Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology.

abstract：:Oxygen free radicals have the ability to oxidize cholesterol. However, nothing is known about the effects of cholesterol oxidation on ion transport in isolated myocardial membranes. The purpose of the present study was to investigate the effects of in situ oxidative modification of sarcolemmal cholesterol on Ca2+ flux...

journal_title：Circulation research

authors： Kutryk MJ,Maddaford TG,Ramjiawan B,Pierce GN

更新日期：1991-01-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a widely distributed mitogen that mediates the growth-promoting effects of platelet-derived growth factor in mesenchymal cells. We show that rat aortic IGF-I messenger RNA (mRNA) is induced 24 hours after deendothelialization, at a time when smooth muscle cell proliferation with...

journal_title：Circulation research

authors： Cercek B,Fishbein MC,Forrester JS,Helfant RH,Fagin JA

更新日期：1990-06-01 00:00:00

abstract：:Connexins have been hypothesized to play an important role in intercellular communication within the vascular wall and may provide a mechanistic explanation for conduction of vasomotor responses. To test this hypothesis, we studied the transmission of vasomotor responses in the intact skeletal muscle microcirculation ...

journal_title：Circulation research

authors： de Wit C,Roos F,Bolz SS,Kirchhoff S,Krüger O,Willecke K,Pohl U

更新日期：2000-03-31 00:00:00

abstract：:Recent evidence suggests that dopamine may alter kidney function by actions not only in the renal vasculature but also at the glomerular-mesangial level. We studied this phenomenon by examining the ability of dopamine to antagonize the contractile properties of angiotensin II in isolated rat glomeruli and cultured mes...

journal_title：Circulation research

authors： Barnett R,Singhal PC,Scharschmidt LA,Schlondorff D

更新日期：1986-11-01 00:00:00

abstract：RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

journal_title：Circulation research

authors： Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

更新日期：2012-06-08 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：RATIONALE:Unlike conventional dendritic cells, plasmacytoid DCs (PDC) are poor in antigen presentation and critical for type I interferon response. Though proposed to be present in human atherosclerotic lesions, their role in atherosclerosis remains elusive. OBJECTIVE:To investigate the role of PDC in atherosclerosis....

journal_title：Circulation research

authors： Daissormont IT,Christ A,Temmerman L,Sampedro Millares S,Seijkens T,Manca M,Rousch M,Poggi M,Boon L,van der Loos C,Daemen M,Lutgens E,Halvorsen B,Aukrust P,Janssen E,Biessen EA

更新日期：2011-12-09 00:00:00

abstract：RATIONALE:Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs. OBJECTIVE:We investigated the possible function of NK cells in the pathogenesis of congestive heart failure after myocardial infarction. METHODS AND RESULTS:Depletion of N...

journal_title：Circulation research

authors： Yan X,Hegab AE,Endo J,Anzai A,Matsuhashi T,Katsumata Y,Ito K,Yamamoto T,Betsuyaku T,Shinmura K,Shen W,Vivier E,Fukuda K,Sano M

更新日期：2014-02-14 00:00:00

abstract：:To test the hypothesis that the capacity to develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aort...

journal_title：Circulation research

authors： Isoyama S,Wei JY,Izumo S,Fort P,Schoen FJ,Grossman W

更新日期：1987-09-01 00:00:00

abstract：:Ca2+ influx through the L-type calcium channel (LTCC) induces Ca2+ release from the sarcoplasmic reticulum (SR) and maintains SR Ca2+ loading. Alterations in LTCC properties, their contribution to the blunted adrenergic responsiveness in failing hearts and their recovery after support with LV assist devices (LVAD) wer...

journal_title：Circulation research

authors： Chen X,Piacentino V 3rd,Furukawa S,Goldman B,Margulies KB,Houser SR

更新日期：2002-09-20 00:00:00

abstract：:To elucidate the local effects of renin in the coronary circulation, we examined local angiotensin (Ang) I and II formation, as well as coronary vasoconstriction in response to renin administration, and compared the effects with exogenous infused Ang I. We perfused isolated hearts from rats overexpressing the human an...

journal_title：Circulation research

authors： Müller DN,Fischli W,Clozel JP,Hilgers KF,Bohlender J,Ménard J,Busjahn A,Ganten D,Luft FC

更新日期：1998-01-09 00:00:00

abstract：RATIONALE:Studies have demonstrated that exosomes can repair cardiac tissue post-myocardial infarction and recapitulate the benefits of cellular therapy. OBJECTIVE:We evaluated the role of donor age and hypoxia of human pediatric cardiac progenitor cell (CPC)-derived exosomes in a rat model of ischemia-reperfusion inj...

journal_title：Circulation research

authors： Agarwal U,George A,Bhutani S,Ghosh-Choudhary S,Maxwell JT,Brown ME,Mehta Y,Platt MO,Liang Y,Sahoo S,Davis ME

更新日期：2017-02-17 00:00:00

abstract：:The precise, temporal order of gene expression during development is critical to ensure proper lineage commitment, cell fate determination, and ultimately, organogenesis. Epigenetic regulation of chromatin structure is fundamental to the activation or repression of genes during embryonic development. In recent years, ...

journal_title：Circulation research

authors： Boland MJ,Nazor KL,Loring JF

更新日期：2014-07-07 00:00:00

abstract：RATIONALE:MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions. Because microRNAs are products of ...

journal_title：Circulation research

authors： Matkovich SJ,Hu Y,Dorn GW 2nd

更新日期：2013-06-21 00:00:00

abstract：RATIONALE:Hypoxia promotes renal damage and progression of chronic kidney disease (CKD). The erythrocyte is the only cell type for oxygen (O2) delivery. Sphingosine 1-phosphate (S1P)-a highly enriched biolipid in erythrocytes-is recently reported to be induced under high altitude in normal humans to enhance O2 delivery...

journal_title：Circulation research

authors： Xie T,Chen C,Peng Z,Brown BC,Reisz JA,Xu P,Zhou Z,Song A,Zhang Y,Bogdanov MV,Kellems RE,D'Alessandro A,Zhang W,Xia Y

更新日期：2020-07-17 00:00:00

abstract：:Intussusceptive angiogenesis is a novel mode of blood vessel formation and remodeling, which occurs by internal division of the preexisting capillary plexus without sprouting. In this study, the process is demonstrated in developing chicken eye vasculature and in the chorioallantoic membrane by methylmethacrylate (Mer...

journal_title：Circulation research

authors： Djonov V,Schmid M,Tschanz SA,Burri PH

更新日期：2000-02-18 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors controlling lipid and glucose metabolism as well as inflammation. PPARs are expressed in macrophages, cells that also generate reactive oxygen species (ROS). In this study, we investigated whether PPARs regulate ROS production in macrophages. Di...

journal_title：Circulation research

authors： Teissier E,Nohara A,Chinetti G,Paumelle R,Cariou B,Fruchart JC,Brandes RP,Shah A,Staels B

更新日期：2004-12-10 00:00:00

abstract：:Two characteristic features of the rapid component of the cardiac delayed rectifier current (IKr) are prominent inward rectification and an unexpected reduction in activating current with decreased [K+]o. Similar features are observed with heterologous expression of HERG, the gene thought to encode the channel carryin...

journal_title：Circulation research

authors： Yang T,Snyders DJ,Roden DM

更新日期：1997-06-01 00:00:00

abstract：:Although the ultrasonic pulsatility index (PI) is used as a test of arterial inflow, the relationship between proximal arterial stenosis and PI has not been fully evaluated. In a series of experiments on dogs, over 200 measurements of pressure, flow (using an indwelling electromagnetic flowmeter), and PI were made dis...

journal_title：Circulation research

authors： Evans DH,Barrie WW,Asher MJ,Bentley S,Bell PR

更新日期：1980-04-01 00:00:00

abstract：:Whole-cell voltage-clamp experiments were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to test the hypothesis that the differences in the amplitude of transient outward current (Ito) contribute to the difference ...

journal_title：Circulation research

authors： Furukawa T,Myerburg RJ,Furukawa N,Bassett AL,Kimura S

更新日期：1990-11-01 00:00:00

abstract：:Cardiovascular aging is associated with decreased endothelial vasoreactivity and prolonged diastolic relaxation. As diminished NO signaling contributes to age-associated endothelial dysfunction, we tested the hypothesis that impaired NO signaling or bioactivity also contributes to slowed ventricular relaxation with ag...

journal_title：Circulation research

authors： Zieman SJ,Gerstenblith G,Lakatta EG,Rosas GO,Vandegaer K,Ricker KM,Hare JM

更新日期：2001-01-19 00:00:00

abstract：:We determined the effects of changing the spatial dispersion of acetylcholine release on the phase-dependent chronotropic responses to vagal stimulation in anesthetized dogs. We stimulated the vagus nerves with one brief burst of electrical pulses each cardiac cycle, and we changed the timing of the stimulus by a smal...

journal_title：Circulation research

authors： Yang TE,Cheng J,Levy MN

更新日期：1990-10-01 00:00:00

abstract：:Pulsatile pulmonary hemodynamics were analyzed in a chronic awake canine high flow model. Standard mean flow and pulsatile flow hemodynamics were measured and alterations in the proximal pulmonary vascular physical properties were quantified by the characteristic impedance (Zo). Pulmonary vascular resistance (PVR), wh...

journal_title：Circulation research

authors： Hopkins RA,Hammon JW Jr,McHale PA,Smith PK,Anderson RW

更新日期：1979-08-01 00:00:00

abstract：:Angiotensin II (Ang II) has powerful modulatory actions on cardiovascular function that are mediated by specific receptors located on neurons within the hypothalamus and brain stem. Incubation of neuronal cocultures of rat hypothalamus and brain stem with Ang II elicits an Ang II type 1 (AT1) receptor-mediated inhibit...

journal_title：Circulation research

authors： Gelband CH,Warth JD,Mason HS,Zhu M,Moore JM,Kenyon JL,Horowitz B,Sumners C

更新日期：1999-02-19 00:00:00

abstract：:Ventricular repolarization was analyzed by measuring epicardial potential distributions in intact dogs with single or multiple ectopic foci and a minimum at the terminal site(s) of excitation. During the latter half of the T wave the distributions became more complex, and two maxima evolved from the initial one at eac...

journal_title：Circulation research

authors： Spach MS,Barr RC

更新日期：1976-10-01 00:00:00

abstract：:Patients with severe heart failure are at high risk of sudden cardiac death. In the majority of these patients, sudden cardiac death is thought to be due to ventricular tachyarrhythmias. Alterations of the electric properties of single myocytes in heart failure may favor the occurrence of ventricular arrhythmias in th...

journal_title：Circulation research

authors： Priebe L,Beuckelmann DJ

更新日期：1998-06-15 00:00:00

abstract：:Therapeutic angiogenesis using vascular endothelial growth factor (VEGF) is considered a promising new therapy for patients with arterial obstructive disease. Clinical improvements observed consist of improved muscle function and regression of rest pain or angina. However, direct evidence for improved vascularization,...

journal_title：Circulation research

authors： van Weel V,Deckers MM,Grimbergen JM,van Leuven KJ,Lardenoye JH,Schlingemann RO,van Nieuw Amerongen GP,van Bockel JH,van Hinsbergh VW,Quax PH

更新日期：2004-07-09 00:00:00

abstract：:Cardiac hypertrophy induced by thyrotoxic stress leads to an increase in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity. We did studies to see whether alterations in covalent phosphorylation of myofibrillar proteins correlate with these changes. The...

journal_title：Circulation research

authors： Litten RZ 3rd,Martin BJ,Howe ER,Alpert NR,Solaro RJ

更新日期：1981-04-01 00:00:00

abstract：RATIONALE:Smooth muscle precursor cells have previously been reported to reside in bone marrow and in the circulation, but little is currently known regarding the proximate stimuli for smooth muscle cell differentiation of these putative progenitors. OBJECTIVE:Because local thrombin generation occurs as an initial res...

journal_title：Circulation research

authors： Martin K,Weiss S,Metharom P,Schmeckpeper J,Hynes B,O'Sullivan J,Caplice N

更新日期：2009-07-31 00:00:00

abstract：:Nonlaminar flow is a major predisposing factor to atherosclerosis. Yet little is known regarding hemodynamic gene regulation in disease-prone areas of the vascular tree in vivo. We have determined spatial patterns of expression of endothelial cell receptors in the arterial tree and of reporter gene constructs in trans...

journal_title：Circulation research

authors： Porat RM,Grunewald M,Globerman A,Itin A,Barshtein G,Alhonen L,Alitalo K,Keshet E

更新日期：2004-02-20 00:00:00