Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson's disease in experimental animals.

abstract：:We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fea...

journal_title：Behavioural pharmacology

authors： Pickens CL,Theberge FR

更新日期：2014-02-01 00:00:00

abstract：:The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse ...

journal_title：Behavioural pharmacology

authors： Bond RA,Giles H

更新日期：2011-09-01 00:00:00

abstract：:Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

journal_title：Behavioural pharmacology

authors： Kos T,Popik P

更新日期：2005-05-01 00:00:00

abstract：:The effects of d-amphetamine, chlorpromazine and pentobarbital on single alternation were compared in mice and rats. Chlorpromazine and d-amphetamine produced dose-related decreases in both accuracy and rate of responding with no differences in species sensitivity. Pentobarbital also produced dose-dependent decreases ...

journal_title：Behavioural pharmacology

authors： Donald JM,McMillan DE

更新日期：1990-01-01 00:00:00

abstract：:There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher suscepti...

journal_title：Behavioural pharmacology

authors： Morais LH,Felice D,Golubeva AV,Moloney G,Dinan TG,Cryan JF

更新日期：2018-04-01 00:00:00

abstract：:There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....

journal_title：Behavioural pharmacology

authors： Babalonis S,Lile JA,Martin CA,Kelly TH

更新日期：2011-09-01 00:00:00

abstract：:In a modified light-dark exploration test in mice, 5-hydroxytryptophan, at doses (25-50 mg/kg) that approximately doubled the 5-HT content in the cerebral cortex, reduced the time spent by mice in the white compartment, suggesting an anxiogenic effect. Depletion of brain 5-HT content with p-chlorophenylalanine (300 mg...

journal_title：Behavioural pharmacology

authors： Artaiz I,Zazpe A,Del Río J

更新日期：1998-03-01 00:00:00

abstract：:The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25, and 0.5 mg/70 kg) and the imidazopyridine hypnotic zolpidem (5, 10, and 20 mg/70 kg) were compared in 11 volunteers, in a double-blind, placebo-controlled, crosso...

journal_title：Behavioural pharmacology

authors： Mintzer MZ,Frey JM,Yingling JE,Griffiths RR

更新日期：1997-11-01 00:00:00

abstract：:A range of selective dopamine D1 and D2 receptor agonists and antagonists was used to characterize to the discriminative stimuli produced by d-amphetamine (0.5mg/kg) and the D1 agonists SKF 81297 (0.1mg/kg). In rats trained to discriminate d-amphetamine (0.5mg/kg) from saline, d-amphetamine produced a dose-related inc...

journal_title：Behavioural pharmacology

authors： Reavill C,B Bond,Overend P,Hunter AJ

更新日期：1993-04-01 00:00:00

abstract：:Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

journal_title：Behavioural pharmacology

authors： Glautier S,Rigney U,Willner P

更新日期：2001-04-01 00:00:00

abstract：:The behaviour of rats in a novel environment was studied using a rapid time-sampling observation procedure followed by a principal component analysis (PCA) of the data. This approach revealed that novel environment behaviour can be described by two factors or principal components. The first factor comprised rearing, s...

journal_title：Behavioural pharmacology

authors： Exner M,Clark D

更新日期：1993-02-01 00:00:00

abstract：:Phencyclidine (PCP) can induce a model psychosis in humans that mimics the positive and negative symptoms of schizophrenia. The purpose of the present study was to determine whether PCP can induce similar behavioural effects in rats and whether these effects can be alleviated by neuroleptic drug treatment. Rats were t...

journal_title：Behavioural pharmacology

authors： Sams-Dodd F

更新日期：1996-01-01 00:00:00

abstract：:Intact and gonadectomized male and female rats pressed a lever to obtain food on different fixed-ratio (FR) schedules in a three-component multiple schedule. The values of a small, intermediate and large FR schedule were individually determined and were higher for intact male rats than for most subjects in the other g...

journal_title：Behavioural pharmacology

authors： van Haaren F,Anderson KG

更新日期：1994-10-01 00:00:00

abstract：:The behavioural effects of six compounds with N-methyl-D-aspartate (NMDA) antagonist properties were compared on the responding of rats maintained by a differential reinforcement of low rate 15s (DRL-15s) schedule. This schedule requires that responses be temporally spaced in order to be reinforced (timing behaviour)....

journal_title：Behavioural pharmacology

authors： Sanger DJ

更新日期：1992-12-01 00:00:00

abstract：:The role of dopamine (DA) receptors in the expression of opioid dependence was examined by use of an unbiased conditioned place preference paradigm. Male Sprague-Dawley rats were implanted s.c. with two pellets containing placebo or 75mg morphine. Animals received one conditioning session with saline and one with the ...

journal_title：Behavioural pharmacology

authors： Funada M,Shippenberg TS

更新日期：1996-10-01 00:00:00

abstract：:Glutamate, an excitatory neurotransmitter in the brain, produces excitotoxicity through its agonistic action on postsynaptic N-methyl-D-aspartate receptor, resulting in neurodegeneration. We hypothesized that the administration of low doses of glutamate in cerebral ischemia could attenuate the excitotoxicity in neuron...

journal_title：Behavioural pharmacology

authors： Ramanathan M,Abdul KK,Justin A

更新日期：2016-10-01 00:00:00

abstract：:The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohe...

journal_title：Behavioural pharmacology

authors： Willetts J,Rice A,Balster RL

更新日期：1990-01-01 00:00:00

abstract：:A large body of data suggests that potassium channels may play an important role in learning and memory. Previous in-vitro research in a number of species including Hermissenda and the rabbit suggests that a 4-aminopyridine-sensitive transient potassium channel may be involved in classical conditioning. We investigate...

journal_title：Behavioural pharmacology

authors： Wang D,Darwish DS,Schreurs BG

更新日期：2006-06-01 00:00:00

abstract：:The technique of microdialysis was employed to investigate in vivo 5-hydroxytryptamine (5-HT) release in isolation-reared rats compared with socially reared rats. Two methods were employed to stimulate 5-HT release: local KCI injection into the frontal cortex of chloral hydrate anaesthetized rats, and the exposure of ...

journal_title：Behavioural pharmacology

authors： Bickerdike MJ,Wright IK,Marsden CA

更新日期：1993-06-01 00:00:00

abstract：:Dopamine receptors are implicated in the reinforcing effects of food and drug reinforcement. The purpose of this study was to evaluate whether blocking D2 dopamine receptors during extinction (secondary reinforcement) would affect reacquisition of responding for food pellets (primary reinforcement). Food-restricted ra...

journal_title：Behavioural pharmacology

authors： Koerber J,Goodman D,Barnes JL,Grimm JW

更新日期：2013-12-01 00:00:00

abstract：:Sensorimotor gating disruptions are seen in various psychiatric illnesses with putatively different pathologies, including schizophrenia and bipolar disorder. Interestingly, mice lacking the dopamine (DA) transporter (DAT) gene display markedly increased levels of DA, deficits in sensorimotor gating, and hyperactivity...

journal_title：Behavioural pharmacology

authors： Powell SB,Young JW,Ong JC,Caron MG,Geyer MA

更新日期：2008-09-01 00:00:00

abstract：:Both depression and cancer are related to a dysregulation of inflammatory and immune pathways. Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α). In contrast, reductions of the activity of major histocompatibility complex protein molecules -...

journal_title：Behavioural pharmacology

authors： Barreto FS,Chaves Filho AJM,de Araújo MCCR,de Moraes MO,de Moraes MEA,Maes M,de Lucena DF,Macedo DS

更新日期：2018-04-01 00:00:00

abstract：:Although the role of genetic factors in the response to drugs of abuse has been emphasized, no earlier studies have applied selective breeding to intravenous drug self-administration. Here we report the effects of six generations of selective breeding for rat lines with low or high levels of intravenous drug self-admi...

journal_title：Behavioural pharmacology

authors： He S,Yang Y,Mathur D,Grasing K

更新日期：2008-12-01 00:00:00

abstract：:Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...

journal_title：Behavioural pharmacology

authors： Alatorre A,Oviedo-Chávez A,Villalobos N,Ríos A,Barrientos R,Querejeta E

更新日期：2015-02-01 00:00:00

abstract：:Individuals with attention-deficit/hyperactivity disorder tend to make risker choices during probabilistic-discounting procedures. Thus, how common attention-deficit/hyperactivity disorder medications affect probabilistic discounting is of interest. In general, d-amphetamine increases risk-taking while atomoxetine has...

journal_title：Behavioural pharmacology

authors： Ozga-Hess JE,Anderson KG

更新日期：2019-10-01 00:00:00

abstract：:An individual's susceptibility to psychological and physical disorders associated with chronic stress exposure, for example, cardiovascular and infectious disease, may also be predicted by their reactivity to acute stress. One factor associated with both stress resilience and health outcomes is personality. An underst...

journal_title：Behavioural pharmacology

authors： Childs E,White TL,de Wit H

更新日期：2014-09-01 00:00:00

abstract：:Drug withdrawal is often conceptualized as an aversive state that motivates drug-seeking and drug-taking behaviors in humans. Stress is more difficult to define, but is also frequently associated with aversive states. Here we describe evidence for the simple theory that drug withdrawal is a stress-like state, on the b...

journal_title：Behavioural pharmacology

authors： Chartoff EH,Carlezon WA Jr

更新日期：2014-09-01 00:00:00

abstract：:Few studies have investigated the effects of chronic cannabinoid exposure on memory performance and whether tolerance occurs to cannabinoid-induced memory impairment. Here, we studied the effects of repeated exposure to Delta-tetrahydrocannabinol (THC: 1 mg/kg) on spatial memory and zif268 expression in mice. One grou...

journal_title：Behavioural pharmacology

authors： Boucher AA,Vivier L,Metna-Laurent M,Brayda-Bruno L,Mons N,Arnold JC,Micheau J

更新日期：2009-02-01 00:00:00

abstract：:This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2003-11-01 00:00:00

abstract：:In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...

journal_title：Behavioural pharmacology

authors： Zarrindast MR,Jafari MR,Shafaghi B,Djahanguiri B

更新日期：2004-03-01 00:00:00