Abstract:
:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion boundary were determined with myocardial blood flow (microspheres) maps constructed from multiple, small tissue samples. Five minutes after circumflex occlusion, systolic wall thickening in the central ischemic zone decreased from 3.00 +/- 0.61 (mean +/- SD) mm to -0.61 +/- 0.36 mm (P less than 0.01). In nonischemic myocardium greater than 10 mm from the perfusion boundary, systolic wall thickening increased from 2.56 +/- 0.57 to 3.24 +/- 0.72 mm (P less than 0.01). In nonischemic myocardium within 10 mm of the perfusion boundary, systolic wall thickening was slightly but significantly reduced compared with control (2.72 +/- 0.80 to 2.44 +/- 0.79 mm, P less than 0.05), supporting the concept of regional dysfunction in nonischemic myocardium at the lateral borders of an ischemic area. Sigmoid curves were fitted to the data to model changes in wall thickening as a continuous function of distance from the perfusion boundary. This allowed estimation of the extent of dysfunction into nonischemic myocardium which averaged less than 8 mm (approximately 30 degrees of endocardial circumference) at one border. The level of functional impairment in this zone was relatively modest, and systolic wall thickening in the immediate border area was reduced more than 50% from control only in tissue characterized by a blood supply of mixed ischemic and nonischemic origin. We conclude that a functional border zone exists lateral to an acutely ischemic area, but measurement of regional function produces relatively small exaggeration of the size of the acutely ischemic zone if severe reduction in mechanical performance is used to define the extent of the ischemic area.
journal_name
Circ Resjournal_title
Circulation researchauthors
Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WRdoi
10.1161/01.res.58.4.570subject
Has Abstractpub_date
1986-04-01 00:00:00pages
570-83issue
4eissn
0009-7330issn
1524-4571journal_volume
58pub_type
杂志文章abstract::A method was developed for recording isometric tension from isolated small arteries (mean internal diameter, 169 microns) and veins (mean internal diameter, 273 microns) of the term fetal lung and was then applied to the study of the mechanisms controlling perinatal pulmonary hemodynamics. The specific purpose was to ...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.71.2.320
更新日期:1992-08-01 00:00:00
abstract:RATIONALE:We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, th...
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doi:10.1161/CIRCRESAHA.116.308700
更新日期:2016-07-22 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-06-05 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.RES.0000266970.34017.8d
更新日期:2007-05-11 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.75.6.1006
更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.65.4.1136
更新日期:1989-10-01 00:00:00
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更新日期:2011-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.85.10.931
更新日期:1999-11-12 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.76.4.600
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.51.4.439
更新日期:1982-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.76.2.284
更新日期:1995-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-04-10 00:00:00
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pub_type: 杂志文章
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更新日期:1998-04-20 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.76.3.335
更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-04-13 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.63.3.621
更新日期:1988-09-01 00:00:00
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更新日期:2014-11-07 00:00:00
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pub_type: 杂志文章
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更新日期:1985-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-09-21 00:00:00
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更新日期:2010-04-02 00:00:00
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更新日期:2021-01-22 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.66.2.511
更新日期:1990-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-02-07 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.68.3.847
更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-08-23 00:00:00
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pub_type: 杂志文章
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更新日期:2005-03-18 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:2014-02-14 00:00:00
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pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00