Mechanisms promoting dendritic cell-mediated transmission of HIV.

abstract：:Leprosy is a bacterial disease caused by M. leprae. Its clinical spectrum reflects the host's immune response to the M. leprae and provide an ideal model to investigate the host pathogen interaction and immunological dysregulation. Tregs are high in leprosy patients and responsible for immune suppression of the host b...

journal_title：Molecular immunology

authors： Tarique M,Saini C,Naqvi RA,Khanna N,Sharma A,Rao DN

更新日期：2017-03-01 00:00:00

abstract：:Kappa light chains were investigated in sera of several groups of wild derived mouse strains by radioimmunological analysis using xenogeneic anti-mouse kappa light chain antibodies. Although the majority of strains tested expressed serologically indistinguishable kappa chains, several significant exceptions were obser...

journal_title：Molecular immunology

authors： Mami F,Gris C,Guenet JL,Bonhomme F,Cazenave PA

更新日期：1986-08-01 00:00:00

abstract：:This study analyzes the gene repertoire coding for antibodies to an evolutionary novel immunogenic carbohydrate antigen in mice. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) is an autoantigen, abundantly expressed in wild type mice, but absent in alpha 1,3galactosyltransferase knock-out (KO) mice, where i...

journal_title：Molecular immunology

authors： Chen ZC,Radic MZ,Galili U

更新日期：2000-06-01 00:00:00

abstract：:A microchemical assay for phosphorus was applied to the measurement of DNA in immune complexes formed with monoclonal or serum anti-DNA autoantibodies and DNA of varying size and conformation. Two monoclonal antibodies were produced by hybridomas derived from spleen cells of autoimmune MRL-lpr/lpr mice and were purifi...

journal_title：Molecular immunology

authors： Ali R,Dersimonian H,Stollar BD

更新日期：1985-12-01 00:00:00

abstract：:The recognition structure responsible for binding to conventional antigen on target cells has not previously been described for nonspecific cytotoxic cells (NCC) or for mammalian natural killer (NK) cells. Although several biochemical pathways may be available for initiation of the lytic cycle in NCC, evidence present...

journal_title：Molecular immunology

authors： Jaso-Friedmann L,Leary JH 3rd,Evans DL

更新日期：1997-08-01 00:00:00

abstract：:Chicken host defense peptide cathelicidin-2 (CATH-2) is known to exert antimicrobial and immunomodulatory activities and consists of two alpha-helices connected by a hinge region. Here we report the biological properties of the separate alpha-helical segments and the importance of the proline residue in the hinge regi...

journal_title：Molecular immunology

authors： van Dijk A,Molhoek EM,Veldhuizen EJ,Bokhoven JL,Wagendorp E,Bikker F,Haagsman HP

更新日期：2009-08-01 00:00:00

abstract：:When 5-fluorouracil (5-FU) resistant bone marrow (BM) cells are depleted of B-cells and then cultured in insert chambers [separated from a layer of adherent BM (aBM) cells by a nucleopore membrane], no mature, lipopolysaccharide (LPS) reactive B-cells are formed. Factors acting on B-cell precursors are not produced un...

journal_title：Molecular immunology

authors： Gisler RH,Schlienger C,Söderberg A,Ledermann F,Lambris JD

更新日期：1988-11-01 00:00:00

abstract：:The capacity of α-galactosylceramide (α-GalCer) to act as an anti-cancer agent in mice through the specific stimulation of type I NKT (iNKT) cells has prompted extensive investigation to translate this finding to the clinic. However, low frequencies of iNKT cells in cancer patients and their hypo-responsiveness to rep...

journal_title：Molecular immunology

authors： Painter GF,Burn OK,Hermans IF

更新日期：2021-02-01 00:00:00

abstract：:Recombinant IL-2 (rIL-2) produced in prokaryotes, is widely used in lieu of native IL-2, which is secreted by T cells, to assess the functional profile of this cytokine. We provide evidence that a naturally occurring species of post-translationally modified IL-2 (moIL-2) exhibits enhanced bioactivity compared to rIL-2...

journal_title：Molecular immunology

authors： Denis MC,Huber BT

更新日期：2003-09-01 00:00:00

abstract：:In this study we constructed two phage libraries displaying non-immunized natural human IgM derived HCDR3 repertoires. One library was structurally constrained by a Gly to Cys substitution at position 104 enabling the formation of a disulfide bridge with the Cys at position 92. Panning of these libraries on an anti-hu...

journal_title：Molecular immunology

authors： Deroo S,Fischer A,Beaupain N,Counson M,Boutonnet N,Pletinckx J,Loverix S,Beirnaert E,De Haard H,Schmit JC,Lasters I

更新日期：2008-03-01 00:00:00

abstract：:Members of the genus Ebolavirus cause fulminating outbreaks of disease in human and non-human primate populations with a mortality rate up to 90%. To facilitate rapid detection of these pathogens in clinical and environmental samples, robust reagents capable of providing sensitive and specific detection are required. ...

journal_title：Molecular immunology

authors： Goodchild SA,Dooley H,Schoepp RJ,Flajnik M,Lonsdale SG

更新日期：2011-09-01 00:00:00

abstract：:The thermal effects associated with the binding reaction of concanavalin A and immunoglobulins have been measured by calorimetry. IgG solutions do not generate heat on mixing with concanavalin A, confirming the low reactivity of IgG for the lectin molecule. IgM solutions, on the other hand, show a substantial enthalpi...

journal_title：Molecular immunology

authors： Dani M,Manca F,Rialdi G

更新日期：1982-07-01 00:00:00

abstract：:The binding of CD40 ligand on activated T cells to CD40 on resting B cells induces the expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86). The induction of B7 molecules by CD40 ligand-CD40 interaction represents a critical step in rendering B cells competent for antigen presentation. The CBA/N mouse has...

journal_title：Molecular immunology

authors： Goldstein MD,Debenedette MA,Hollenbaugh D,Watts TH

更新日期：1996-04-01 00:00:00

abstract：:Scygonadin is a novel antimicrobial peptide, which was originally isolated from the seminal plasma of the mud crab, Scylla serrata. Based on the partial 20-residue NH(2)-terminal sequence of the peptide, H-Gly-Gln-Ala-Leu-Asn-Lys-Leu-Met-Pro-Lys-Ile-Val-Ser-Ala-Ile-Ile-Tyr-Met-Val-Gly-OH, scygonadin was cloned from th...

journal_title：Molecular immunology

authors： Wang KJ,Huang WS,Yang M,Chen HY,Bo J,Li SJ,Wang GZ

更新日期：2007-03-01 00:00:00

abstract：:Increasing indication is unveiling a role for poly(ADP-ribose) polymerase (PARP)-1 in the regulation of inflammatory/immune responses. The aim of the present study was to determine the potential anti-inflammatory effects of PARP-1 inhibitor 5-aminoisoquinolinone (5-AIQ) to explore the role of PARP-1 inhibitor in a mou...

journal_title：Molecular immunology

authors： Ahmad SF,Zoheir KM,Ansari MA,Korashy HM,Bakheet SA,Ashour AE,Al-Shabanah OA,Al-harbi MM,Attia SM

更新日期：2015-02-01 00:00:00

abstract：:The S100A12 gene belongs to the S100 family of genes, which are specific to vertebrates. It is involved in many inflammatory diseases of human and has been considered as a powerful diagnostic gene. In the present study, we identified the porcine S100A12 (pS100A12) gene, provided evidence that pS100A12 is located on ch...

journal_title：Molecular immunology

authors： Chen H,Cheng L,Yang S,Liu X,Liu Y,Tang J,Li X,He Q,Zhao S

更新日期：2010-04-01 00:00:00

abstract：:This study identified the peptide-binding motif of HLA-DRA/DRB1*1401 (DR1401). First, peptides containing DR1401 restricted epitopes were identified using tetramer-guided epitope mapping. Among these, an influenza B peptide was selected for the motif study. After confirming the binding register for this peptide using ...

journal_title：Molecular immunology

authors： James EA,Moustakas AK,Berger D,Huston L,Papadopoulos GK,Kwok WW

更新日期：2008-05-01 00:00:00

abstract：:The complement system is a vital component of the immune-priveliged human eye that is always active at a low-grade level, preventing harmful intraocular injuries caused by accumulation of turnover products and controlling pathogens to preserve eye homeostasis and vision. The complement system is a double-edged sword t...

journal_title：Molecular immunology

authors： Mohlin C,Sandholm K,Ekdahl KN,Nilsson B

更新日期：2017-09-01 00:00:00

abstract：:Stimulation of cells of the rat basophilic leukemia line RBL-2H3, which are used as a model in biochemical studies of mast cells, by antigen or by the calcium ionophore ionomycin, are known to cause secretion of mediators of inflammation. These stimuli have now been found to cause a decrease in the cells' cytosolic pH...

journal_title：Molecular immunology

authors： Gertler R,Pecht I

更新日期：1988-11-01 00:00:00

abstract：:Complement per se has been shown to play an important role in demyelinating disease but controversy remains regarding the role of C3 in the development and progression of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. In this study, we used C3(-/-) mice to confirm previous fi...

journal_title：Molecular immunology

authors： Szalai AJ,Hu X,Adams JE,Barnum SR

更新日期：2007-05-01 00:00:00

abstract：:Complement plays a dual role in the progression of systemic lupus erythematosus since it has important protective functions, such as the clearance of immune complexes and apoptotic cells, but is also a mediator of renal inflammation. To investigate this balance in a clinically relevant setting, we investigated how tar...

journal_title：Molecular immunology

authors： Sekine H,Ruiz P,Gilkeson GS,Tomlinson S

更新日期：2011-10-01 00:00:00

abstract：:Placental growth factor (PlGF), a member of vascular endothelial growth factors (VEGF) family, is considered as an important antigen associated with pathological conditions such as cancer cell growth, and metastasis. PlGF-targeting via nanobody (Nb) therefore could be beneficial to modulate these pathologies. In this ...

journal_title：Molecular immunology

authors： Arezumand R,Mahdian R,Zeinali S,Hassanzadeh-Ghassabeh G,Mansouri K,Khanahmad H,Namvar-Asl N,Rahimi H,Behdani M,Cohan RA,Eavazalipour M,Ramazani A,Muyldermans S

更新日期：2016-10-01 00:00:00

abstract：:Rabbits hyperimmunized with fluorescyl-conjugated KLH exhibited bound ligand associated with a high affinity circulating IgG anti-fluorescein population. After cessation of immunogen administration the liganded complexes were eventually spontaneously cleared from the circulation. Individual rabbits synthesized autolog...

journal_title：Molecular immunology

authors： Voss EW Jr,Moore JK,Weidner-McGufficke KM,Denzin LK,Bedzyk WD,Voss VH

更新日期：1992-02-01 00:00:00

abstract：:A monoclonal antibody (vpg15) has been described which can block infection with feline immunodeficiency virus (FIV) and which recognizes the feline homologue of CD9. In order to study the role of feline CD9 in infection with FIV we have molecularly cloned a cDNA encoding feline CD9 by R.A.C.E (rapid amplification of c...

journal_title：Molecular immunology

authors： Willett BJ,Neil JC

更新日期：1995-04-01 00:00:00

abstract：:Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune syste...

journal_title：Molecular immunology

authors： Thiel S,Frederiksen PD,Jensenius JC

更新日期：2006-01-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) functions in leukocyte trafficking, activation, and the formation of the immunological synapse. ICAM-1 is a member of the immunoglobulin superfamily of adhesion proteins, which share a similar structure of repeating Ig-like domains. Many genes in this family, including ICAM-1...

journal_title：Molecular immunology

authors： Hu X,Barnum SR,Wohler JE,Schoeb TR,Bullard DC

更新日期：2010-05-01 00:00:00

abstract：:The capsid protein of hepatitis B virus (P19) is made of 183 amino acids and carries the antigenic sites of hepatitis B core antigen (HBcAg) and hepatitis B e antigen (HBeAg) on the amino-terminal domain. The carboxyl-terminal domain of P19 (amino acids 150-183) is arginine-rich (47%) and faces the interior of the nuc...

journal_title：Molecular immunology

authors： Machida A,Ohnuma H,Takai E,Tsuda F,Tanaka T,Naito M,Munekata E,Miyakawa Y,Mayumi M

更新日期：1989-04-01 00:00:00

abstract：:Dendritic cells (DCs) play an important role in antigen presentation, which is an essential step for the induction of antigen-specific adaptive immunity. Inactivated bacterial whole cell vaccines have been widely used to prevent many bacterial infections because they elicit good immunogenicity due to the presence of v...

journal_title：Molecular immunology

authors： Kim HY,Kim SK,Seo HS,Jeong S,Ahn KB,Yun CH,Han SH

更新日期：2018-09-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is known as a unique member of the cyclin-dependent family of serine/threonine kinases. Previously, we demonstrated Cdk5 to be an important regulator of T cell function and that disruption of Cdk5 expression ameliorates T cell mediated neuroinflammation. Here, we show a novel role of C...

journal_title：Molecular immunology

authors： Lam E,Choi SH,Pareek TK,Kim BG,Letterio JJ

更新日期：2015-10-01 00:00:00

abstract：:The characterization of the site on the IgE molecule which accommodates the high affinity receptor for IgE (Fc epsilon RI) should allow the design of IgE analogues which can be utilized to block allergic responses. Using chimeric human IgE molecules in which different constant region domains were exchanged with their ...

journal_title：Molecular immunology

authors： Nissim A,Eshhar Z

更新日期：1992-09-01 00:00:00