Microvesicles as cell-cell messengers in cardiovascular diseases.

abstract：:Cation channels activated by Ca(2+) store depletion have been proposed to mediate Ca(2+) influx in vascular smooth muscle cells. The aim of this study was to determine if store-operated channels have a functional role in pulmonary artery smooth muscle cells (PASMCs). In intact rat pulmonary artery rings, cyclopiazonic...

journal_title：Circulation research

authors： Ng LC,Gurney AM

更新日期：2001-11-09 00:00:00

abstract：:The lung parenchyma as a tissue has a rather unusual stress-strain relationship. A theoretical derivation of this relationship is presented which connects the surface tension and the tissue elastic stress in the alveolar septa with the alveolar geometry. The mathematical expression contains a few meaningful physical c...

journal_title：Circulation research

authors： Fung YC

更新日期：1975-10-01 00:00:00

abstract：:Angiotensin II (Ang II) increases renal sympathetic nerve activity in anesthetized mice before and after ganglionic blockade, suggesting that Ang II may directly activate postganglionic sympathetic neurons. The present study directly tested this hypothesis in vitro. Neurons were dissociated from aortic-renal and celia...

journal_title：Circulation research

authors： Ma X,Chapleau MW,Whiteis CA,Abboud FM,Bielefeldt K

更新日期：2001-04-27 00:00:00

abstract：:Hearts from rabbits with 8-16 weeks of alloxan-diabetes were compared with hearts from normal rabbits to determine whether diabetic myocardium is more sensitive to ischemic injury. In isolated buffer-perfused hearts, left ventricular developed pressure, diastolic pressure, time to peak pressure (TTPP), time to half-ma...

journal_title：Circulation research

authors： Vogel WM,Apstein CS

更新日期：1988-05-01 00:00:00

abstract：:We examined the mechanism(s) of hypotensive action of platelet-activating factor (PAF) in anesthetized dogs. PAF (0.5 micrograms/kg i.v.) caused a biphasic hypotension; the first phase was transient and was accompanied by a decrease in systemic vascular resistance and an increase in cardiac output. Aspirin-DL-lysine, ...

journal_title：Circulation research

authors： Yamanaka S,Miura K,Yukimura T,Okumura M,Yamamoto K

更新日期：1992-05-01 00:00:00

abstract：:Astrocyte signals can modulate arteriolar tone, contributing to regulation of cerebral blood flow, but specific intercellular communication mechanisms are unclear. Here we used isolated cerebral arteriole myocytes, astrocytes, and brain slices to investigate whether carbon monoxide (CO) generated by the enzyme heme ox...

journal_title：Circulation research

authors： Li A,Xi Q,Umstot ES,Bellner L,Schwartzman ML,Jaggar JH,Leffler CW

更新日期：2008-02-01 00:00:00

abstract：:Pharmacological evidence indicates that angiotensin (Ang II) converting enzyme inhibitors attenuate cardiovascular responses to sympathetic stimulation. To investigate the physiological significance of this attenuation, the pressor and heart rate responses to bilateral carotid occlusion (BCO) were studied before and a...

journal_title：Circulation research

authors： Isaacson JS,Reid IA

更新日期：1990-03-01 00:00:00

abstract：RATIONALE:There is a critical need to develop robust, mechanistic strategies to identify patients at increased risk of cancer therapeutics-related cardiac dysfunction (CTRCD). OBJECTIVE:We aimed to discover new biomarkers associated with doxorubicin- and trastuzumab-induced CTRCD using high-throughput proteomic profil...

journal_title：Circulation research

authors： Beer LA,Kossenkov AV,Liu Q,Luning Prak E,Domchek S,Speicher DW,Ky B

更新日期：2016-10-28 00:00:00

abstract：:Neuropeptide Y is stored in sympathetic nerve terminals throughout the heart and has direct and indirect effects on cardiac function. Although neuropeptide Y has been shown to be released upon intense (16-30 Hz) cardiac sympathetic stimulation, we sought to determine whether effective quantities of neuropeptide Y were...

journal_title：Circulation research

authors： Warner MR,Levy MN

更新日期：1989-05-01 00:00:00

abstract：:In this review current hypotheses for the regulation of filtration rate and the subsequent reabsorption of that filtrate by the proximal tubule are discussed. In the rat the filtration rate is highly plasma flow dependent because of the phenomenon of filtration equilibrium. On the other hand, in man and dog filtration...

journal_title：Circulation research

authors： Knox FG,Cuche J-L,Ott CE,Diaz-Buxo JA,Marchand G

更新日期：1975-06-01 00:00:00

abstract：:Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss of endothelial and smooth muscle cells (SMC) is evident in remod...

journal_title：Circulation research

authors： Keogh RJ,Harris LK,Freeman A,Baker PN,Aplin JD,Whitley GS,Cartwright JE

更新日期：2007-03-30 00:00:00

abstract：:The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden o...

journal_title：Circulation research

authors： Chan NC,Eikelboom JW,Weitz JI

更新日期：2016-04-29 00:00:00

abstract：:3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can exert beneficial effects independently of serum cholesterol reduction by increasing the bioavailability of nitric oxide. However, it is unclear whether statins can exert such effects directly on cardiac myocytes and whether mitochondria...

journal_title：Circulation research

authors： Jones SP,Teshima Y,Akao M,Marbán E

更新日期：2003-10-17 00:00:00

abstract：:Current management of ventricular septal defect (VSD) after myocardial infarction (MI) is aimed at improving left ventricular (LV) performance by afterload reduction as a means of hemodynamic stabilization or shunt control. The current investigation was undertaken to determine whether primary manipulation of right ven...

journal_title：Circulation research

authors： Babb JD,Waldhausen JA,Zelis R

更新日期：1977-04-01 00:00:00

abstract：:Recent studies have shown that the primary heart tube continues to grow by addition of cells from the coelomic wall. This growth occurs concomitantly with embryonic folding and formation of the coelomic cavity, making early heart formation morphologically complex. A scarcity of data on localized growth parameters furt...

journal_title：Circulation research

authors： van den Berg G,Abu-Issa R,de Boer BA,Hutson MR,de Boer PA,Soufan AT,Ruijter JM,Kirby ML,van den Hoff MJ,Moorman AF

更新日期：2009-01-30 00:00:00

abstract：:G-protein receptor kinase 2 (GRK2) is 1 of 7 mammalian GRKs that phosphorylate ligand-bound 7-transmembrane receptors, causing receptor uncoupling from G proteins and potentially activating non-G-protein signaling pathways. GRK2 is unique among members of the GRK family in that its genetic ablation causes embryonic le...

journal_title：Circulation research

authors： Matkovich SJ,Diwan A,Klanke JL,Hammer DJ,Marreez Y,Odley AM,Brunskill EW,Koch WJ,Schwartz RJ,Dorn GW 2nd

更新日期：2006-10-27 00:00:00

abstract：:Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure. Elevated serum concentrations of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen...

journal_title：Circulation research

authors： Quehenberger P,Exner M,Sunder-Plassmann R,Ruzicka K,Bieglmayer C,Endler G,Muellner C,Speiser W,Wagner O

更新日期：2002-04-05 00:00:00

abstract：:Changes in the behavior of the sarcoplasmic reticulum (SR) in rat ventricular myocytes were investigated under conditions of metabolic inhibition using laser-scanning confocal microscopy to measure intracellular Ca(2+) and the perforated patch-clamp technique to measure SR Ca(2+) content. Metabolic inhibition had seve...

journal_title：Circulation research

authors： Overend CL,Eisner DA,O'Neill SC

更新日期：2001-02-02 00:00:00

abstract：:Ventricular repolarization was analyzed by measuring epicardial potential distributions in intact dogs with single or multiple ectopic foci and a minimum at the terminal site(s) of excitation. During the latter half of the T wave the distributions became more complex, and two maxima evolved from the initial one at eac...

journal_title：Circulation research

authors： Spach MS,Barr RC

更新日期：1976-10-01 00:00:00

abstract：:Beta(1)- and beta(2)-adrenergic receptors (betaARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the hypothesis that these differences are attributable to spatial compartmentation of the second messenger cAMP. Using a fluorescent resonance energy transfer (FRET)-based approach, ...

journal_title：Circulation research

authors： Nikolaev VO,Bünemann M,Schmitteckert E,Lohse MJ,Engelhardt S

更新日期：2006-11-10 00:00:00

abstract：RATIONALE:Cardiac muscle adapts to increase workload by altering cardiomyocyte size and function resulting in cardiac hypertrophy. G protein-coupled receptor signaling is known to govern the hypertrophic response through the regulation of ion channel activity and downstream signaling in failing cardiomyocytes. OBJECTI...

journal_title：Circulation research

authors： Seth M,Zhang ZS,Mao L,Graham V,Burch J,Stiber J,Tsiokas L,Winn M,Abramowitz J,Rockman HA,Birnbaumer L,Rosenberg P

更新日期：2009-11-06 00:00:00

abstract：:Blocking brain mineralocorticoid receptors (MRs) reduces the high circulating levels of tumor necrosis factor (TNF)-alpha in heart failure (HF) rats. TNF-alpha and other proinflammatory cytokines activate neurons in the paraventricular nucleus (PVN) of hypothalamus, including corticotropin-releasing hormone (CRH) neur...

journal_title：Circulation research

authors： Kang YM,Zhang ZH,Johnson RF,Yu Y,Beltz T,Johnson AK,Weiss RM,Felder RB

更新日期：2006-09-29 00:00:00

abstract：RATIONALE:The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain, but visualization and experimental analysis of these vessels is challenging in mammals. Although the optical clarity and experimental advantages of zebrafish ...

journal_title：Circulation research

authors： Castranova D,Samasa B,Venero Galanternik M,Jung HM,Pham VN,Weinstein BM

更新日期：2021-01-08 00:00:00

abstract：:Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depressio...

journal_title：Circulation research

authors： Rowe GT,Manson NH,Caplan M,Hess ML

更新日期：1983-11-01 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:A mathematical model for the regulation of mechanical activity in cardiac muscle has been developed based on a three-element rheological model of this muscle. The contractile element has been modeled taking into account the results of extensive mechanical tests that involved the recording of length-force and force-vel...

journal_title：Circulation research

authors： Izakov VYa,Katsnelson LB,Blyakhman FA,Markhasin VS,Shklyar TF

更新日期：1991-11-01 00:00:00

abstract：:We examined the late coronary vascular response to carotid chemoreceptor reflex activation in normal, conscious dogs instrumented for the measurement of right main and left circumflex coronary artery blood flows, arterial and right ventricular pressures, and arterial and coronary sinus blood gases and O2 contents. Wit...

journal_title：Circulation research

authors： Murray PA,Lavallee M,Vatner SF

更新日期：1984-01-01 00:00:00

abstract：:Purkinje cells contain sarcoplasmic reticulum (SR) directly under the surface membrane, are devoid of t-tubuli, and are packed with myofibrils surrounded by central SR. Several studies have reported that electrical excitation induces a biphasic Ca(2+) transient in Purkinje fiber bundles. We determined the nature of th...

journal_title：Circulation research

authors： Boyden PA,Pu J,Pinto J,Keurs HE

更新日期：2000-03-03 00:00:00

abstract：:During myocardial ischemia, electrical uncoupling and contracture herald irreversible damage. In the present study, we tested the hypothesis that an increase of intracellular Ca2+ is an important factor initiating these events. Therefore, we simultaneously determined tissue resistance, mechanical activity, pH(0), and ...

journal_title：Circulation research

authors： Dekker LR,Fiolet JW,VanBavel E,Coronel R,Opthof T,Spaan JA,Janse MJ

更新日期：1996-08-01 00:00:00

abstract：:Left ventricular (LV) remodeling after experimental myocardial infarction (MI) is associated with hypertrophy of noninfarcted myocardium and electrophysiological alterations. We have recently shown that post-MI hypertrophied LV myocytes have prolonged action potential duration (APD) and generate triggered activity fro...

journal_title：Circulation research

authors： Gidh-Jain M,Huang B,Jain P,el-Sherif N

更新日期：1996-10-01 00:00:00