Functional characterization of the ferroxidase, permease high-affinity iron transport complex from Candida albicans.

abstract：:We report here the formation of symbiotic plasmids (pSyms), by genetic recombination between rearranged pSyms, which lack symbiotic information, and resistance plasmids carrying parts of different symbiotic plasmids (R's). This recombination was found to occur both between plasmids derived from different Rhizobium pha...

journal_title：Molecular microbiology

authors： Soberón-Chávez G,Nájera R,Espín G,Moreno S

更新日期：1991-04-01 00:00:00

abstract：:Agrobacterium tumefaciens uses a type IV secretion (T4S) system composed of VirB proteins and VirD4 to deliver oncogenic DNA (T-DNA) and protein substrates to susceptible plant cells during the course of infection. Here, by use of the Transfer DNA ImmunoPrecipitation (TrIP) assay, we present evidence that the mobiliza...

journal_title：Molecular microbiology

authors： Cascales E,Atmakuri K,Liu Z,Binns AN,Christie PJ

更新日期：2005-10-01 00:00:00

abstract：:The GATA factor AreA is a wide-domain regulator in Aspergillus nidulans with transcriptional activation and chromatin remodelling functions. AreA interacts with the nitrate-specific Zn(2)-C(6) cluster protein NirA and both proteins cooperate to synergistically activate nitrate-responsive genes. We have previously esta...

journal_title：Molecular microbiology

authors： Berger H,Pachlinger R,Morozov I,Goller S,Narendja F,Caddick M,Strauss J

更新日期：2006-01-01 00:00:00

abstract：:Dps is a nucleoid-associated protein that plays a major role in condensation of the Escherichia coli chromosome in stationary phase. Here we show that two other nucleoid-associated proteins, Fis and H-NS, can bind at the dps gene promoter and downregulate its activity. Both Fis and H-NS selectively repress the dps pro...

journal_title：Molecular microbiology

authors： Grainger DC,Goldberg MD,Lee DJ,Busby SJ

更新日期：2008-06-01 00:00:00

abstract：:Escherichia coli loses its rod shape by inactivation of PBP2 (penicillin-binding protein 2), target of the beta-lactam mecillinam. Under these conditions, cell division is blocked in rich medium. Division in the absence of PBP2 activity is restored (and resistance to mecillinam is conferred) when the three cell divisi...

journal_title：Molecular microbiology

authors： Navarro F,Robin A,D'Ari R,Joseleau-Petit D

更新日期：1998-08-01 00:00:00

abstract：:The ArsAB extrusion pump encoded by the ars operon of Escherichia coli plasmid R773 confers resistance to the toxic trivalent metalloids arsenite [As(III)] and antimonite [Sb(III)]. The ArsA ATPase, the catalytic subunit of the pump, has two homologous halves, A1 and A2. At the interface of these two halves are two nu...

journal_title：Molecular microbiology

authors： Ruan X,Bhattacharjee H,Rosen BP

更新日期：2008-01-01 00:00:00

abstract：:While Vipp1 (also known as IM30) clearly is essential for proper biogenesis of thylakoid membranes in chloroplasts and cyanobacteria, the exact function of Vipp1/IM30 still remains unclear. The recent in vivo study of Gutu et al. now demonstrates that Vipp1/IM30 forms localized puncta specifically at highly curved mem...

journal_title：Molecular microbiology

authors： Junglas B,Schneider D

更新日期：2018-04-01 00:00:00

abstract：:Lipopolysaccharides (LPS), particularly the O-antigen component, are one of many virulence determinants necessary for Shigella flexneri pathogenesis. O-antigen biosynthesis is determined mostly by genes located in the rfb region of the chromosome. The rfc/wzy gene encodes the O-antigen polymerase, an integral membrane...

journal_title：Molecular microbiology

authors： Daniels C,Vindurampulle C,Morona R

更新日期：1998-06-01 00:00:00

abstract：:Bordetella bronchiseptica is a pathogen that can acquire iron using its native alcaligin siderophore system, but can also use the catechol xenosiderophore enterobactin via the BfeA outer membrane receptor. Transcription of bfeA is positively controlled by a regulator that requires induction by enterobactin. Catecholam...

journal_title：Molecular microbiology

authors： Armstrong SK,Brickman TJ,Suhadolc RJ

更新日期：2012-05-01 00:00:00

abstract：:Protein kinase G of Mycobacterium tuberculosis has been implicated in virulence and in regulation of glutamate metabolism. Here we show that this kinase undergoes a pattern of autophosphorylation that is distinct from that of other M. tuberculosis protein kinases characterized to date and we identify GarA as a substra...

journal_title：Molecular microbiology

authors： O'Hare HM,Durán R,Cerveñansky C,Bellinzoni M,Wehenkel AM,Pritsch O,Obal G,Baumgartner J,Vialaret J,Johnsson K,Alzari PM

更新日期：2008-12-01 00:00:00

abstract：:In cyanobacteria and chloroplasts, exposure to HL damages the photosynthetic apparatus, especially the D1 subunit of Photosystem II. To avoid chronic photoinhibition, a PSII repair cycle operates to replace damaged PSII subunits with newly synthesised versions. To determine the sub-cellular location of this process, w...

journal_title：Molecular microbiology

authors： Sacharz J,Bryan SJ,Yu J,Burroughs NJ,Spence EM,Nixon PJ,Mullineaux CW

更新日期：2015-05-01 00:00:00

abstract：:Coli surface antigen 6 (CS6) is a widely expressed enterotoxigenic Escherichia coli (ETEC) colonization factor that mediates bacterial attachment to the small intestinal epithelium. CS6 is a polymer of two protein subunits CssA and CssB, which are secreted and assembled on the cell surface via the CssC/CssD chaperone ...

journal_title：Molecular microbiology

authors： Roy SP,Rahman MM,Yu XD,Tuittila M,Knight SD,Zavialov AV

更新日期：2012-12-01 00:00:00

abstract：:Members of the bacterial genus Brucella are facultative intracellular pathogens that reside predominantly within membrane-bound compartments within two host cell types, macrophages and placental trophoblasts. Within macrophages, the brucellae route themselves to an intracellular compartment that is favourable for surv...

journal_title：Molecular microbiology

authors： Roop RM 2nd,Bellaire BH,Valderas MW,Cardelli JA

更新日期：2004-05-01 00:00:00

abstract：:Almost all bacterial genomes contain DNA of viral origin, including functional prophages or degenerated phage elements. A frequent but often unnoted phenomenon is the spontaneous induction of prophage elements (SPI) even in the absence of an external stimulus. In this study, we have analyzed SPI of the large, degenera...

journal_title：Molecular microbiology

authors： Helfrich S,Pfeifer E,Krämer C,Sachs CC,Wiechert W,Kohlheyer D,Nöh K,Frunzke J

更新日期：2015-11-01 00:00:00

abstract：:Pseudomonas syringae pv. tomato (Pst) strain DC3000 infects the model plants Arabidopsis thaliana and tomato, causing disease symptoms characterized by necrotic lesions surrounded by chlorosis. One mechanism used by Pst DC3000 to infect host plants is the type III protein secretion system, which is thought to deliver ...

journal_title：Molecular microbiology

authors： Zwiesler-Vollick J,Plovanich-Jones AE,Nomura K,Bandyopadhyay S,Joardar V,Kunkel BN,He SY

更新日期：2002-09-01 00:00:00

abstract：:We have previously shown that in the human pathogen Neisseria meningitidis group B (MenB) more than 200 genes are regulated in response to growth with iron. Among the Fur-dependent, upregulated genes identified by microarray analysis was a putative operon constituted by three genes, annotated as NMB1436, NMB1437 and N...

journal_title：Molecular microbiology

authors： Grifantini R,Frigimelica E,Delany I,Bartolini E,Giovinazzi S,Balloni S,Agarwal S,Galli G,Genco C,Grandi G

更新日期：2004-11-01 00:00:00

abstract：:Many proteins have developed the potential to sequester a client polypeptide chain in its various folding states as a specific intermolecular ligand and, thus, exhibit the properties of a holding chaperone. The resulting complexes can be of a diverse nature in terms of structure and reaction dynamics and are character...

journal_title：Molecular microbiology

authors： Fischer G,Wawra S

更新日期：2006-09-01 00:00:00

abstract：:The yeast Candida glabrata rapidly autoactivates transcription of the AMT1 gene in response to potentially toxic copper levels through the copper-inducible binding of the Amt1 transcription factor to a metal response element (MRE) within a positioned nucleosome. Our previous studies have characterized the role of a 16...

journal_title：Molecular microbiology

authors： Koch KA,Allard S,Santoro N,Côté J,Thiele DJ

更新日期：2001-06-01 00:00:00

abstract：:The DnaA protein of Escherichia coli is a multi-functional protein which, In addition to promoting initiation of replication, can regulate the initiation or termination of transcription of a variety of genes. It acts by binding to DNA at a defined sequence, termed a DnaA-box. Three candidate DnaA-boxes which occur wit...

journal_title：Molecular microbiology

authors： Smith RW,McAteer S,Masters M

更新日期：1996-07-01 00:00:00

abstract：:Recent footprinting, sedimentation and neutron-scattering results obtained in vivo or on pre-translocation and post-translocation ribosomal complexes are integrated with cross-linking and immunoelectron microscopy information. It is proposed that the 30S subunit pulses during translocation and that its pre- and post-t...

journal_title：Molecular microbiology

authors： Laughrea M

更新日期：1994-03-01 00:00:00

abstract：:pAM beta 1 is a low-copy-number, promiscuous plasmid from Gram-positive bacteria that replicates by a unidirectional theta-type mode. Its replication is initiated by an original mechanism, involving the positive rate-limiting RepE protein. Here we show that the pAM beta 1-encoded CopF protein is involved in negative r...

journal_title：Molecular microbiology

authors： Le Chatelier E,Ehrlich SD,Jannière L

更新日期：1994-11-01 00:00:00

abstract：:In the mouse model for systemic infection, natural a/alpha strains of C. albicans are more virulent and more competitive than their spontaneous MTL-homozygous offspring, which arise primarily by loss of one chromosome 5 homologue followed by duplication of the retained homologue (uniparental disomy). Deletion of eithe...

journal_title：Molecular microbiology

authors： Wu W,Lockhart SR,Pujol C,Srikantha T,Soll DR

更新日期：2007-06-01 00:00:00

abstract：:Previous studies with purified variants of the 434 repressor having different operator-binding specificities have demonstrated the interactions of a heterodimeric repressor with a hybrid operator site. The present study investigates the interactions between the 434 repressor and its operator site. The optimum 434 oper...

journal_title：Molecular microbiology

authors： Webster C,Merryweather A,Brammar W

更新日期：1992-02-01 00:00:00

abstract：:Sequence-inherent targeting information directs polypeptides synthesized in the cytosol to their respective cellular compartment. Some proteins use ambiguous sorting signals or specific folding properties to be dually distributed between the cytosol and mitochondria. A study published in this issue of Molecular Microb...

journal_title：Molecular microbiology

authors： Herrmann JM

更新日期：2009-04-01 00:00:00

abstract：:The heterotrimeric G-protein pathway is a ubiquitous eukaryotic signalling module that is known to regulate growth and differentiation in many plant pathogens. We previously identified Pigpa1, a gene encoding a G-protein alpha subunit from the potato late blight pathogen Phytophthora infestans. P. infestans belongs to...

journal_title：Molecular microbiology

authors： Latijnhouwers M,Ligterink W,Vleeshouwers VG,van West P,Govers F

更新日期：2004-02-01 00:00:00

abstract：:The bvg locus contains two genes, bvgA and bvgS, which control the expression of the virulence-associated genes in Bordetella species by a system similar to the two-component systems used by a variety of bacterial species to respond to environmental stimuli. We determined the nucleotide sequence of the bvg loci of Bor...

journal_title：Molecular microbiology

authors： Aricò B,Scarlato V,Monack DM,Falkow S,Rappuoli R

更新日期：1991-10-01 00:00:00

abstract：:Computer analysis of the crystallographic structure of the A subunit of Escherichia coli heat-labile toxin (LT) was used to predict residues involved in NAD binding, catalysis and toxicity. Following site-directed mutagenesis, the mutants obtained could be divided into three groups. The first group contained fully ass...

journal_title：Molecular microbiology

authors： Pizza M,Domenighini M,Hol W,Giannelli V,Fontana MR,Giuliani MM,Magagnoli C,Peppoloni S,Manetti R,Rappuoli R

更新日期：1994-10-01 00:00:00

abstract：:Understanding the basis of bacterial persistence in latent infections is critical for eradication of tuberculosis. Analysis of Mycobacterium tuberculosis mRNA expression in an in vitro model of non-replicating persistence indicated that the bacilli require electron transport chain components and ATP synthesis for surv...

journal_title：Molecular microbiology

authors： Dhiman RK,Mahapatra S,Slayden RA,Boyne ME,Lenaerts A,Hinshaw JC,Angala SK,Chatterjee D,Biswas K,Narayanasamy P,Kurosu M,Crick DC

更新日期：2009-04-01 00:00:00

abstract：:Recently, sexual development in the heterothallic ascomycete Trichoderma reesei (anamorph of Hypocrea jecorina) has been achieved and thus initiated attempts to elucidate regulation and determinants of this process. While the α-type pheromone of this fungus fits the consensus known from other fungi, the assumed a-type...

journal_title：Molecular microbiology

authors： Schmoll M,Seibel C,Tisch D,Dorrer M,Kubicek CP

更新日期：2010-09-01 00:00:00

abstract：:The four motor proteins PomA, PomB, MotX and MotY, which are believed to be stator proteins, are essential for motility by the Na(+)-driven flagella of Vibrio alginolyticus. When we purified the flagellar basal bodies, MotX and MotY were detected in the basal body, which is the supramolecular complex comprised of the ...

journal_title：Molecular microbiology

authors： Terashima H,Fukuoka H,Yakushi T,Kojima S,Homma M

更新日期：2006-11-01 00:00:00