Genetic mapping of genes conferring permethrin resistance in the malaria vector, Anopheles gambiae.

Abstract:

:Resistance to permethrin in an East African population of the major malaria vector, Anopheles gambiae is multifactorial. A mutated sodium channel allele and enhanced insecticide metabolism contribute to the resistance phenotype. We used microsatellite markers to scan the genome for quantitative trait loci (QTL) associated with permethrin resistance. Two major and one minor QTL were identified. The first QTL, rtp1, colocalizes with the sodium channel gene on chromosome 2L thus further supporting the importance of mutations in this gene in conferring permethrin resistance. The second two loci are located on the third chromosome and one of these, rtp2, flanks a large cluster of cytochrome P450 genes. Further detailed mapping of these regions will help elucidate the molecular mechanisms of metabolic resistance to insecticides.

journal_name

Insect Mol Biol

journal_title

Insect molecular biology

authors

Ranson H,Paton MG,Jensen B,McCarroll L,Vaughan A,Hogan JR,Hemingway J,Collins FH

doi

10.1111/j.0962-1075.2004.00495.x

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

379-86

issue

4

eissn

0962-1075

issn

1365-2583

pii

IMB495

journal_volume

13

pub_type

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