Abstract:
:Parkinson's disease (PD) is a neurodegenerative disorder classically associated with motor symptoms, but several nonmotor disturbances appear decades before the clinical diagnosis of the disease. A variety of hypotheses exist to explain the onset of PD, and neuroinflammation is one of the most investigated processes. In fact, strong evidence suggests that PD begins with an inflammatory process; currently, however, no anti-inflammatory therapy is clinically employed to alleviate the typical motor and the prodromal disturbances such as olfactory loss, cognitive impairments, depression and anxiety, sleep disturbances, and autonomic disorders. In fact, the classical dopaminergic therapies are not effective in alleviating these symptoms and there is no other specific therapy for these outcomes. Therefore, in this review, we will discuss novel potential pharmacological therapeutic strategies focusing on cannabinoids, caffeine, melatonin, and dietary compounds, which could act as adjuvants to regular PD therapy. These described chemicals have been extensively investigated as anti-inflammatory agents possibly promoting beneficial effects on nonmotor symptoms of PD. The investigation of the inflammatory process at different stages of PD progression should give us a better view of the therapeutic scenario and could improve our understanding of the mechanisms of this disease.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
Rodrigues LS,Fagotti J,D S Targa A,D Noseda AC,L Ilkiwa J,Chuproski AP,W C Dorieux F,D Dos Santos P,M S Lima Mdoi
10.1097/FBP.0000000000000512subject
Has Abstractpub_date
2019-12-01 00:00:00pages
676-688issue
8eissn
0955-8810issn
1473-5849pii
00008877-201912000-00008journal_volume
30pub_type
杂志文章,评审abstract::Insufficient research has been carried out on the effects of repeated treatments with psychostimulants on agonistic behaviour. These effects were studied in mice using different schedules of administration and employing a low dose of amphetamine (1.5 mg/kg) which did not produce significant motor disruptions. After tw...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199708000-00004
更新日期:1997-08-01 00:00:00
abstract::Opioid-maintained volunteers were trained to distinguish between a low dose of the opioid antagonist naloxone (0.15 mg/70 kg, i.m.; i.e. Drug A) and placebo (i.e. Drug B), under an instructed novel-response drug discrimination procedure in which subjects identify the drug condition as 'A', 'B', or 'N' (neither A nor B...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00008877-200303000-00001
更新日期:2003-03-01 00:00:00
abstract::Tolerance develops to the cardiovascular and subjective effects of intravenous cocaine during single self-administration sessions, but diminishes within 3 h after the session ends. To examine whether a similar pattern of tolerance occurs to smoked cocaine, seven adult 'crack' cocaine users completed a protocol investi...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章
doi:10.1097/00008877-199712000-00009
更新日期:1997-12-01 00:00:00
abstract::There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher suscepti...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000374
更新日期:2018-04-01 00:00:00
abstract::This study examined effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 in an assay of pain-related behavioral depression. Adult, male Sprague-Dawley rats responded for electrical brain stimulation in a frequency-rate intracranial self-stimulation (ICSS) procedure. Intraperito...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000464
更新日期:2019-08-01 00:00:00
abstract::The present experiments investigated the effects of excitatory amino acid antagonists, infused into core and shell subregions of the nucleus accumbens, on spatial behavior in the rat. A food-search task was used, in which animals learn a specific pattern of food gathering; duration of each trial (time taken to gather ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199911000-00015
更新日期:1999-11-01 00:00:00
abstract::In spite of the current availability of several pharmacological therapies for the treatment of Parkinson's disease, side effects are invariably manifested during long-term treatment. Dyskinesia, wearing-off and on-off are among the most disabling side effects produced by the dopamine precursor L-dihydroxyphenylalanine...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/00008877-200609000-00005
更新日期:2006-09-01 00:00:00
abstract::The aim of this study was to investigate the effects of a mixed dietary intervention on behavioral symptoms in serotonin transporter knockout (5-HTT⁻/⁻) rats modeling the human 5-HTT length polymorphic region short-allele. Twenty female 5-HTT⁻/⁻ and 19 wild-type (5-HTT⁺/⁺) rats were fed for 3 months on a mixed polyuns...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e328347881b
更新日期:2011-08-01 00:00:00
abstract::There is a considerable degree of individual vulnerability for alcohol use disorder (AUD) as only a subpopulation of individuals who regularly consume alcohol develop AUD. It is therefore very important to understand the factors and mechanisms that contribute towards the individual risk for AUD. In this respect, socia...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000165
更新日期:2015-10-01 00:00:00
abstract::A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK & F 38393, reduced food consumption in rats and mice. The aim of this study was to undertake a microstructural analys...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by scopolamine, a muscarinic antagonist, using the Y-maze and Morris water maze tests in mice. One hour before the tests, mice were treated with (PhSe)2 (50 mg/kg, oral) and 30 min later memory i...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833befcf
更新日期:2010-09-01 00:00:00
abstract::A runway was used to measure locomotor responses to quinpirole (200µg/kg), in rats. The locomotor stimulant effect of quinpirole increased progressively over successive trials at 3-day intervals. Animals administered quinpirole in the home cage were also sensitized, but to a lesser degree than animals tested in the ru...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199203010-00007
更新日期:1992-02-01 00:00:00
abstract::Twenty male Wistar rats were trained under an alternating-lever cyclic-ratio (ALCR) schedule of food reinforcement. When responding showed no trends, each subject was subcutaneously implanted with an Alzet osmotic mini-pump, connected to a chronic indwelling cannula extending into the lateral ventricle of the brain. T...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/01.fbp.0000179278.03868.96
更新日期:2005-11-01 00:00:00
abstract::In a step-down passive avoidance task, the pre-training injection of 1.25-10 mg/kg of morphine impaired memory. This was restored when injection of the same dose of morphine (pre-test treatment) was repeated 24 h later (morphine state-dependent learning: morphine St-D). ATP-dependent potassium (K(ATP)) channels have b...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200403000-00002
更新日期:2004-03-01 00:00:00
abstract::This study assessed whether access to a sweet solution in the home cage could change sensitivity to cocaine, using a drug discrimination procedure. Rats were trained to discriminate 10 mg/kg cocaine from saline. After acquisition, rats were tested with a cumulative dose-response procedure (0-18 mg/kg) for 12 consecuti...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833a5bdf
更新日期:2010-05-01 00:00:00
abstract::Drug-addicted individuals show high levels of impulsive choice, characterized by preference for small immediate over larger but delayed rewards. Although the causal relationship between chronic drug use and elevated impulsive choice in humans has been unclear, a small but growing body of literature over the past decad...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3283305eb4
更新日期:2009-09-01 00:00:00
abstract::Dopamine receptors are implicated in the reinforcing effects of food and drug reinforcement. The purpose of this study was to evaluate whether blocking D2 dopamine receptors during extinction (secondary reinforcement) would affect reacquisition of responding for food pellets (primary reinforcement). Food-restricted ra...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000002
更新日期:2013-12-01 00:00:00
abstract::It has been reported that, in animals trained to discriminate ethanol, stimulus control generalized to the non-competitive NMDA antagonists phencyclidine, ketamine and dizocilpine. In the present study, rats were trained to discriminate a dose of ethanol (1g/kg, i.p.) and substitution tests were carried out with phenc...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Flavonoids are natural substances obtained from plants. Most flavonoids cross the blood-brain barrier and exert a wide range of effects on the central nervous system. These actions have been attributed to the modulation of GABA-A receptors. Although motor systems in the central nervous system express a high density of...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000100
更新日期:2015-02-01 00:00:00
abstract::The recent recreational use of synthetic cannabinoid ligands, collectively referred to as 'Spice', has raised concerns about their safety and possible differences in their biological effect(s) from marijuana/Δ-tetrahydrocannabinol (THC). AM2201, a highly efficacious, potent cannabinoid receptor 1 (CB1R) agonist, is a ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000196
更新日期:2016-04-01 00:00:00
abstract::Methoxetamine (MXE) is a chemical analogue of ketamine. Originally proposed as a ketamine-like fast-acting antidepressant, owing to similar N-methyl-D-aspartate blocker properties, it is now scheduled for reports of hallucinations and psychosis similar to ketamine and lysergic acid. As little is known about the addict...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000221
更新日期:2016-04-01 00:00:00
abstract::The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate-decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chroni...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199909000-00012
更新日期:1999-09-01 00:00:00
abstract::Relatively little is known about the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in extinction of appetitively motivated tasks. The benzodiazepine (BZ) chlordiazepoxide (CDP) was administered during extinction and re-acquisition of lever pressing by mice following food reinforced discrete-tr...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::Drugs that increase monoamine neurotransmission are effective in both anxiety and depression. The therapeutic effects of monoamine-based antidepressant drugs may involve indirect effects on neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPAR). Thus, chronic antidep...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000243
更新日期:2016-09-01 00:00:00
abstract::The effects of the competitive NMDA antagonists, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626) and 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP), were compared to those of the noncompetitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10, 11-dihydro-5H-dibenzo (a,d) cyclohe...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::The purpose of this experiment was to examine the substitution patterns produced by opioids with activity at the mu receptor in pigeons trained to discriminate the delta opioid BW373U86 from saline. A low dose of naltrindole (0.1 mg/kg) produced at least a 16-fold rightward shift in the dose-effect curve for the stimu...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::The effects on memory of drugs of abuse from several pharmacological classes were examined in four adult male squirrel monkeys responding under a delayed matching-to-sample schedule of food presentation. Subjects were required to emit 20 responses on a sample key transilluminated by either a constant white or a flashi...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200107000-00003
更新日期:2001-07-01 00:00:00
abstract::The objective of this experiment was to evaluate the comparative value of cigarettes versus high dose e-cigarettes among nicotine-dependent cigarette smokers when compared with money or use of their usual cigarette brand. The experiment used a within-subject design with four sessions. After baseline assessment, partic...
journal_title:Behavioural pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1097/FBP.0000000000000226
更新日期:2016-04-01 00:00:00
abstract::Baclofen has shown promise in treating substance use disorders and also reduced binge frequency in an open-label trial. This placebo-controlled, double-blind, crossover study further assessed the effects of baclofen on binge eating. Twelve individuals who self-reported binge eating completed the study. Data were colle...
journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/FBP.0b013e328357bd62
更新日期:2012-09-01 00:00:00