Mast cells in the rat heart during normal growth and in cardiac hypertrophy.


:Mast cells in rat hearts were studied quantitatively during normal postnatal growth and in two types of cardiac hypertrophy. Normally, cardiac mast cell density in 11-12-day-old animals is very low, but increases markedly in the following 2-3 weeks to its highest values, with a subsequent decline toward adult values. At the peak of mast cell density, the percentage of mast cells in close proximity to capillaries is also highest. In adult animals, mast cell counts are significantly higher in the right ventricle than in the left. This relation is preserved even when the right ventricle is hypertrophic, as in rats born at simulated high altitude. Chronic hypertension and swimming have little effect on the mast cell density in rat hearts. Conspicuous changes in the mast cell density at the time of capillary proliferation seem to indicate a special role played by these cells in the formation of new vessels.


Circ Res


Circulation research


Rakusan K,Sarkar K,Turek Z,Wicker P




Has Abstract


1990-02-01 00:00:00












  • Identification of receptor binding and activation sites in endothelin-1 by use of site-directed mutagenesis.

    abstract::This study addresses the structural requirements for the intracellular processing and receptor binding properties of endothelin-1 (ET-1). Point mutants of preproendothelin-1 cDNA, with replacement of the codons for Lys9 of ET-1 by ones for Ala and Glu and of Ile20 and Trp21 by ones encoding Ala, were expressed in COS-...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Ergul A,Tackett RL,Puett D

    更新日期:1995-12-01 00:00:00

  • Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

    abstract::Mitogen-activated protein kinase kinase (MKK)4 is a critical member of the mitogen-activated protein kinase family. It is able to activate the c-Jun NH(2)-terminal protein kinase (JNK) and p38 mitogen-activated protein kinase in response to environmental stresses. JNK and p38 are strongly implicated in pathological ca...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Liu W,Zi M,Jin J,Prehar S,Oceandy D,Kimura TE,Lei M,Neyses L,Weston AH,Cartwright EJ,Wang X

    更新日期:2009-04-10 00:00:00

  • Left ventricular myocardial edema. Lymph flow, interstitial fibrosis, and cardiac function.

    abstract::We hypothesized that both acute and chronic accumulation of myocardial interstitial edema (extravascular fluid [EVF]) would compromise cardiac function. We also postulated that excess fluid within the myocardial interstitial space would potentiate interstitial fibrosis, thus further compromising function. Dogs were di...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Laine GA,Allen SJ

    更新日期:1991-06-01 00:00:00

  • Tissue- and species-specific expression of inhibitory guanine nucleotide-binding proteins. Cloning of a full-length complementary DNA from canine heart.

    abstract::Three different isoforms of the inhibitory guanine nucleotide-binding protein alpha-subunit (Gi alpha) have been cloned. However, little information on the cardiac-specific expression of these isoforms is available. The deduced amino acid sequence of a full-length Gi alpha 2 complementary DNA from a canine ventricular...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Holmer SR,Stevens S,Homcy CJ

    更新日期:1989-10-01 00:00:00

  • Response of superficial proximal convoluted tubule to decreased and increased renal perfusion pressure. In vivo microperfusion study in rats.

    abstract::Although urinary sodium excretion is positively influenced by acute changes in renal perfusion pressure, micropuncture studies show highly conflicting results concerning the response of superficial proximal tubule sodium reabsorption to changes in renal perfusion pressure. In the present study, the changes of superfic...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Kinoshita Y,Knox FG

    更新日期:1990-05-01 00:00:00

  • Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta.

    abstract::The goals of this article were (1) to identify cell surface proteins whose expression was regulated by diabetes and (2) to assess their contribution to diabetic complications. We purified heat shock protein 90alpha (Hsp90alpha) from the membrane fraction of high glucose-treated endothelial cells (ECs) as a binding par...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Lei H,Romeo G,Kazlauskas A

    更新日期:2004-04-16 00:00:00

  • Cardiovascular Metabolomics.

    abstract::Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studi...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CB

    更新日期:2018-04-27 00:00:00

  • Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.

    abstract::Genome-wide association studies have uncovered over a 100 genetic loci associated with atrial fibrillation (AF), the most common arrhythmia. Many of the top AF-associated loci harbor key cardiac transcription factors, including PITX2, TBX5, PRRX1, and ZFHX3. Moreover, the vast majority of the AF-associated variants li...

    journal_title:Circulation research

    pub_type: 评审


    authors: van Ouwerkerk AF,Hall AW,Kadow ZA,Lazarevic S,Reyat JS,Tucker NR,Nadadur RD,Bosada FM,Bianchi V,Ellinor PT,Fabritz L,Martin JF,de Laat W,Kirchhof P,Moskowitz IP,Christoffels VM

    更新日期:2020-06-19 00:00:00

  • Dilated Cardiomyopathy: Genetic Determinants and Mechanisms.

    abstract::Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subty...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: McNally EM,Mestroni L

    更新日期:2017-09-15 00:00:00

  • Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells.

    abstract::Several time- and voltage-dependent ionic currents have been identified in cardiac pacemaker cells, including Na(+) current, L- and T-type Ca(2+) currents, hyperpolarization-activated cation current, and various types of delayed rectifier K(+) currents. Mathematical models have demonstrated that spontaneous action pot...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: Mitsuiye T,Shinagawa Y,Noma A

    更新日期:2000-07-21 00:00:00

  • Interaction of capillary, interstitial, and lymphatic forces in the canine hindpaw.

    abstract::We used plethysmograph techniques to measure or calculate the tissue and capillary forces and flows (capillary pressure, tissue and plasma oncotic pressure, transcapillary pressure drop, lymph flow, and interstitial pressure) in a dog hindpaw preparation in situ at three different venous pressures (PV). Since lymph wa...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Chen HI,Granger HJ,Taylor AE

    更新日期:1976-08-01 00:00:00

  • Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

    abstract::Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Jolly SR,Kane WJ,Bailie MB,Abrams GD,Lucchesi BR

    更新日期:1984-03-01 00:00:00

  • Inhibition of versican synthesis by antisense alters smooth muscle cell phenotype and induces elastic fiber formation in vitro and in neointima after vessel injury.

    abstract::The proteoglycan versican is implicated in several atherogenic events, including stimulation of vascular smooth muscle cell (VSMC) growth and migration, retention of lipoproteins, and promotion of thrombogenesis. A high content of intimal versican also correlates with a low content of elastin, suggesting an inhibitory...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Huang R,Merrilees MJ,Braun K,Beaumont B,Lemire J,Clowes AW,Hinek A,Wight TN

    更新日期:2006-02-17 00:00:00

  • Regulation of calcium current by intracellular calcium in smooth muscle cells of rabbit portal vein.

    abstract::Effects of concentrations of intracellular calcium, [Ca2+]i, on the voltage-dependent Ca2+ current (ICa) recorded from dispersed single smooth muscle cells of the rabbit portal vein were studied, using a whole cell voltage clamp method combined with an intracellular perfusion technique. Outward currents were minimized...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Ohya Y,Kitamura K,Kuriyama H

    更新日期:1988-02-01 00:00:00

  • "Prorenin" in human plasma?

    abstract::An increase in plasma renin activity was demonstrated in plasma from normal subjects and most patients with essential hypertension after prolonged storage of the plasma at -20 degrees C. No change in renin substrate concentration was observed after storage for 12 months, and the rate of angiotensin generation during i...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Sealey JE,Laragh JH

    更新日期:1975-06-01 00:00:00

  • Emigrated rat neutrophils adhere to cardiac myocytes via alpha 4 integrin.

    abstract::Previous work has shown that neutrophils isolated from whole blood adhere to cardiac-myocytes via CD18 (beta 2 integrin) to cause injury to the heart cells. In vitro, we have found that upon endothelial transmigration, neutrophils can also express alpha 4 beta 1; however, whether this contributes to neutrophil adhesio...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Reinhardt PH,Ward CA,Giles WR,Kubes P

    更新日期:1997-08-01 00:00:00

  • Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

    abstract:RATIONALE:Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, cellular mechanisms tha...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Luong le A,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC

    更新日期:2013-06-07 00:00:00

  • Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease.

    abstract:RATIONALE:7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. OBJECTIVE:We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease. ME...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Song J,Wang D,Chen H,Huang X,Zhong Y,Jiang N,Chen C,Xia M

    更新日期:2017-05-12 00:00:00

  • Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia.

    abstract::Electrical uncoupling at gap junctions during acute myocardial ischemia contributes to conduction abnormalities and reentrant arrhythmias. Increased levels of intracellular Ca(2+) and H(+) and accumulation of amphipathic lipid metabolites during ischemia promote uncoupling, but other mechanisms may play a role. We tes...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Beardslee MA,Lerner DL,Tadros PN,Laing JG,Beyer EC,Yamada KA,Kléber AG,Schuessler RB,Saffitz JE

    更新日期:2000-10-13 00:00:00

  • Spread of contraction in rabbit ear artery preparations in response to stimulation by norepinephrine.

    abstract::To investigate the spread of contraction in the rabbit ear artery, changes in segment diameter were measured after local stimulation. No spread of contraction was produced by direct current or local application of norepinephrine (NE). Repetitive electrical stimulation caused contraction which spread far from the point...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Vonderlage M

    更新日期:1981-09-01 00:00:00

  • Innate and adaptive immunity in the pathogenesis of atherosclerosis.

    abstract::This review considers critically the evidence for the involvement of mediators of innate and acquired immunity in various stages of atherosclerosis. Rapidly mobilized arms of innate immunity, including phagocytic leukocytes, complement, and proinflammatory cytokines, contribute to atherogenesis. In addition, adaptive ...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: Hansson GK,Libby P,Schönbeck U,Yan ZQ

    更新日期:2002-08-23 00:00:00

  • Uptake of infarct-imaging agents in reversibly and irreversibly injured myocardium in cultured fetal mouse heart.

    abstract::We studied the specificity of uptake of infarct-imaging agents for reversibly or irreversibly injured myocardium independently of blood flow by using intact beating fetal mouse hearts in organ culture. Reversible injury resulted from deprivation of oxygen and glucose for 4 hours at 37 degrees C; irreversible injury, f...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Schelbert HR,Ingwall JS,Sybers HD,Ashburn WL

    更新日期:1976-12-01 00:00:00

  • Apoptosis during cardiovascular development.

    abstract::Morphogenesis and developmental remodeling of cardiovascular tissues involve coordinated regulation of cell proliferation and apoptosis. In the heart, clear evidence points toward focal apoptosis as a contributor to development of the embryonic outflow tract, cardiac valves, conducting system, and the developing coron...

    journal_title:Circulation research

    pub_type: 杂志文章,评审


    authors: Fisher SA,Langille BL,Srivastava D

    更新日期:2000-11-10 00:00:00

  • MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.

    abstract::Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whethe...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Verschuren L,Kooistra T,Bernhagen J,Voshol PJ,Ouwens DM,van Erk M,de Vries-van der Weij J,Leng L,van Bockel JH,van Dijk KW,Fingerle-Rowson G,Bucala R,Kleemann R

    更新日期:2009-07-02 00:00:00

  • Combined inhibition of endothelin and angiotensin II receptors blocks volume load-induced cardiac hormone release.

    abstract::Volume expansion has been shown to increase plasma atrial natriuretic peptide (ANP) levels, but the precise role of paracrine and autocrine factors in stretch-induced cardiac hormone release is not clear. In the present study, we report the effects of endothelin (ET) and angiotensin receptor (AT receptor) antagonists ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Leskinen H,Vuolteenaho O,Ruskoaho H

    更新日期:1997-01-01 00:00:00

  • Selective modulation of coupled ryanodine receptors during microdomain activation of calcium/calmodulin-dependent kinase II in the dyadic cleft.

    abstract:RATIONALE:In ventricular myocytes of large mammals with low T-tubule density, a significant number of ryanodine receptors (RyRs) are not coupled to the sarcolemma; cardiac remodeling increases noncoupled RyRs. OBJECTIVE:Our aim was to test the hypothesis that coupled and noncoupled RyRs have distinct microdomain-depen...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Dries E,Bito V,Lenaerts I,Antoons G,Sipido KR,Macquaide N

    更新日期:2013-11-08 00:00:00

  • Protein synthesis and degradation during starvation-induced cardiac atrophy in rabbits.

    abstract::To determine the relative importance of protein degradation in the development of starvation-induced cardiac atrophy, in vivo fractional synthetic rates of total cardiac protein, myosin heavy chain, actin, light chain 1, and light chain 2 were measured in fed and fasted rabbits by continuous infusion of [3H] leucine. ...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Samarel AM,Parmacek MS,Magid NM,Decker RS,Lesch M

    更新日期:1987-06-01 00:00:00

  • Bradykinin B2-receptor activation augments norepinephrine exocytosis from cardiac sympathetic nerve endings. Mediation by autocrine/paracrine mechanisms.

    abstract::We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Seyedi N,Win T,Lander HM,Levi R

    更新日期:1997-11-01 00:00:00

  • Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression.

    abstract:RATIONALE:Giant-cell arteritis (GCA) is a large-vessel vasculitis characterized by immune cell infiltration, yet the potential involvement of neutrophils has rarely been studied. OBJECTIVE:We investigated whether alterations in neutrophil reactivity occurred in the pathogenesis of GCA or during its clinical management...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Nadkarni S,Dalli J,Hollywood J,Mason JC,Dasgupta B,Perretti M

    更新日期:2014-01-17 00:00:00

  • Myocardial oxygenation in dogs during partial and complete coronary artery occlusion.

    abstract::Regional myocardial oxygenation was assessed during partial and complete coronary artery occlusion using near infrared spectroscopy. In eight open-chest dogs, partial occlusions resulting in an approximately 42% decrease in left anterior descending coronary artery (LAD) blood flow produced an approximately 21% decreas...

    journal_title:Circulation research

    pub_type: 杂志文章


    authors: Parsons WJ,Rembert JC,Bauman RP,Duhaylongsod FG,Greenfield JC Jr,Piantadosi CA

    更新日期:1993-09-01 00:00:00