The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2.

abstract：:Haemophilus influenzae is a human-specific pathogen and a major source of morbidity worldwide. Infection with this organism begins with colonization of the nasopharynx, a process that probably depends on adherence to respiratory epithelium. The Hia autotransporter protein is the major adhesin ex-pressed by a subset of...

journal_title：Molecular microbiology

authors： Laarmann S,Cutter D,Juehne T,Barenkamp SJ,St Geme JW

更新日期：2002-11-01 00:00:00

abstract：:Whereas tetrahydrofolate is an essential cofactor in all bacteria, the gene that encodes the enzyme dihydrofolate reductase (DHFR) could not be identified in many of the bacteria whose genomes have been entirely sequenced. In this communication we show that the halophilic archaea Halobacterium salinarum and Haloarcula...

journal_title：Molecular microbiology

authors： Levin I,Giladi M,Altman-Price N,Ortenberg R,Mevarech M

更新日期：2004-12-01 00:00:00

abstract：:Whereas in Bacillus subtilis, a general stress response stimulon under the control of a single sigma factor (SigB) is induced by different physiological and environmental stresses (heat, salt or ethanol shock), in Streptomyces coelicolor, these environmental stresses induce independent sets of proteins, and its genome...

journal_title：Molecular microbiology

authors： Viollier PH,Kelemen GH,Dale GE,Nguyen KT,Buttner MJ,Thompson CJ

更新日期：2003-02-01 00:00:00

abstract：:In Saccharomyces cerevisiae MATa cells, export of the a-factor mating pheromone is mediated by Ste6p, a member of the ATP-binding cassette (ABC) superfamily of transporters and a close homologue of mammalian multidrug transporter P-glycoproteins (Pgps). We have used functional complementation of a ste6delta mutation t...

journal_title：Molecular microbiology

authors： Raymond M,Dignard D,Alarco AM,Mainville N,Magee BB,Thomas DY

更新日期：1998-02-01 00:00:00

abstract：:Red cell invasion by Plasmodium merozoites involves multiple steps such as attachment, apical reorientation, junction formation and entry into a parasitophorous vacuole. These steps are mediated by specific molecular interactions. P. vivax and the simian parasite P. knowlesi require interaction with the Duffy blood gr...

journal_title：Molecular microbiology

authors： Singh AP,Ozwara H,Kocken CH,Puri SK,Thomas AW,Chitnis CE

更新日期：2005-03-01 00:00:00

abstract：:The tprK gene sequence of Treponema pallidum subspecies pallidum (T. pallidum) is heterogeneous within and among isolates. Heterogeneity in the tprK open reading frame is localized in seven discrete variable (V) regions, and variability results from apparent base changes, insertions or deletions. The TprK V regions ar...

journal_title：Molecular microbiology

authors： Centurion-Lara A,LaFond RE,Hevner K,Godornes C,Molini BJ,Van Voorhis WC,Lukehart SA

更新日期：2004-06-01 00:00:00

abstract：:In Aspergillus nidulans, proline can serve both as a carbon and a nitrogen source. The transcription of the prnB gene, encoding the proline transporter, is efficiently repressed only by the simultaneous presence of ammonium and glucose. Thus, repression of this gene demands the activation of the CreA repressor and the...

journal_title：Molecular microbiology

authors： Gómez D,García I,Scazzocchio C,Cubero B

更新日期：2003-10-01 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa produces type 4 fimbriae which promote adhesion to epithelial cells and are associated with a form of surface translocation called twitching motility. Transposon mutagenesis was used to identify loci required for fimbrial assembly or function by screening for mutants t...

journal_title：Molecular microbiology

authors： Martin PR,Watson AA,McCaul TF,Mattick JS

更新日期：1995-05-01 00:00:00

abstract：:Cell wall lipids of Mycobacterium tuberculosis containing multiple methylbranched fatty acids play critical roles in pathogenesis and thus offer targets for new antimycobacterial drugs. Mycocerosicacid synthase gene (mas) encodes the enzyme that produces one class of such acids. Seven mas-like genes (msls) were identi...

journal_title：Molecular microbiology

authors： Dubey VS,Sirakova TD,Kolattukudy PE

更新日期：2002-09-01 00:00:00

abstract：:The Leishmania major aquaglyceroporin, LmAQP1, is responsible for the transport of trivalent metalloids, arsenite and antimonite. We have earlier shown that downregulation of LmAQP1 provides resistance to trivalent antimony compounds whereas increased expression of LmAQP1 in drug-resistant parasites can reverse the re...

journal_title：Molecular microbiology

authors： Figarella K,Uzcategui NL,Zhou Y,LeFurgey A,Ouellette M,Bhattacharjee H,Mukhopadhyay R

更新日期：2007-08-01 00:00:00

abstract：:Until recently, rare-earth elements (REEs) had been thought to be biologically inactive. This view changed with the discovery of the methanol dehydrogenase XoxF that strictly relies on REEs for its activity. Some methylotrophs only contain xoxF, while others, including the model phyllosphere colonizer Methylobacterium...

journal_title：Molecular microbiology

authors： Ochsner AM,Hemmerle L,Vonderach T,Nüssli R,Bortfeld-Miller M,Hattendorf B,Vorholt JA

更新日期：2019-05-01 00:00:00

abstract：:Elevated expression of the plasma membrane drug efflux pump proteins Cdr1p and Cdr2p was shown to accompany decreased azole susceptibility in Candida albicans clinical isolates. DNA sequence analysis revealed extensive allelic heterozygosity, particularly of CDR2. Cdr2p alleles showed different abilities to transport ...

journal_title：Molecular microbiology

authors： Holmes AR,Tsao S,Ong SW,Lamping E,Niimi K,Monk BC,Niimi M,Kaneko A,Holland BR,Schmid J,Cannon RD

更新日期：2006-10-01 00:00:00

abstract：:The Escherichia coli UvrD helicase (or helicase II) is known for its involvement in DNA repair. We report that UvrD is required for DNA replication of several different rolling-circle plasmids in E. coli, whereas its homologue, the Rep helicase, is not. Lack of UvrD helicase does not impair the first step of plasmid r...

journal_title：Molecular microbiology

authors： Bruand C,Ehrlich SD

更新日期：2000-01-01 00:00:00

abstract：:Many proteins have developed the potential to sequester a client polypeptide chain in its various folding states as a specific intermolecular ligand and, thus, exhibit the properties of a holding chaperone. The resulting complexes can be of a diverse nature in terms of structure and reaction dynamics and are character...

journal_title：Molecular microbiology

authors： Fischer G,Wawra S

更新日期：2006-09-01 00:00:00

abstract：:Streptococcus mutans, a commensal of the human oral cavity, can survive in the bloodstream and cause infective endocarditis (IE). However, the virulence factors associated with this manifestation of disease are not known. Here, we demonstrate that AtlA, an autolysin of S. mutans is a newly identified fibronectin (Fn) ...

journal_title：Molecular microbiology

authors： Jung CJ,Zheng QH,Shieh YH,Lin CS,Chia JS

更新日期：2009-11-01 00:00:00

abstract：:The predatory bacterium Bdellovibrio bacteriovorus swims rapidly by rotation of a single, polar flagellum comprised of a helical filament of flagellin monomers, contained within a membrane sheath and powered by a basal motor complex. Bdellovibrio collides with, enters and replicates within bacterial prey, a process pr...

journal_title：Molecular microbiology

authors： Lambert C,Evans KJ,Till R,Hobley L,Capeness M,Rendulic S,Schuster SC,Aizawa S,Sockett RE

更新日期：2006-04-01 00:00:00

abstract：:Protein phosphatases 2C are a family of conserved enzymes involved in many aspects of the cell biology. We reported that, in the yeast Saccharomyces cerevisiae, overexpression of the Ptc3p isoform resulted in increased lithium tolerance in the hypersensitive hal3 background. We have found that the tolerance induced by...

journal_title：Molecular microbiology

authors： Ruiz A,González A,García-Salcedo R,Ramos J,Ariño J

更新日期：2006-10-01 00:00:00

abstract：:Fungi defend their ecological niche against antagonists by producing antibiosis molecules. Some of these molecules are only produced upon confrontation with the antagonist. The basidiomycete Coprinopsis cinerea induces the expression of the sesquiterpene synthase-encoding gene cop6 and its two neighboring genes coding...

journal_title：Molecular microbiology

authors： Stöckli M,Morinaka BI,Lackner G,Kombrink A,Sieber R,Margot C,Stanley CE,deMello AJ,Piel J,Künzler M

更新日期：2019-08-01 00:00:00

abstract：:We demonstrate that disruption of the htrA (high temperature requirement A) gene in either the virulent Bacillus anthracis Vollum (pXO1(+) , pXO2(+) ), or in the ΔVollum (pXO1(-), pXO2(-), nontoxinogenic and noncapsular) strains, affect significantly the ability of the resulting mutants to withstand heat, oxidative, e...

journal_title：Molecular microbiology

authors： Chitlaru T,Zaide G,Ehrlich S,Inbar I,Cohen O,Shafferman A

更新日期：2011-09-01 00:00:00

abstract：:The transmembrane protein ToxR plays a key role in the virulence expression system of Vibrio cholerae. The activity of ToxR is dependent on its periplasmic sensor domain (ToxRp) and on the inner membrane protein ToxS. Herein, we present the Nuclear Magnetic Resonance NMR solution structure of the sensory ToxRp contain...

journal_title：Molecular microbiology

authors： Gubensäk N,Wagner GE,Schrank E,Falsone FS,Berger TMI,Pavkov-Keller T,Reidl J,Zangger K

更新日期：2020-12-23 00:00:00

abstract：:Polyadenylation is a universal post-transcriptional modification involved in degradation and quality control of bacterial RNAs. In Escherichia coli, it is admitted that any accessible RNA 3' end can be tagged by a poly(A) tail for decay. However, we do not have yet an overall view of the population of polyadenylated m...

journal_title：Molecular microbiology

authors： Maes A,Gracia C,Hajnsdorf E,Régnier P

更新日期：2012-01-01 00:00:00

abstract：:Saccharomyces cerevisiae expresses two proteins that together support high-affinity Fe-uptake. These are a multicopper oxidase, Fet3p, with specificity towards Fe²⁺ and a ferric iron permease, Ftr1p, which supports Fe-accumulation. Homologues of the genes encoding these two proteins are found in all fungal genomes inc...

journal_title：Molecular microbiology

authors： Ziegler L,Terzulli A,Gaur R,McCarthy R,Kosman DJ

更新日期：2011-07-01 00:00:00

abstract：:Pseudomonas putida WCS358 can transport iron complexed to a wide variety of pseudobactins produced by other Pseudomonas strains. The pupB gene encoding an outer membrane ferric-pseudobactin receptor was isolated from a genomic library of P. putida WCS358. The PupB receptor facilitated iron transport via two distinct h...

journal_title：Molecular microbiology

authors： Koster M,van de Vossenberg J,Leong J,Weisbeek PJ

更新日期：1993-05-01 00:00:00

abstract：:Several Fusarium species produce the polyketide mycotoxin zearalenone (ZEA), a causative agent of hyperestrogenic syndrome in animals that is often found in F. graminearum-infected cereals in temperate regions. The ZEA biosynthetic cluster genes PKS4, PKS13, ZEB1 and ZEB2 encode a reducing polyketide synthase, a non-r...

journal_title：Molecular microbiology

authors： Park AR,Son H,Min K,Park J,Goo JH,Rhee S,Chae SK,Lee YW

更新日期：2015-09-01 00:00:00

abstract：:A decline in our ability to successfully treat patients with malaria infections of the parasitic protozoan Plasmodium falciparum with cheap quinoline drugs has led to a huge escalation in morbidity and mortality in recent years. Many approaches have been taken, including classical genetics, reverse genetics and molecu...

journal_title：Molecular microbiology

authors： Duraisingh MT,Refour P

更新日期：2005-08-01 00:00:00

abstract：:The collective function of secreted pathogen effector molecules is to enhance the virulence and avirulence activity of the pathogen during the infection of its host. While the activity of a majority of pathogen effectors is unknown, several classes of effector molecules have been well characterized. Among these includ...

journal_title：Molecular microbiology

authors： Tian M,Day B

更新日期：2006-09-01 00:00:00

abstract：:Dimerization and inactivation of ribosomes in Escherichia coli is a two-step process that involves the binding of ribosome modulation factor (RMF) and hibernation promotion factor (HPF). Lactococcus lactis MG1363 expresses a protein, YfiA(L) (l) , which associates with ribosomes in the stationary phase of growth and i...

journal_title：Molecular microbiology

authors： Puri P,Eckhardt TH,Franken LE,Fusetti F,Stuart MC,Boekema EJ,Kuipers OP,Kok J,Poolman B

更新日期：2014-01-01 00:00:00

abstract：:Bacterial autotransporters consist of an N-terminal 'passenger domain' that is transported into the extracellular space by an unknown mechanism and a C-terminal 'beta-domain' that forms a beta-barrel in the outer membrane. Recent studies have revealed that fully assembled autotransporters have an unusual architecture ...

journal_title：Molecular microbiology

authors： Ieva R,Skillman KM,Bernstein HD

更新日期：2008-01-01 00:00:00

abstract：:The identical partial deep-core structure of Hep alpha 1-3Hep alpha 1-5KDO in Salmonella typhimurium LT2 LPS and Neisseria gonorrhoeae LOS enabled us to isolate a DNA fragment from N. gonorrhoeae that was able to complement the alpha 1,5 LOS heptosyltransferase defect in the S. typhimurium rfaC630 (SA1377) mutant. SDS...

journal_title：Molecular microbiology

authors： Zhou D,Lee NG,Apicella MA

更新日期：1994-11-01 00:00:00

abstract：SUMMARY:The conserved bacterial protein RloC, a distant homologue of the tRNA(Lys) anticodon nuclease (ACNase) PrrC, is shown here to act as a wobble nucleotide-excising and Zn(++)-responsive tRNase. The more familiar PrrC is silenced by a genetically linked type I DNA restriction-modification (R-M) enzyme, activated b...

journal_title：Molecular microbiology

authors： Davidov E,Kaufmann G

更新日期：2008-09-01 00:00:00