Drug withdrawal conceptualized as a stressor.

abstract：:Intact and gonadectomized male and female rats pressed a lever to obtain food on different fixed-ratio (FR) schedules in a three-component multiple schedule. The values of a small, intermediate and large FR schedule were individually determined and were higher for intact male rats than for most subjects in the other g...

journal_title：Behavioural pharmacology

authors： van Haaren F,Anderson KG

更新日期：1994-10-01 00:00:00

abstract：:Opioid-maintained volunteers were trained to distinguish between a low dose of the opioid antagonist naloxone (0.15 mg/70 kg, i.m.; i.e. Drug A) and placebo (i.e. Drug B), under an instructed novel-response drug discrimination procedure in which subjects identify the drug condition as 'A', 'B', or 'N' (neither A nor B...

journal_title：Behavioural pharmacology

authors： Oliveto A,Sevarino K,McCance-Katz E,Benios T,Poling J,Feingold A

更新日期：2003-03-01 00:00:00

abstract：:A core symptom of human depressive disorder is anhedonia, the loss of interest or pleasure in daily activities. Anhedonia, measured as subsensitivity to reward, can be induced in rats by a regimen of repeated, mild, unpredictable stressors. Here, the hedonic state of rats was assessed using an intracranial self-stimul...

journal_title：Behavioural pharmacology

authors： Moreau JL,Scherschlicht R,Jenck F,Martin JR

更新日期：1995-11-01 00:00:00

abstract：:Benzodiazepines are generally reported to be active in tests based on punished responding and in procedures involving exploratory behaviour, but the effects of 5-HT drugs thus far reported are inconsistent. The effects of the two 5-HT(1A) agonists 8-OH-DPAT and buspirone were studied in a passive avoidance test and in...

journal_title：Behavioural pharmacology

authors： Klint T

更新日期：1991-12-01 00:00:00

abstract：:Behavioral flexibility or 'set-shifting' refers to the ability to modify ongoing behavior in response to changing goals or environmental contingencies. Impaired behavioral flexibility is associated with disorders such as schizophrenia and addiction. Hypofunction of N-methyl-D-aspartate (NMDA) receptors has been implic...

journal_title：Behavioural pharmacology

authors： Darrah JM,Stefani MR,Moghaddam B

更新日期：2008-05-01 00:00:00

abstract：:Memantine (1-amino-3,5-dimethyl-adamantane) is the only clinically used NMDA (N-methyl-D-aspartate) glutamate receptor antagonist. The present experiments were carried out to compare the dose-response for memantine's predictive therapeutic and side-effects in a variety of tests in C57BL/6J/Han mice, and to elucidate i...

journal_title：Behavioural pharmacology

authors： Kos T,Popik P

更新日期：2005-05-01 00:00:00

abstract：:Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined wheth...

journal_title：Behavioural pharmacology

authors： Jung TD,Jung PS,Raveendran L,Farbod Y,Dvorkin-Gheva A,Sakic B,Surette MG,Szechtman H

更新日期：2018-04-01 00:00:00

abstract：:The dopamine D3/D2 receptor agonists 7-OH-DPAT, quinpirole, quinelorane, and PD128907, the mixed dopamine agonist apomorphine, the D2 agonist bromocriptine, and the D1/D5 agonist SKF38393 were examined in models of hypothermia and prepulse inhibition (PPI) in Wistar rats. As dopamine agonist-induced hypothermia has be...

journal_title：Behavioural pharmacology

authors： Varty GB,Higgins GA

更新日期：1998-09-01 00:00:00

abstract：:Altered motivation for drugs of abuse is a central feature of most definitions of drug dependence and the impact of drug-related cues on motivation is of current interest. However, since most studies of cue-reactivity have not used behavioural measures of motivation, their results are often difficult to interpret in m...

journal_title：Behavioural pharmacology

authors： Glautier S,Rigney U,Willner P

更新日期：2001-04-01 00:00:00

abstract：:Ultrasonic vocalizations are widely used to examine affective states in rats, yet relatively few studies explore the acoustic features of vocalizations, especially in relation to drug exposure, and no studies have explored alterations in acoustic features over time. The goal of this study was to examine nicotine- and ...

journal_title：Behavioural pharmacology

authors： Swalve N,Mulholland MM,Li M

更新日期：2019-08-01 00:00:00

abstract：:Ketamine is the prototype of a new generation of antidepressant drugs, which is reported in clinical studies to be effective in treatment-resistant patients, with an effect that appears within hours and lasts for a few days. Chronic mild stress (CMS) is a well-established and widely used animal model of depression, in...

journal_title：Behavioural pharmacology

authors： Papp M,Gruca P,Lason-Tyburkiewicz M,Willner P

更新日期：2017-02-01 00:00:00

abstract：:Sensitization induced by repeated drug exposure has been proposed to increase 'wanting' the drug and to facilitate the transition from moderate to excessive drug intake. The present study examined the effects of cocaine-induced sensitization on ethanol-drinking behavior in male and female rats from different strains. ...

journal_title：Behavioural pharmacology

authors： Cailhol S,Mormède P

更新日期：2000-08-01 00:00:00

abstract：:Much evidence has shown that the inferior colliculus may be part of a brain system commanding defensive behavior. In the present work, evidence is presented for the serotonergic modulation of the neural substrate of aversive states elaborated in this structure. Rats implanted with a cannula in the inferior colliculus ...

journal_title：Behavioural pharmacology

authors： Melo LL,Brando ML

更新日期：1995-06-01 00:00:00

abstract：:This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measu...

journal_title：Behavioural pharmacology

authors： Tirelli E,Reggers J,Terry P

更新日期：1997-06-01 00:00:00

abstract：:There is accumulating evidence that sex plays a critical role in drug abuse. Female sex hormones have been shown to affect central nervous system function and modulate the effects of drugs of abuse. For example, γ-aminobutyric acid type A (GABA(A)) receptor function is positively modulated by progesterone metabolites....

journal_title：Behavioural pharmacology

authors： Babalonis S,Lile JA,Martin CA,Kelly TH

更新日期：2011-09-01 00:00:00

abstract：:The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse ...

journal_title：Behavioural pharmacology

authors： Bond RA,Giles H

更新日期：2011-09-01 00:00:00

abstract：:Central nicotinc acetylcholine receptors have been targeted for the development of novel treatments for memory deficits in Alzheimer's disease (AD) and other neurodegenerative disorders. Nicotine itself has been shown to improve memory-related task performance in aged animals and in AD patients. Administration of nico...

journal_title：Behavioural pharmacology

authors： Buccafusco JJ,Jackson WJ,Jonnala RR,Terry AV Jr

更新日期：1999-11-01 00:00:00

abstract：:The present experiment was conducted to determine whether the modification of the effects of morphine by food deprivation would occur under conditions of strong stimulus control. Four pigeons pecked response keys under a multiple fixed-interval (FI) 5-min and clocked fixed-interval (CFI) 5-min schedule of food present...

journal_title：Behavioural pharmacology

authors： Odum AL,Schaal DW

更新日期：1999-05-01 00:00:00

abstract：:Methylphenidate (MPD) is clinically effective in treating the symptoms of attention-deficit hyperactivity disorder; however, its relatively widespread availability has raised public health concerns on nonmedical use of MPD among certain adult populations. Most preclinical studies investigate whether presumed therapeut...

journal_title：Behavioural pharmacology

authors： Baladi MG,Nielsen SM,Umpierre A,Hanson GR,Fleckenstein AE

更新日期：2014-12-01 00:00:00

abstract：:Different approaches to measuring stimulus generalization in drug discrimination experiments are compared. The main issue, with implications for interpreting partial generalization, has been whether it is preferable to use graded or quantal indices. The first step is to determine whether discriminative drug effects ar...

journal_title：Behavioural pharmacology

authors： Stoleman IP

更新日期：1991-11-01 00:00:00

abstract：:An individual's susceptibility to psychological and physical disorders associated with chronic stress exposure, for example, cardiovascular and infectious disease, may also be predicted by their reactivity to acute stress. One factor associated with both stress resilience and health outcomes is personality. An underst...

journal_title：Behavioural pharmacology

authors： Childs E,White TL,de Wit H

更新日期：2014-09-01 00:00:00

abstract：:Does the effect of amphetamine on behavior (wheel running) differ depending on the functional role (operant, reinforcement) of that behavior? This study addressed this question using a multiple schedule of reinforcement in which wheel running served as reinforcement for lever pressing in one component and as operant b...

journal_title：Behavioural pharmacology

authors： Belke TW,Pierce WD,Sexton CA

更新日期：2019-10-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter and functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a prominent role in regulating various types of psychological processes and functions, including mood and emotion, particularly anxiety, but also in regu...

journal_title：Behavioural pharmacology

authors： Wöhr M,van Gaalen MM,Schwarting RK

更新日期：2015-09-01 00:00:00

abstract：:The development of Parkinson's disease (PD) involves the degeneration of dopaminergic neurons caused by oxidative stress. Accumulating clinical evidence indicates that high blood levels of uric acid (UA), an intrinsic antioxidative substance, are associated with reduced risk of PD. However, this hypothesis has not bee...

journal_title：Behavioural pharmacology

authors： Nakashima A,Yamauchi A,Matsumoto J,Dohgu S,Takata F,Koga M,Fukae J,Tsuboi Y,Kataoka Y

更新日期：2019-02-01 00:00:00

abstract：:This study compared fixed-ratio (FR) and fixed-interval (FI) schedules to investigate the discriminative stimulus properties of μ-opioid and/or κ-opioid receptor agonists. Pigeons were trained to discriminate among morphine (μ agonist), U50488 (κ agonist), the combination, and saline under FR 20-s or FI-300-s schedule...

journal_title：Behavioural pharmacology

authors： Wessinger WD,Li M,McMillan DE

更新日期：2011-09-01 00:00:00

abstract：:Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel dr...

journal_title：Behavioural pharmacology

authors： Wu Z,Yang Z,Zhang M,Bao X,Han F,Li L

更新日期：2018-02-01 00:00:00

abstract：:Cocaine demand is a behavioral economic measure assessing drug reward value and motivation to use drug. The purpose of the current study was to develop a brief assessment of cocaine demand (BACD). Results from the BACD were compared with self-report measures of cocaine use. Participants consisted of treatment-seeking ...

journal_title：Behavioural pharmacology

authors： Yoon JH,de Dios C,Suchting R,Vincent JN,McKay SA,Lane SD,Schmitz JM

更新日期：2020-12-24 00:00:00

abstract：:The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the involvement of adenosinergic neuromodulation in the SHR's short-term ...

journal_title：Behavioural pharmacology

authors： Pires VA,Pamplona FA,Pandolfo P,Fernandes D,Prediger RD,Takahashi RN

更新日期：2009-03-01 00:00:00

abstract：:This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100...

journal_title：Behavioural pharmacology

authors： Hale MW,Crowe SF

更新日期：2003-11-01 00:00:00

abstract：:The present study used the microdialysis technique to investigate the effect of treadmill running, without the use of an electric grid, on extracellular serotonin in the ventral hippocampus of male Lister hooded rat. Extracellular hippocampal serotonin was measured during 60min of treadmill running at 20m/min and comp...

journal_title：Behavioural pharmacology

authors： Wilson WM,Marsden CA

更新日期：1996-01-01 00:00:00