Developmental hemodynamic changes in the chick embryo from stage 18 to 27.

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：:We compared the effects of the newer inotropic drugs, pimobendan (UD-CG 115 BS) and milrinone (Win 47203), on the electrical, mechanical and biochemical activity of intact and detergent-skinned preparations of cardiac muscle. Both of these agents increased contractile force of guinea pig papillary muscle preparations ...

journal_title：Circulation research

authors： Fujino K,Sperelakis N,Solaro RJ

更新日期：1988-11-01 00:00:00

abstract：:This review reflects and expands on the contents of my presentation at the Thomas W. Smith Memorial Lecture at American Heart Association Scientific Sessions, 2011. "Decoding the cardiac message" refers to accumulating results from ongoing microRNA research that is altering longstanding concepts of the mechanisms for,...

journal_title：Circulation research

authors： Dorn GW 2nd

更新日期：2012-03-02 00:00:00

abstract：:Purkinje cells contain sarcoplasmic reticulum (SR) directly under the surface membrane, are devoid of t-tubuli, and are packed with myofibrils surrounded by central SR. Several studies have reported that electrical excitation induces a biphasic Ca(2+) transient in Purkinje fiber bundles. We determined the nature of th...

journal_title：Circulation research

authors： Boyden PA,Pu J,Pinto J,Keurs HE

更新日期：2000-03-03 00:00:00

abstract：:The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from ...

journal_title：Circulation research

authors： Mak IT,Arroyo CM,Weglicki WB

更新日期：1989-10-01 00:00:00

abstract：:Rho regulates various cell functions, including cell morphology and motility. However, the functional role of Rho on the signaling pathway in myocardial cells (MCs) is unknown. In the present study, we attempted to explore the mode of Rho action for c-fos gene expression in MCs. Expression of the c-fos promoter/enhanc...

journal_title：Circulation research

authors： Ueyama T,Sakoda T,Kawashima S,Hiraoka E,Hirata K,Akita H,Yokoyama M

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Aortic valve disease is a cell-mediated process without effective pharmacotherapy. CNP (C-type natriuretic peptide) inhibits myofibrogenesis and osteogenesis of cultured valve interstitial cells and is downregulated in stenotic aortic valves. However, it is unknown whether CNP signaling regulates aortic valve...

journal_title：Circulation research

authors： Blaser MC,Wei K,Adams RLE,Zhou YQ,Caruso LL,Mirzaei Z,Lam AY,Tam RKK,Zhang H,Heximer SP,Henkelman RM,Simmons CA

更新日期：2018-02-02 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：RATIONALE:Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the key regulators that are responsible for maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) may confer vascular hom...

journal_title：Circulation research

authors： Zhao G,Fu Y,Cai Z,Yu F,Gong Z,Dai R,Hu Y,Zeng L,Xu Q,Kong W

更新日期：2017-12-08 00:00:00

abstract：:Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whethe...

journal_title：Circulation research

authors： Verschuren L,Kooistra T,Bernhagen J,Voshol PJ,Ouwens DM,van Erk M,de Vries-van der Weij J,Leng L,van Bockel JH,van Dijk KW,Fingerle-Rowson G,Bucala R,Kleemann R

更新日期：2009-07-02 00:00:00

abstract：RATIONALE:Diabetes mellitus is frequently complicated by cardiovascular disease, such as vascular calcification and endothelial dysfunction, which have been associated with bone morphogenetic proteins (BMPs). OBJECTIVE:To determine whether hyperglycemia in vitro and diabetes in vivo promote vascular BMP activity and c...

journal_title：Circulation research

authors： Boström KI,Jumabay M,Matveyenko A,Nicholas SB,Yao Y

更新日期：2011-02-18 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) are short noncoding RNA species generated by the processing of longer precursors by the ribonucleases Drosha and Dicer. Platelets contain large amounts of miRNA that are altered by disease, in particular diabetes mellitus. OBJECTIVE:This study determined why platelet miRNA levels are atten...

journal_title：Circulation research

authors： Elgheznawy A,Shi L,Hu J,Wittig I,Laban H,Pircher J,Mann A,Provost P,Randriamboavonjy V,Fleming I

更新日期：2015-07-03 00:00:00

abstract：RATIONALE:Mutations in vascular endothelial growth factor (VEGF) receptor-3 (VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema. Mutations in VEGFR3 are identified in only 70% of patients with classic Milroy disease, suggesting genetic heterogeneity. OBJECTIV...

journal_title：Circulation research

authors： Gordon K,Schulte D,Brice G,Simpson MA,Roukens MG,van Impel A,Connell F,Kalidas K,Jeffery S,Mortimer PS,Mansour S,Schulte-Merker S,Ostergaard P

更新日期：2013-03-15 00:00:00

abstract：:Computer simulations and nonlinear dynamics have provided invaluable tools for illuminating the underlying mechanisms of cardiac arrhythmias. Here, we review how this approach has led to major insights into the mechanisms of spatially discordant alternans, a key arrhythmogenic factor predisposing the heart to re-entry...

journal_title：Circulation research

authors： Weiss JN,Karma A,Shiferaw Y,Chen PS,Garfinkel A,Qu Z

更新日期：2006-05-26 00:00:00

abstract：:We recorded 60 DC simultaneous electrograms from isolated porcine and canine hearts in the first minutes after coronary occlusion. Ventricular premature beats (VPB) originated from the normal side of the ischemic border, which was frequently separated from the central ischemic area showing delayed activity by a small ...

journal_title：Circulation research

authors： Janse MJ,van Capelle FJ

更新日期：1982-04-01 00:00:00

abstract：:We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...

journal_title：Circulation research

authors： Arai AE,Pantely GA,Anselone CG,Bristow J,Bristow JD

更新日期：1991-12-01 00:00:00

abstract：:The cardiac high molecular weight proteins/ryanodine receptors were purified to homogeneity from junctional sarcoplasmic reticulum membranes and shown to exhibit large conductance calcium channel activity. High molecular weight proteins were solubilized from junctional sarcoplasmic reticulum in zwitterionic detergent ...

journal_title：Circulation research

authors： Rardon DP,Cefali DC,Mitchell RD,Seiler SM,Jones LR

更新日期：1989-04-01 00:00:00

abstract：:Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-...

journal_title：Circulation research

authors： Shorofsky SR,January CT

更新日期：1992-03-01 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：:Acute increases in arterial pulsatile load imposed on the left ventricle can increase coronary flow without commensurate changes in myocardial oxygen consumption. One explanation is that augmenting pulsatile perfusion at the same mean pressure itself stimulates flow by releasing endothelium-mediated vasorelaxant facto...

journal_title：Circulation research

authors： Recchia FA,Senzaki H,Saeki A,Byrne BJ,Kass DA

更新日期：1996-10-01 00:00:00

abstract：:The responses of cardiac mitochondria to anoxia may be evaluated in terms of the oxidation-reduction state of the electron carriers and the ability of the mitochondria to function in energy-linked reactions. The previous detailed evaluation of the oxygen requirements for electron transfer in mitochondria is here exten...

journal_title：Circulation research

authors： Chance B

更新日期：1976-05-01 00:00:00

abstract：:Many indices have been proposed to describee the diastolic pressure-volume curve mathematically and permit quantification of the elastic properties of the myocardium itself in hopes that changes in the muscle caused by disease would b.e reflected in the diastolic pressure-volume curve. To date, none of the proposed in...

journal_title：Circulation research

authors： Glantz SA

更新日期：1976-12-01 00:00:00

abstract：:Recent evidence suggests that dopamine may alter kidney function by actions not only in the renal vasculature but also at the glomerular-mesangial level. We studied this phenomenon by examining the ability of dopamine to antagonize the contractile properties of angiotensin II in isolated rat glomeruli and cultured mes...

journal_title：Circulation research

authors： Barnett R,Singhal PC,Scharschmidt LA,Schlondorff D

更新日期：1986-11-01 00:00:00

abstract：:Hemodynamic shear stress elicits a rise in endothelial [Ca2+]i, which may serve as a key second messenger to regulate many flow-associated physiological and biochemical processes. In the present study, we used Mn2+ quenching of fluorescent dye Fluo3 as an assay to investigate the Ca2+ influx of rat aortic endothelial ...

journal_title：Circulation research

authors： Kwan HY,Leung PC,Huang Y,Yao X

更新日期：2003-02-21 00:00:00

abstract：:The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an att...

journal_title：Circulation research

authors： Duisters RF,Tijsen AJ,Schroen B,Leenders JJ,Lentink V,van der Made I,Herias V,van Leeuwen RE,Schellings MW,Barenbrug P,Maessen JG,Heymans S,Pinto YM,Creemers EE

更新日期：2009-01-30 00:00:00

abstract：:To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transgenic mouse model of heart failure that displays phenotypic characte...

journal_title：Circulation research

authors： Welch S,Plank D,Witt S,Glascock B,Schaefer E,Chimenti S,Andreoli AM,Limana F,Leri A,Kajstura J,Anversa P,Sussman MA

更新日期：2002-04-05 00:00:00

abstract：:Obesity results in marked alterations in cardiac energy metabolism, with a prominent effect being an increase in fatty acid uptake and oxidation by the heart. Obesity also results in dramatic changes in the release of adipokines, such as leptin and adiponectin, both of which have emerged as important regulators of car...

journal_title：Circulation research

authors： Lopaschuk GD,Folmes CD,Stanley WC

更新日期：2007-08-17 00:00:00

abstract：:Heme oxygenase (HO) is a cytoprotective enzyme that degrades heme (a potent oxidant) to generate carbon monoxide (a vasodilatory gas that has anti-inflammatory properties), bilirubin (an antioxidant derived from biliverdin), and iron (sequestered by ferritin). Because of properties of HO and its products, we hypothesi...

journal_title：Circulation research

authors： Wiesel P,Patel AP,Carvajal IM,Wang ZY,Pellacani A,Maemura K,DiFonzo N,Rennke HG,Layne MD,Yet SF,Lee ME,Perrella MA

更新日期：2001-05-25 00:00:00

abstract：RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous response after myocardial infarction (MI). Extracellular matrix undergoes dramatic changes after MI and therefore might be linked to CPC-mediated repair. OBJECTIV...

journal_title：Circulation research

authors： Konstandin MH,Toko H,Gastelum GM,Quijada P,De La Torre A,Quintana M,Collins B,Din S,Avitabile D,Völkers M,Gude N,Fässler R,Sussman MA

更新日期：2013-07-05 00:00:00