Cytosolic alkalinization of vascular endothelial cells produced by an abrupt reduction in fluid shear stress.

abstract：:Calcineurin, a calcium/calmodulin-regulated protein phosphatase, modulates gene expression in cardiac and skeletal muscles during development and in remodeling responses such as cardiac hypertrophy that are evoked by environmental stresses or disease. Recently, we identified two genes encoding proteins (MCIP1 and MCIP...

journal_title：Circulation research

authors： Yang J,Rothermel B,Vega RB,Frey N,McKinsey TA,Olson EN,Bassel-Duby R,Williams RS

更新日期：2000-12-08 00:00:00

abstract：:Collagens are abundant within the atherosclerotic plaque, where they contribute to lesion volume and mechanical stability and influence cell signaling. The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds to collagen, is expressed in blood vessels, but evidence for a functional role during ath...

journal_title：Circulation research

authors： Franco C,Hou G,Ahmad PJ,Fu EY,Koh L,Vogel WF,Bendeck MP

更新日期：2008-05-23 00:00:00

abstract：:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calci...

journal_title：Circulation research

authors： Collett GD,Canfield AE

更新日期：2005-05-13 00:00:00

abstract：RATIONALE:Nuclear factor of activated T-cells (NFAT) is importantly implicated in pathological cardiac remodeling and vascular lesion formation. NFAT functionality is mainly regulated by calcineurin, a Ca(2+)-dependent multi-effector phosphatase. Calcineurin inhibitors such as cyclosporine A (CsA) were shown to be effe...

journal_title：Circulation research

authors： Yu H,Bot I,Sliedregt K,Xu X,Bot M,van Heiningen SH,van der Marel GA,Bennett MR,Overkleeft H,van Berkel TJ,Biessen EA

更新日期：2012-01-20 00:00:00

abstract：:A method was developed for recording isometric tension from isolated small arteries (mean internal diameter, 169 microns) and veins (mean internal diameter, 273 microns) of the term fetal lung and was then applied to the study of the mechanisms controlling perinatal pulmonary hemodynamics. The specific purpose was to ...

journal_title：Circulation research

authors： Wang Y,Coceani F

更新日期：1992-08-01 00:00:00

abstract：:Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in response to extracellular stimulants. The strength of signal transduction is controlled by intracellular cyclic nucleot...

journal_title：Circulation research

authors： Omori K,Kotera J

更新日期：2007-02-16 00:00:00

abstract：:The solid angle theory has long been applied to the interpretation of the ECG; however, quantitative evaluation of its applicability has been minimal. We applied solid angle analysis to the interpretation of the TQ-ST deflection during acute ischemia. Five anesthetized pigs were studied 1--3 hours after coronary occlu...

journal_title：Circulation research

authors： Richeson JF,Akiyama T,Schenk E

更新日期：1978-12-01 00:00:00

abstract：:Increased activity of matrix metalloproteinases (MMPs) has been implicated in numerous disease processes, including tumor growth and metastasis, arthritis, and periodontal disease. It is now becoming increasingly clear that extracellular matrix degradation by MMPs is also involved in the pathogenesis of cardiovascular...

journal_title：Circulation research

authors： Creemers EE,Cleutjens JP,Smits JF,Daemen MJ

更新日期：2001-08-03 00:00:00

abstract：:We investigated expression of the 5'-spliced isoform of smooth muscle myosin heavy chain (SM-MHC-B) in smooth muscle cells of cardiac vessels of the left ventricle of normotensive (Wistar-Kyoto) and spontaneously hypertensive rats of the stroke-prone strain by immunofluorescence microscopy. In parallel, liver and blad...

journal_title：Circulation research

authors： Wetzel U,Lutsch G,Haase H,Ganten U,Morano I

更新日期：1998-07-27 00:00:00

abstract：:Alternans in heart is important as pulsus alternans in cardiac failure and electrophysiological alternans in myocardial ischemia. The explanation of this phenomenon is still unclear. We attempted to investigate the cellular mechanisms of alternans by measuring intracellular free calcium concentration [( Ca2+]i) with t...

journal_title：Circulation research

authors： Lab MJ,Lee JA

更新日期：1990-03-01 00:00:00

abstract：:Studies of the stellate ganglion and middle cervical ganglion indicate that sympathetic efferent nerve activity can be modified by peripheral excitatory inputs and that these neural connections may function as pathways for a peripheral reflex at the level of the thoracic sympathetic ganglia. This excitatory synaptic i...

journal_title：Circulation research

authors： Bosnjak ZJ,Kampine JP

更新日期：1989-03-01 00:00:00

abstract：:Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein E-null (ApoE(-/-)) and wild-type mice fed a high cholesterol diet. I...

journal_title：Circulation research

authors： Ryoo S,Gupta G,Benjo A,Lim HK,Camara A,Sikka G,Lim HK,Sohi J,Santhanam L,Soucy K,Tuday E,Baraban E,Ilies M,Gerstenblith G,Nyhan D,Shoukas A,Christianson DW,Alp NJ,Champion HC,Huso D,Berkowitz DE

更新日期：2008-04-25 00:00:00

abstract：:AR-L 115BS, a benzimidazole derivative, is a positive inotropic agent that has been shown to increase active tension development and unloaded shortening velocity of chemically skinned heart muscle preparations at submaximal activating levels of free Ca++. We measured the effect of AR-L on relations between free Ca++, ...

journal_title：Circulation research

authors： Solaro RJ,Rüegg JC

更新日期：1982-09-01 00:00:00

abstract：RATIONALE:Mitochondria are key integrators of convergent intracellular signaling pathways. Two important second messengers modulated by mitochondria are calcium and reactive oxygen species. To date, coherent mechanisms describing mitochondrial integration of calcium and oxidative signaling in arterial smooth muscle are...

journal_title：Circulation research

authors： Chaplin NL,Nieves-Cintrón M,Fresquez AM,Navedo MF,Amberg GC

更新日期：2015-12-04 00:00:00

abstract：:Heparin inhibits the development of intimal thickening after carotid injury in the rat; however, the specific cellular events responsible for this effect have not been defined. In this study, smooth muscle cell growth fraction and migration into the intima were quantitatively measured in heparin-treated animals. All r...

journal_title：Circulation research

authors： Clowes AW,Clowes MM

更新日期：1986-06-01 00:00:00

abstract：:As described in earlier reviews in this series on the molecular basis of hypertrophic cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders to be understood at the molecular level. Twenty years after the discovery of the first HCM disease gene, genetic studies still confirm that HCM is ...

journal_title：Circulation research

authors： Ashrafian H,McKenna WJ,Watkins H

更新日期：2011-06-24 00:00:00

abstract：:Angiotensin II (Ang II) has profound effects in the central nervous system (CNS), including promotion of thirst, regulation of vasopressin secretion, and modulation of sympathetic outflow. Despite its importance in cardiovascular and volume homeostasis, angiotensinergic mechanisms are incompletely understood in the CN...

journal_title：Circulation research

authors： Zimmerman MC,Lazartigues E,Lang JA,Sinnayah P,Ahmad IM,Spitz DR,Davisson RL

更新日期：2002-11-29 00:00:00

abstract：:To test the hypothesis that early interventional treatment with insulin-like growth factor-1 (IGF-1) alleviates subsequent development of dilated cardiomyopathy, cardiac-specific IGF-1 expression was introduced by selective cross-breeding into a transgenic mouse model of heart failure that displays phenotypic characte...

journal_title：Circulation research

authors： Welch S,Plank D,Witt S,Glascock B,Schaefer E,Chimenti S,Andreoli AM,Limana F,Leri A,Kajstura J,Anversa P,Sussman MA

更新日期：2002-04-05 00:00:00

abstract：:Five fetal sheep (gestational age, 118 to 125 days) were instrumented to measure impedances of the lower abdominal aorta. Four days after surgery, flow and pressure pulses were recorded during control conditions and during infusion of norepinephrine (0.3 to 3 micrograms.min-1.kg-1 body weight) or angiotensin II (0.2 t...

journal_title：Circulation research

authors： Schröder H,Cetin E,Hüneke B,Carstensen M

更新日期：1994-04-01 00:00:00

abstract：:In this study, anti-basic fibroblast growth factor (anti-bFGF) antibody was used to determine whether the mitogenic effect of angiotensin II in vivo could be blocked by neutralizing bFGF in the vessel wall. Animals, divided into six experimental groups, were given (1) angiotensin II, (2) angiotensin II + anti-bFGF ant...

journal_title：Circulation research

authors： Su EJ,Lombardi DM,Wiener J,Daemen MJ,Reidy MA,Schwartz SM

更新日期：1998-02-23 00:00:00

abstract：RATIONALE:Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time outside the optimal glucose range. These glucose variations, termed tra...

journal_title：Circulation research

authors： Flynn MC,Kraakman MJ,Tikellis C,Lee MKS,Hanssen NMJ,Kammoun HL,Pickering RJ,Dragoljevic D,Al-Sharea A,Barrett TJ,Hortle F,Byrne FL,Olzomer E,McCarthy DA,Schalkwijk CG,Forbes JM,Hoehn K,Makowski L,Lancaster GI,El-Ost

更新日期：2020-09-11 00:00:00

abstract：:Lipid rafts are discrete membrane subdomains rich in sphingolipids and cholesterol. In ventricular myocytes a function of caveolae, a type of lipid rafts, is to concentrate in close proximity several proteins of the beta-adrenergic transduction pathway. We have investigated the subcellular localization of HCN4 channel...

journal_title：Circulation research

authors： Barbuti A,Gravante B,Riolfo M,Milanesi R,Terragni B,DiFrancesco D

更新日期：2004-05-28 00:00:00

abstract：:The recent discovery of neutral active choline and ethanolamine glycerophospholipid specific phospholipase C in myocardium (Wolf RA, Gross RW. J Biol Chem 1985;260:7295) has demonstrated a novel catabolic pathway that potentially contributes to the accumulation of amphiphilic metabolites during myocardial ischemia. To...

journal_title：Circulation research

authors： Ford DA,Gross RW

更新日期：1989-01-01 00:00:00

abstract：:To investigate the relation of pressure and vascular wall thickening in hypertension, we coarcted the abdominal aorta upstream to the renal arteries in 14 rats. Sham-coarcted (n = 16) and two-kidney, one-clip (Goldblatt) hypertensive rats (n = 13) served as controls. Tail, femoral, and carotid arterial pressures rose ...

journal_title：Circulation research

authors： Liu JL,Bishop SP,Overbeck HW

更新日期：1988-05-01 00:00:00

abstract：:The present study investigated the effect of adrenomedullin, a novel vasorelaxant peptide, on the migration of cultured rat vascular smooth muscle cells (SMCs) by using the Boyden-chamber method. Fetal calf serum (FCS) and platelet-derived growth factor (PDGF)-BB strongly stimulated SMC migration. Adrenomedullin clear...

journal_title：Circulation research

authors： Horio T,Kohno M,Kano H,Ikeda M,Yasunari K,Yokokawa K,Minami M,Takeda T

更新日期：1995-10-01 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have an antihypertensive effect in vivo, the precise mechanism has not been fully elucidated. We examined their effects on Rho/Rho kinase pathway, a key regulator of vascular tone. In cultured rat aortic smooth muscle cells (RASMC), Rho kina...

journal_title：Circulation research

authors： Wakino S,Hayashi K,Kanda T,Tatematsu S,Homma K,Yoshioka K,Takamatsu I,Saruta T

更新日期：2004-09-03 00:00:00

abstract：:We recently showed that the transient expression of a hemagglutinin (HA) epitope-tagged, constitutively active mutant of the G protein alpha(q) subunit (HAalpha(q)*) in the hearts of transgenic mice is sufficient to induce cardiac hypertrophy and dilatation that continue to progress after HAalpha(q)* protein becomes u...

journal_title：Circulation research

authors： Mende U,Kagen A,Meister M,Neer EJ

更新日期：1999-11-26 00:00:00

abstract：:Mechanical overload elicits functional and structural adaptive mechanisms in cardiac muscle. Signaling pathways linked to integrin/cytoskeleton complexes may have a function in mediation of the effects of mechanical stimulus in myocardial cells. We investigated the tyrosine phosphorylation and the assembly of the mult...

journal_title：Circulation research

authors： Franchini KG,Torsoni AS,Soares PH,Saad MJ

更新日期：2000-09-29 00:00:00

abstract：RATIONALE:Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in patients with chronic kidney disease. The nuclear receptor farnesoid X receptor (FXR) has been implicated in the control of lipid, carbohydrate and bile acid metabolism in several cell types. Although recent...

journal_title：Circulation research

authors： Miyazaki-Anzai S,Levi M,Kratzer A,Ting TC,Lewis LB,Miyazaki M

更新日期：2010-06-25 00:00:00

abstract：:Genetically hypertensive (GH) rats of the New Zealand strain and normotensive (N) rats were sympathectomized from birth with 6-hydroxydopamine (100 mg/kg,s.c, on alternate days, seven treatments). In adult treated rats from each strain (GHTr and NTr), blood pressure was lower than normal. Functional tests and electron...

journal_title：Circulation research

authors： Clark DW,Jones DR,Phelan EL,Devine CE

更新日期：1978-08-01 00:00:00