Abstract：
:Susceptibility or resistance to infection with Cryptosporidium parvum correlates with the ability of mice to produce characteristic panels of cytokines in response to infection. Both adult healing and nonhealing mouse models of cryptosporidiosis were used to study the cell-mediated immune response during the course of C. parvum infection. Mesenteric lymph node (MLN) lymphocytes from both mouse models were proliferated after ex vivo re-stimulation with C. parvum sporozoite antigen. Study of the cytokine profile from the supernatant of proliferated MLN cells revealed that healing mice produced greater levels of Th1 (IFN-gamma and IL-2) and moderate amounts of Th2 (IL-4, IL-5, IL-6, and IL-10) cytokines throughout the course of infection. Whereas, MLN cells from nonhealing mice produced no IFN-gamma, low levels of IL-2 and IL-4, and higher levels of IL-5, IL-6, and IL-10 cytokines. These results suggest that the capacity to produce both Th1 and Th2 cytokines, rather than the presence of Th2 cytokines alone, determines the effective immune response against C. parvum infection.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Singh I,Theodos C,Li W,Tzipori Sdoi
10.1007/s00436-005-1436-1subject
Has Abstractpub_date
2005-10-01 00:00:00pages
309-17issue
4eissn
0932-0113issn
1432-1955journal_volume
97pub_type
杂志文章abstract：:Histochemical investigations of Sarcocystis microcysts found in two hindleg muscles of cats were carried out. Genus identification was based on the reinforced cyst membrane structure and its dimensions, the structure of the sarcocysts, and an electron microscopic survey of bradyzoite characteristics. The cyst membrane...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932712
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journal_title：Parasitology research
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journal_title：Parasitology research
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journal_title：Parasitology research
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更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Parasitology research
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