Collagen-stimulated human platelet aggregation is mediated by endogenous calcium-activated neutral protease.

abstract：:Alpha1-adrenoceptor (alpha1-AR) stimulation increases sarcolemmal Na+-H+ exchanger (NHE) activity. The present study was designed to determine the role(s) of alpha1-AR subtype(s) in mediating this response. As an index of NHE activity, acid efflux rates (JHs) were determined in single rat ventricular myocytes loaded w...

journal_title：Circulation research

authors： Yokoyama H,Yasutake M,Avkiran M

更新日期：1998-06-01 00:00:00

abstract：:Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high incidence of death due to electric abnormalities or outflow tract obstruction. In many of the families afflicted with either disease, causative mutations have been identified in various sarcomeric proteins. In this review, we focu...

journal_title：Circulation research

authors： Moore JR,Leinwand L,Warshaw DM

更新日期：2012-07-20 00:00:00

abstract：:Fluid shear stress caused by blood flow is a major determinant of vascular remodeling and arterial tone and can lead to development of atherosclerosis. The endothelial monolayer in vivo acts as a signal transduction interface for hemodynamic forces; these forces determine the shape, cytoskeletal organization, and func...

journal_title：Circulation research

authors： Tzima E

更新日期：2006-02-03 00:00:00

abstract：:The migration of medial smooth muscle cells (SMCs) into the intima is proposed to be an important process of intimal thickening in atherosclerotic lesions. The present study examined the possible effect of a novel endothelium-derived relaxing peptide, C-type natriuretic peptide (CNP), on oxidized low-density lipoprote...

journal_title：Circulation research

authors： Kohno M,Yokokawa K,Yasunari K,Kano H,Minami M,Ueda M,Yoshikawa J

更新日期：1997-10-01 00:00:00

abstract：:Although Ca(2+) waves in cardiac myocytes are regarded as arrhythmogenic substrates, their properties in the heart in situ are poorly understood. On the hypothesis that Ca(2+) waves in the heart behave diversely and some of them influence the cardiac function, we analyzed their incidence, propagation velocity, and int...

journal_title：Circulation research

authors： Kaneko T,Tanaka H,Oyamada M,Kawata S,Takamatsu T

更新日期：2000-05-26 00:00:00

abstract：RATIONALE:Shear stress (SS) has an established role in atherosclerotic plaque localization, but how it exerts its protective effect is not fully understood. OBJECTIVE:To test the hypothesis that SS may downregulate angiotensin type 1 receptors (AT(1)Rs). Angiotensin II has been shown to be proinflammatory and to promo...

journal_title：Circulation research

authors： Ramkhelawon B,Vilar J,Rivas D,Mees B,de Crom R,Tedgui A,Lehoux S

更新日期：2009-10-23 00:00:00

abstract：:alpha-Adrenergic stimulation (alpha-AS) and beta-adrenergic stimulation (beta-AS) of the myocardium are associated respectively with an increase and a decrease in myofilament responsiveness to Ca2+. We hypothesized that changes in cytosolic pH (pH(i)) may modulate these opposite actions of alpha-AS and beta-AS. The ef...

journal_title：Circulation research

authors： Gambassi G,Spurgeon HA,Lakatta EG,Blank PS,Capogrossi MC

更新日期：1992-10-01 00:00:00

abstract：:Trimetazidine is a clinically effective antianginal agent that has no negative inotropic or vasodilator properties. Although it is thought to have direct cytoprotective actions on the myocardium, the mechanism(s) by which this occurs is as yet undefined. In this study, we determined what effects trimetazidine has on b...

journal_title：Circulation research

authors： Kantor PF,Lucien A,Kozak R,Lopaschuk GD

更新日期：2000-03-17 00:00:00

abstract：:Advances in immunosuppression have decreased the incidence of acute rejection, but the development of vasculopathy in the coronary arteries of transplants continues to limit the survival of cardiac allografts. Transplant vasculopathy has also been referred to as accelerated graft arteriosclerosis because it has featur...

journal_title：Circulation research

authors： Wehner J,Morrell CN,Reynolds T,Rodriguez ER,Baldwin WM 3rd

更新日期：2007-02-02 00:00:00

abstract：:We have recently shown that adult canine ventricular myocytes express three distinct gap junction channel proteins, connexin40 (Cx40), connexin43 (Cx43), and connexin45 (Cx45). These proteins have unique cytoplasmic domains that likely confer connexin-specific physiological properties. To determine whether the three d...

journal_title：Circulation research

authors： Kanter HL,Laing JG,Beyer EC,Green KG,Saffitz JE

更新日期：1993-08-01 00:00:00

abstract：:We used a genetic approach to determine whether increasing the level of A3 adenosine receptors (A3ARs) expressed in the heart confers protection against ischemia without causing cardiac pathology. We generated mice carrying one (A3tg.1) or six (A3tg.6) copies of a transgene consisting of the cardiomyocyte-specific alp...

journal_title：Circulation research

authors： Black RG Jr,Guo Y,Ge ZD,Murphree SS,Prabhu SD,Jones WK,Bolli R,Auchampach JA

更新日期：2002-07-26 00:00:00

abstract：:L-type Ca(2+) channel (LTCC) blockers, represented by amlodipine and verapamil, are widely used antihypertensive drugs that also have antiinflammatory activities. Plasminogen (Plg) is an important mediator of macrophage recruitment, and this role depends on its interaction with Plg receptors (Plg-Rs). Plg-Rs include h...

journal_title：Circulation research

authors： Das R,Burke T,Van Wagoner DR,Plow EF

更新日期：2009-07-17 00:00:00

abstract：:Blockade of angiotensin type 1 (AT1) receptors induces smooth muscle cell (SMC) death and regression of aortic hypertrophy in spontaneously hypertensive rats (SHR). We postulated that SMC death and vascular remodeling in this model may be attenuated by z-Val-Ala-Asp(OMe)-CH2F (z-VAD-fmk), a tripeptide inhibitor of cas...

journal_title：Circulation research

authors： Marchand EL,Der Sarkissian S,Hamet P,deBlois D

更新日期：2003-04-18 00:00:00

abstract：:We have shown that the cellular contractile dysfunction characteristic of pressure-overload cardiac hypertrophy results not from an abnormality intrinsic to the myofilament portion of the cardiocyte cytoskeleton but rather from an increased density of the microtubule component of the extramyofilament portion of the ca...

journal_title：Circulation research

authors： Tagawa H,Wang N,Narishige T,Ingber DE,Zile MR,Cooper G 4th

更新日期：1997-02-01 00:00:00

abstract：:Stem cells can differentiate into a variety of cells to replace dead cells or to repair damaged tissues. Recent evidence indicates that stem cells are involved in the pathogenesis of transplant arteriosclerosis, an alloimmune initiated vascular stenosis that often results in transplant organ failure. Although the path...

journal_title：Circulation research

authors： Xu Q

更新日期：2008-05-09 00:00:00

abstract：:The structure of the mouse natriuretic peptide type-B (BNP) gene was determined by isolating and sequencing genomic clones. The mouse BNP gene was structurally similar to other natriuretic peptide genes and comprised three exons and two introns. Expression of the mouse BNP gene was found only in cardiac tissue as dete...

journal_title：Circulation research

authors： Steinhelper ME

更新日期：1993-05-01 00:00:00

abstract：:It is well known that electrical pacing may either terminate or change the rate and/or ECG appearance of reentrant ventricular tachycardia. However, the dynamics of interaction of reentrant waves with waves initiated by external pacing are poorly understood. Prevailing concepts are based on simplistic models in which ...

journal_title：Circulation research

authors： Davidenko JM,Salomonsz R,Pertsov AM,Baxter WT,Jalife J

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Mitochondria, although required for cellular ATP production, are also known to have other important functions that may include modulating cellular responses to environmental stimuli. However, the mechanisms whereby mitochondria impact cellular phenotype are not yet clear. OBJECTIVE:To determine how mitochond...

journal_title：Circulation research

authors： Shimasaki Y,Pan N,Messina LM,Li C,Chen K,Liu L,Cooper MP,Vita JA,Keaney JF Jr

更新日期：2013-09-13 00:00:00

abstract：:Reactive oxygen species and reactive nitrogen species are biological molecules that play important roles in cardiovascular physiology and contribute to disease initiation, progression, and severity. Because of their ephemeral nature and rapid reactivity, these species are difficult to measure directly with high accura...

journal_title：Circulation research

authors： Griendling KK,Touyz RM,Zweier JL,Dikalov S,Chilian W,Chen YR,Harrison DG,Bhatnagar A,American Heart Association Council on Basic Cardiovascular Sciences.

更新日期：2016-08-19 00:00:00

abstract：:Osteopontin (OPN) is a cytokine upregulated in diabetic vascular disease. To better understand its role in vascular remodeling, we assessed how OPN controls metalloproteinase (MMP) activation in aortic adventitial myofibroblasts (AMFs) and A7r5 vascular smooth muscle cells (VSMCs). By zymography, OPN and tumor necrosi...

journal_title：Circulation research

authors： Lai CF,Seshadri V,Huang K,Shao JS,Cai J,Vattikuti R,Schumacher A,Loewy AP,Denhardt DT,Rittling SR,Towler DA

更新日期：2006-06-23 00:00:00

abstract：:Experimental and clinical studies have suggested an increased production of reactive oxygen species (ROS) in the failing myocardium. The present study aimed to obtain direct evidence for increased ROS and to determine the contribution of superoxide anion (*O(2)(-)), H(2)O(2), and hydroxy radical (*OH) in failing myoca...

journal_title：Circulation research

authors： Ide T,Tsutsui H,Kinugawa S,Suematsu N,Hayashidani S,Ichikawa K,Utsumi H,Machida Y,Egashira K,Takeshita A

更新日期：2000-02-04 00:00:00

abstract：RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms tha...

journal_title：Circulation research

authors： Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

更新日期：2013-06-07 00:00:00

abstract：:Nitroglycerin dilates large (greater than or equal to 100 microns) but not small coronary arterial microvessels, and a putative metabolite of nitroglycerin, S-nitroso-L-cysteine, has been shown in vitro to dilate both large and small coronary microvessels. Based on this evidence, we tested the hypothesis that the lack...

journal_title：Circulation research

authors： Kurz MA,Lamping KG,Bates JN,Eastham CL,Marcus ML,Harrison DG

更新日期：1991-03-01 00:00:00

abstract：:Morphometric data from stable (nonedematous) isolated dog lungs, perfused with nearly cell-free perfusates, were compared to similar stereological evaluations of isolated dog lungs after induction of severe acute hydrostatic edema. In the edematous lungs, capillary surface and volume densities were substantially incre...

journal_title：Circulation research

authors： DeFouw DO,Berendsen PB

更新日期：1978-07-01 00:00:00

abstract：:Previous studies have shown that integrin activation and fluid shear stress can modulate the activity of sterol regulatory element binding proteins (SREBPs) in vascular endothelial cells. We investigated the role of small GTPase Rho-mediated signal transduction pathway in this mode of SREBP activation. Fluid shear str...

journal_title：Circulation research

authors： Lin T,Zeng L,Liu Y,DeFea K,Schwartz MA,Chien S,Shyy JY

更新日期：2003-06-27 00:00:00

abstract：:We discuss the recent finding by Mizishima's group regarding the role of the autophagy-related conjugation system in mediating the closure of autophagosomes and its implication in the study of autophagy in mammalian cells. The study not only shows a novel function of the autophagy-related conjugation system but also i...

journal_title：Circulation research

authors： Saito T,Sadoshima J

更新日期：2017-02-17 00:00:00

abstract：RATIONALE:Thousands of mutations across >50 genes have been implicated in inherited cardiomyopathies. However, options for sequencing this rapidly evolving gene set are limited because many sequencing services and off-the-shelf kits suffer from slow turnaround, inefficient capture of genomic DNA, and high cost. Further...

journal_title：Circulation research

authors： Wilson KD,Shen P,Fung E,Karakikes I,Zhang A,InanlooRahatloo K,Odegaard J,Sallam K,Davis RW,Lui GK,Ashley EA,Scharfe C,Wu JC

更新日期：2015-09-11 00:00:00

abstract：:Propagation in cardiac muscle is faster in the longitudinal than in the transverse axis of the cells. Yet, as a result of the larger upstroke velocity of action potentials propagating transversely, it has been suggested that longitudinal propagation is more vulnerable to block. To study the relation between conduction...

journal_title：Circulation research

authors： Delmar M,Michaels DC,Johnson T,Jalife J

更新日期：1987-05-01 00:00:00

abstract：:Autoregulatory responses to alterations in arterial or venous perfusion pressure were determined for individual arterioles within the rat cremaster muscle. The cremaster muscle of pentobarbital anesthetized rats (50 mg/kg, ip) was surgically exposed and maintained in a controlled tissue bath for visualization by in vi...

journal_title：Circulation research

authors： Morff RJ,Granger HJ

更新日期：1982-07-01 00:00:00

abstract：:[3H](+/-)Carazolol, a newly available beta-adrenergic receptor antagonist, can be used to characterize beta-adrenergic receptor subtypes present in membrane vesicles derived from canine ventricular myocardium and canine lung. [3H](+/-)Carazolol binding is saturable, of high affinity, and is displaceable by beta-adrene...

journal_title：Circulation research

authors： Manalan AS,Besch HR Jr,Watanabe AM

更新日期：1981-08-01 00:00:00