Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.

abstract：:Previous studies have suggested that intravenous infusion of arginine vasopressin (AVP) inhibits sympathetic nerve activity (SNA) in rabbits by its action at the brainstem. This study aimed to determine, first, whether this action of AVP depended on functioning baroreflex mechanisms. The second aim was to determine th...

journal_title：Circulation research

authors： Suzuki S,Takeshita A,Imaizumi T,Hirooka Y,Yoshida M,Ando S,Nakamura M

更新日期：1989-11-01 00:00:00

abstract：:Increasing evidence indicates that the control of cell proliferation and apoptosis are linked. The c-myc proto-oncogene is induced early after cell-cycle entry in vascular smooth muscle cells (VSMCs) in vitro and after arterial injury and regulates both cell proliferation and apoptosis. Although both proliferation and...

journal_title：Circulation research

authors： Macdonald K,Bennett MR

更新日期：1999-04-16 00:00:00

abstract：:Electrocardiogram (ECG) electrodes and carotid arterial and superior vena caval (SVC) catheters were placed in eight nonpregnant ewes and 11 fetuses (109-129 days gestation) to measure heart rate, arterial presssure, P-R interval, left ventricular pre-ejection period (PEP), and left ventricular ejection time (LVET), b...

journal_title：Circulation research

authors： Berman W Jr,Ravenscroft PJ,Sheiner LB,Heymann MA,Melmon KL,Rudolph AM

更新日期：1977-11-01 00:00:00

abstract：:We studied the effects of rapid atrial pacing during the final 10 minutes of a 70-minute, 31% reduction in coronary blood flow in anesthetized swine to understand the significance of apparent metabolic improvements during the initial 60 minutes of segmental ischemia. Within 5-10 minutes of ischemia, subendocardial pho...

journal_title：Circulation research

authors： Arai AE,Pantely GA,Anselone CG,Bristow J,Bristow JD

更新日期：1991-12-01 00:00:00

abstract：RATIONALE:Sustained cardiac hypertrophy is often accompanied by maladaptive cardiac remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive hypertrophy is considered to be a therapeutic target for heart failure. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have various biolo...

journal_title：Circulation research

authors： Wang K,Liu F,Zhou LY,Long B,Yuan SM,Wang Y,Liu CY,Sun T,Zhang XJ,Li PF

更新日期：2014-04-25 00:00:00

abstract：:We measured pressure-volume curves in nine excised dog ventricles and stress-strain curves in two to five muscle specimens from each ventricle to verify a derived formula that relates muscle stiffness to the ventricular pressure-volume curve. The assumptions underlying this formula are: (1) the ventricle is a uniform ...

journal_title：Circulation research

authors： Glantz SA,Kernoff RS

更新日期：1975-12-01 00:00:00

abstract：:Picrotoxin, an antagonist of gamma-aminobutyric acid, produces an increase in coronary vascular resistance, S-T segment elevation, and ventricular arrhythmias after an intravenous injection of 2 mg/kg in chloralose-anesthetized cats. To determine whether these responses were due to blockade of central nervous system G...

journal_title：Circulation research

authors： Segal SA,Jacob T,Gillis RA

更新日期：1984-09-01 00:00:00

abstract：:Calcium channel blockers (CCBs), which are used clinically for treatment of angina and hypertension, are known to inhibit calcium influx into arterial smooth muscle cells and thereby decrease smooth muscle cell contraction. In addition, they prevent cholesteryl ester (CE) accumulation, the hallmark of human atheroscle...

journal_title：Circulation research

authors： Etingin OR,Hajjar DP

更新日期：1990-01-01 00:00:00

abstract：:To investigate the possible contributions of cardiac volume overload and cardiac sympathetic hyperactivity in the effects of sodium on cardiac mass, we evaluated the effects of treatment with saline (1%) and deoxycorticosterone acetate + saline (DOCA/saline) for 10 days and 3 and 6 weeks on ventricular anatomy and int...

journal_title：Circulation research

authors： Fields NG,Yuan BX,Leenen FH

更新日期：1991-03-01 00:00:00

abstract：RATIONALE:Thioredoxin (Trx)1 inhibits pathological cardiac hypertrophy. MicroRNAs (miRNAs) are small noncoding RNAs that downregulate posttranscriptional expression of target molecules. OBJECTIVES:We investigated the role of miRNAs in mediating the antihypertrophic effect of Trx1 on angiotensin II (Ang II)-induced car...

journal_title：Circulation research

authors： Yang Y,Ago T,Zhai P,Abdellatif M,Sadoshima J

更新日期：2011-02-04 00:00:00

abstract：RATIONALE:Gamma aminobutyric acid (GABA), a neurotransmitter of the central nervous system, is found in the systemic circulation of humans at a concentration between 0.5 and 3 μmol/L. However, the potential source of circulating GABA and its significance on the vascular system remains unknown. We hypothesized that endo...

journal_title：Circulation research

authors： Sen S,Roy S,Bandyopadhyay G,Scott B,Xiao D,Ramadoss S,Mahata SK,Chaudhuri G

更新日期：2016-08-19 00:00:00

abstract：:We tested the hypothesis that impairment of flow-dependent dilator mechanisms of skeletal muscle arterioles is one of the underlying reasons for the increased peripheral resistance in hypertension. Isolated, cannulated arterioles (approximately 55 microns) of gracilis muscle of 12-week-old spontaneously hypertensive (...

journal_title：Circulation research

authors： Koller A,Huang A

更新日期：1994-03-01 00:00:00

abstract：:The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal function, and cell metabolism. mTOR interacts with specific adaptor proteins to form 2 multiprotein complexes, called mTORC1 (mTOR co...

journal_title：Circulation research

authors： Sciarretta S,Forte M,Frati G,Sadoshima J

更新日期：2018-02-02 00:00:00

abstract：:Matrix metalloproteinases (MMPs) include most major constituents of the arterial wall as substrates. A common promotor polymorphism (5A/6A) is associated with differences in MMP-3 (stromelysin-1) activity, and associations with certain forms of vascular disease have been shown. This study investigated whether the MMP-...

journal_title：Circulation research

authors： Medley TL,Kingwell BA,Gatzka CD,Pillay P,Cole TJ

更新日期：2003-06-13 00:00:00

abstract：RATIONALE:Microparticles are cell-derived membrane vesicles, relevant to a range of biological responses and known to be elevated in cardiovascular disease. OBJECTIVE:To investigate microparticle release during cardiac stress and how this response differs in those with vascular disease. METHODS AND RESULTS:We measure...

journal_title：Circulation research

authors： Augustine D,Ayers LV,Lima E,Newton L,Lewandowski AJ,Davis EF,Ferry B,Leeson P

更新日期：2014-01-03 00:00:00

abstract：:Although clinical studies suggest that chronic hypercapnic acidosis may be associated with renal sodium retention, little information is available on the effect of acute hypercapnic acidosis on renal sodium excretion. We, therefore, increased PCO2 from 23 to 74 mm Hg in anesthetized dogs and observed a marked antinatr...

journal_title：Circulation research

authors： Anderson RJ,Henrich WL,Gross PA,Dillingham MA

更新日期：1982-02-01 00:00:00

abstract：:Alpha1-adrenoceptor (alpha1-AR) stimulation increases sarcolemmal Na+-H+ exchanger (NHE) activity. The present study was designed to determine the role(s) of alpha1-AR subtype(s) in mediating this response. As an index of NHE activity, acid efflux rates (JHs) were determined in single rat ventricular myocytes loaded w...

journal_title：Circulation research

authors： Yokoyama H,Yasutake M,Avkiran M

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:Transmural dispersion of repolarization has been shown to play a role in the genesis of ventricular tachycardia and fibrillation in different animal models of heart failure (HF). Heterogeneous changes of repolarization within the midmyocardial population of ventricular cells have been considered an important ...

journal_title：Circulation research

authors： Glukhov AV,Fedorov VV,Lou Q,Ravikumar VK,Kalish PW,Schuessler RB,Moazami N,Efimov IR

更新日期：2010-03-19 00:00:00

abstract：RATIONALE:Lipid-free apolipoprotein (apo) A-I and discoidal reconstituted high-density lipoproteins (rHDL) containing apoA-I, (A-I)rHDL, inhibit vascular inflammation by increasing 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression. OBJECTIVE:To determine whether the lipid-free apoA-I-mediated and (A-I)rHDL-mediated ...

journal_title：Circulation research

authors： Wu BJ,Chen K,Shrestha S,Ong KL,Barter PJ,Rye KA

更新日期：2013-01-18 00:00:00

abstract：:Although clinical trials of cell-based approaches to cardiovascular disease have yielded some promising results, no cell-based therapy has achieved regulatory approval for a cardiovascular indication. To broadly assess the challenges to regulatory approval and identify strategies to facilitate this goal, the Cardiac S...

journal_title：Circulation research

authors： Fanaroff AC,Morrow V,Krucoff MW,Seltzer JH,Perin EC,Taylor DA,Miller LW,Zeiher AM,Fernández-Avilés F,Losordo DW,Henry TD,Povsic TJ

更新日期：2018-08-03 00:00:00

abstract：:The dynamic interaction of simultaneously changing heart period and single vagal stimuli on atrioventricular conduction (AV interval) was quantified by subtracting the vagally induced responses of the paced heart preparation from those of the unpaced heart preparation. This difference was significantly greater (P less...

journal_title：Circulation research

authors： Martin P

更新日期：1977-01-01 00:00:00

abstract：:The mechanism of adenosine-induced inhibition of Ca2+ currents was studied by recording single-channel Ca2+ currents from cell-attached patches on isolated guinea pig ventricular cells with pipettes containing 50 or 100 mM Ba2+. Numerous 100-msec depolarization steps were applied repetitively at 2 Hz from the resting ...

journal_title：Circulation research

authors： Kato M,Yamaguchi H,Ochi R

更新日期：1990-11-01 00:00:00

abstract：:A number of scavengers of reactive oxygen metabolites reduce myocardial injury when given before ischemia and reperfusion, but few, if any, have proven to be effective when given near the onset of reperfusion. This is particularly true when infarct size is measured after at least 48 hours of reperfusion, when the full...

journal_title：Circulation research

authors： Carrea FP,Lesnefsky EJ,Repine JE,Shikes RH,Horwitz LD

更新日期：1991-06-01 00:00:00

abstract：:The mechanism(s) by which mutations in sarcomeric proteins cause hypertrophic cardiomyopathy (HCM) remains unknown. A leading hypothesis proposes that mutant sarcomeric proteins impair cardiac myocyte contractility, providing an impetus for compensatory hypertrophy. To test this hypothesis, we determined the impact of...

journal_title：Circulation research

authors： Marian AJ,Zhao G,Seta Y,Roberts R,Yu QT

更新日期：1997-07-01 00:00:00

abstract：:Limitation of infarct size by ischemic/pharmacological pre- and postconditioning involves activation of a complex set of cell-signaling pathways. Multiple lines of evidence implicate the mitochondrial permeability transition pore (mPTP) as a key end effector of ischemic/pharmacological pre- and postconditioning. Incre...

journal_title：Circulation research

authors： Juhaszova M,Zorov DB,Yaniv Y,Nuss HB,Wang S,Sollott SJ

更新日期：2009-06-05 00:00:00

abstract：:The effects of sodium pump inhibition produced by exposure to the cardiac glycosides, ouabain or dihydroouabain, or by reduction in extracellular potassium to 1.0 mM, on contractile state and sodium-calcium exchange were studied in primary monolayer cultures of chick embryo ventricular cells. Ouabain, 10(-6)M, dihydro...

journal_title：Circulation research

authors： Barry WH,Hasin Y,Smith TW

更新日期：1985-02-01 00:00:00

abstract：:Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depressio...

journal_title：Circulation research

authors： Rowe GT,Manson NH,Caplan M,Hess ML

更新日期：1983-11-01 00:00:00

abstract：RATIONALE:Specialized pro-resolving mediators (SPM-lipoxins, resolvins, protectins, and maresins) are produced via the enzymatic conversion of essential fatty acids, including the omega-3 fatty acids docosahexaenoic acid and n-3 docosapentaenoic acid. These mediators exert potent leukocyte directed actions and control ...

journal_title：Circulation research

authors： Souza PR,Marques RM,Gomez EA,Colas RA,De Matteis R,Zak A,Patel M,Collier DJ,Dalli J

更新日期：2020-01-03 00:00:00

abstract：:Na(v)1.5, the cardiac isoform of the voltage-gated Na+ channel, is critical to heart excitability and conduction. However, the mechanisms regulating its expression at the cell membrane are poorly understood. The Na(v)1.5 C-terminus contains a PY-motif (xPPxY) that is known to act as binding site for Nedd4/Nedd4-like u...

journal_title：Circulation research

authors： van Bemmelen MX,Rougier JS,Gavillet B,Apothéloz F,Daidié D,Tateyama M,Rivolta I,Thomas MA,Kass RS,Staub O,Abriel H

更新日期：2004-08-06 00:00:00

abstract：:Many members of the two-pore-domain potassium (K(+)) channel family have been detected in the mammalian heart but the endogenous correlates of these channels still have to be identified. We investigated whether I(KAA), a background K(+) current activated by negative pressure (stretch) and by arachidonic acid (AA) and ...

journal_title：Circulation research

authors： Terrenoire C,Lauritzen I,Lesage F,Romey G,Lazdunski M

更新日期：2001-08-17 00:00:00