Gap junctions and connexin expression in the normal and pathological central nervous system.

Abstract:

:Gap junctions are widely expressed in the various cell types of the central nervous system. These specialized membrane intercellular junctions provide the morphological support for direct electrical and biochemical communication between adjacent cells. This intercellular coupling is controlled by neurotransmitters and other endogenous compounds produced and released in basal as well as in pathological situations. Changes in the expression and the function of connexins are associated with number of brain pathologies and lesions suggesting that they could contribute to the expansion of brain damages. The purpose of this review is to summarize data presently available concerning gap junctions and the expression and function of connexins in different cell types of the central nervous system and to present their physiopathological relevance in three major brain dysfunctions: inflammation, epilepsy and ischemia.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Rouach N,Avignone E,Même W,Koulakoff A,Venance L,Blomstrand F,Giaume C

doi

10.1016/s0248-4900(02)00016-3

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

457-75

issue

7-8

eissn

0248-4900

issn

1768-322X

pii

S0248490002000163

journal_volume

94

pub_type

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