Responses of rats to noxious mechanical stimulation of their tails during tail reperfusion following transient ischaemia.

Abstract:

:We investigated whether conscious rats exhibit hyperalgesia to noxious mechanical stimuli during tail reperfusion following transient tail ischaemia. Mechanical stimuli were delivered by three mechanical algometers, differing in contact area, geometry and rate of application. Tail ischaemia was induced by applying a pneumatic tourniquet to the base of the tail until the rats exhibited escape behaviour. Control animals had a sham tourniquet placed on their tails. During tail reperfusion, there was significant hyperalgesia when the noxious mechanical stimulus was applied by a narrow bar transverse to the tail, less when applied by a rubber piston, and there was no hyperalgesia when the stimulus was punctate, similar to a von Frey hair. Repeated application of the mechanical stimuli themselves, at 30-min intervals, did not induce hyperalgesia. Rats subjected repetitively to the combination of the bar algometer and tail ischaemia at intervals of at least 48 h, for a total period of three weeks, exhibited progressively enhanced hyperalgesia to the bar algometer, and also enhanced hyperalgesia to noxious ischaemic and thermal stimuli. Rats therefore do exhibit hyperalgesia to mechanical stimuli following conditioning ischaemia, but the nature of the hyperalgesia depends critically on the geometry of the algometer, and the time course of the hyperalgesia was different to that which manifests to a noxious thermal stimulus.

journal_name

J Neurosci Methods

authors

Vidulich L,Mitchell D

doi

10.1016/s0165-0270(00)00313-7

subject

Has Abstract

pub_date

2000-11-30 00:00:00

pages

173-80

issue

2

eissn

0165-0270

issn

1872-678X

pii

S0165027000003137

journal_volume

103

pub_type

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