Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis.

abstract：:The blood pressure of rabbits with chronic one-kidney hypertension can be lowered to normal by immunization with hog kidney cortex preparations that do not contain renin, thus providing evidence for a new factor essential for the maintenance of an elevated blood pressure. A search for the new factor has led to the dis...

journal_title：Circulation research

authors： Skeggs LT,Kahn JR,Levine M,Dorer FE,Lentz KE

更新日期：1977-02-01 00:00:00

abstract：:The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To...

journal_title：Circulation research

authors： Ford DA,Gross RW

更新日期：1989-01-01 00:00:00

abstract：:The effects of Bay K 8644 on the high-threshold calcium channel was investigated by means of the whole-cell patch-clamp technique in single guinea pig ventricular myocytes. The goal of the experiments was to characterize the inhibitory effects of Bay K 8644 on the calcium channel, and identify the factors that influen...

journal_title：Circulation research

authors： Hadley RW,Hume JR

更新日期：1988-01-01 00:00:00

abstract：:Some statistical techniques for analyzing the kinds of studies typically reported in Circulation Research are described. Particular emphasis is given to the comparison of means from more than two populations, the joint effect of several experimentally controlled variables, and the analysis of studies with repeated mea...

journal_title：Circulation research

authors： Wallenstein S,Zucker CL,Fleiss JL

更新日期：1980-07-01 00:00:00

abstract：:Tissue factor (TF) is a low-molecular-weight glycoprotein that initiates the extrinsic clotting cascade and is considered a major regulator of arterial thrombogenicity. TF pathway inhibitor (TFPI) is a major physiological inhibitor of TF-initiated coagulation. The aim of this study was to define the complex interplay ...

journal_title：Circulation research

authors： Singh R,Pan S,Mueske CS,Witt T,Kleppe LS,Peterson TE,Slobodova A,Chang JY,Caplice NM,Simari RD

更新日期：2001-07-06 00:00:00

abstract：:Matrix metalloproteinases (MMPs) include most major constituents of the arterial wall as substrates. A common promotor polymorphism (5A/6A) is associated with differences in MMP-3 (stromelysin-1) activity, and associations with certain forms of vascular disease have been shown. This study investigated whether the MMP-...

journal_title：Circulation research

authors： Medley TL,Kingwell BA,Gatzka CD,Pillay P,Cole TJ

更新日期：2003-06-13 00:00:00

abstract：:Dystrophin has a key role in striated muscle mechanotransduction. In mice lacking the gene encoding for dystrophin (mdx mice), the absence of dystrophin and several other proteins of the dystrophin-glycoprotein complex induces a defect in flow (shear stress)-mediated NO-dependent dilation (FMD). Because the endotheliu...

journal_title：Circulation research

authors： Loufrani L,Levy BI,Henrion D

更新日期：2002-12-13 00:00:00

abstract：:The endothelial cell membrane glycoprotein thrombomodulin (TM) plays a critical role in the regulation of coagulation. TM is an essential cofactor in protein C activation by thrombin, and a direct inhibitor of thrombin-induced platelet activation and fibrinogen clotting. Protease nexin-1 (PN-1) is a serpin synthesized...

journal_title：Circulation research

authors： Bouton MC,Venisse L,Richard B,Pouzet C,Arocas V,Jandrot-Perrus M

更新日期：2007-04-27 00:00:00

abstract：:Mitral regurgitation (MR) causes ventricular dilation, a blunted myocardial force-frequency relation, and increased crossbridge force-time integral (FTI). The mechanism of FTI increase was investigated using sinusoidal length perturbation analysis to compare crossbridge function in skinned left ventricular (LV) epicar...

journal_title：Circulation research

authors： Mulieri LA,Barnes W,Leavitt BJ,Ittleman FP,LeWinter MM,Alpert NR,Maughan DW

更新日期：2002-01-11 00:00:00

abstract：:We sought to determine the ejection variables that are principally responsible for increases in isovolumic ventricular relaxation rate observed with increases in stroke volume. In nine isolated canine hearts, left ventricular ejection was controlled by patterns specially designed to isolate the ejection parameters mos...

journal_title：Circulation research

authors： Hori M,Kitakaze M,Ishida Y,Fukunami M,Kitabatake A,Inoue M,Kamada T,Yue DT

更新日期：1991-01-01 00:00:00

abstract：:14-3-3 family members are dimeric phosphoserine-binding proteins that regulate signal transduction, apoptotic, and checkpoint control pathways. Targeted expression of dominant-negative 14-3-3eta (DN-14-3-3) to murine postnatal cardiac tissue potentiates Ask1, c-jun N-terminal kinase (JNK), and p38 mitogen-activated pr...

journal_title：Circulation research

authors： Zhang S,Ren J,Zhang CE,Treskov I,Wang Y,Muslin AJ

更新日期：2003-11-28 00:00:00

abstract：:Nitrite has recently emerged as an important bioactive molecule, capable of conferring cardioprotection and a variety of other benefits in the cardiovascular system and elsewhere. The mechanisms by which it accomplishes these functions remain largely unclear. To characterize the dose response and corresponding cardiac...

journal_title：Circulation research

authors： Perlman DH,Bauer SM,Ashrafian H,Bryan NS,Garcia-Saura MF,Lim CC,Fernandez BO,Infusini G,McComb ME,Costello CE,Feelisch M

更新日期：2009-03-27 00:00:00

abstract：RATIONALE:Cardiac myosin-binding protein-C (cMyBP-C) phosphorylation at Ser-273, Ser-282, and Ser-302 regulates myocardial contractility. In vitro and in vivo experiments suggest the nonequivalence of these sites and the potential importance of Ser-282 phosphorylation in modulating the protein's overall phosphorylation...

journal_title：Circulation research

authors： Sadayappan S,Gulick J,Osinska H,Barefield D,Cuello F,Avkiran M,Lasko VM,Lorenz JN,Maillet M,Martin JL,Brown JH,Bers DM,Molkentin JD,James J,Robbins J

更新日期：2011-07-08 00:00:00

abstract：RATIONALE:Congenital heart disease (CHD) is among the most common birth defects. Most cases are of unknown pathogenesis. OBJECTIVE:To determine the contribution of de novo copy number variants (CNVs) in the pathogenesis of sporadic CHD. METHODS AND RESULTS:We studied 538 CHD trios using genome-wide dense single nucle...

journal_title：Circulation research

authors： Glessner JT,Bick AG,Ito K,Homsy J,Rodriguez-Murillo L,Fromer M,Mazaika E,Vardarajan B,Italia M,Leipzig J,DePalma SR,Golhar R,Sanders SJ,Yamrom B,Ronemus M,Iossifov I,Willsey AJ,State MW,Kaltman JR,White PS,Shen Y

更新日期：2014-10-24 00:00:00

abstract：:Prolongation of the action potential has been postulated to be a major reason for the altered diastolic relaxation of the heart in patients with severe heart failure. To investigate the electrophysiological basis for this action potential prolongation in terminal heart failure, K+ currents were recorded in single vent...

journal_title：Circulation research

authors： Beuckelmann DJ,Näbauer M,Erdmann E

更新日期：1993-08-01 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:Fibroblast growth factor-1 (FGF-1), a prototype member of the heparin-binding growth factor family, is a potent mitogen for vascular endothelial cells and a variety of other cell types. FGF-1 can induce the expression of the platelet-derived growth factor-A chain (PDGF-A) gene in endothelial cells; however, the underl...

journal_title：Circulation research

authors： Delbridge GJ,Khachigian LM

更新日期：1997-08-01 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：RATIONALE:The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into cardiomyocytes. Not much is known about the relation between the myocardial and epicardial lineage durin...

journal_title：Circulation research

authors： van Wijk B,van den Berg G,Abu-Issa R,Barnett P,van der Velden S,Schmidt M,Ruijter JM,Kirby ML,Moorman AF,van den Hoff MJ

更新日期：2009-08-28 00:00:00

abstract：:The objective of this study was to elucidate the mechanisms associated with the reciprocal relation between magnesium and calcium on vascular smooth muscle tone in bovine pulmonary artery and vein. Rapid removal of magnesium from Krebs-bicarbonate medium used to bathe isolated rings of precontracted artery or vein cau...

journal_title：Circulation research

authors： Gold ME,Buga GM,Wood KS,Byrns RE,Chaudhuri G,Ignarro LJ

更新日期：1990-02-01 00:00:00

abstract：:Vascular restenosis involves contraction, proliferation, and remodeling of the arterial wall in response to overstretch injury. Mitogen-activated protein kinases (MAPKs) are implicated in both contraction and proliferation of vascular smooth muscle (VSM), and studies of porcine carotid arterial muscle strips have show...

journal_title：Circulation research

authors： Pyles JM,March KL,Franklin M,Mehdi K,Wilensky RL,Adam LP

更新日期：1997-12-01 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:Intracellular recordings were made from eustachian ridge of cat right atrium to determine mechanisms responsible for subsidiary pacemaker automaticity. Pacemaker action potentials exhibited two phases of diastolic depolarization: an initial steeper slope (D1) followed by a more gradual slope (D2). Cesium (1 mM) decrea...

journal_title：Circulation research

authors： Rubenstein DS,Lipsius SL

更新日期：1989-04-01 00:00:00

abstract：:Oxidative stress through the production of oxygen metabolites such as hydrogen peroxide (H2O2) increases vascular endothelial permeability. H2O2 stimulates ADP-ribose formation, which in turn opens transient receptor potential melastatin (TRPM)2 channels. Here, in endothelial cells, we demonstrate transcript and prote...

journal_title：Circulation research

authors： Hecquet CM,Ahmmed GU,Vogel SM,Malik AB

更新日期：2008-02-15 00:00:00

abstract：:Despite the absence of a systematic development plan, β-blockers have reached the top tier of medical therapies for chronic heart failure. The successful outcome was due to the many dedicated investigators who produced, over a 30-year period, increasing evidence that β-blocking agents should or actually did improve th...

journal_title：Circulation research

authors： Bristow MR

更新日期：2011-10-28 00:00:00

abstract：RATIONALE:Calcium channel blockers (CCBs) are an important class of drugs in managing cardiovascular diseases. Patients usually rely on these medications for the remainder of their lives after diagnosis. Although the acute pharmacological actions of CCBs in the hearts are well-defined, little is known about the drug-sp...

journal_title：Circulation research

authors： Lam CK,Tian L,Belbachir N,Wnorowski A,Shrestha R,Ma N,Kitani T,Rhee JW,Wu JC

更新日期：2019-07-05 00:00:00

abstract：:Ventricular arrhythmias that accompany myocardial infarction in dogs may be secondary to the altered electrophysiological properties of the subendocardial Purkinje fibers that survive 24 hours after the coronary occlusion. To better understand the ionic mechanisms that underlie the altered electrical activity of these...

journal_title：Circulation research

authors： Boyden PA,Albala A,Dresdner KP Jr

更新日期：1989-10-01 00:00:00

abstract：RATIONALE:Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. OBJECTIVE:This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism. METHODS AND RESULTS:Overexpression of...

journal_title：Circulation research

authors： Margariti A,Zampetaki A,Xiao Q,Zhou B,Karamariti E,Martin D,Yin X,Mayr M,Li H,Zhang Z,De Falco E,Hu Y,Cockerill G,Xu Q,Zeng L

更新日期：2010-04-16 00:00:00

abstract：:To clarify the physiological role of calcium-activated neutral protease (CANP) in human platelets, we loaded the platelets with a Ca2+ -sensitive fluorescent dye, fura-2, and measured the degree of aggregation, cytosolic calcium ion concentration [( Ca2+]i), and proteolysis by sodium dodecyl sulfate-polyacrylamide gel...

journal_title：Circulation research

authors： Toyo-oka T,Shin WS,Okai Y,Dan Y,Morita M,Iizuka M,Sugimoto T

更新日期：1989-02-01 00:00:00

abstract：:Mechanisms of denervation supersensitivity to sympathomimetic amines were studied in conscious animals. Norepinephrine, 0.1 micrograms/kg, increased left ventricular dP/dt significantly more (4208 +/- 828 mm Hg/sec) in dogs with cardiac denervation than in intact dogs (1029 +/- 280 mm Hg/sec), P less than 0.01, wherea...

journal_title：Circulation research

authors： Vatner DE,Lavallee M,Amano J,Finizola A,Homcy CJ,Vatner SF

更新日期：1985-07-01 00:00:00