Paradoxical dynamic interaction of heart period and vagal activity on atrioventricular conduction in the dog.

abstract：:Accumulation of plasminogen activator inhibitor type 1 (PAI-1) in the arterial wall may accelerate atherogenesis by inhibiting fibrinolysis, diminishing proteolysis of extracellular matrix proteins, or modifying migration of vascular smooth muscle cells. Increased intramural expression of the PAI-1 gene is induced by ...

journal_title：Circulation research

authors： Sawa H,Sobel BE,Fujii S

更新日期：1993-10-01 00:00:00

abstract：:During cardiac development, the epicardium is the source of multipotent mesenchymal cells, which give rise to endothelial and smooth muscle cells in coronary vessels and also, possibly, to cardiomyocytes. The aim of the present study was to determine whether stem cells are retained in the adult human and murine epicar...

journal_title：Circulation research

authors： Limana F,Zacheo A,Mocini D,Mangoni A,Borsellino G,Diamantini A,De Mori R,Battistini L,Vigna E,Santini M,Loiaconi V,Pompilio G,Germani A,Capogrossi MC

更新日期：2007-12-07 00:00:00

abstract：:Available data demonstrate that oxygen free radicals and derived reactive species of oxygen are produced during myocardial ischemia as well as upon reperfusion of the ischemic tissue. The present study was designed to determine if polyethylene glycol-conjugated superoxide dismutase (PEG-SOD), with its extended plasma ...

journal_title：Circulation research

authors： Chi LG,Tamura Y,Hoff PT,Macha M,Gallagher KP,Schork MA,Lucchesi BR

更新日期：1989-04-01 00:00:00

abstract：RATIONALE:Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively, are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient lymph transport relies on the coordinated contractions of lymphatic muscle cells (LMCs) and their electrical coupling through Cxs, Cx-related lym...

journal_title：Circulation research

authors： Castorena-Gonzalez JA,Zawieja SD,Li M,Srinivasan RS,Simon AM,de Wit C,de la Torre R,Martinez-Lemus LA,Hennig GW,Davis MJ

更新日期：2018-09-28 00:00:00

abstract：RATIONALE:Elevations in C-reactive protein (CRP) are associated with increased cardiovascular disease risk and endothelial dysfunction. CRP antagonizes endothelial nitric oxide synthase (eNOS) through processes mediated by the IgG receptor Fcγ receptor IIB (FcγRIIB), its immunoreceptor tyrosine-based inhibitory motif, ...

journal_title：Circulation research

authors： Sundgren NC,Zhu W,Yuhanna IS,Chambliss KL,Ahmed M,Tanigaki K,Umetani M,Mineo C,Shaul PW

更新日期：2011-10-28 00:00:00

abstract：:Cardiovascular disease is a major killer in postmenopausal women in the industrialized societies. To investigate the effect of progestogen and 17 beta-estradiol replacement therapy on atherogenesis, we studied 60 cholesterol-fed ovariectomized rabbits for 13 weeks. They were randomly assigned to four groups of 15 rabb...

journal_title：Circulation research

authors： Haarbo J,Svendsen OL,Christiansen C

更新日期：1992-06-01 00:00:00

abstract：:Cyclic GMP modulates gene expression in vascular smooth muscle cells (SMCs) in part by stimulating cGMP-dependent protein kinase I (PKGI) and the phosphorylation of transcription factors. In some cells, cGMP increases nuclear translocation of PKGI and PKGI-dependent phosphorylation of transcription regulators; however...

journal_title：Circulation research

authors： Sugiura T,Nakanishi H,Roberts JD Jr

更新日期：2008-07-03 00:00:00

abstract：:Myocytes overlying a zone of infarction form the primary substrate for serious reentrant ventricular arrhythmias. In vitro and in vivo studies suggest that antiarrhythmic agents affect Na+ channels of cells from the epicardial border zone (EBZ) of the 5-day infarcted heart differently than they affect those of normal ...

journal_title：Circulation research

authors： Pu J,Balser JR,Boyden PA

更新日期：1998-08-24 00:00:00

abstract：:The aim of this study was to determine whether prolonged loss of NO activity, in endothelial NO synthase knockout (eNOS(-/-)) mice, influences endothelin (ET) ETA receptor-mediated smooth muscle contraction and, if so, to define the underlying mechanism(s). In isolated endothelium-denuded abdominal aortas, contraction...

journal_title：Circulation research

authors： Zhou Y,Mitra S,Varadharaj S,Parinandi N,Zweier JL,Flavahan NA

更新日期：2006-06-09 00:00:00

abstract：:Oxidized phospholipids, including oxidation products of palmitoyl-arachidonyl-phosphatidyl choline (PAPC), are mediators of inflammation in endothelial cells (ECs) and known to induce several chemokines, including interleukin-8 (IL-8). In this study, we show that oxidized PAPC (OxPAPC), which accumulates in atheroscle...

journal_title：Circulation research

authors： Yeh M,Cole AL,Choi J,Liu Y,Tulchinsky D,Qiao JH,Fishbein MC,Dooley AN,Hovnanian T,Mouilleseaux K,Vora DK,Yang WP,Gargalovic P,Kirchgessner T,Shyy JY,Berliner JA

更新日期：2004-10-15 00:00:00

abstract：:Fractalkine, a chemokine expressed by inflamed endothelium, induces leukocyte adhesion and migration via the receptor CX3CR1, and the CX3CR1 polymorphism V249I affects receptor expression and function. Here we show that this polymorphism is an independent risk factor for atherosclerotic coronary artery disease (CAD). ...

journal_title：Circulation research

authors： McDermott DH,Halcox JP,Schenke WH,Waclawiw MA,Merrell MN,Epstein N,Quyyumi AA,Murphy PM

更新日期：2001-08-31 00:00:00

abstract：:The contractile response of the aged adult heart to beta-adrenergic stimulation is known to be reduced compared with the young adult heart. Since endogenous adenosine exerts an antiadrenergic action in the heart, this study was undertaken to determine if the basal endogenous level of myocardial adenosine increases wit...

journal_title：Circulation research

authors： Dobson JG Jr,Fenton RA,Romano FD

更新日期：1990-05-01 00:00:00

abstract：:The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been define...

journal_title：Circulation research

authors： Mommersteeg MT,Hoogaars WM,Prall OW,de Gier-de Vries C,Wiese C,Clout DE,Papaioannou VE,Brown NA,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-02-16 00:00:00

abstract：:To investigate the regulation of the actomyosin crossbridge cycle in cardiac muscles, the effects of ATP, ADP, Pi, and creatine phosphate (CP) on the rate of force redevelopment (ktr) were measured. We report that CP is a primary determinant in controlling the actomyosin crossbridge cycling kinetics of cardiac muscles...

journal_title：Circulation research

authors： Ogut O,Brozovich FV

更新日期：2003-07-11 00:00:00

abstract：:We tested the hypothesis that TNF-alpha induces early-onset endothelial adhesivity toward PMN by activating the constitutive endothelial cell surface ICAM-1, the beta2-integrin (CD11/CD18) counter-receptor. Stimulation of human pulmonary artery endothelial cells with TNF-alpha resulted in phosphorylation of ICAM-1 wit...

journal_title：Circulation research

authors： Javaid K,Rahman A,Anwar KN,Frey RS,Minshall RD,Malik AB

更新日期：2003-05-30 00:00:00

abstract：RATIONALE:During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring...

journal_title：Circulation research

authors： Li RC,Tao J,Guo YB,Wu HD,Liu RF,Bai Y,Lv ZZ,Luo GZ,Li LL,Wang M,Yang HQ,Gao W,Han QD,Zhang YY,Wang XJ,Xu M,Wang SQ

更新日期：2013-02-15 00:00:00

abstract：:alpha-Adrenergic stimulation (alpha-AS) and beta-adrenergic stimulation (beta-AS) of the myocardium are associated respectively with an increase and a decrease in myofilament responsiveness to Ca2+. We hypothesized that changes in cytosolic pH (pH(i)) may modulate these opposite actions of alpha-AS and beta-AS. The ef...

journal_title：Circulation research

authors： Gambassi G,Spurgeon HA,Lakatta EG,Blank PS,Capogrossi MC

更新日期：1992-10-01 00:00:00

abstract：RATIONALE:The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into cardiomyocytes. Not much is known about the relation between the myocardial and epicardial lineage durin...

journal_title：Circulation research

authors： van Wijk B,van den Berg G,Abu-Issa R,Barnett P,van der Velden S,Schmidt M,Ruijter JM,Kirby ML,Moorman AF,van den Hoff MJ

更新日期：2009-08-28 00:00:00

abstract：:We have previously studied the relation between long-chain fatty acid and pyruvate metabolism in reperfused myocardium and noted a rapid return of fatty acid oxidation to at least preischemic values accompanied by a marked decrease in pyruvate oxidation. The purpose of the present report is to further characterize car...

journal_title：Circulation research

authors： Renstrom B,Nellis SH,Liedtke AJ

更新日期：1989-10-01 00:00:00

abstract：:This study aimed to characterize the interaction between nitric oxide (NO)- and cAMP-related pathways in the control of renal blood flow. Using the isolated perfused rat kidney model, we determined the effects of inhibition of NO formation by Nomega-nitro-L-arginine methyl ester (L-NAME; 1 mmol/L) and of NO administra...

journal_title：Circulation research

authors： Sandner P,Kornfeld M,Ruan X,Arendshorst WJ,Kurtz A

更新日期：1999-02-05 00:00:00

abstract：:Although coronary artery spasm has been implicated as an important cause of myocardial ischemia in humans, an animal model of reversible segmental coronary constriction has not been described. To provoke coronary spasm in open-chest dogs, selected vasoconstricting agents adsorbed to viscous ion exchange gels were appl...

journal_title：Circulation research

authors： Pérez JE,Saffitz JE,Gutiérrez FA,Henry PD

更新日期：1983-04-01 00:00:00

abstract：:Aging of the vasculature plays a central role in morbidity and mortality of older people. To develop novel treatments for amelioration of unsuccessful vascular aging and prevention of age-related vascular pathologies, it is essential to understand the cellular and functional changes that occur in the vasculature durin...

journal_title：Circulation research

authors： Ungvari Z,Tarantini S,Donato AJ,Galvan V,Csiszar A

更新日期：2018-09-14 00:00:00

abstract：:Angiotensin II (Ang II) has profound effects in the central nervous system (CNS), including promotion of thirst, regulation of vasopressin secretion, and modulation of sympathetic outflow. Despite its importance in cardiovascular and volume homeostasis, angiotensinergic mechanisms are incompletely understood in the CN...

journal_title：Circulation research

authors： Zimmerman MC,Lazartigues E,Lang JA,Sinnayah P,Ahmad IM,Spitz DR,Davisson RL

更新日期：2002-11-29 00:00:00

abstract：RATIONALE:The vascular adventitia is a complex layer of the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells. Adventitial progenitors express the stem cell markers, Sca1 and CD34 (adventitial sca1-positive progenitor cells [AdvSca1]), have the potenti...

journal_title：Circulation research

authors： Majesky MW,Horita H,Ostriker A,Lu S,Regan JN,Bagchi A,Dong XR,Poczobutt J,Nemenoff RA,Weiser-Evans MC

更新日期：2017-01-20 00:00:00

abstract：:Fluid shear stress caused by blood flow is a major determinant of vascular remodeling and arterial tone and can lead to development of atherosclerosis. The endothelial monolayer in vivo acts as a signal transduction interface for hemodynamic forces; these forces determine the shape, cytoskeletal organization, and func...

journal_title：Circulation research

authors： Tzima E

更新日期：2006-02-03 00:00:00

abstract：RATIONALE:There is a critical need to develop robust, mechanistic strategies to identify patients at increased risk of cancer therapeutics-related cardiac dysfunction (CTRCD). OBJECTIVE:We aimed to discover new biomarkers associated with doxorubicin- and trastuzumab-induced CTRCD using high-throughput proteomic profil...

journal_title：Circulation research

authors： Beer LA,Kossenkov AV,Liu Q,Luning Prak E,Domchek S,Speicher DW,Ky B

更新日期：2016-10-28 00:00:00

abstract：:Nitric oxide (NO) functions principally as a diffusible paracrine effector. The exception is in cardiomyocytes where both NO synthases (NOS) and target proteins coexist, allowing NO to work in an autocrine/intracrine fashion. However, the most abundant myocyte isoform (NOS3) is far more expressed in vascular endotheli...

journal_title：Circulation research

authors： Champion HC,Georgakopoulos D,Takimoto E,Isoda T,Wang Y,Kass DA

更新日期：2004-03-19 00:00:00

abstract：:Vascular disease in diabetics could arise in part from altered vessel wall catebolism. Specific activities of hydrolases in aortic smooth muscle cells from rats with streptozotocin-induced diabetes were measured. Enyzmes included: neutral alpha-glucosidase, alpha-mannosidase, and lysosomal N-acetyl beta-glucosaminidas...

journal_title：Circulation research

authors： Wolinsky H,Goldfischer S,Capron L,Capron F,Coltoff-Schiller B,Kasak L

更新日期：1978-06-01 00:00:00

abstract：:The abundance of membrane cholesterol is an important determinant of the functional properties of biomembranes. To determine whether arterial smooth muscle acquires altered contractile properties in a high cholesterol environment, isolated canine coronary arteries were exposed to cholesterol in stable aqueous solution...

journal_title：Circulation research

authors： Yokoyama M,Henry PD

更新日期：1979-10-01 00:00:00

abstract：:Baroreceptor reflexes can be demonstrated during fetal life, but whether baroreceptors normally regulate fetal arterial pressure is unknown. This problem was addressed directly by measuring arterial pressure and analyzing its variation in eight unanesthetized fetal lambs throughout the last third of gestation, and com...

journal_title：Circulation research

authors： Yardley RW,Bowes G,Wilkinson M,Cannata JP,Maloney JE,Ritchie BC,Walker AM

更新日期：1983-05-01 00:00:00