Copper loading of hearts increases postischemic reperfusion injury.

abstract：:The potential for heparin to enhance the training-induced increase in collateral-dependent blood flow to the distal hind-limb muscles was evaluated after bilateral femoral artery ligation in adult male rats (approximately 350 g). Rats received either saline (n = 34) or heparin (n = 36) injections and were kept sedenta...

journal_title：Circulation research

authors： Yang HT,Ogilvie RW,Terjung RL

更新日期：1995-03-01 00:00:00

abstract：:Electrical responses induced by perivasascular nerve stimulation were recorded intracellularly from the smooth muscle of dog middle cerebral artery. With nerve stimulation, the muscle membrane produced excitatory junction potential and then a slow hyperpolarization. The excitatory junction potential showed facilitatio...

journal_title：Circulation research

authors： Suzuki H,Fujiwara S

更新日期：1982-12-01 00:00:00

abstract：:We used two experimental techniques to study the effect of lidocaine hydrochloride on the early inward transient (sodium) current as it is reflected by the maximum rate of change of action potential phase 0 (Vmax). We assessed the effect of lidocaine on Vmax as Purkinje fibers were slowly depolarized by increasing the...

journal_title：Circulation research

authors： Weld FM,Bigger JT Jr

更新日期：1975-11-01 00:00:00

abstract：:The purpose of this study was to develop an isolated tissue model in which arrhythmic activity could be generated in response to conditions encountered in ischemia followed by reperfusion, and in which intracellular recordings could be used to identify and study arrhythmogenic mechanisms. Isolated canine Purkinje fibe...

journal_title：Circulation research

authors： Ferrier GR,Moffat MP,Lukas A

更新日期：1985-02-01 00:00:00

abstract：:During an investigation of the effect of ryanodine on contractions in cardiac muscle, it was found that long rest periods removed all or most of the drug's effect. Therefore, we studied the kinetics of block development and recovery from block produced by low concentrations of ryanodine (1-100 pM) on the postrest cont...

journal_title：Circulation research

authors： Malecot CO,Katzung BG

更新日期：1987-04-01 00:00:00

abstract：:Cell-cell communication has proven to be even more complex than previously thought since the discovery that extracellular vesicles serve as containers of biological information on various pathophysiological settings. Extracellular vesicles are classified into exosomes, microvesicles/microparticles, or apoptotic bodies...

journal_title：Circulation research

authors： Loyer X,Vion AC,Tedgui A,Boulanger CM

更新日期：2014-01-17 00:00:00

abstract：:It has been demonstrated by other investigators that endothelium-dependent vasodilators are more effective on arterial tissue than on venous tissue. The purpose of this study was to determine if this was due to a difference in the sensitivity of arterial and venous smooth muscle to the endothelial dilator (EDRF) or to...

journal_title：Circulation research

authors： Seidel CL,LaRochelle J

更新日期：1987-04-01 00:00:00

abstract：:Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and com...

journal_title：Circulation research

authors： Yardley RW,Bowes G,Wilkinson M,Cannata JP,Maloney JE,Ritchie BC,Walker AM

更新日期：1983-05-01 00:00:00

abstract：:The predominant cardiac Ca2+/calmodulin-dependent protein kinase (CaMK) is CaMKIIdelta. Here we acutely overexpress CaMKIIdeltaC using adenovirus-mediated gene transfer in adult rabbit ventricular myocytes. This circumvents confounding adaptive effects in CaMKIIdeltaC transgenic mice. CaMKIIdeltaC protein expression a...

journal_title：Circulation research

authors： Kohlhaas M,Zhang T,Seidler T,Zibrova D,Dybkova N,Steen A,Wagner S,Chen L,Brown JH,Bers DM,Maier LS

更新日期：2006-02-03 00:00:00

abstract：:The aim of this study was to examine the effect of exercise training on reflex control of vascular resistance in human males. Forearm vascular responses to lower body negative pressure (LBNP) at -10 and -40 mm Hg were compared between highly trained young athletes (21.5 +/- 0.5 years old, n = 14) and age-matched nonat...

journal_title：Circulation research

authors： Takeshita A,Jingu S,Imaizumi T,Kunihiko Y,Koyanagi S,Nakamura M

更新日期：1986-07-01 00:00:00

abstract：:Endothelial cells release several compounds, including prostacyclin, NO, and endothelium-derived hyperpolarizing factor (EDHF), that mediate the vascular effects of vasoactive hormones. The identity of EDHF remains unknown. Since arachidonic acid causes endothelium-dependent relaxations of coronary arteries through it...

journal_title：Circulation research

authors： Campbell WB,Gebremedhin D,Pratt PF,Harder DR

更新日期：1996-03-01 00:00:00

abstract：:In nonischemic heart failure (HF), ventricular tachycardia initiates by a nonreentrant mechanism, but there is altered conduction (that could lead to re-entry) that could arise from changes in gap junctional proteins, especially connexin43 (Cx43). We studied Cx43 expression and phosphorylation state in the left ventri...

journal_title：Circulation research

authors： Ai X,Pogwizd SM

更新日期：2005-01-07 00:00:00

abstract：:Myocardial stunning is a form of reversible myocardial ischemia/reperfusion injury associated with systolic and diastolic contractile dysfunction. In the isolated rat heart model, myocardial stunning is characterized by specific C-terminal proteolysis of the myofilament protein, troponin I (cTnI) that yields cTnI1-193...

journal_title：Circulation research

authors： Foster DB,Noguchi T,VanBuren P,Murphy AM,Van Eyk JE

更新日期：2003-11-14 00:00:00

abstract：:G-protein receptor kinase 2 (GRK2) is 1 of 7 mammalian GRKs that phosphorylate ligand-bound 7-transmembrane receptors, causing receptor uncoupling from G proteins and potentially activating non-G-protein signaling pathways. GRK2 is unique among members of the GRK family in that its genetic ablation causes embryonic le...

journal_title：Circulation research

authors： Matkovich SJ,Diwan A,Klanke JL,Hammer DJ,Marreez Y,Odley AM,Brunskill EW,Koch WJ,Schwartz RJ,Dorn GW 2nd

更新日期：2006-10-27 00:00:00

abstract：:Patients with diabetes mellitus have >2× the risk for developing heart failure (HF; HF with reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular outcomes, hospitalization, and prognosis are worse for patients with diabetes mellitus relative to those without. Beyond the structural and func...

journal_title：Circulation research

authors： Kenny HC,Abel ED

更新日期：2019-01-04 00:00:00

abstract：RATIONALE:Congenital heart disease (CHD) is among the most common birth defects. Most cases are of unknown pathogenesis. OBJECTIVE:To determine the contribution of de novo copy number variants (CNVs) in the pathogenesis of sporadic CHD. METHODS AND RESULTS:We studied 538 CHD trios using genome-wide dense single nucle...

journal_title：Circulation research

authors： Glessner JT,Bick AG,Ito K,Homsy J,Rodriguez-Murillo L,Fromer M,Mazaika E,Vardarajan B,Italia M,Leipzig J,DePalma SR,Golhar R,Sanders SJ,Yamrom B,Ronemus M,Iossifov I,Willsey AJ,State MW,Kaltman JR,White PS,Shen Y

更新日期：2014-10-24 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules and engages diverse ligands relevant to distinct pathological processes. One class of RAGE ligands includes glycoxidation products, termed advanced glycation end products, which occur in diabetes...

journal_title：Circulation research

authors： Schmidt AM,Yan SD,Wautier JL,Stern D

更新日期：1999-03-19 00:00:00

abstract：:Previous studies have demonstrated that in adult rats with chronic hyponatremia, both symptoms of encephalopathy and mortality largely depend upon the gender of the animal and the presence of elevated plasma levels of vasopressin (AVP). Since effects of AVP on blood vessels may be gender dependent, the present study w...

journal_title：Circulation research

authors： Kozniewska E,Roberts TP,Vexler ZS,Oseka M,Kucharczyk J,Arieff AI

更新日期：1995-04-01 00:00:00

abstract：:On the basis of animal models of arterial injury, smooth muscle cell proliferation has been posited as a dominant event in restenosis. Unfortunately, little is known about this proliferation in the human restenotic lesion. The purpose of this study was to determine the extent and time course of proliferation in primar...

journal_title：Circulation research

authors： O'Brien ER,Alpers CE,Stewart DK,Ferguson M,Tran N,Gordon D,Benditt EP,Hinohara T,Simpson JB,Schwartz SM

更新日期：1993-08-01 00:00:00

abstract：:Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF possesses a binding site for ECM components that maintain i...

journal_title：Circulation research

authors： Ehrbar M,Djonov VG,Schnell C,Tschanz SA,Martiny-Baron G,Schenk U,Wood J,Burri PH,Hubbell JA,Zisch AH

更新日期：2004-04-30 00:00:00

abstract：:A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct size is measured after at least 48 hours of reperfusion, when the full...

journal_title：Circulation research

authors： Carrea FP,Lesnefsky EJ,Repine JE,Shikes RH,Horwitz LD

更新日期：1991-06-01 00:00:00

abstract：:When exposed to an increasing transmural pressure, middle cerebral arteries of the cat exhibit reduction of internal diameter which is mediated by vascular muscle cell depolarization. This laboratory has recently demonstrated that this "pressure-induced" activation is dependent upon the presence of an intact endotheli...

journal_title：Circulation research

authors： Harder DR,Sanchez-Ferrer C,Kauser K,Stekiel WJ,Rubanyi GM

更新日期：1989-07-01 00:00:00

abstract：:Catecholamines have been implicated in the phenomenon of ischemic preconditioning. We have previously demonstrated that ischemic preconditioning against postischemic mechanical dysfunction in the isolated rat heart is mediated by the alpha 1-adrenergic receptor. The purpose of this study was to delineate the signal tr...

journal_title：Circulation research

authors： Mitchell MB,Meng X,Ao L,Brown JM,Harken AH,Banerjee A

更新日期：1995-01-01 00:00:00

abstract：:To study whether atrial fibrillation might produce local changes in the atrium which could facilitate the tendency of this arrhythmia to become chronic and self-perpetuating, we compared the effect of atrial fibrillation, atrial pacing, and acute volume loading on the perfusion and oxygen consumption of the atrium in ...

journal_title：Circulation research

authors： White CW,Kerber RE,Weiss HR,Marcus ML

更新日期：1982-08-01 00:00:00

abstract：:Endothelial cells release nitric oxide (NO) more potently in response to increased shear stress than to agonists which elevate intracellular free calcium concentration ([Ca2+]i). To determine mechanistic differences in the regulation of endothelial constitutive NO synthase (ecNOS), we measured NO production by bovine ...

journal_title：Circulation research

authors： Corson MA,James NL,Latta SE,Nerem RM,Berk BC,Harrison DG

更新日期：1996-11-01 00:00:00

abstract：:Cyclic nucleotides are known to modify voltage-gated (L-type) Ca2+ channel activity in vascular smooth muscle cells, but the exact mechanism(s) underlying these effects is not well defined. The purpose of the present study was to investigate the modulatory role of the cAMP- and cGMP-dependent protein kinase (PKA and P...

journal_title：Circulation research

authors： Ruiz-Velasco V,Zhong J,Hume JR,Keef KD

更新日期：1998-03-23 00:00:00

abstract：:To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant alpha-TM in the adult heart. The missense mutation, which results in the substitution of asparagine for aspartic acid at amino acid posi...

journal_title：Circulation research

authors： Muthuchamy M,Pieples K,Rethinasamy P,Hoit B,Grupp IL,Boivin GP,Wolska B,Evans C,Solaro RJ,Wieczorek DF

更新日期：1999-07-09 00:00:00

abstract：:The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2+]i, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both...

journal_title：Circulation research

authors： Luo CH,Rudy Y

更新日期：1994-06-01 00:00:00

abstract：:Experiments were designed to determine the contribution of endothelial cells to the heterogeneous behavior of the arterial and venous wall. Rings of canine femoral, pulmonary, saphenous, and splenic arteries and veins, with and without endothelium, were mounted for isometric tension recording in Krebs-Ringer bicarbona...

journal_title：Circulation research

authors： De Mey JG,Vanhoutte PM

更新日期：1982-10-01 00:00:00

abstract：RATIONALE:The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit of the slowly activating delayed-rectifier K(+) (I(Ks)) channel, predisposes to a severe long-QT1 syndrome with sympathetic-triggered ventricular tachyarrhythmias and sudden cardiac death. OBJECTIVE:Several genetic risk modifiers have...

journal_title：Circulation research

authors： Heijman J,Spätjens RL,Seyen SR,Lentink V,Kuijpers HJ,Boulet IR,de Windt LJ,David M,Volders PG

更新日期：2012-01-20 00:00:00