Modification of the discriminative stimulus effects of 8-OH-DPAT, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-HT(1A) agonist 8-OH-DPAT in the pigeon.

abstract：:Adolescence is one of the most important periods of brain development in mammals. There is increasing evidence that some medicines during this period can affect brain and behavioral functions in adulthood. Silymarin (SM), a mixture of flavonolignans extracted from the milk thistle Silybum marianum, is known as a hepat...

journal_title：Behavioural pharmacology

authors： Kosari-Nasab M,Rabiei A,Doosti MH,Salari AA

更新日期：2014-08-01 00:00:00

abstract：:Relatively little is known about the behavioral effects of the neurosteroids compared with other drugs that modulate the γ-aminobutyric acid A (GABAA) receptor complex. This study examined the acute effects of pregnanolone and dehydroepiandrosterone (DHEA) in male rats responding under a differential-reinforcement-of-...

journal_title：Behavioural pharmacology

authors： Amato RJ,Lewis PB,He H,Winsauer PJ

更新日期：2010-12-01 00:00:00

abstract：:Effects of environmental modulation of methamphetamine (MA)-induced behavior on the establishment and mode of expression of behavioral sensitization were examined. Rats received daily injection of MA for 10 days (1mg/kg, s.c.). Half of them were immediately returned to the home cage (home cage group) and the other hal...

journal_title：Behavioural pharmacology

authors： Ohmori T,Abekawa T,Koyama T

更新日期：1995-03-01 00:00:00

abstract：:The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling fol...

journal_title：Behavioural pharmacology

authors： Bahari Z,Meftahi GH,Meftahi MA

更新日期：2018-10-01 00:00:00

abstract：:There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....

journal_title：Behavioural pharmacology

authors： Babalonis S,Lile JA,Martin CA,Kelly TH

更新日期：2011-09-01 00:00:00

abstract：:Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...

journal_title：Behavioural pharmacology

authors： Alatorre A,Oviedo-Chávez A,Villalobos N,Ríos A,Barrientos R,Querejeta E

更新日期：2015-02-01 00:00:00

abstract：:The pathophysiological role of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone) in neuropsychiatric disorders has been highlighted in several recent investigations. For instance, allopregnanolone levels are decreased in the CSF of patients with post-traumatic stress disorder (PTSD) and major un...

journal_title：Behavioural pharmacology

authors： Pinna G

更新日期：2010-09-01 00:00:00

abstract：:The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

journal_title：Behavioural pharmacology

authors： Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

更新日期：2009-03-01 00:00:00

abstract：:The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participa...

journal_title：Behavioural pharmacology

authors： Tsagareli MG,Nozadze I

更新日期：2020-08-01 00:00:00

abstract：:Individuals with attention-deficit/hyperactivity disorder tend to make risker choices during probabilistic-discounting procedures. Thus, how common attention-deficit/hyperactivity disorder medications affect probabilistic discounting is of interest. In general, d-amphetamine increases risk-taking while atomoxetine has...

journal_title：Behavioural pharmacology

authors： Ozga-Hess JE,Anderson KG

更新日期：2019-10-01 00:00:00

abstract：:We studied the effects of cannabinoids on contextual conditioned fear responses. CB1 knockout and wild-type (CD1) mice were exposed to a brief session of electric shocks, and their behavior was studied in the same context 24 h later. In wild-type mice, shock exposure increased freezing and resting, and decreased locom...

journal_title：Behavioural pharmacology

authors： Mikics E,Dombi T,Barsvári B,Varga B,Ledent C,Freund TF,Haller J

更新日期：2006-05-01 00:00:00

abstract：:The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

journal_title：Behavioural pharmacology

authors： Mariathasan EA,White JA,Stolerman IP

更新日期：1996-08-01 00:00:00

abstract：:Much evidence has shown that the inferior colliculus may be part of a brain system commanding defensive behavior. In the present work, evidence is presented for the serotonergic modulation of the neural substrate of aversive states elaborated in this structure. Rats implanted with a cannula in the inferior colliculus ...

journal_title：Behavioural pharmacology

authors： Melo LL,Brando ML

更新日期：1995-06-01 00:00:00

abstract：:A symposium held at the 50th annual meeting of the Behavioral Pharmacology Society in May 2007 reviewed progress in the human behavioral pharmacology of drug abuse. Studies on drug self-administration in humans are reviewed that assessed reinforcing and subjective effects of drugs of abuse. The close parallels observe...

journal_title：Behavioural pharmacology

authors： Comer SD,Bickel WK,Yi R,de Wit H,Higgins ST,Wenger GR,Johanson CE,Kreek MJ

更新日期：2010-07-01 00:00:00

abstract：:Pineal melatonin secretion occurs at night in all vertebrates and the duration of its secretion is negatively correlated with day length. As short-day exposure was previously shown to decrease emotional behaviour of mice toward an unfamiliar environment, the present study was designed to determine whether such behavio...

journal_title：Behavioural pharmacology

authors： Kopp C,Vogel E,Rettori MC,Delagrange P,Renard P,Lesieur D,Misslin R

更新日期：1999-12-01 00:00:00

abstract：:The purpose of this study was to examine, in healthy volunteers without histories of extensive sedative use, the acute behavioral effects of doses of alprazolam used in clinical applications. Subjects participated in daily sessions over 12 study days. They consumed a standard breakfast, received an oral drug dose (0, ...

journal_title：Behavioural pharmacology

authors： Kelly TH,Foltin RW,Serpick E,Fischman MW

更新日期：1997-02-01 00:00:00

abstract：:Smokers often report that the first cigarette of the day is the most rewarding, and subsequent smoking is less rewarding. Reduction in smoking enjoyment later in the day may be related to acute tolerance to the discriminative stimulus effects of nicotine. We examined changes in nicotine discrimination behaviour in hum...

journal_title：Behavioural pharmacology

authors： Perkins KA,Fonte C,Meeker J,White W,Wilson A

更新日期：2001-02-01 00:00:00

abstract：:Evidence is mounting that prenatal protein malnutrition affects the physiological properties of the GABAergic neurotransmitter system in rats. To investigate the functional behavioral consequences of these changes, chlordiazepoxide (CDP, a positive modulator of the GABA(A) receptor) was applied directly to the medial ...

journal_title：Behavioural pharmacology

authors： Tonkiss J,Trzcińska M,Shultz P,Vincitore M,Galler JR

更新日期：2000-09-01 00:00:00

abstract：:The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather ...

journal_title：Behavioural pharmacology

authors： Maldonado-Irizarry CS,Kelley AE

更新日期：1995-08-01 00:00:00

abstract：:The effects of µ agonists fentanyl, methadone and morphine and kappa agonist U50,488 on behavior maintained by negative reinforcement were determined. Rats were trained on concurrent schedules in which pressing one lever postponed shock on a Sidman avoidance schedule and pressing the other lever produced signaled peri...

journal_title：Behavioural pharmacology

authors： Galizio M,Robinson EG,Ordronneau C

更新日期：1994-04-01 00:00:00

abstract：:We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor. We have hypothesized that reduction of apoptosis in the limbic system can attenuate the depressive behaviour occurring post-MI. The p...

journal_title：Behavioural pharmacology

authors： Bah TM,Kaloustian S,Rousseau G,Godbout R

更新日期：2011-12-01 00:00:00

abstract：:There is clinical and experimental evidence that treatment with immunosuppressive and antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) is associated with mental health problems and neuropsychological disturbances in patients. However, it remains unclear whether and to what extent cognitiv...

journal_title：Behavioural pharmacology

authors： Kahl AL,Kirchhof J,Füting A,Hütter BO,Wilde B,Witzke O,Benson S,Hadamitzky M,Schedlowski M

更新日期：2017-06-01 00:00:00

abstract：:This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...

journal_title：Behavioural pharmacology

authors： Souza AC,Brüning CA,Leite MR,Zeni G,Nogueira CW

更新日期：2010-09-01 00:00:00

abstract：:In the present study, we focused on γ-aminobutyric acid (GABA) signaling through the γ-aminobutyric acid transporter (GAT) in the developing rat cerebral cortex. Tiagabine was used as a GAT inhibitor. The offspring received injections from birth until postnatal day 21 intraperitoneally. Physical development and neurol...

journal_title：Behavioural pharmacology

authors： Shahrokhi A,Hassanzadeh G,Vousooghi N,Joghataei MT,Eftekhari S,Zarrindast MR

更新日期：2013-10-01 00:00:00

abstract：:In previous studies, it was shown that apomorphine-induced stereotyped behaviour could be conditioned when apomorphine was repeatedly paired with sensory stimuli (CS). Since in these experiments, the sum of various sensory stimuli were applied, it seemed of interest to use each sensory stimulus separately in order to ...

journal_title：Behavioural pharmacology

authors： Ferger B,Kuschinsky K

更新日期：1995-01-01 00:00:00

abstract：:Scopolamine has been used in neuropsychopharmacology as a standard drug that leads to symptoms mimicking cognitive deficits seen during the aging process in healthy humans and animals. Scopolamine is known to be a nonselective muscarinic receptor blocker, but its chronic effect on the expression of certain hippocampal...

journal_title：Behavioural pharmacology

authors： Doguc DK,Delibas N,Vural H,Altuntas I,Sutcu R,Sonmez Y

更新日期：2012-12-01 00:00:00

abstract：:Serotonin-selective reuptake inhibitors (SSRIs) have been shown to enhance the locomotor stimulatory, discriminative-stimulus, and convulsive effects of cocaine in rodents. A pharmacokinetic mechanism for the interaction is supported by increases in the brain levels of cocaine by fluoxetine treatment. Furthermore, the...

journal_title：Behavioural pharmacology

authors： Soto PL,Hiranita T,Katz JL

更新日期：2009-12-01 00:00:00

abstract：:Pair-housed, water-deprived rats were trained to run in a two-way shuttle box, using water reinforcement. Animals were tested either singly or in pairs; in the paired condition, the animals were required to shuttle in close physical proximity. Paired performance, but not single performance was severely disrupted by si...

journal_title：Behavioural pharmacology

authors： Willner P,Sampson D,Phillips G,Fichera R,Foxlow P,Muscat R

更新日期：1989-01-01 00:00:00

abstract：:Adult male Wistar rats were bilaterally implanted with indwelling cannulae in the agranular insular cortex of the prefrontal cortex. After recovery, animals were trained in a step-down inhibitory avoidance task (3.0-s, 0.4-mA footshock) and received, immediately after training, a 0.5-microl infusion of the serotonergi...

journal_title：Behavioural pharmacology

authors： Mello e Souza T,Rodrigues C,Souza MM,Vinadé E,Coitinho A,Choi H,Izquierdo I

更新日期：2001-09-01 00:00:00

abstract：:Post-training administration of different doses of baclofen (a GABAB agonist) has been shown to impair memory retention, in a step-down passive avoidance test in mice. We have studied the effects of beta-adrenergic agonists and antagonists on baclofen-induced memory impairment in mice. Dobutamine (a beta 1-agonist) or...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Haidari H,Jafari MR,Djahanguiri B

更新日期：2004-07-01 00:00:00