Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction.

abstract：RATIONALE:Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration. OBJECTIVE:To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and ...

journal_title：Circulation research

authors： Pinto AR,Ilinykh A,Ivey MJ,Kuwabara JT,D'Antoni ML,Debuque R,Chandran A,Wang L,Arora K,Rosenthal NA,Tallquist MD

更新日期：2016-02-05 00:00:00

abstract：:F2-Isoprostanes are novel bioactive prostaglandin F2-like compounds produced by nonenzymatic free radical-catalyzed peroxidation of arachidonic acid. F2-Isoprostanes are initially formed in situ on phospholipids and subsequently released. Quantification of the F2-isoprostanes has been found to represent a valuable and...

journal_title：Circulation research

authors： Moore KP,Darley-Usmar V,Morrow J,Roberts LJ 2nd

更新日期：1995-08-01 00:00:00

abstract：:Proteases of the plasminogen activator (PA) and matrix metalloproteinase (MMP) system play an important role in smooth muscle cell (SMC) migration and neointima formation after vascular injury. Inhibition of either PAs or MMPs has previously been shown to result in decreased neointima formation in vivo. To inhibit bot...

journal_title：Circulation research

authors： Lamfers ML,Grimbergen JM,Aalders MC,Havenga MJ,de Vries MR,Huisman LG,van Hinsbergh VW,Quax PH

更新日期：2002-11-15 00:00:00

abstract：:The beta-adrenergic agonist isoproterenol stimulates immunoreactive atrial natriuretic peptide (IR-ANP) secretion by superfused rat atria in vitro. beta-Adrenergic agonists alter the cellular handling of calcium, which culminates in a rise in the systolic calcium concentration. This is achieved by increasing calcium i...

journal_title：Circulation research

authors： Schiebinger RJ

更新日期：1989-09-01 00:00:00

abstract：:Cardiovascular disease continues to be the leading cause of death among women in the United States, accounting for ≈1 of every 3 female deaths. Sex-specific data focused on cardiovascular disease have been increasing steadily, yet is not routinely collected nor translated into practice. This comprehensive review focus...

journal_title：Circulation research

authors： Garcia M,Mulvagh SL,Merz CN,Buring JE,Manson JE

更新日期：2016-04-15 00:00:00

abstract：:Collagens are abundant within the atherosclerotic plaque, where they contribute to lesion volume and mechanical stability and influence cell signaling. The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds to collagen, is expressed in blood vessels, but evidence for a functional role during ath...

journal_title：Circulation research

authors： Franco C,Hou G,Ahmad PJ,Fu EY,Koh L,Vogel WF,Bendeck MP

更新日期：2008-05-23 00:00:00

abstract：:Angiotensin II and its metabolites, [des-Asp-1]-angiotensin II (angiotensin III), [des-(Asp-1,Arg-2)]angiotensin II, and [des-(Asp-1,Arg-2,val-3)]angiotensin II, were measured in arterial and venous plasma from normal rats. Paper chromatography was used to separate the peptides which were measured with a radioimmunoas...

journal_title：Circulation research

authors： Semple PF,Morton JJ

更新日期：1976-06-01 00:00:00

abstract：:Studies were carried out to determine the contribution of cardiopulmonary receptors to the renal responses to head-out water immersion in the nonhuman primate. Immersion to the suprasternal notch was associated with significant increases in central venous pressure, urine flow, and sodium excretion. The increased sodiu...

journal_title：Circulation research

authors： Gilmore JP,Zucker IH

更新日期：1978-02-01 00:00:00

abstract：:We recently showed that the transient expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the G protein alpha(q) subunit (HAalpha(q)*) in the hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after HAalpha(q)* protein becomes u...

journal_title：Circulation research

authors： Mende U,Kagen A,Meister M,Neer EJ

更新日期：1999-11-26 00:00:00

abstract：:We have previously shown that a cryoactivatable inactive form of renin, which we have tentatively termed prorenin, occurs in human plasma. Plasma prorenin is measured by subtracting the endogenous plasma renin activity (PRA) from the total renin activity measured after cryoactivation. Cryoactivation is accomplished by...

journal_title：Circulation research

authors： Sealey JE,Moon C,Laragh JH,Atlas SA

更新日期：1977-05-01 00:00:00

abstract：:We administered ascitic fluid containing atrial natriuretic factor (ANF) monoclonal antibody to rats after 3 weeks of exposure to hypoxia while the rats were still hypoxic. In additional chronically hypoxic rats, we infused synthetic rat ANF. In conscious chronically instrumented rats, after a bolus dose of 5 microgra...

journal_title：Circulation research

authors： Raffestin B,Levame M,Eddahibi S,Viossat I,Braquet P,Chabrier PE,Cantin M,Adnot S

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE:The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS:In 110 patients with systolic heart failu...

journal_title：Circulation research

authors： Parisi V,Rengo G,Perrone-Filardi P,Pagano G,Femminella GD,Paolillo S,Petraglia L,Gambino G,Caruso A,Grimaldi MG,Baldascino F,Nolano M,Elia A,Cannavo A,De Bellis A,Coscioni E,Pellegrino T,Cuocolo A,Ferrara N,Leosco D

更新日期：2016-04-15 00:00:00

abstract：:Atrial fibrillation (AF) may result from stationary reentry in the left atrium (LA), with fibrillatory conduction toward the right atrium (RA). We hypothesize that periodic input to the RA at an exceedingly high frequency results in disorganized wave propagation, compatible with fibrillatory conduction. Simultaneous e...

journal_title：Circulation research

authors： Berenfeld O,Zaitsev AV,Mironov SF,Pertsov AM,Jalife J

更新日期：2002-06-14 00:00:00

abstract：:Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was ...

journal_title：Circulation research

authors： Jolly SR,Kane WJ,Bailie MB,Abrams GD,Lucchesi BR

更新日期：1984-03-01 00:00:00

abstract：:Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human vessels has not been explored. We introduced an adenovirus vector encoding a marker gene human placental alkaline phosphatase into normal and atherosclerotic human v...

journal_title：Circulation research

authors： Rekhter MD,Simari RD,Work CW,Nabel GJ,Nabel EG,Gordon D

更新日期：1998-06-29 00:00:00

abstract：:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calci...

journal_title：Circulation research

authors： Collett GD,Canfield AE

更新日期：2005-05-13 00:00:00

abstract：:We report the hemodynamic parameters of stage 18, 21, 24, and 27 chick embryos (from 3 to 5 days of incubation). Dorsal aortic blood velocity and mean vitelline artery blood pressure are measured with a 20 MHz pulsed-Doppler meter and servo-null pressure system respectively. We also measure heart rate, dorsal aortic d...

journal_title：Circulation research

authors： Clark EB,Hu N

更新日期：1982-12-01 00:00:00

abstract：:Adenosine, a vasodilator metabolite, is often produced in tissues where the demand for oxygen exceeds the supply. We have recently demonstrated in isolated cannulated arterioles that adenosine and its metabolite, inosine, can also cause vasoconstriction by stimulation of mast cells. Secondary release of histamine and ...

journal_title：Circulation research

authors： Shepherd RK,Linden J,Duling BR

更新日期：1996-04-01 00:00:00

abstract：:The predominant cardiac Ca2+/calmodulin-dependent protein kinase (CaMK) is CaMKIIdelta. Here we acutely overexpress CaMKIIdeltaC using adenovirus-mediated gene transfer in adult rabbit ventricular myocytes. This circumvents confounding adaptive effects in CaMKIIdeltaC transgenic mice. CaMKIIdeltaC protein expression a...

journal_title：Circulation research

authors： Kohlhaas M,Zhang T,Seidler T,Zibrova D,Dybkova N,Steen A,Wagner S,Chen L,Brown JH,Bers DM,Maier LS

更新日期：2006-02-03 00:00:00

abstract：:An increase in plasma renin activity was demonstrated in plasma from normal subjects and most patients with essential hypertension after prolonged storage of the plasma at -20 degrees C. No change in renin substrate concentration was observed after storage for 12 months, and the rate of angiotensin generation during i...

journal_title：Circulation research

authors： Sealey JE,Laragh JH

更新日期：1975-06-01 00:00:00

abstract：:We compared the blocking effects of the local anesthetics, lidocaine and benzocaine, on the sodium current, using single rat ventricular cells to obtain further information about the voltage dependence and kinetics of local anesthetic interaction with cardiac sodium channels. We used a hybrid voltage clamp system whic...

journal_title：Circulation research

authors： Sanchez-Chapula J,Tsuda Y,Josephson IR

更新日期：1983-05-01 00:00:00

abstract：RATIONALE:The vascular adventitia is a complex layer of the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells. Adventitial progenitors express the stem cell markers, Sca1 and CD34 (adventitial sca1-positive progenitor cells [AdvSca1]), have the potenti...

journal_title：Circulation research

authors： Majesky MW,Horita H,Ostriker A,Lu S,Regan JN,Bagchi A,Dong XR,Poczobutt J,Nemenoff RA,Weiser-Evans MC

更新日期：2017-01-20 00:00:00

abstract：:Our objective was to test the hypotheses that 1) myoplasmic [Ca2+] is the primary determinant of crossbridge phosphorylation and that 2) phosphorylation is the primary determinant of crossbridge interactions with the thin filament in swine carotid arterial smooth muscle. We tested these hypotheses by evaluating the re...

journal_title：Circulation research

authors： Rembold CM,Murphy RA

更新日期：1988-09-01 00:00:00

abstract：:Experimental and clinical studies have suggested an increased production of reactive oxygen species (ROS) in the failing myocardium. The present study aimed to obtain direct evidence for increased ROS and to determine the contribution of superoxide anion (*O(2)(-)), H(2)O(2), and hydroxy radical (*OH) in failing myoca...

journal_title：Circulation research

authors： Ide T,Tsutsui H,Kinugawa S,Suematsu N,Hayashidani S,Ichikawa K,Utsumi H,Machida Y,Egashira K,Takeshita A

更新日期：2000-02-04 00:00:00

abstract：:Cardiovascular dysfunction as a result of sepsis is the leading cause of death in the critically ill. Cardiomyocytes respond to infectious pathogens with a Toll-like receptor-initiated proinflammatory response in conjunction with a decrease in contractility, although the downstream events linking Toll-like receptor ac...

journal_title：Circulation research

authors： Boyd JH,Kan B,Roberts H,Wang Y,Walley KR

更新日期：2008-05-23 00:00:00

abstract：:The aim of this study is to quantify the porcine coronary arterial branching pattern and to use this quantification for the interpretation of flow heterogeneity. Two casts of the coronary arterial tree were made at diastolic arrest and maximal dilation. The relation between length and diameter of arterial segments was...

journal_title：Circulation research

authors： VanBavel E,Spaan JA

更新日期：1992-11-01 00:00:00

abstract：RATIONALE:Macrophages are essential regulators of atherosclerosis. They secrete cytokines, process lipoproteins and cholesterol, and take up apoptotic cells. Multiple subsets of plaque macrophages exist and their differential roles are emerging. OBJECTIVE:Here, we explore macrophage heterogeneity in atherosclerosis pl...

journal_title：Circulation research

authors： McArdle S,Buscher K,Ghosheh Y,Pramod AB,Miller J,Winkels H,Wolf D,Ley K

更新日期：2019-12-06 00:00:00

abstract：:Experiments were performed to investigate whether balloon injury induces nitric oxide synthase activity in the blood vessel wall. Contractions to phenylephrine were compared in left carotid arteries of the rat, previously injured by balloon catheterization and excised either immediately (t = 0), 6, or 24 hours after t...

journal_title：Circulation research

authors： Joly GA,Schini VB,Vanhoutte PM

更新日期：1992-08-01 00:00:00

abstract：:Ryanodine receptor (RyR) phosphorylation by protein kinase A (PKA) may be important in modulating resting sarcoplasmic reticulum (SR) Ca2+ release, especially in heart failure. However, clear cellular data on PKA-dependent modulation of cardiac RyRs is limited because of difficulty in distinguishing between PKA effect...

journal_title：Circulation research

authors： Li Y,Kranias EG,Mignery GA,Bers DM

更新日期：2002-02-22 00:00:00

abstract：:Hypercholesterolemia induces atheroma formation, and the concentration of sphingomyelin is increased compared with that in the normal aortic intima-media. The aortic intima-media sphingomyelin concentration appears to increase exponentially with time on the cholesterol diet. Moreover, the entry rate of serum sphingomy...

journal_title：Circulation research

authors： Seth SK,Newman AI

更新日期：1975-02-01 00:00:00