Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells.

abstract：RATIONALE:Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis. To understand the pathophysiology of atherosclerotic disease, we need to understand the characteristics of lipid-laden foamy macrophages in the subintimal space during a...

journal_title：Circulation research

authors： Kim K,Shim D,Lee JS,Zaitsev K,Williams JW,Kim KW,Jang MY,Seok Jang H,Yun TJ,Lee SH,Yoon WK,Prat A,Seidah NG,Choi J,Lee SP,Yoon SH,Nam JW,Seong JK,Oh GT,Randolph GJ,Artyomov MN,Cheong C,Choi JH

更新日期：2018-10-26 00:00:00

abstract：:An affinity gel for the purification of renin was prepared by coupling pepstatin to aminohexylagarose gel. Partially purified human renin (Haas et al., Arch. Biochem. Biophys., 110, 534-543, 1965) was purified further by affinity chromatography on the pepstatin-aminohexyl-agarose gel, gel filtration on a Sephadex G-75...

journal_title：Circulation research

authors： Murakami K,Inagami T,Haas E

更新日期：1977-10-01 00:00:00

abstract：:We have shown previously that tyrosine 319 in a conserved YIPP motif in the C terminus of angiotensin II (Ang II) type 1 receptors (AT(1)Rs) is essential for transactivation of epidermal growth factor receptor (EGFR) in vitro. We hypothesized that the signaling mechanism mediated through the specific amino acid sequen...

journal_title：Circulation research

authors： Zhai P,Galeotti J,Liu J,Holle E,Yu X,Wagner T,Sadoshima J

更新日期：2006-09-01 00:00:00

abstract：RATIONALE:Several studies have demonstrated links between infectious diseases and cardiovascular conditions. Malaria and hypertension are widespread in many low- and middle-income countries, but the possible link between them has not been considered. OBJECTIVE:In this article, we outline the basis for a possible link ...

journal_title：Circulation research

authors： Etyang AO,Smeeth L,Cruickshank JK,Scott JA

更新日期：2016-06-24 00:00:00

abstract：:Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest a potential causal role of C-peptide in atherogenesis by promoting monocyte and T-lymphocyte recruitment into the vessel wall. The present study examine...

journal_title：Circulation research

authors： Walcher D,Babiak C,Poletek P,Rosenkranz S,Bach H,Betz S,Durst R,Grüb M,Hombach V,Strong J,Marx N

更新日期：2006-11-24 00:00:00

abstract：:Mitochondria have long been known to play a critical role in maintaining the bioenergetic status of cells under physiological conditions. It was also recognized early in mitochondrial research that the reduction of oxygen to generate the free radical superoxide occurs at various sites in the respiratory chain and was ...

journal_title：Circulation research

authors： Gutierrez J,Ballinger SW,Darley-Usmar VM,Landar A

更新日期：2006-10-27 00:00:00

abstract：RATIONALE:Although not fully understood, the phenotypic transition of vascular smooth muscle cells exhibits at the early onset of the pathology of aortic aneurysms. Exploring the key regulators that are responsible for maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) may confer vascular hom...

journal_title：Circulation research

authors： Zhao G,Fu Y,Cai Z,Yu F,Gong Z,Dai R,Hu Y,Zeng L,Xu Q,Kong W

更新日期：2017-12-08 00:00:00

abstract：:We have measured the apparent Ca2+ sensitivities of force development in skinned cardiac trabeculae at different sarcome lengths together with shifts in troponin (Tn) T subunits on specimens from the same hearts and drawn insights into the pathogenesis of myocardial dysfunction in the diabetic rat. The Ca(2+)-force re...

journal_title：Circulation research

authors： Akella AB,Ding XL,Cheng R,Gulati J

更新日期：1995-04-01 00:00:00

abstract：RATIONALE:Allogeneic mesenchymal precursor cells (MPCs) have been effective in large animal models of ischemic and nonischemic heart failure (HF). OBJECTIVE:To evaluate the feasibility and safety of 3 doses (25, 75, or 150 million cells) of immunoselected allogeneic MPCs in chronic HF patients in a phase 2 trial. MET...

journal_title：Circulation research

authors： Perin EC,Borow KM,Silva GV,DeMaria AN,Marroquin OC,Huang PP,Traverse JH,Krum H,Skerrett D,Zheng Y,Willerson JT,Itescu S,Henry TD

更新日期：2015-08-28 00:00:00

abstract：:The arterial pressure of rabbits with chronic one-kidney hypertension can be lowered to normotensive levels by direct immunization with preparations made from the cortex of hog kidneys. Hypertensive rabbits that are immunized with large amounts of renin may develop high plasma antirenin titers without affecting their ...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1976-09-01 00:00:00

abstract：:Pharmacological modulation of [K+]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new antiarrhythmic and cardioprotective strategy during myocardial ischemia and reperfusion. We studied the effects of cromakalim, a K+ channel opener that activates ATP-sen...

journal_title：Circulation research

authors： Venkatesh N,Stuart JS,Lamp ST,Alexander LD,Weiss JN

更新日期：1992-12-01 00:00:00

abstract：:Neuropeptide Y is stored in sympathetic nerve terminals throughout the heart and has direct and indirect effects on cardiac function. Although neuropeptide Y has been shown to be released upon intense (16-30 Hz) cardiac sympathetic stimulation, we sought to determine whether effective quantities of neuropeptide Y were...

journal_title：Circulation research

authors： Warner MR,Levy MN

更新日期：1989-05-01 00:00:00

abstract：:We studied the role of copper as a potential mediator of postischemic reperfusion injury in the isolated, perfused rat heart. Hearts were equilibrated with Krebs-Henseleit buffer for 10 minutes and then loaded with copper by way of perfusion with buffer containing 20 microM copper(II)-bis-histidial for 30 minutes. Con...

journal_title：Circulation research

authors： Powell SR,Hall D,Shih A

更新日期：1991-09-01 00:00:00

abstract：:Long QT syndrome (LQTS) type 3 (LQT3), typified by the DeltaKPQ mutation (LQT3 mutation in which amino acid residues 1505 to 1507 [KPQ] are deleted), is caused by increased sodium entry during the action potential plateau resulting from mutation-altered inactivation of the Na(v)1.5 channel. Although rare, LQT3 is the ...

journal_title：Circulation research

authors： Fredj S,Lindegger N,Sampson KJ,Carmeliet P,Kass RS

更新日期：2006-11-24 00:00:00

abstract：:The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To...

journal_title：Circulation research

authors： Ford DA,Gross RW

更新日期：1989-01-01 00:00:00

abstract：:The purpose of these studies was to evaluate cardiovascular structural and functional changes in a model of hypertension-induced myocardial hypertrophy in which vasodilator therapy decreased blood pressure to normal levels. Thus, we determined the separate contributions of hypertension and hypertrophy on myocardial an...

journal_title：Circulation research

authors： Anderson PG,Bishop SP,Digerness SB

更新日期：1989-06-01 00:00:00

abstract：RATIONALE:Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacti...

journal_title：Circulation research

authors： Wang Q,Liu Z,Ren J,Morgan S,Assa C,Liu B

更新日期：2015-02-13 00:00:00

abstract：:In this study, anti-basic fibroblast growth factor (anti-bFGF) antibody was used to determine whether the mitogenic effect of angiotensin II in vivo could be blocked by neutralizing bFGF in the vessel wall. Animals, divided into six experimental groups, were given (1) angiotensin II, (2) angiotensin II + anti-bFGF ant...

journal_title：Circulation research

authors： Su EJ,Lombardi DM,Wiener J,Daemen MJ,Reidy MA,Schwartz SM

更新日期：1998-02-23 00:00:00

abstract：RATIONALE:Human heregulins, neuregulin-1 type I polypeptides that activate proliferation, differentiation, and survival of glial cells, neurons, and myocytes, are expressed in macrophage foam cells within human coronary atherosclerotic lesions. Macrophage foam cell formation, characterized by cholesterol ester accumula...

journal_title：Circulation research

authors： Xu G,Watanabe T,Iso Y,Koba S,Sakai T,Nagashima M,Arita S,Hongo S,Ota H,Kobayashi Y,Miyazaki A,Hirano T

更新日期：2009-08-28 00:00:00

abstract：:Heart failure is associated with death of cardiomyocytes leading to loss of contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition of cell death and prevention of pathogenesis induced by cardiomyopathic stimuli. However, recent s...

journal_title：Circulation research

authors： Shiraishi I,Melendez J,Ahn Y,Skavdahl M,Murphy E,Welch S,Schaefer E,Walsh K,Rosenzweig A,Torella D,Nurzynska D,Kajstura J,Leri A,Anversa P,Sussman MA

更新日期：2004-04-16 00:00:00

abstract：:This study examined intracellular signal events of arterial cells following balloon catheter injury to rat carotid artery. Within 30 minutes, a marked increase in extracellular signal-regulated kinase-1/2 (ERK1/2) activity was observed. This activity remained elevated for 12 hours but had decreased to control levels b...

journal_title：Circulation research

authors： Koyama H,Olson NE,Dastvan FF,Reidy MA

更新日期：1998-04-06 00:00:00

abstract：:Membrane current abnormalities have been described in human heart failure. To determine whether similar current changes are observed in a large animal model of heart failure, we studied dogs with pacing-induced cardiomyopathy. Myocytes isolated from the midmyocardium of 13 dogs with heart failure induced by 3 to 4 wee...

journal_title：Circulation research

authors： Kääb S,Nuss HB,Chiamvimonvat N,O'Rourke B,Pak PH,Kass DA,Marban E,Tomaselli GF

更新日期：1996-02-01 00:00:00

abstract：:Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K+ current in addition to an inward rectifier current whose conductance is unaffected by ACh. The cholinergic K+ current is specifically blocked by atropine (1 microM) and shows single saturation kinetics with ACh (half-maximal stim...

journal_title：Circulation research

authors： Olesen SP,Davies PF,Clapham DE

更新日期：1988-06-01 00:00:00

abstract：RATIONALE:PCSKs (Proprotein convertase subtilisins/kexins) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaques associated with smooth muscle cells (SMCs), inflammation, extracellular matrix remodeling, and mitogens. OBJECTIVE:Here...

journal_title：Circulation research

authors： Rykaczewska U,Suur BE,Röhl S,Razuvaev A,Lengquist M,Sabater-Lleal M,van der Laan SW,Miller CL,Wirka RC,Kronqvist M,Gonzalez Diez M,Vesterlund M,Gillgren P,Odeberg J,Lindeman JH,Veglia F,Humphries SE,de Faire U,Baldass

更新日期：2020-02-28 00:00:00

abstract：:Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was ...

journal_title：Circulation research

authors： Jolly SR,Kane WJ,Bailie MB,Abrams GD,Lucchesi BR

更新日期：1984-03-01 00:00:00

abstract：RATIONALE:Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood. OBJECTIVE:We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential...

journal_title：Circulation research

authors： Ponomaryov T,Payne H,Fabritz L,Wagner DD,Brill A

更新日期：2017-09-29 00:00:00

abstract：:Myocardial responses to acute ischemia/reperfusion and to chronic ischemic conditions have been studied extensively at all levels of organization. These include subcellular (eg, mitochondria in vitro); intact, large animal models (eg, swine with chronic coronary stenosis); as well as human subjects. Investigations in ...

journal_title：Circulation research

authors： Gewirtz H,Dilsizian V

更新日期：2017-03-31 00:00:00

abstract：:To assess the relation between atrial natriuretic peptide and ventricular dysfunction, we simultaneously measured both atrial and plasma immunoreactive atrial natriuretic peptide concentrations in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. When compared to controls (n = 39), rat...

journal_title：Circulation research

authors： Tsunoda K,Hodsman GP,Sumithran E,Johnston CI

更新日期：1986-09-01 00:00:00

abstract：:Calcific aortic valve sclerosis involves inflammatory processes and occurs preferentially on the aortic side of endothelialized valve leaflets. Although the endothelium is recognized to play critical roles in focal vascular sclerosis, the contributions of valvular endothelial phenotypes to aortic valve sclerosis and s...

journal_title：Circulation research

authors： Simmons CA,Grant GR,Manduchi E,Davies PF

更新日期：2005-04-15 00:00:00

abstract：:The precise, temporal order of gene expression during development is critical to ensure proper lineage commitment, cell fate determination, and ultimately, organogenesis. Epigenetic regulation of chromatin structure is fundamental to the activation or repression of genes during embryonic development. In recent years, ...

journal_title：Circulation research

authors： Boland MJ,Nazor KL,Loring JF

更新日期：2014-07-07 00:00:00