Abstract：
:The bioassay-guided phytochemical investigation of the leaf extract of Serjania yucatanensis, a woody climbing plant endemic to the Yucatan peninsula, led to the identification of a mixture of a triterpene [lup-20(29)-en-3-one] and an oxygenated sesquiterpene (β-caryophyllene oxide), as that responsible for the originally detected trypanocidal activity in the organic crude extract. Results showed that the mixture of lup-20(29)-en-3-one and β-caryophyllene oxide is active against trypomastigotes of Trypanosoma cruzi (IC(50) =80.3 μg/mL) and inhibits the egress of trypomastigotes from infected Vero cells (when tested at 100 μg/mL) without being cytotoxic.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Polanco-Hernández G,Escalante-Erosa F,García-Sosa K,Chan-Bacab MJ,Sagua-Franco H,González J,Osorio-Rodríguez L,Peña-Rodríguez LMdoi
10.1007/s00436-012-2861-6subject
Has Abstractpub_date
2012-07-01 00:00:00pages
451-5issue
1eissn
0932-0113issn
1432-1955journal_volume
111pub_type
杂志文章abstract：:Schistosomiasis is the second widespread tropical disease that affects the health of over 240 million people of 78 countries. Questionnaires have been commonly used to diagnose schistosomiasis, while no meta-analysis of their efficacy had been reported previously. This meta-analysis was conducted to assess their diagn...
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