Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients.

Abstract:

:Regional cerebral blood flow was studied in 17 bipolar I depressed patients (DSM-IV criteria) with single photon emission computed tomography (SPECT). Visual analysis of images revealed no abnormality in eight patients and abnormal findings in nine patients. In the nine patients with abnormal findings, all showed regional decreases of the uptake of (99m)Tc-D,L-hexamethylpropylene amine oxime (HMPAO, four in the frontal region, two in the basal ganglia, and three in both the frontal region and the basal ganglia). The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS).

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Benabarre A,Vieta E,Martín F,Lomeña F,Martínez-Aràn A,Colom F,Corbella B,Gastó C,Valdés M

doi

10.1016/j.pscychresns.2003.11.003

subject

Has Abstract

pub_date

2004-12-30 00:00:00

pages

285-9

issue

3

eissn

0165-1781

issn

1872-7123

pii

S0925-4927(04)00106-4

journal_volume

132

pub_type

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