Effects of chronic scopolamine administration on spatial working memory and hippocampal receptors related to learning.

Abstract:

:Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal receptors is not clear. The aim of the present study was to determine the effect of chronic scopolamine administration on hippocampal receptor expression and spatial working memory in two different learning tasks, the water maze and the eight-arm radial maze. Male rats (8-12 months) were trained in both tasks. Subsequently, different groups received physiological saline or 0.1, 0.8, or 2 mg/kg scopolamine hydrobromide, respectively, for 15 days. After drug administration, the rats were retested for both tasks, and hippocampal expressions of NR2A, NR2B, nAChRα7, and mAChRM1 receptors were assessed by western blotting analysis. In both tasks, the spatial working memory was decreased dose dependently in all groups compared with the control group. In terms of receptor expressions, 0.8 and 2 mg/kg scopolamine administration significantly decreased NR2A protein expression, which corroborates suggestions of an interaction between cholinergic and glutamatergic receptors in the hippocampus.

journal_name

Behav Pharmacol

journal_title

Behavioural pharmacology

authors

Doguc DK,Delibas N,Vural H,Altuntas I,Sutcu R,Sonmez Y

doi

10.1097/FBP.0b013e32835a38af

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

762-70

issue

8

eissn

0955-8810

issn

1473-5849

journal_volume

23

pub_type

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