Abstract：
:The Porsolt forced swim test (FST) is one of the most widely used behavioral tests in the evaluation of the antidepressant effects of drugs. It is based on the fact that these drugs reduce the depression-related behaviors of learned helplessness. The model has been modified for use in mice. In contrast to rats, mice are exposed to forced swimming only once and their immobility behavior is measured and considered a "depression-like" phenotype. Like many other behavioral tests, FST can be affected by observer-related artifacts. In recent years, automated testing systems have been developed to decrease artifacts that may greatly influence the interpretation of results. In this work, we used two strains of mice, i.e., C3H/HeJ and C57BL/6J, which differ in their FST immobility times. We employed a new commercially available automated FST device and a blinded observer-based FST, and we examined their ability to measure behavioral differences between these two mouse strains. Our results suggest that the tested automated FST system generates reliable data comparable to results obtained by trained observers.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Kurtuncu M,Luka LJ,Dimitrijevic N,Uz T,Manev Hdoi
10.1016/j.jneumeth.2005.04.010subject
Has Abstractpub_date
2005-11-30 00:00:00pages
26-30issue
1eissn
0165-0270issn
1872-678Xpii
S0165-0270(05)00145-7journal_volume
149pub_type
杂志文章abstract：BACKGROUND:Intracranial electrical recordings (iEEG) and brain stimulation (iEBS) are invaluable human neuroscience methodologies. However, the value of such data is often unrealized as many laboratories lack tools for localizing electrodes relative to anatomy. To remedy this, we have developed a MATLAB toolbox for int...
journal_title：Journal of neuroscience methods
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journal_title：Journal of neuroscience methods
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更新日期：1985-08-01 00:00:00
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更新日期：2015-05-30 00:00:00
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journal_title：Journal of neuroscience methods
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更新日期：2008-06-15 00:00:00
