Mast cells in the rat heart during normal growth and in cardiac hypertrophy.


:Mast cells in rat hearts were studied quantitatively during normal postnatal growth and in two types of cardiac hypertrophy. Normally, cardiac mast cell density in 11-12-day-old animals is very low, but increases markedly in the following 2-3 weeks to its highest values, with a subsequent decline toward adult values. At the peak of mast cell density, the percentage of mast cells in close proximity to capillaries is also highest. In adult animals, mast cell counts are significantly higher in the right ventricle than in the left. This relation is preserved even when the right ventricle is hypertrophic, as in rats born at simulated high altitude. Chronic hypertension and swimming have little effect on the mast cell density in rat hearts. Conspicuous changes in the mast cell density at the time of capillary proliferation seem to indicate a special role played by these cells in the formation of new vessels.


Circ Res


Circulation research


Rakusan K,Sarkar K,Turek Z,Wicker P




Has Abstract


1990-02-01 00:00:00












  • The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489.

    abstract:RATIONALE:Sustained cardiac hypertrophy is often accompanied by maladaptive cardiac remodeling leading to decreased compliance and increased risk for heart failure. Maladaptive hypertrophy is considered to be a therapeutic target for heart failure. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have various biolo...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Wang K,Liu F,Zhou LY,Long B,Yuan SM,Wang Y,Liu CY,Sun T,Zhang XJ,Li PF

    更新日期:2014-04-25 00:00:00

  • Coronary arteriolar myogenic response is independent of endothelium.

    abstract::The purpose of this study was to investigate if myogenic responses of isolated coronary arterioles were dependent on an intact, functional endothelium. Arterioles were located in situ by intracoronary perfusion with india ink-gelatin solution and then dissected and cannulated at both ends with glass micropipettes. Int...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Kuo L,Chilian WM,Davis MJ

    更新日期:1990-03-01 00:00:00

  • Genetic manipulation of cardiac K(+) channel function in mice: what have we learned, and where do we go from here?

    abstract::In the mammalian myocardium, potassium (K(+)) channels control resting potentials, action potential waveforms, automaticity, and refractory periods and, in most cardiac cells, multiple types of K(+) channels that subserve these functions are expressed. Molecular cloning has revealed the presence of a large number of K...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: Nerbonne JM,Nichols CG,Schwarz TL,Escande D

    更新日期:2001-11-23 00:00:00

  • Decreased atrial natriuretic peptide binding in renal medulla in rats with chronic heart failure.

    abstract::The relations between atrial natriuretic peptide (ANP) binding sites in the renal medulla, plasma ANP concentration, and ventricular dysfunction have been studied in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. Plasma ANP concentration was measured by radioimmunoassay, and quantit...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Tsunoda K,Mendelsohn FA,Sexton PM,Chai SY,Hodsman GP,Johnston CI

    更新日期:1988-01-01 00:00:00

  • Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium.

    abstract::Myocardial damage due to reperfusion of ischemic tissue is caused primarily by infiltrating neutrophils. Although leukocyte beta2 integrins (CD18) play a critical role, significant neutrophil emigration persists when CD18 is neutralized or absent. This study examined the role of leukocyte beta1 integrin (alpha4) and i...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Bowden RA,Ding ZM,Donnachie EM,Petersen TK,Michael LH,Ballantyne CM,Burns AR

    更新日期:2002-03-22 00:00:00

  • Myofibroblasts induce ectopic activity in cardiac tissue.

    abstract::Focal ectopic activity in cardiac tissue is a key factor in the initiation and perpetuation of tachyarrhythmias. Because myofibroblasts as present in fibrotic remodeled myocardia and infarct scars depolarize cardiomyocytes by heterocellular electrotonic interactions via gap junctions in vitro, we investigated using st...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Miragoli M,Salvarani N,Rohr S

    更新日期:2007-10-12 00:00:00

  • "Prorenin" in human plasma?

    abstract::An increase in plasma renin activity was demonstrated in plasma from normal subjects and most patients with essential hypertension after prolonged storage of the plasma at -20 degrees C. No change in renin substrate concentration was observed after storage for 12 months, and the rate of angiotensin generation during i...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Sealey JE,Laragh JH

    更新日期:1975-06-01 00:00:00

  • Functional roles of a Ca2+-activated K+ channel in atrioventricular nodes.

    abstract::Since the first description of the anatomical atrioventricular nodes (AVNs), a large number of studies have provided insights into the heterogeneity of the structure as well as a repertoire of ion channel proteins that govern this complex conduction pathway between the atria and ventricles. These studies have revealed...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Zhang Q,Timofeyev V,Lu L,Li N,Singapuri A,Long MK,Bond CT,Adelman JP,Chiamvimonvat N

    更新日期:2008-02-29 00:00:00

  • Response of superficial proximal convoluted tubule to decreased and increased renal perfusion pressure. In vivo microperfusion study in rats.

    abstract::Although urinary sodium excretion is positively influenced by acute changes in renal perfusion pressure, micropuncture studies show highly conflicting results concerning the response of superficial proximal tubule sodium reabsorption to changes in renal perfusion pressure. In the present study, the changes of superfic...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Kinoshita Y,Knox FG

    更新日期:1990-05-01 00:00:00

  • MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes.

    abstract:RATIONALE:Mammalian cardiomyocytes withdraw from the cell cycle during early postnatal development, which significantly limits the capacity of the adult mammalian heart to regenerate after injury. The regulatory mechanisms that govern cardiomyocyte cell cycle withdrawal and binucleation are poorly understood. OBJECTIV...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Porrello ER,Johnson BA,Aurora AB,Simpson E,Nam YJ,Matkovich SJ,Dorn GW 2nd,van Rooij E,Olson EN

    更新日期:2011-09-02 00:00:00

  • Mechanisms of supersensitivity to sympathomimetic amines in the chronically denervated heart of the conscious dog.

    abstract::Mechanisms of denervation supersensitivity to sympathomimetic amines were studied in conscious animals. Norepinephrine, 0.1 micrograms/kg, increased left ventricular dP/dt significantly more (4208 +/- 828 mm Hg/sec) in dogs with cardiac denervation than in intact dogs (1029 +/- 280 mm Hg/sec), P less than 0.01, wherea...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Vatner DE,Lavallee M,Amano J,Finizola A,Homcy CJ,Vatner SF

    更新日期:1985-07-01 00:00:00

  • Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro.

    abstract::The regulation of mitogen-activated protein kinase (MAPK) and MAPK kinase (MEK) was studied in freshly isolated adult rat heart preparations. In contrast to the situation in ventricular myocytes cultured from neonatal rat hearts, stimulation of MAPK activity by 1 mumol/L phorbol 12-myristate 13-acetate (PMA) was not c...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Lazou A,Bogoyevitch MA,Clerk A,Fuller SJ,Marshall C J,Sugden PH

    更新日期:1994-11-01 00:00:00

  • Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries.

    abstract:RATIONALE:T-type (CaV3.1/CaV3.2) Ca(2+) channels are expressed in rat cerebral arterial smooth muscle. Although present, their functional significance remains uncertain with findings pointing to a variety of roles. OBJECTIVE:This study tested whether CaV3.2 channels mediate a negative feedback response by triggering C...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Harraz OF,Abd El-Rahman RR,Bigdely-Shamloo K,Wilson SM,Brett SE,Romero M,Gonzales AL,Earley S,Vigmond EJ,Nygren A,Menon BK,Mufti RE,Watson T,Starreveld Y,Furstenhaupt T,Muellerleile PR,Kurjiaka DT,Kyle BD,Braun AP,W

    更新日期:2014-09-12 00:00:00

  • High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system.

    abstract::Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical impulses. Video maps of the ventricular epicardium and the proximal segment of the right bundle branch (RBB) were obtained u...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Tamaddon HS,Vaidya D,Simon AM,Paul DL,Jalife J,Morley GE

    更新日期:2000-11-10 00:00:00

  • Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death.

    abstract::Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a major cause of death worldwide. Disturbed Na and Ca handling is known to be a major predisposing factor for life-threatening tachyarrhythmias. In cardiomyocytes, many ion channels and transporters, including voltage-gated Na and...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: Wagner S,Maier LS,Bers DM

    更新日期:2015-06-05 00:00:00

  • Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription.

    abstract::A potent transcriptional enhancer was previously identified upstream of the mouse renin gene. Within the enhancer is a TGACCT direct-repeat motif, required for enhancer activity, that is the consensus sequence recognized by members of the thyroid hormone subfamily of steroid hormone receptors. We previously reported t...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Liu X,Huang X,Sigmund CD

    更新日期:2003-05-16 00:00:00

  • Autoregulation of blood flow within individual arterioles in the rat cremaster muscle.

    abstract::Autoregulatory responses to alterations in arterial or venous perfusion pressure were determined for individual arterioles within the rat cremaster muscle. The cremaster muscle of pentobarbital anesthetized rats (50 mg/kg, ip) was surgically exposed and maintained in a controlled tissue bath for visualization by in vi...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Morff RJ,Granger HJ

    更新日期:1982-07-01 00:00:00

  • Endothelial cell pathway for conduction of hyperpolarization and vasodilation along hamster feed artery.

    abstract::Acetylcholine (ACh) evokes the conduction of vasodilation along resistance microvessels. However, it is not known which cell layer (endothelium or smooth muscle) serves as the conduction pathway. In isolated, cannulated feed arteries ( approximately 70 microm in diameter at 75 mm Hg; length approximately 4 mm) of the ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Emerson GG,Segal SS

    更新日期:2000-01-07 00:00:00

  • Effects of infarcted myocardium on regional blood flow measurements to ischemic regions in canine heart.

    abstract::The present study assesses effects of acutely infarcted myocardium on apparent microsphere loss as a function of time, determines effects of apparent microsphere loss on blood flow measurements to ischemic regions, and determines to what extent apparent microsphere loss alters interpretation of serial measurements of ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Murdock RH Jr,Cobb FR

    更新日期:1980-11-01 00:00:00

  • Biphasic development of the mammalian ventricular conduction system.

    abstract:RATIONALE:The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction. This system is composed of specialized cardiomyocytes organized in defined structures including central components and a peripheral Purkinje fiber network. How the mammalian ven...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Miquerol L,Moreno-Rascon N,Beyer S,Dupays L,Meilhac SM,Buckingham ME,Franco D,Kelly RG

    更新日期:2010-07-09 00:00:00

  • Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.

    abstract::To test the ability of regenerated endothelium to evoke endothelium-dependent relaxations, male Yorkshire pigs underwent balloon endothelial denudation of the proximal left anterior descending coronary artery. Endothelium-dependent responses were examined in vitro, in rings of coronary segments taken from the denuded ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Shimokawa H,Aarhus LL,Vanhoutte PM

    更新日期:1987-08-01 00:00:00

  • Progestogens do not affect aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits.

    abstract::Cardiovascular disease is a major killer in postmenopausal women in the industrialized societies. To investigate the effect of progestogen and 17 beta-estradiol replacement therapy on atherogenesis, we studied 60 cholesterol-fed ovariectomized rabbits for 13 weeks. They were randomly assigned to four groups of 15 rabb...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Haarbo J,Svendsen OL,Christiansen C

    更新日期:1992-06-01 00:00:00

  • A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.

    abstract:RATIONALE:Human clinical trials using type 1 angiotensin (AT(1)) receptor antagonists indicate that angiotensin II is a critical mediator of cardiovascular and renal disease. However, recent studies have suggested that individual tissue pools of AT(1) receptors may have divergent effects on target organ damage in hyper...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Zhang JD,Patel MB,Song YS,Griffiths R,Burchette J,Ruiz P,Sparks MA,Yan M,Howell DN,Gomez JA,Spurney RF,Coffman TM,Crowley SD

    更新日期:2012-06-08 00:00:00

  • Dilated Cardiomyopathy: Genetic Determinants and Mechanisms.

    abstract::Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subty...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: McNally EM,Mestroni L

    更新日期:2017-09-15 00:00:00

  • Renal myogenic response: kinetic attributes and physiological role.

    abstract::The kinetic attributes of the afferent arteriole myogenic response were investigated using the in vitro perfused hydronephrotic rat kidney. Equations describing the time course for pressure-dependent vasoconstriction and vasodilation, and steady-state changes in diameter were combined to develop a mathematical model o...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Loutzenhiser R,Bidani A,Chilton L

    更新日期:2002-06-28 00:00:00

  • miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.

    abstract:RATIONALE:Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negat...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Distel E,Barrett TJ,Chung K,Girgis NM,Parathath S,Essau CC,Murphy AJ,Moore KJ,Fisher EA

    更新日期:2014-10-10 00:00:00

  • Prejunctional inhibition of norepinephrine release caused by acetylcholine in the human saphenous vein.

    abstract::We performed experiments to determine whether or not acetylcholine exerts a prejunctional inhibitory effect on adrenergic neurotransmission in the human blood vessel wall. Rings of human greater saphenous veins were prepared 2 to 15 hours after death and mounted for isometric tension recording in organ chambers filled...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Rorie DK,Rusch NJ,Shepherd JT,Vanhoutte PM,Tyce GM

    更新日期:1981-08-01 00:00:00

  • Modulation of Ca2+ control of dog and rabbit cardiac myofibrils by Mg2+. Comparison with rabbit skeletal myofibrils.

    abstract::Increases in free Mg2+ from 0.04 to 10.0 mM with constant pH 7.0 TO 0.10 M ionic strength, and 2 mM MgATP2- caused a rightward shift of the free Ca-relative ATPase relation for both cardiac skeletal myofibrils. The specific activity of cardiac myofibrillar ATPase over a wide range of free Ca2+ was, however, depressed ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Solaro RJ,Shiner JS

    更新日期:1976-07-01 00:00:00

  • Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes.

    abstract::We report the cloning of cDNAs encoding two different human nonmuscle myosin heavy chains designated NMMHC-A and NMMHC-B. The mRNAs encoding NMMHC-A and NMMHC-B are both 7.5 kb in size but are shown to be the products of different genes, which are localized to chromosome 22q11.2 and chromosome 17q13, respectively. In ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Simons M,Wang M,McBride OW,Kawamoto S,Yamakawa K,Gdula D,Adelstein RS,Weir L

    更新日期:1991-08-01 00:00:00

  • Pulse wave propagation.

    abstract::This report evaluates pulse wave propagation with respect to contributions by vascular wall elastic and geometric properties, vessel wall and blood viscosity, and nonlinearities in system parameters and in the equations of motion. Discrepancies in results obtained with different experimental methods and theory are dis...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Li JK,Melbin J,Riffle RA,Noordergraaf A

    更新日期:1981-08-01 00:00:00