Abstract:
:A range of selective dopamine D1 and D2 receptor agonists and antagonists was used to characterize to the discriminative stimuli produced by d-amphetamine (0.5mg/kg) and the D1 agonists SKF 81297 (0.1mg/kg). In rats trained to discriminate d-amphetamine (0.5mg/kg) from saline, d-amphetamine produced a dose-related increase in per cent drug lever responding, and SKF 81297 did not show any d-amphetamine-like discriminative stimulus effects; neither did SKF 81297 potentiate nor antagonize the d-amphetamine discriminative stimulus. In rats trained to discriminate SKF 81297 (0.1mg/kg) from saline, SKF 81297 produced a dose-related increase in per cent drug lever responding, and SKF 38393 and SKF 83565 elicited full SKF 81297-like effects despite the fact that these compounds have widely differing efficacies for stimulating adenylate cyclase. SKF 81297 had a 25-fold greater potency than SKF 38393 in this assay. The D2 agonists, PHNO and ropinirole, did not display any SKF 81297-like discriminative stimulus effects. The SKF 81297 discriminative stimulus was completely blocked by the D1 antagonist SCH 23390 but was not blocked by the D2 antagonist BRL 34778.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Reavill C,B Bond,Overend P,Hunter AJsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
135-146issue
2eissn
0955-8810issn
1473-5849journal_volume
4pub_type
杂志文章abstract::The stimulus control by morphine under a fixed-interval (FI) 180-s schedule of reinforcement was examined in five pigeons trained to discriminate 5.0mg/kg of i.m. morphine from saline. After training, dose-response relationships were determined for morphine, d-amphetamine, pentobarbital, fentanyl, and MK-801. At low d...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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journal_title:Behavioural pharmacology
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282f18da6
更新日期:2007-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3283242f6a
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00008877-200411000-00004
更新日期:2004-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282f3cf84
更新日期:2008-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199812000-00006
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pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000172
更新日期:2015-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Behavioural pharmacology
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doi:10.1097/FBP.0b013e32830dc110
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199708000-00004
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journal_title:Behavioural pharmacology
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doi:10.1097/FBP.0b013e32835a3907
更新日期:2012-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::Alcohol consumption acutely increases smoking behavior, but the reverse relationship, the acute effects of smoking on alcohol intake, largely has been ignored. We examined whether smoking acutely increases the reinforcing value of alcohol, first in the absence of recent alcohol intake and then following an alcohol pre...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199203010-00007
更新日期:1992-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Obsessive-compulsive disorder (OCD) is considered a heterogeneous anxiety disorder that includes compulsions. Celecoxib is considered an adjuvant to fluoxetine in the management of OCD in a clinical study. However, the experimental evidence is yet to be established. Therefore, the antianxiety and anticompulsive-like a...
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更新日期:2019-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/01.fbp.0000087739.21047.d8
更新日期:2003-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00