Mast cells in the rat heart during normal growth and in cardiac hypertrophy.

Abstract:

:Mast cells in rat hearts were studied quantitatively during normal postnatal growth and in two types of cardiac hypertrophy. Normally, cardiac mast cell density in 11-12-day-old animals is very low, but increases markedly in the following 2-3 weeks to its highest values, with a subsequent decline toward adult values. At the peak of mast cell density, the percentage of mast cells in close proximity to capillaries is also highest. In adult animals, mast cell counts are significantly higher in the right ventricle than in the left. This relation is preserved even when the right ventricle is hypertrophic, as in rats born at simulated high altitude. Chronic hypertension and swimming have little effect on the mast cell density in rat hearts. Conspicuous changes in the mast cell density at the time of capillary proliferation seem to indicate a special role played by these cells in the formation of new vessels.

journal_name

Circ Res

journal_title

Circulation research

authors

Rakusan K,Sarkar K,Turek Z,Wicker P

doi

10.1161/01.res.66.2.511

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

511-6

issue

2

eissn

0009-7330

issn

1524-4571

journal_volume

66

pub_type

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