A role for alcohol dehydrogenase in the Drosophila immune response?

Abstract:

:In a recent study Drosophila larvae were injected with bacterial lipopolysaccharide (LPS) suspended in 1% ethanol and differentially induced protein fractions were identified. The levels of several proteins, including alcohol dehydrogenase (ADH), increased in LPS-treated flies and were labelled as immune response proteins. However, because control larvae were not injected with ethanol alone the identified proteins could represent a response to ethanol. Here, we injected Drosophila larvae with combinations of ethanol and LPS. While ADH activity increased in larvae receiving 1% ethanol, it was not increased after LPS injection. These results suggest that ADH plays no role in the Drosophila immune response, and that other proteins identified in the previous study may instead mediate ethanol tolerance in flies and other organisms.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Schlenke TA,McKean KA

doi

10.1111/j.1365-2583.2004.00543.x

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

175-8

issue

2

eissn

0962-1075

issn

1365-2583

pii

IMB543

journal_volume

14

pub_type

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