Randomized controlled trials of blood pressure lowering in hypertension: a critical reappraisal.

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) plays a pivotal role in the coordinated transactivation of cytokine and adhesion molecule genes involved in endothelial activation. Although recent reports have documented the contribution of NF-kappaB to apoptosis, it is still controversial. Especially, the r...

journal_title：Circulation research

authors： Matsushita H,Morishita R,Nata T,Aoki M,Nakagami H,Taniyama Y,Yamamoto K,Higaki J,Yasufumi K,Ogihara T

更新日期：2000-05-12 00:00:00

abstract：:First-generation, E1-deleted adenoviral vectors (E1-AV) can transduce the vascular endothelium with high efficiency, but their use is limited by the resulting acute endothelial injury and the long-term development of intimal hyperplasia. To reduce the impact of viral proteins on the gene-modified cells, a second-gener...

journal_title：Circulation research

authors： Qian HS,Channon K,Neplioueva V,Wang Q,Finer M,Tsui L,George SE,McArthur J

更新日期：2001-05-11 00:00:00

abstract：:Although it has been established that myocyte enhancer factor 2 (MEF2) plays pivotal roles in the development of the cardiovascular system as well as skeletal muscle cells, little is known of its role in vascular inflammatory diseases such as atherosclerosis and restenosis after angioplasty. To investigate the role of...

journal_title：Circulation research

authors： Suzuki E,Satonaka H,Nishimatsu H,Oba S,Takeda R,Omata M,Fujita T,Nagai R,Hirata Y

更新日期：2004-07-09 00:00:00

abstract：:Telomeres-the specialized DNA-protein structures at the ends of eukaryotic chromosomes-are essential for maintaining genome stability and integrity and for extended proliferative life span in both cultured cells and in the whole organism. Telomerase and additional telomere-associated proteins are necessary for preserv...

journal_title：Circulation research

authors： Serrano AL,Andrés V

更新日期：2004-03-19 00:00:00

abstract：:Gap junction pharmacology is a nascent field. Previous studies have identified molecules that enhance intercellular communication, and may offer potential for innovative antiarrhythmic therapy. However, their specific molecular target(s) and mechanism(s) of action remain unknown. Previously, we identified a 34-aa pept...

journal_title：Circulation research

authors： Verma V,Larsen BD,Coombs W,Lin X,Spagnol G,Sorgen PL,Taffet SM,Delmar M

更新日期：2009-07-17 00:00:00

abstract：:Hypertrophied cardiac myocytes exhibit prolonged action potentials and decreased transient outward potassium current (I(to)). Because Kv4.3 is a major contributor to I:(to), we studied regulation of its expression in neonatal rat cardiac myocytes in response to the known stimulators of cardiac myocyte hypertrophy, ang...

journal_title：Circulation research

authors： Zhang TT,Takimoto K,Stewart AF,Zhu C,Levitan ES

更新日期：2001-03-16 00:00:00

abstract：:Oxidative stress through the production of oxygen metabolites such as hydrogen peroxide (H2O2) increases vascular endothelial permeability. H2O2 stimulates ADP-ribose formation, which in turn opens transient receptor potential melastatin (TRPM)2 channels. Here, in endothelial cells, we demonstrate transcript and prote...

journal_title：Circulation research

authors： Hecquet CM,Ahmmed GU,Vogel SM,Malik AB

更新日期：2008-02-15 00:00:00

abstract：:The transverse tubular system (t-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. Using 2-photon molecular excitation microscopy and digital image-processing methods, we have obtained a comprehensive overview of the t-system of rat ventricular myocytes in liv...

journal_title：Circulation research

authors： Soeller C,Cannell MB

更新日期：1999-02-19 00:00:00

abstract：:In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the limited regenerative capacity of the myocardium, resulting in the formation of a collagen-based scar. Necrotic cells release danger signals, activating innate immune pathways and triggering an intense inflammatory response. Stimula...

journal_title：Circulation research

authors： Prabhu SD,Frangogiannis NG

更新日期：2016-06-24 00:00:00

abstract：:Trimetazidine is a clinically effective antianginal agent that has no negative inotropic or vasodilator properties. Although it is thought to have direct cytoprotective actions on the myocardium, the mechanism(s) by which this occurs is as yet undefined. In this study, we determined what effects trimetazidine has on b...

journal_title：Circulation research

authors： Kantor PF,Lucien A,Kozak R,Lopaschuk GD

更新日期：2000-03-17 00:00:00

abstract：:Controversy exists regarding the mechanism by which catecholamines stimulate renin secretion in vivo. A sensitive rat kidney slice system was utilized to study the direct effects of adrenergic agonists and antagonists on renin release in vitro. Catecholamines were protected from degradation by the addition of ascorbic...

journal_title：Circulation research

authors： Weinberger MH,Aoi W,Henry DP

更新日期：1975-09-01 00:00:00

abstract：:Brugada syndrome has been linked to mutations in SCN5A. Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tachycardia/fibrillation. Lidocaine, an agent with rapid dissociation kinetics, has previously been sho...

journal_title：Circulation research

authors： Barajas-Martínez HM,Hu D,Cordeiro JM,Wu Y,Kovacs RJ,Meltser H,Kui H,Elena B,Brugada R,Antzelevitch C,Dumaine R

更新日期：2008-08-15 00:00:00

abstract：:Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the c...

journal_title：Circulation research

authors： Poornima IG,Parikh P,Shannon RP

更新日期：2006-03-17 00:00:00

abstract：:The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen...

journal_title：Circulation research

authors： Mukherjee D,Sen S

更新日期：1990-12-01 00:00:00

abstract：:We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bil...

journal_title：Circulation research

authors： Ching LL,Williams AJ,Sitsapesan R

更新日期：2000-08-04 00:00:00

abstract：:Cyclic nucleotides are known to modify voltage-gated (L-type) Ca2+ channel activity in vascular smooth muscle cells, but the exact mechanism(s) underlying these effects is not well defined. The purpose of the present study was to investigate the modulatory role of the cAMP- and cGMP-dependent protein kinase (PKA and P...

journal_title：Circulation research

authors： Ruiz-Velasco V,Zhong J,Hume JR,Keef KD

更新日期：1998-03-23 00:00:00

abstract：:Oxygen free radicals have the ability to oxidize cholesterol. However, nothing is known about the effects of cholesterol oxidation on ion transport in isolated myocardial membranes. The purpose of the present study was to investigate the effects of in situ oxidative modification of sarcolemmal cholesterol on Ca2+ flux...

journal_title：Circulation research

authors： Kutryk MJ,Maddaford TG,Ramjiawan B,Pierce GN

更新日期：1991-01-01 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：:Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicar...

journal_title：Circulation research

authors： Mulieri LA,Barnes W,Leavitt BJ,Ittleman FP,LeWinter MM,Alpert NR,Maughan DW

更新日期：2002-01-11 00:00:00

abstract：:Brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are novel natriuretic peptides, originally isolated from porcine brain. Similar to atrial natriuretic peptide (ANP), BNP is also synthesized in and secreted from cardiocytes, but CNP is not expressed at significant levels in normal adult myocardium. ...

journal_title：Circulation research

authors： Takahashi T,Allen PD,Izumo S

更新日期：1992-07-01 00:00:00

abstract：:The effects of two types of repeated transient coronary artery occlusions on collateral development were examined in chronically instrumented, conscious dogs. A 2-minute coronary occlusion at 32-minute intervals (group 1, n = 11) or a 15-second occlusion at 4-minute intervals (group 2, n = 7) were repeated day and nig...

journal_title：Circulation research

authors： Mohri M,Tomoike H,Noma M,Inoue T,Hisano K,Nakamura M

更新日期：1989-02-01 00:00:00

abstract：:Increases in free Mg2+ from 0.04 to 10.0 mM with constant pH 7.0 TO 0.10 M ionic strength, and 2 mM MgATP2- caused a rightward shift of the free Ca-relative ATPase relation for both cardiac skeletal myofibrils. The specific activity of cardiac myofibrillar ATPase over a wide range of free Ca2+ was, however, depressed ...

journal_title：Circulation research

authors： Solaro RJ,Shiner JS

更新日期：1976-07-01 00:00:00

abstract：:MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Because individual microRNAs often regulate the expression of multiple target genes with related functions, modulating the expression of a single microRNA can, in principle, influence an ...

journal_title：Circulation research

authors： van Rooij E,Marshall WS,Olson EN

更新日期：2008-10-24 00:00:00

abstract：RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms tha...

journal_title：Circulation research

authors： Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

更新日期：2013-06-07 00:00:00

abstract：:Platelet-activating factor (acetyl-glyceryl-ether-phosphorylcholine; 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphorylcholine), which is released by stimulated neutrophils and platelets, possesses the ability to alter vascular tone and permeability and to activate various formed blood elements. We have characterized the he...

journal_title：Circulation research

authors： Jackson CV,Schumacher WA,Kunkel SL,Driscoll EM,Lucchesi BR

更新日期：1986-02-01 00:00:00

abstract：RATIONALE:The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphisms, most are located within regulatory intergenic or intronic sequence...

journal_title：Circulation research

authors： Vincentz JW,Firulli BA,Toolan KP,Arking DE,Sotoodehnia N,Wan J,Chen PS,de Gier-de Vries C,Christoffels VM,Rubart-von der Lohe M,Firulli AB

更新日期：2019-08-30 00:00:00

abstract：:-The vascular endothelial growth factor receptor Flk-1/KDR is highly expressed during development and almost disappears in adult tissues. Despite its biological relevance, little is known about the molecular mechanisms controlling its expression. In the present work, it is shown that cAMP response element binding prot...

journal_title：Circulation research

authors： Illi B,Puri P,Morgante L,Capogrossi MC,Gaetano C

更新日期：2000-06-23 00:00:00

abstract：RATIONALE:A better understanding of the mechanism underlying skeletal muscle repair is required to develop therapies that promote tissue regeneration in adults. Hedgehog signaling has been shown previously to be involved in myogenesis and angiogenesis: 2 crucial processes for muscle development and regeneration. OBJEC...

journal_title：Circulation research

authors： Renault MA,Vandierdonck S,Chapouly C,Yu Y,Qin G,Metras A,Couffinhal T,Losordo DW,Yao Q,Reynaud A,Jaspard-Vinassa B,Belloc I,Desgranges C,Gadeau AP

更新日期：2013-10-25 00:00:00

abstract：:Topical application of sodium arachidonate (50-200 micrograms/ml) or bradykinin (0.1-10 micrograms/ml) on the brain surface of anesthetized cats caused dose-dependent cerebral arteriolar dilation. This dilation was blocked by 67-100% in the presence of superoxide dismutase and catalase. These enzymes did not affect th...

journal_title：Circulation research

authors： Kontos HA,Wei EP,Povlishock JT,Christman CW

更新日期：1984-09-01 00:00:00

abstract：:Hypoxia is a potent coronary-vasodilating signal; its mechanisms are still controversial. We have assessed the possible role of nitric oxide (NO) in hypoxic coronary vasodilatation (HCVD) in isolated guinea pig hearts perfused at constant pressure. HCVD was elicited by a 1-minute 100% N2 exposure; coronary flow double...

journal_title：Circulation research

authors： Park KH,Rubin LE,Gross SS,Levi R

更新日期：1992-10-01 00:00:00