Virus factories: associations of cell organelles for viral replication and morphogenesis.

Abstract:

:Genome replication and assembly of viruses often takes place in specific intracellular compartments where viral components concentrate, thereby increasing the efficiency of the processes. For a number of viruses the formation of 'factories' has been described, which consist of perinuclear or cytoplasmic foci that mostly exclude host proteins and organelles but recruit specific cell organelles, building a unique structure. The formation of the viral factory involves a number of complex interactions and signalling events between viral and cell factors. Mitochondria, cytoplasmic membranes and cytoskeletal components frequently participate in the formation of viral factories, supplying basic and common needs for key steps in the viral replication cycle.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Novoa RR,Calderita G,Arranz R,Fontana J,Granzow H,Risco C

doi

10.1042/BC20040058

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

147-72

issue

2

eissn

0248-4900

issn

1768-322X

pii

BC20040058

journal_volume

97

pub_type

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