Abstract：
:The susceptibility of two Venezuelan (YT and SM) and one Brazilian (BH) strain of Schistosoma mansoni to single oral doses of praziquantel (Pz; 250 or 500 mg/kg), oxamniquine (Ox; 40, 60, or 100 mg/kg) or to low-dose combinations of both drugs (33 mg/kg Pz and 25 mg/kg Ox; 66 mg/kg Pz and 12.5 mg/kg Ox; 250 mg/kg Pz and 40 mg/kg Ox) was experimentally evaluated in mice. At lower doses of either drug, adult worms of the SM isolate were less susceptible than those of the BH and YT isolates. However, no difference in liver or intestinal egg counts (IECs) could be detected among the isolates after this treatment. At such doses, Pz was better than Ox at reducing IECs. In spite of lowered IECs, eggs continued to accumulate in the liver after Ox treatment. At higher individual doses or following treatment with low-dose combinations of both drugs, no difference in susceptibility could be detected among the parasite isolates. Under such conditions, oviposition was drastically reduced in all three isolates. We confirm that Ox preferentially kills male parasites and present for the first time evidence for the preferential killing of female worms by Pz. We propose that the synergistic effect obtained in the present study and in other investigations using low-dose combinations of both drugs may be due to the preferential cytotoxicity of each drug against a different parasite sex.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Delgado VS,Suárez DP,Cesari IM,Incani RNdoi
10.1007/BF00931515subject
Has Abstractpub_date
1992-01-01 00:00:00pages
648-54issue
8eissn
0932-0113issn
1432-1955journal_volume
78pub_type
杂志文章abstract：:Thelaziasis is an ocular infection of several mammals caused by nematodes of the genus Thelazia (Spirurida, Thelaziidae). The adults live in the lachrymal ducts and conjunctival sacs of infected animals, and transmission occurs by means of different species of muscids. T. rhodesi, T. skrjabini, and T. gulosa affect ma...
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pub_type： 更正并重新发布的文章,杂志文章
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更新日期：2011-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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更新日期：2009-10-01 00:00:00
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journal_title：Parasitology research
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更新日期：2007-11-01 00:00:00
