eticlopride in squirrel monkeys responding under a second-order fixed-interval schedule of i.v. self-administration of cocaine. Dose-response curves were determined for a range of doses of self-administered cocaine (0.01-...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Bergman J,Kamien JB,Spealman RD

    更新日期:1990-01-01 00:00:00

  • Zolpidem is differentiated from triazolam in humans using a three-response drug discrimination procedure.

    abstract::The discriminative stimulus effects of the imidazopyridine hypnotic zolpidem and the classic benzodiazepine hypnotic triazolam were examined in seven healthy volunteers using a three-response drug discrimination procedure and a within-subject design. During an initial sampling phase, the training drug conditions (plac...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Mintzer MZ,Frey JM,Griffiths RR

    更新日期:1998-11-01 00:00:00

  • Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol.

    abstract::The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination p...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Lile JA,Wesley MJ,Kelly TH,Hays LR

    更新日期:2016-04-01 00:00:00

  • 5-HT mediation of the antiaversive effect of isamoltane injected into the dorsal periaqueductal grey.

    abstract::A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

    journal_title:Behavioural pharmacology

    pub_type: 杂志文章


    authors: Nogueira RL,Graeff FG

    更新日期:1991-02-01 00:00:00