Open space swimming test to index antidepressant activity.


:Depression is characterized by a lack of "motivation" rather than a lack of "physical space" to move around. This study was designed to evaluate predictivity of an open space swimming test for antidepressant activity of various antidepressants in rats. Without drug treatment, rats showed a significant reduction in the distance moved (increased immobility) over successive trials in an open space water pool. Three major classes of antidepressants and a selective serotonin reuptake inhibitor (SSRI) were tested. Repeated treatment (10 mg/kg x 3 per day) of imipramine, a prototypical tricyclic antidepressant, iproniazid, a monoamine oxidase inhibitor, mianserin, an atypical antidepressant, and alaproclate, an SSRI, all significantly reduced the immobility. These results suggest that the open space swimming test is highly predictive of antidepressant action and is more sensitive to the drug treatments. The measurement is more objective than that of the forced swimming test and does not involve judging and scoring the animals' movement or lack of movement by investigators. The demonstrated effectiveness of three major types of antidepressants and an SSRI suggests that the effects on the test are not restricted to a particular underlying molecular mechanism of action. Thus, this swimming test shows promising potential as a screen for novel antidepressants and, perhaps, for revealing some of the underlying pathophysiology of depression.


J Neurosci Methods


Sun MK,Alkon DL




Has Abstract


2003-06-15 00:00:00














  • Silver staining method for demonstrating Lewy bodies in Parkinson's disease and argyrophilic oligodendrocytes in multiple system atrophy.

    abstract::A reliable and economical silver staining method is recommended for demonstration of Lewy bodies (LB) and Lewy neurites (LN) in Parkinson's disease (PD) and of argyrophilic oligodendrocytes in multiple system atrophy (MSA). The technique can be applied to routinely formalin-fixed autopsy material and does not require ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Braak E,Braak H

    更新日期:1999-02-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章,评审


    authors: Di Chiara G

    更新日期:1990-09-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Gibb AJ,Walmsley B

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Bekkers JM

    更新日期:2003-12-15 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Machado ML,Lefèvre N,Philoxene B,Le Gall A,Madeleine S,Fleury P,Smith PF,Besnard S

    更新日期:2019-11-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Roberts K,Hemmings AJ,McBride SD,Parker MO

    更新日期:2017-12-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


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    更新日期:1985-11-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Liu X,Zhu XH,Qiu P,Chen W

    更新日期:2012-10-15 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Ma C,He J

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Gabriel DA,Lester SM,Lenhardt SA,Cambridge ED

    更新日期:2007-01-15 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


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    更新日期:1996-05-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Pang JC,Aquino KM,Robinson PA,Lacy TC,Schira MM

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Romcy-Pereira RN,de Araujo DB,Leite JP,Garcia-Cairasco N

    更新日期:2008-01-30 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Augustine JR

    更新日期:1981-06-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Kazakov A,Nelken I

    更新日期:2018-11-01 00:00:00

  • Comparison among ultrasonic, electrical apparatus, and toxic chemicals for vestibular lesion in mice.

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    authors: Yamaoka Y,Abe C,Morita H

    更新日期:2018-02-01 00:00:00

  • A novel repetitive mild traumatic brain injury mouse model for chronic traumatic encephalopathy research.

    abstract:BACKGROUND:Athletes, military personnel and mobility-declined elderly people are prone to repetitive mild traumatic brain injury (rmTBI). The injury does not cause acute pathological changes, but leads to chronic neurodegeneration, long-term cognitive dysfunction and even chronic traumatic encephalopathy (CTE). Many ex...

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    authors: Ge X,Yu J,Huang S,Yin Z,Han Z,Chen F,Wang Z,Zhang J,Lei P

    更新日期:2018-10-01 00:00:00

  • Nonlinear analysis of saccade speed fluctuations during combined action and perception tasks.

    abstract:BACKGROUND:Saccades are rapid eye movements used to gather information about a scene which requires both action and perception. These are usually studied separately, so that how perception influences action is not well understood. In a dual task, where the subject looks at a target and reports a decision, subtle change...

    journal_title:Journal of neuroscience methods

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    更新日期:2014-07-30 00:00:00

  • Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice.

    abstract::We investigated the usefulness of YFP-H transgenic mice [Neuron 28 (2000) 41] which express yellow fluorescent protein (YFP) in a restricted subset of neurons to study Wallerian degeneration in the PNS. Quantification of YFP positive axons and myelin basic protein (MBP) immunocytochemistry revealed that YFP was random...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Beirowski B,Berek L,Adalbert R,Wagner D,Grumme DS,Addicks K,Ribchester RR,Coleman MP

    更新日期:2004-03-15 00:00:00

  • Application of autoradiographic analysis of 2-deoxyglucose in the study of locomotion.

    abstract::Trace amounts of [14C]2-deoxyglucose (2-DG) were used to detect regions of the brainstem involved in forelimb stepping in thalamic and low spinal cats. Under ether anesthesia, cats were transected at the stereotaxic A12 level and T10 segment. Two hours later, 50 microCi/kg of 2-DG was infused i.v. and one of 4 procedu...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Shimamura M,Edgerton VR,Kogure I

    更新日期:1987-10-01 00:00:00

  • Multi-channel metallic electrode for threshold stimulation of frog's retina.

    abstract::A simple method for making a stimulating multi-channel metallic electrode is proposed. The method uses furnace-shaped multiple fine glass tubes as channel guides for inserted tungsten wires that are pulled as a unit to produce multi-channel metallic electrode with a tapered tip. By shortening the tip, the desired inte...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Kuras A,Gutmaniene N

    更新日期:1997-07-18 00:00:00

  • Cellular composition of human glial cultures from adult biopsy brain tissue.

    abstract::Microglia and astrocytes play vital roles in normal human brain function and in neurological disorders. To study their physiological and pathological roles it is desirable to establish in vitro systems that are derived from the adult human brain. Although several groups have successfully cultured cells from the human ...

    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Gibbons HM,Hughes SM,Van Roon-Mom W,Greenwood JM,Narayan PJ,Teoh HH,Bergin PM,Mee EW,Wood PC,Faull RL,Dragunow M

    更新日期:2007-10-15 00:00:00

  • Machine learning on brain MRI data for differential diagnosis of Parkinson's disease and Progressive Supranuclear Palsy.

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Salvatore C,Cerasa A,Castiglioni I,Gallivanone F,Augimeri A,Lopez M,Arabia G,Morelli M,Gilardi MC,Quattrone A

    更新日期:2014-01-30 00:00:00

  • Vibrating glass stylets: tools for precise microsurgery on cuticular structures.

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Gödde J

    更新日期:1989-07-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Nam Y,Brown EA,Ross JD,Blum RA,Wheeler BC,DeWeerth SP

    更新日期:2009-03-30 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章


    authors: Tang IN,Jao T,Huang YA,Li CW,Yu YC,Chen JH

    更新日期:2020-10-01 00:00:00

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    journal_title:Journal of neuroscience methods

    pub_type: 杂志文章,评审


    authors: Simanaviciute U,Ahmed J,Brown RE,Connor-Robson N,Farr TD,Fertan E,Gambles N,Garland H,Morton AJ,Staiger JF,Skillings EA,Trueman RC,Wade-Martins R,Wood NI,Wong AA,Grant RA

    更新日期:2020-02-01 00:00:00