Role of troponin I proteolysis in the pathogenesis of stunned myocardium.

abstract：:The ionic currents that cross the myocardial membrane during cardiac activation have a corresponding return path in the extracellular space. The transmembrane current (Im) during activation of cardiac cells in situ has previously been envisioned only in mathematical models. We have developed a remarkably simple in viv...

journal_title：Circulation research

authors： Witkowski FX,Kavanagh KM,Penkoske PA,Plonsey R

更新日期：1993-02-01 00:00:00

abstract：RATIONALE:Despite significant interest in bone marrow mononuclear cell (BMC) therapy for ischemic heart disease, current techniques have resulted in only modest benefits. However, selected patients have shown improvements after autologous BMC therapy, but the contributing factors are unclear. OBJECTIVE:The purpose of ...

journal_title：Circulation research

authors： Schutt RC,Trachtenberg BH,Cooke JP,Traverse JH,Henry TD,Pepine CJ,Willerson JT,Perin EC,Ellis SG,Zhao DX,Bhatnagar A,Johnstone BH,Lai D,Resende M,Ebert RF,Wu JC,Sayre SL,Orozco A,Zierold C,Simari RD,Moyé L,Cogle

更新日期：2015-01-02 00:00:00

abstract：:To determine whether or not salt loading restricted to the brain would elevate blood pressure, chronically implanted osmotic minipumps were used to infuse hypertonic sodium chloride solutions made in artificial cerebrospinal fluid into a jugular vein intravenously or the third cerebral ventricle, intracerebroventricul...

journal_title：Circulation research

authors： Miyajima E,Buñag RD

更新日期：1984-05-01 00:00:00

abstract：:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calci...

journal_title：Circulation research

authors： Collett GD,Canfield AE

更新日期：2005-05-13 00:00:00

abstract：:Freshly dispersed rabbit ear artery cells were studied using patch-clamp techniques to measure membrane currents in whole cells and single-channel currents in membrane patches. Whole-cell calcium currents recorded at physiologic extracellular calcium concentrations were small (approximately 10 pA). Recordings with 110...

journal_title：Circulation research

authors： Benham CD,Hess P,Tsien RW

更新日期：1987-10-01 00:00:00

abstract：:The effect of sulfinpyrazone on endothelial injury induced by homocysteine has been studied both in vitro, using cultured human umbilical vein endothelial cells, and in vivo, using a primate model of homocysteine-induced arteriosclerosis. Oral sulfinpyrazone (250 mumol/kg body weight per day in three divided doses) in...

journal_title：Circulation research

authors： Harker LA,Harlan JM,Ross R

更新日期：1983-12-01 00:00:00

abstract：RATIONALE:The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction. This system is composed of specialized cardiomyocytes organized in defined structures including central components and a peripheral Purkinje fiber network. How the mammalian ven...

journal_title：Circulation research

authors： Miquerol L,Moreno-Rascon N,Beyer S,Dupays L,Meilhac SM,Buckingham ME,Franco D,Kelly RG

更新日期：2010-07-09 00:00:00

abstract：:The migration of medial smooth muscle cells (SMCs) into the intima is proposed to be an important process of intimal thickening in atherosclerotic lesions. The present study examined the possible effect of a novel endothelium-derived relaxing peptide, C-type natriuretic peptide (CNP), on oxidized low-density lipoprote...

journal_title：Circulation research

authors： Kohno M,Yokokawa K,Yasunari K,Kano H,Minami M,Ueda M,Yoshikawa J

更新日期：1997-10-01 00:00:00

abstract：:Apolipoprotein E-deficient (ApoE-/-) mice develop atherosclerotic lesions throughout the arterial tree, including the carotid bifurcation. Although the expression of adhesion molecules such as ICAM-1, vascular cell adhesion molecule-1 (VCAM-1), and P-selectin on endothelium that overlie atherosclerotic plaques has bee...

journal_title：Circulation research

authors： Ramos CL,Huo Y,Jung U,Ghosh S,Manka DR,Sarembock IJ,Ley K

更新日期：1999-06-11 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) plays an important role in regulating vascular smooth muscle cell (VSMC) proliferation and directed migration. The mitogenic and chemotactic actions of IGF-I are mediated through the IGF-I receptor, but how the activation of the IGF-I receptor leads to these biological responses is...

journal_title：Circulation research

authors： Duan C,Bauchat JR,Hsieh T

更新日期：2000-01-07 00:00:00

abstract：:Angiotensin II (Ang II) plays an important role in post-myocardial infarction (MI) remodeling. Most Ang II effects related to remodeling involve activation of the type 1 receptor (AT(1)). Although the AT(1) receptor is upregulated on cardiac fibroblasts post-MI, little is known about the mechanisms involved in the pro...

journal_title：Circulation research

authors： Gurantz D,Cowling RT,Villarreal FJ,Greenberg BH

更新日期：1999-08-06 00:00:00

abstract：:Physiological or pathological stresses and strains produce longer or wider muscle cells, but resting sarcomere length remains constant. Our goal was to investigate the cellular mechanisms for controlling this optimal, resting sarcomere length. To do so, we cultured neonatal rat cardiomyocytes on microfabricated peg-an...

journal_title：Circulation research

authors： Mansour H,de Tombe PP,Samarel AM,Russell B

更新日期：2004-03-19 00:00:00

abstract：RATIONALE:Allogeneic mesenchymal precursor cells (MPCs) have been effective in large animal models of ischemic and nonischemic heart failure (HF). OBJECTIVE:To evaluate the feasibility and safety of 3 doses (25, 75, or 150 million cells) of immunoselected allogeneic MPCs in chronic HF patients in a phase 2 trial. MET...

journal_title：Circulation research

authors： Perin EC,Borow KM,Silva GV,DeMaria AN,Marroquin OC,Huang PP,Traverse JH,Krum H,Skerrett D,Zheng Y,Willerson JT,Itescu S,Henry TD

更新日期：2015-08-28 00:00:00

abstract：:If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and stroke has been the success story of the century's past 4 decades. The early phase of this decline in coronary heart disease and stroke was unex...

journal_title：Circulation research

authors： Mensah GA,Wei GS,Sorlie PD,Fine LJ,Rosenberg Y,Kaufmann PG,Mussolino ME,Hsu LL,Addou E,Engelgau MM,Gordon D

更新日期：2017-01-20 00:00:00

abstract：:The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors have frequently been implicated in human cardiovascular malformations. A novel mechanism involving posttranscriptional regulation by small, noncod...

journal_title：Circulation research

authors： Cordes KR,Srivastava D

更新日期：2009-03-27 00:00:00

abstract：RATIONALE:Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovascular, and ga...

journal_title：Circulation research

authors： Ren X,Ustiyan V,Pradhan A,Cai Y,Havrilak JA,Bolte CS,Shannon JM,Kalin TV,Kalinichenko VV

更新日期：2014-09-26 00:00:00

abstract：:The microelectrode technique of intracellular constant current application and intracellular transmembrane voltage recording was used to study the effects of procaine amide (PA) on cardiac excitability. We measured the effect of PA in a concentration equivalent to clinically effective antiarrhythmic plasma levels (5 m...

journal_title：Circulation research

authors： Arnsdorf MF,Bigger JT Jr

更新日期：1976-02-01 00:00:00

abstract：:High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with many minor proteins and lipids that influence the function of HDL. Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cel...

journal_title：Circulation research

authors： Lüscher TF,Landmesser U,von Eckardstein A,Fogelman AM

更新日期：2014-01-03 00:00:00

abstract：:A method was developed for recording isometric tension from isolated small arteries (mean internal diameter, 169 microns) and veins (mean internal diameter, 273 microns) of the term fetal lung and was then applied to the study of the mechanisms controlling perinatal pulmonary hemodynamics. The specific purpose was to ...

journal_title：Circulation research

authors： Wang Y,Coceani F

更新日期：1992-08-01 00:00:00

abstract：:Leukocyte rolling along the endothelium in inflammation is caused by continuous formation and breakage of bonds between selectin adhesion molecules and their ligands. We investigated trauma-induced leukocyte rolling in venules (diameter, 23 to 58 microns; wall shear stress, 1.2 to 35 dyne/cm2) of the exteriorized rat ...

journal_title：Circulation research

authors： Damiano ER,Westheider J,Tözeren A,Ley K

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood. OBJECTIV...

journal_title：Circulation research

authors： Porrello ER,Johnson BA,Aurora AB,Simpson E,Nam YJ,Matkovich SJ,Dorn GW 2nd,van Rooij E,Olson EN

更新日期：2011-09-02 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：:We hypothesized that both acute and chronic accumulation of myocardial interstitial edema (extravascular fluid [EVF]) would compromise cardiac function. We also postulated that excess fluid within the myocardial interstitial space would potentiate interstitial fibrosis, thus further compromising function. Dogs were di...

journal_title：Circulation research

authors： Laine GA,Allen SJ

更新日期：1991-06-01 00:00:00

abstract：RATIONALE:The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain, but visualization and experimental analysis of these vessels is challenging in mammals. Although the optical clarity and experimental advantages of zebrafish ...

journal_title：Circulation research

authors： Castranova D,Samasa B,Venero Galanternik M,Jung HM,Pham VN,Weinstein BM

更新日期：2021-01-08 00:00:00

abstract：:The positive inotropic response to angiotensin I and II in cardiac tissue of most mammalian species, as well as the exact site in the heart for conversion of local and systemic angiotensin I into angiotensin II, remains to be elucidated. In isolated cat papillary muscles, angiotensin I and angiotensin II (0.1 nM to 1 ...

journal_title：Circulation research

authors： Meulemans AL,Andries LJ,Brutsaert DL

更新日期：1990-06-01 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：:CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation. CD40 has recently been described on platelets but platelet activation by CD40 has not been descr...

journal_title：Circulation research

authors： Inwald DP,McDowall A,Peters MJ,Callard RE,Klein NJ

更新日期：2003-05-16 00:00:00

abstract：:Postnatal development of the mammalian heart is associated with changes in the population of isoforms of the thin filament proteins. We correlated the change in thin filament proteins, which occur in rabbit hearts between 5 days and 22 days of age, with changes in Ca2+ dependence of myofibrillar ATPase activity, force...

journal_title：Circulation research

authors： McAuliffe JJ,Gao LZ,Solaro RJ

更新日期：1990-05-01 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：:In 57 normal subjects (age 20-60 years), we analyzed the spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90 degrees upright tilt, controlled respiration (n = 16) and acute (n = 10) and chronic (n = 12) beta-adrenergic receptor blockade. Automatic computer analysis provided the a...

journal_title：Circulation research

authors： Pagani M,Lombardi F,Guzzetti S,Rimoldi O,Furlan R,Pizzinelli P,Sandrone G,Malfatto G,Dell'Orto S,Piccaluga E

更新日期：1986-08-01 00:00:00