Abstract:
:Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to directly affect sarcomeric regulation. This review focuses on physiologically relevant covalent and noncovalent modifications in troponin as part of a thematic series on cardiac thin filament function in health and disease.
journal_name
Circ Resjournal_title
Circulation researchauthors
Metzger JM,Westfall MVdoi
10.1161/01.RES.0000110083.17024.60subject
Has Abstractpub_date
2004-02-06 00:00:00pages
146-58issue
2eissn
0009-7330issn
1524-4571pii
94/2/146journal_volume
94pub_type
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