Abstract：
:Antimicrobial peptides are increasingly being explored as alternative agents for therapy against the parasitic protozoan Leishmania. Previously, we reported that the synthetic magainin analog, pexiganan, induced apoptosis of surface protease-deficient Leishmania. Here, we report the development of an arginine-rich variant of this peptide which has reduced protease susceptibility and enhanced activity against wild type Leishmania in vitro. This peptide induces calcium delocalization and caspase 3/7 activity indicative of apoptosis, demonstrating that structural modification of pexiganan leads to drastic changes in biologic activity against Leishmania.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Kulkarni MM,Karafova A,Kamysz W,McGwire BSdoi
10.1007/s00436-014-3847-3subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1971-6issue
5eissn
0932-0113issn
1432-1955journal_volume
113pub_type
杂志文章abstract：:Acanthamoeba are found in the environment, particularly in water, all over the world. The genus is currently classified into 20 different genotypes, T1-T20. In this study, 63 natural water samples from 11 provinces in northeast Thailand were collected and cultured on non-nutrient agar plates. Positive samples by cultu...
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pub_type： 杂志文章,已发布勘误
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