Abstract：
:Neodiplostomum seoulense (Digenea: Neodiplostomidae), an intestinal trematode infecting humans and rodents, is known to be highly pathogenic and lethal to experimentally infected mice. Only a small proportion of mice can survive from its infection. This study aimed to assess the reproductive capacity of surviving BALB/c mice. The fertility of male and female mice, birth time (period from mating to birth of litters), number of litters, size and weight of testes or ovary-oviduct-uterus, apoptosis of testicular cells, and serum levels of sex hormones were determined. Our results revealed that surviving mice underwent severe fecundity reduction and finally became infertile. They could not be able to produce generations beyond F4. Fertility rate, birth time, and number of litters of N. seoulense-infected mice were all significantly (p < 0.05) lower than those of uninfected controls, Metagonimus miyatai (less pathogenic intestinal trematode)-infected, or castor oil (severe diarrheal agent)-administered controls. The size and weight of testes or ovary-oviduct-uterus were markedly (p < 0.05) decreased after N. seoulense infection. Moreover, the number of apoptotic cells in the testicular tissue was significantly (p < 0.05) increased (up to 10-50-folds) during weeks 1-3 post-infection. Serum testosterone levels in infertile mice were reduced to 1/10 level of fertile mice. These results indicated that BALB/c mice surviving N. seoulense infection underwent destruction and apoptosis of gonad tissues with fecundity reduction. They were finally infertile, with no ability to produce their next generations.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Shin EH,Im TK,Park YK,Cho J,Kim JL,Chai JYdoi
10.1007/s00436-016-4949-xsubject
Has Abstractpub_date
2016-05-01 00:00:00pages
2051-9issue
5eissn
0932-0113issn
1432-1955pii
10.1007/s00436-016-4949-xjournal_volume
115pub_type
杂志文章abstract：:We have investigated how knowledge of endoplasmic reticulum (ER) retrieval signals can be used to study specific trafficking pathways in the malaria-infected erythrocyte. We show that addition of various lumenal ER retrieval signals to soluble green fluorescent protein (GFP) chimaera causes retrieval of the fusion pro...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-009-1397-x
更新日期：2009-06-01 00:00:00
abstract：:Phalloidin fluorescence technique, enzyme cytochemistry and immunocytochemistry in conjunction with confocal scanning laser microscopy have been used for the first time to describe the nervous and muscle systems of the viviparous monogenean gill parasite, Macrogyrodactylus clarii. The gross spatial arrangement of musc...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1198-1
更新日期：2004-10-01 00:00:00
abstract：:We investigated the prevalence and genotypes of Cryptosporidium parasite in 50 brown rats (Rattus norvegicus) inhabiting an urban area of Japan. Fecal samples collected from the animals were examined by an immuno-fluorescence assay (IFA). Genomic DNA was extracted directly from fecal sample of each animal and nested P...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0488-9
更新日期：2007-05-01 00:00:00
abstract：:The diagnosis of toxoplasmosis is often complicated by the lack of specific clinical symptoms or postmortem features, in humans and other animals. The only diagnostic test described so far for the serological diagnosis of Toxoplasma gondii in marine mammals is the modified agglutination test (Dubey et al., Am J Vet Re...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3674-y
更新日期：2014-02-01 00:00:00
abstract：:Haemonchus contortus isolates were evaluated for benzimidazole (BZ) resistance or susceptibility by allele-specific PCR based on β-tubulin isotype 1 gene polymorphisms at the F167Y, E198A, and F200Y sites. Two isolates, one presumed susceptible from wild pronghorn antelope (PH) and one known to be resistant from goats...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5357-y
更新日期：2017-02-01 00:00:00
abstract：:Discoid granules were isolated from the tegument of adult Schistosoma mansoni by differential centrifugation of freeze-thaw extracts. Comparison of proteins and glycoproteins from discoid granules, surface membranes and the soluble fraction implied that discoid granules and the surface membrane were functionally linke...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00539573
更新日期：1988-01-01 00:00:00
abstract：:The effect of the adult worms and migrating L1 larvae of Trichinella spiralis on the production of specific IgE antibodies was determined in BCF1 mice. To achieve this, we combined the effect of two anthelminthics: thiabendazole, to produce chemosterilization of adult females, and napthalophos, to expel adult worms fr...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00531638
更新日期：1988-01-01 00:00:00
abstract：:The third larval stage (L3) of Anisakis simplex (Anisakidae) is one of the zoonotic parasitic nematodes in the musculature and visceral organs of marine fishes belonging to family Moronidae. The consumption of these high-commercial-value fish is widespread in many countries around the Mediterranean Sea including Egypt...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4500-5
更新日期：2015-08-01 00:00:00
abstract：:The ethanolic leaf extract of Cassia obtusifolia was investigated for their larvicidal and oviposition deterrence effects against Anopheles stephensi. Concentrations ranging from 25 to 125 mg/l were assessed at 24 h post-treatment against late third instar larvae. The leaf extract had significant larvicidal effect wit...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1197-8
更新日期：2009-01-01 00:00:00
abstract：:Infection with helminth parasites or the administration of their antigens can prevent or attenuate autoimmune diseases. To date, the specific molecules that prime the amelioration are only limited. In this study, recombinant Schistosoma japonicum cystatin (rSjcystatin) and fructose-1,6-bisphosphate aldolase (rSjFBPA) ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06511-7
更新日期：2020-01-01 00:00:00
abstract：:Nitric oxide (NO) production by peritoneal macrophages was evaluated in Calomys callosus and Swiss mice during the course of infection with two strains of Trypanosoma cruzi. In C. callosus, no NO production was detected throughout the period of observation in animals infected with either parasite strain, except for a ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050336
更新日期：1997-01-01 00:00:00
abstract：:Investigations on the occurrence of trichodinid ciliates from fish caught in the Kiel Bight and Kiel Fjord (western Baltic Sea) were carried out between September 1996 and March 1997. Smears of the gills, fins, and skin of 120 Gadus morhua and 92 Platichthys flesus caught by fish traps and trammel nets revealed the pr...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050622
更新日期：1999-08-01 00:00:00
abstract：:Hysterothylacium zhoushanensis sp. nov. collected from the intestine of the flatfish Pseudorhombus oligodon (Bleeker) (Pleuronectiformes: Paralichthyidae) in the East China Sea is described and illustrated by light and scanning electron microscopy. The new species can be easily distinguished from its congeners by the ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3095-3
更新日期：2012-12-01 00:00:00
abstract：:In schistosomiasis a systemic hyperplasia of the monomacrophagic cell lineage is associated with its mild modifications in myelograms and hemograms. We monitored the in vitro proliferation of myeloid precursors obtained from bone marrow, blood, spleen, and liver. The macrophage colony-forming unit (M-CFU) numbers were...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050467
更新日期：1998-08-01 00:00:00
abstract：:Blastocytis sp. is the most common enteric protozoan in human, but its pathogenesis is still unclear. To study the infectious effects of Blastocytis sp. on tissue damage, we orally challenged the Sprague Dawley (SD) rats with different doses of Blastocytis subtype1 (ST1) and examined the histological changes. We found...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3536-7
更新日期：2013-10-01 00:00:00
abstract：:Limited information exists on serum biochemistry and haematology of the European wild boar, and few correlations have been found between parasitic burden and clinical parameters in this species. Naturally infected wild boars were experimentally treated to study the effect of nematode parasites and ivermectin treatment...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-0099-2
更新日期：2006-05-01 00:00:00
abstract：:The present study evaluated the distribution and viability of Toxoplasma gondii tissue cysts in the organs and Brazilian commercial cuts of experimentally infected pigs. The pigs were infected with 3 × 103 oocysts of the T. gondii isolate TgCkBr57 (Type BrII). Mouse bioassays were performed on the brain, retina, tongu...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06229-6
更新日期：2019-04-01 00:00:00
abstract：:The experimental study investigated the ability of tortoise tick Hyalomma aegyptium to play a role in forming and maintaining natural foci of Q fever. We tested the competence of H. aegyptium larvae to acquire Coxiella burnetii infection from mammals, serve as a C. burnetii vector between mammalian hosts, and be a lon...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2037-1
更新日期：2010-11-01 00:00:00
abstract：:Leishmaniasis is one of the most important diseases transmitted by arthropod. This disease is present in 88 countries. Approximately 400 million people are at risk, and 12 million are involved. We aimed to examine the application of ethanolic extract of the root bark of Berberis vulgaris L. for treatment of mice infec...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3727-2
更新日期：2014-03-01 00:00:00
abstract：:The bioassay-guided phytochemical investigation of the leaf extract of Serjania yucatanensis, a woody climbing plant endemic to the Yucatan peninsula, led to the identification of a mixture of a triterpene [lup-20(29)-en-3-one] and an oxygenated sesquiterpene (β-caryophyllene oxide), as that responsible for the origin...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-2861-6
更新日期：2012-07-01 00:00:00
abstract：:Eimeria tenella-specific antibodies were examined for the cross-reactivity on the sporozoites and merozoites of E. tenella, Eimeria maxima, Eimeria acervulina and Eimeria brunetti in an indirect fluorescence antibody test. Two of nine antibodies showed cross-reactivity with sporozoites of E. maxima, E. acervulina and ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2171-9
更新日期：2011-03-01 00:00:00
abstract：:Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4339-9
更新日期：2015-04-01 00:00:00
abstract：:In latest years, the importance of the Melaleuca alternifolia essential oil (EO) has been greatly empathised due to its anti-microbial and anti-inflammatory effects, as well as to its toxic properties towards many arthropods of great medical and veterinary importance. In this research, the EO extracted from aerial par...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3651-5
更新日期：2014-01-01 00:00:00
abstract：:Praziquantel is still very effective for the treatment of schistosomiasis, but there are rising concerns on the potential risk of developing resistances because of the extensive use of this drug. Triclabendazole, a systemic anthelmintic, is very effective against other trematodes such as Paragonimus spp. and Fasciola ...
journal_title：Parasitology research
pub_type： 临床试验,杂志文章
doi：10.1007/s00436-007-0802-6
更新日期：2008-03-01 00:00:00
abstract：:Two of the three vector species of Schistosoma mansoni Sambon, 1907 in Brazil occur in the state of Maranhão: Biomphalaria glabrata (Say, 1818) and Biomphalaria straminea (Dunker, 1848). For the implementation of effective measures to combat schistosomiasis, it is necessary to identify the spatial and seasonal dynamic...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-018-5810-1
更新日期：2018-05-01 00:00:00
abstract：:The problems of resistant lines of Plasmodium falciparum are escalating. Twelve seaweeds species belong to five different families (Sargassaceae, Gracilariaceae, Hypneaceae, Corallinaceae and Halimedaceae) were collected from Mandapam coastal area, and the seaweeds extracts were tested for in vitro antiplasmodial acti...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2219-x
更新日期：2011-07-01 00:00:00
abstract：:An optimized protocol is presented to visualize gene expression in the sedentary beet cyst nematode, Heterodera schachtii, by whole-mount in situ hybridization. Two different probes were used for genes with known expression pattern in other nematodes. Vacuum infiltration of the fixative significantly increased its eff...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0661-0
更新日期：2002-08-01 00:00:00
abstract：:In patients infected with Trichuris trichiura, large eggs as well as more typical eggs were frequently found in the feces; these large eggs have been attributed to human infection by T. vulpis. To clarify whether the female worms laying the large eggs were T. trichiura or T. vulpis, we examined the morphology of adult...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00930964
更新日期：1989-01-01 00:00:00
abstract：:Infections of Eimeria tenella in chicken embryos were used to compare the anticoccidial activity of ten drugs. The minimal inhibitory concentration (MIC) and minimal toxic concentration (MTC) were affected by the time of inoculation into the embryos and by the chemical nature of the compounds. Some compounds (nicarbaz...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00931020
更新日期：1991-01-01 00:00:00
abstract：:In Europe, mosquito-related public health concerns are growing due to the increasing spread of invasive mosquito species and the recent emergence of mosquito-borne arboviruses. A vital backbone in the assessment of these issues is detailed knowledge of the mosquito fauna, i.e. regional mosquito inventories. It was the...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3952-3
更新日期：2014-08-01 00:00:00
