Abstract:
:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calcification in several ways. First, many angiogenic factors are now known to exert both direct and indirect effects on bone and cartilage formation. Second, cytokines released by endothelial cells can induce the differentiation of osteoprogenitor cells. Third, the new blood vessels provide oxygen and nutrients to support the growing bone. Finally, the new blood vessels can serve as a conduit for osteoprogenitor cells. These osteoprogenitor cells may be derived from the circulation or from pericytes that are present in the neovessels themselves. Indeed, there is now compelling evidence that pericytes can differentiate into osteoblasts and chondrocytes both in vitro and in vivo. Other vascular cells, including adventitial myofibroblasts, calcifying vascular cells, smooth muscle cells, and valvular interstitial cells, have also been shown to exhibit multilineage potential in vitro. Although these cells share many properties with pericytes, the precise relationship between them is not known. Furthermore, it still remains to be determined whether all or some of these cells contribute to the ectopic calcification observed in vivo. A better understanding of the underlying mechanisms that link angiogenesis, pericytes, and ectopic calcification should provide a basis for development of therapeutic strategies to treat or arrest this clinically significant condition.
journal_name
Circ Resjournal_title
Circulation researchauthors
Collett GD,Canfield AEdoi
10.1161/01.RES.0000163634.51301.0dsubject
Has Abstractpub_date
2005-05-13 00:00:00pages
930-8issue
9eissn
0009-7330issn
1524-4571pii
96/9/930journal_volume
96pub_type
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journal_title:Circulation research
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doi:10.1161/01.res.68.1.300
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更新日期:1993-10-01 00:00:00
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更新日期:1989-07-01 00:00:00
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更新日期:2019-12-06 00:00:00
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更新日期:1976-05-01 00:00:00
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更新日期:2014-06-06 00:00:00
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pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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更新日期:1998-09-07 00:00:00
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更新日期:1991-12-01 00:00:00
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更新日期:1987-12-01 00:00:00
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2001-02-16 00:00:00