Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals.

abstract：:The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...

journal_title：Behavioural pharmacology

authors： Baron SP,Wenger GR

更新日期：2001-07-01 00:00:00

abstract：:The present study used the microdialysis technique to investigate the effect of treadmill running, without the use of an electric grid, on extracellular serotonin in the ventral hippocampus of male Lister hooded rat. Extracellular hippocampal serotonin was measured during 60min of treadmill running at 20m/min and comp...

journal_title：Behavioural pharmacology

authors： Wilson WM,Marsden CA

更新日期：1996-01-01 00:00:00

abstract：:The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...

journal_title：Behavioural pharmacology

authors： McPherson S,Howell D,Lewis J,Barbosa-Leiker C,Bertotti Metoyer P,Roll J

更新日期：2016-04-01 00:00:00

abstract：:The effects of µ agonists fentanyl, methadone and morphine and kappa agonist U50,488 on behavior maintained by negative reinforcement were determined. Rats were trained on concurrent schedules in which pressing one lever postponed shock on a Sidman avoidance schedule and pressing the other lever produced signaled peri...

journal_title：Behavioural pharmacology

authors： Galizio M,Robinson EG,Ordronneau C

更新日期：1994-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder classically associated with motor symptoms, but several nonmotor disturbances appear decades before the clinical diagnosis of the disease. A variety of hypotheses exist to explain the onset of PD, and neuroinflammation is one of the most investigated processes. ...

journal_title：Behavioural pharmacology

authors： Rodrigues LS,Fagotti J,D S Targa A,D Noseda AC,L Ilkiwa J,Chuproski AP,W C Dorieux F,D Dos Santos P,M S Lima M

更新日期：2019-12-01 00:00:00

abstract：:The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohe...

journal_title：Behavioural pharmacology

authors： Willetts J,Rice A,Balster RL

更新日期：1990-01-01 00:00:00

abstract：:Previous data indicate that ethanol intoxication (3 g/kg, intragastric) on postnatal day (PD) 7 and 8 increases ethanol acceptance, but on PD 10 and 11 generates an aversion in infant rats. We investigated the participation of the opioid system in these effects. Subcutaneous administration of naloxone (1 or 10 mg/kg) ...

journal_title：Behavioural pharmacology

authors： Gabriela Chotro M,Arias C

更新日期：2007-11-01 00:00:00

abstract：:The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1992-12-01 00:00:00

abstract：:The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

更新日期：1997-11-01 00:00:00

abstract：:The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and...

journal_title：Behavioural pharmacology

authors： Gris G,Merlos M,Vela JM,Zamanillo D,Portillo-Salido E

更新日期：2014-06-01 00:00:00

abstract：:A previous study from this laboratory reported an antiaversive effect of the beta-adrenoceptor blocker propranolol microinjected into the dorsal periaqueductal grey (DPAG) of the rat, that was antagonized by the 5-HT(2) receptor blocker ritanserin. The present results show that microinjection into the DPAG of isamolta...

journal_title：Behavioural pharmacology

authors： Nogueira RL,Graeff FG

更新日期：1991-02-01 00:00:00

abstract：:We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor. We have hypothesized that reduction of apoptosis in the limbic system can attenuate the depressive behaviour occurring post-MI. The p...

journal_title：Behavioural pharmacology

authors： Bah TM,Kaloustian S,Rousseau G,Godbout R

更新日期：2011-12-01 00:00:00

abstract：:Alcohol consumption acutely increases smoking behavior, but the reverse relationship, the acute effects of smoking on alcohol intake, largely has been ignored. We examined whether smoking acutely increases the reinforcing value of alcohol, first in the absence of recent alcohol intake and then following an alcohol pre...

journal_title：Behavioural pharmacology

authors： Perkins KA,Fonte C,Grobe JE

更新日期：2000-02-01 00:00:00

abstract：:Neonatal ventral hippocampal lesions in the rat result in post-pubertal onset of behavioural abnormalities, modelling some aspects of schizophrenia. We further assessed the behavioural effects of neonatal lesions in rats in a variety of cognitive tasks and in the prepulse inhibition (PPI) of startle response paradigm....

journal_title：Behavioural pharmacology

authors： Le Pen G,Grottick AJ,Higgins GA,Martin JR,Jenck F,Moreau JL

更新日期：2000-06-01 00:00:00

abstract：:Current concepts of basal ganglia function have evolved from the essentially motoric, to include a range of extramotoric functions that involve not only dopaminergic but also cholinergic, γ-aminobutyric acid (GABA)ergic and glutamatergic mechanisms. We consider these mechanisms and their efferent systems, including sp...

journal_title：Behavioural pharmacology

authors： Ikeda H,Adachi K,Fujita S,Tomiyama K,Saigusa T,Kobayashi M,Koshikawa N,Waddington JL

更新日期：2015-02-01 00:00:00

abstract：:To investigate the role of the nucleus accumbens core (NAc) in the development of quinpirole-induced compulsive checking, rats received an excitotoxic lesion of NAc or sham lesion and were injected with quinpirole (0.5 mg/kg) or saline; development of checking behavior was monitored for 10 biweekly tests. The results ...

journal_title：Behavioural pharmacology

authors： Ballester González J,Dvorkin-Gheva A,Silva C,Foster JA,Szechtman H

更新日期：2015-02-01 00:00:00

abstract：:This study was designed to compare the reinforcing efficacy of PCP (phencyclidine:phenylcyclohexyl-piperidine) and the PCP-derivatives BTCP (N-[1-(2-benzo(b)thiophenyl) cyclohexyl]piperidine) and TCP (N-[1-(2-thienyl)cyclohexyl]-piperidine) to that of cocaine, using a progressive ratio schedule of reinforcement (PR). ...

journal_title：Behavioural pharmacology

authors： French ED,Lopez M,Peper S,Kamenka JM,Roberts DC

更新日期：1995-04-01 00:00:00

abstract：:The recent recreational use of synthetic cannabinoid ligands, collectively referred to as 'Spice', has raised concerns about their safety and possible differences in their biological effect(s) from marijuana/Δ-tetrahydrocannabinol (THC). AM2201, a highly efficacious, potent cannabinoid receptor 1 (CB1R) agonist, is a ...

journal_title：Behavioural pharmacology

authors： Järbe TU,Gifford RS,Zvonok A,Makriyannis A

更新日期：2016-04-01 00:00:00

abstract：:These studies investigated the role of serotonin-1A (5-HT1A) and 5-HT2A receptors in the behavioral effects of dipropyltryptamine (DPT). Eight rats discriminated 0.56 mg/kg 2,5-dimethoxy-4-methylamphetamine (DOM) from saline and responded under a fixed ratio 5 schedule of food presentation; 12 other rats were used for...

journal_title：Behavioural pharmacology

authors： Li JX,Rice KC,France CP

更新日期：2007-07-01 00:00:00

abstract：:Environmental and situational factors are important determinants of recreational drug use in humans. We aimed to develop a reliable animal model for studying the effects of environmental variables on drug-seeking behavior using the 'social isolation/social restriction' paradigm. Adult Wistar rats housed in short-term ...

journal_title：Behavioural pharmacology

authors： Raz S,Berger BD

更新日期：2010-02-01 00:00:00

abstract：:Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...

journal_title：Behavioural pharmacology

authors： Alatorre A,Oviedo-Chávez A,Villalobos N,Ríos A,Barrientos R,Querejeta E

更新日期：2015-02-01 00:00:00

abstract：:We studied the effects of cannabinoids on contextual conditioned fear responses. CB1 knockout and wild-type (CD1) mice were exposed to a brief session of electric shocks, and their behavior was studied in the same context 24 h later. In wild-type mice, shock exposure increased freezing and resting, and decreased locom...

journal_title：Behavioural pharmacology

authors： Mikics E,Dombi T,Barsvári B,Varga B,Ledent C,Freund TF,Haller J

更新日期：2006-05-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter and functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a prominent role in regulating various types of psychological processes and functions, including mood and emotion, particularly anxiety, but also in regu...

journal_title：Behavioural pharmacology

authors： Wöhr M,van Gaalen MM,Schwarting RK

更新日期：2015-09-01 00:00:00

abstract：:The prefrontal cortex (PFC) plays a critical role in mediating executive functions and orchestrating the way in which we think, decide, and behave. Many studies have shown that PFC neurons not only play a major role in mediating behavioral responses to stress but are also sensitive to stress and undergo remodeling fol...

journal_title：Behavioural pharmacology

authors： Bahari Z,Meftahi GH,Meftahi MA

更新日期：2018-10-01 00:00:00

abstract：:Separate groups of rats were trained to discriminate either 0.1mg/kg (low dose; L) or 2.5mg/kg (high dose; H) of 8-OH-DPAT from saline, in a standard operant task. Both cues were found to be dose, time and route dependent and generalized completely to the 5-HT(1A) agonists ipsapirone and flesinoxan. Buspirone substitu...

journal_title：Behavioural pharmacology

authors： Ybema CE,Slangen JL,Olivier B,Mos J

更新日期：1993-12-01 00:00:00

abstract：:The impact of training dose on the characteristics of a discrimination maintained by a mixture of two dissimilar drugs has been investigated in order to refine this approach to the study of drug interactions. Three groups of rats (n = 10) were trained to discriminate mixtures of (+)-amphetamine (0.2-0.8mg/kg) plus pen...

journal_title：Behavioural pharmacology

authors： Mariathasan EA,White JA,Stolerman IP

更新日期：1996-08-01 00:00:00

abstract：:The stimulus control by morphine under a fixed-interval (FI) 180-s schedule of reinforcement was examined in five pigeons trained to discriminate 5.0mg/kg of i.m. morphine from saline. After training, dose-response relationships were determined for morphine, d-amphetamine, pentobarbital, fentanyl, and MK-801. At low d...

journal_title：Behavioural pharmacology

authors： Massey BW,McMillan DE,Wessinger WD

更新日期：1992-10-01 00:00:00

abstract：:Behavioural sensitization to the locomotor stimulant effect of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Once established, endogenous dopamine release (DA) was measured in slices containing nucleus accumbens using fast cyclic voltammetry. DA release induced by single pulse ...

journal_title：Behavioural pharmacology

authors： Muscat R,Patel J,Trout SJ,Wieczorek W,Kruk ZL

更新日期：1993-01-01 00:00:00

abstract：:Acute (10mg/kg, i.p.) and chronic (10mg/kg/day, i.p. for 10 days) diazepam treatments decreased hippocampal dialysate 5-HT (but not 5-HIAA) concentrations in freely moving rats, suggesting decreased availability of 5-HT to receptors. Twenty-four hours after the last chronic diazepam injection, hippocampal dialysate 5-...

journal_title：Behavioural pharmacology

authors： Gibson EL,Barnfield AM,Curzon G

更新日期：1996-03-01 00:00:00

abstract：:Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageous substi...

journal_title：Behavioural pharmacology

authors： Rawls SM,Patil T,Yuvasheva E,Raffa RB

更新日期：2010-07-01 00:00:00