Abstract:
:A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms. The use of this test for detecting such drug effects was validated behaviourally, physiologically, and pharmacologically. Rats made significantly fewer entries into the open arms than into the closed arms, and spent significantly less time in open arms. Confinement to the open arms was associated with the observation of significantly more anxiety-related behaviours, and of significantly greater plasma corticosterone concentrations, than confinement to the closed arms. Neither novelty nor illumination was a significant contributor to the behaviour of the rats on the + -maze. A significant increase in the percentage of time spent on the open arms and the number of entries into the open arms was observed only within clinically effective anxiolytics (chlordiazepoxide, diazepam and, less effectively, phenobarbitone). Compounds that cause anxiety in man significantly reduced the percentage of entries into, and time spent on, the open arms (yohimbine, pentylenetetrazole, caffeine, amphetamine). Neither antidepressants nor major tranquilisers had a specific effect. Exposure to a holeboard immediately before placement on the + -maze showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Pellow S,Chopin P,File SE,Briley Mdoi
10.1016/0165-0270(85)90031-7subject
Has Abstractpub_date
1985-08-01 00:00:00pages
149-67issue
3eissn
0165-0270issn
1872-678Xpii
0165-0270(85)90031-7journal_volume
14pub_type
杂志文章abstract::The paper presents in detail a method for approximating the spatial position of neural spike activity from tetrode recordings. The method uses a nonlinear mapping of a set of tetrode tip amplitudes into three-dimensional (3D) space, followed by a self-organizing map clustering technique. Viewed as a spike sorting meth...
journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2004.09.004
更新日期:2005-03-30 00:00:00
abstract::A combination of two procedures, embedding of specimens and horseradish peroxidase (HRP) histochemistry on mounted serial sections, is proposed for three-dimensional reconstruction of neuronal projections. To clarify the intrinsic organization of the peripheral nervous system, this simple method is more adequate than ...
journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/0165-0270(86)90130-5
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Military personnel and civilians living in areas of armed conflict have increased risk of exposure to blast overpressures that can cause significant hearing loss and/or brain injury. The equipment used to simulate comparable blast overpressures in animal models within laboratory settings is typically very la...
journal_title:Journal of neuroscience methods
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更新日期:2015-03-15 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2007.06.015
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/s0165-0270(01)00350-8
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journal_title:Journal of neuroscience methods
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doi:10.1016/j.jneumeth.2014.02.004
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/0165-0270(88)90046-5
更新日期:1988-01-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/0165-0270(95)00149-2
更新日期:1996-07-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2009.06.026
更新日期:2009-10-15 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/s0165-0270(03)00068-2
更新日期:2003-06-15 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2020.109013
更新日期:2020-12-11 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2019.03.006
更新日期:2019-05-15 00:00:00
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journal_title:Journal of neuroscience methods
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doi:10.1016/j.jneumeth.2009.04.016
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/S0165-0270(96)00046-5
更新日期:1996-11-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2018.07.020
更新日期:2018-10-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2006.05.002
更新日期:2006-10-30 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/0165-0270(85)90012-3
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章,评审
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journal_title:Journal of neuroscience methods
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pub_type: 杂志文章
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journal_title:Journal of neuroscience methods
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更新日期:2012-09-15 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
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更新日期:2020-01-15 00:00:00
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journal_title:Journal of neuroscience methods
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更新日期:2017-01-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章,评审
doi:10.1016/s0165-0270(98)00160-5
更新日期:1999-01-01 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 临床试验,杂志文章
doi:10.1016/j.jneumeth.2006.05.035
更新日期:2006-12-15 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2015.02.013
更新日期:2015-04-30 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2007.05.017
更新日期:2007-09-15 00:00:00
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journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/s0165-0270(96)00131-8
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Eye tracking is an important component of many human and non-human primate behavioral experiments. As behavioral paradigms have become more complex, including unconstrained viewing of natural images, eye movements measured in these paradigms have become more variable and complex as well. Accordingly, the com...
journal_title:Journal of neuroscience methods
pub_type: 杂志文章
doi:10.1016/j.jneumeth.2014.01.032
更新日期:2014-04-30 00:00:00