Abstract:
:This study was designed to compare the reinforcing efficacy of PCP (phencyclidine:phenylcyclohexyl-piperidine) and the PCP-derivatives BTCP (N-[1-(2-benzo(b)thiophenyl) cyclohexyl]piperidine) and TCP (N-[1-(2-thienyl)cyclohexyl]-piperidine) to that of cocaine, using a progressive ratio schedule of reinforcement (PR). On the PR schedule the number of responses required to obtain an i.v. infusion of drug was escalated with each injection until a breaking point was reached when the animal stopped responding. Since BTCP has an affinity for the DA uptake site comparable to that of cocaine, it was hypothesized that BTCP and cocaine would show similar patterns of self-administration and comparable breaking points. In contrast, the high affinity of TCP and PCP for the NMDA-ion channel complex suggested that these two compounds would also support comparable self-administration behaviors. Rats were trained to self-administer i.v. cocaine during daily 5h sessions under a fixed-ratio-1 (FR1) schedule. Once consistent lever-pressing behavior was established, BTCP, PCP or TCP was substituted for cocaine. Under the FRI schedule, BTCP elicited a regular pattern of lever pressing, unlike PCP and TCP. However, under the PR schedule BTCP elicited breaking points comparable to those produced by equivalent doses of cocaine, whereas TCP and PCP produced considerably lower breaking points. These results suggest that BTCP has comparable rewarding properties to that of cocaine, and that like those of cocaine they are most probably mediated through a site of action at the DA transporter. In contrast, the relatively weak reinforcing efficacy of PCP and TCP would correlate better with their primary site of action on the PCP binding site within the NMDA-ion channel complex.
journal_name
Behav Pharmacoljournal_title
Behavioural pharmacologyauthors
French ED,Lopez M,Peper S,Kamenka JM,Roberts DCsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
223-228issue
3eissn
0955-8810issn
1473-5849journal_volume
6pub_type
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0000000000000284
更新日期:2017-04-01 00:00:00
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journal_title:Behavioural pharmacology
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pub_type: 杂志文章
doi:10.1097/FBP.0000000000000020
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
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journal_title:Behavioural pharmacology
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doi:10.1097/FBP.0000000000000064
更新日期:2014-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e3282d9e9f9
更新日期:2007-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-200211000-00001
更新日期:2002-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199406000-00008
更新日期:1994-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199404000-00003
更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/FBP.0000000000000129
更新日期:2015-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199909000-00012
更新日期:1999-09-01 00:00:00
abstract::The involvement of adrenoreceptor blocking drugs with the 5-HT(1A)-mediated discriminative stimulus was studied in pigeons trained to discriminate the 5-HT(1A) receptor agonist 8-OH-DPAT (0.3mg/kg) from saline. Cumulative dose-response curves were determined for 8-OH-DPAT, the beta-adrenergic antagonist pindolol, the ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199506000-00012
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journal_title:Behavioural pharmacology
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pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e3282df3cde
更新日期:2007-09-01 00:00:00
abstract::Rats were trained on a three-panel runway task prior to injections of N-methyl-D-aspartate (NMDA; 40nmoles/µl/side) into the dorsal hippocampus. One week after the treatment, animals did not show any change in the number of errors on the first runway trial (reference memory), with one correct white and two incorrect b...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::The purpose of the present experiment was to assess the degree of tolerance and cross-tolerance to the response rate-decreasing effects of opioids with different degrees of intrinsic efficacy at the mu receptor. The mu opioids included buprenorphine, etorphine, l-methadone, morphine, and sufentanil. Lever pressing of ...
journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0000000000000350
更新日期:2018-06-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/00008877-199812000-00006
更新日期:1998-12-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章,评审
doi:10.1097/FBP.0b013e32833d8ba0
更新日期:2010-09-01 00:00:00
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journal_title:Behavioural pharmacology
pub_type: 杂志文章
doi:10.1097/FBP.0b013e32833befcf
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00