Myocardin-related transcription factor A mediates OxLDL-induced endothelial injury.

abstract：:Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart disease. Such remodeling involves the production and destruction of extracellular matrix proteins, cell proliferation and migration, and apoptotic and necrotic cell death. Cardiac fibroblasts are crucially involved in these...

journal_title：Circulation research

authors： Manabe I,Shindo T,Nagai R

更新日期：2002-12-13 00:00:00

abstract：:Successful implementation of local arterial drug delivery requires transmural distribution of drug. The physicochemical properties of the applied compound, which govern its transport and tissue binding, become as important as the mode of delivery. Hydrophilic compounds distribute freely but are cleared rapidly. Hydrop...

journal_title：Circulation research

authors： Creel CJ,Lovich MA,Edelman ER

更新日期：2000-04-28 00:00:00

abstract：:Tissue repair after injury is generally inversely related to the extent of scarring, suggesting the possibility that regeneration could be promoted by interventions that inhibit scar formation. New work by Dulauroy et al has identified a myofibroblast progenitor with pericyte characteristics as an important mediator o...

journal_title：Circulation research

authors： Steinhauser ML,Lee RT

更新日期：2013-01-18 00:00:00

abstract：:Human peripheral blood leukocytes, activated by phorbol myristate acetate, disrupt canine sarcoplasmic reticulum calcium transport, in vitro, by an oxygen-derived free radical mechanism. Activated leukocytes significantly depress Ca++ uptake activity and Ca++ -stimulated, Mg++ -dependent ATPase activity. The depressio...

journal_title：Circulation research

authors： Rowe GT,Manson NH,Caplan M,Hess ML

更新日期：1983-11-01 00:00:00

abstract：:Multiple voltage-gated K+ channels contribute to the repolarization phases of the cardiac action potential and are targets of several antiarrhythmic drugs. The Kv1.5 K+ channel gene is expressed in the heart, and heterologous expression of this gene generates a slowly inactivating K+ current. Previously, we found that...

journal_title：Circulation research

authors： Takimoto K,Levitan ES

更新日期：1994-12-01 00:00:00

abstract：:Endothelial cells, either in vivo or freshly isolated, respond when exposed to muscarinic agonists with an increase in cytosolic free calcium concentration ([Ca2+]i) and release of endothelium-derived relaxing factor (EDRF). When placed in culture, however, endothelial cells rapidly lose these responses, which may be ...

journal_title：Circulation research

authors： Tracey WR,Peach MJ

更新日期：1992-02-01 00:00:00

abstract：:Reperfusion of globally ischemic rat hearts causes the generation of inositol(1,4,5)trisphosphate [Ins(1,4,5)P3] and the initiation of arrhythmias. These responses are mediated by alpha1-adrenergic receptors (ARs), but the subtype of receptor involved has not been identified. Under normoxic conditions, hearts from tra...

journal_title：Circulation research

authors： Harrison SN,Autelitano DJ,Wang BH,Milano C,Du XJ,Woodcock EA

更新日期：1998-12-14 00:00:00

abstract：RATIONALE:Abnormal phenotypic switch of vascular smooth muscle cell (VSMC) is a hallmark of vascular disorders such as atherosclerosis and restenosis after angioplasty. MicroRNAs (miRNAs) have emerged as important regulators for VSMC function, and we recently identified miR-663 as critical for controlling human aortic ...

journal_title：Circulation research

authors： Li P,Zhu N,Yi B,Wang N,Chen M,You X,Zhao X,Solomides CC,Qin Y,Sun J

更新日期：2013-10-25 00:00:00

abstract：:Advances in immunosuppression have decreased the incidence of acute rejection, but the development of vasculopathy in the coronary arteries of transplants continues to limit the survival of cardiac allografts. Transplant vasculopathy has also been referred to as accelerated graft arteriosclerosis because it has featur...

journal_title：Circulation research

authors： Wehner J,Morrell CN,Reynolds T,Rodriguez ER,Baldwin WM 3rd

更新日期：2007-02-02 00:00:00

abstract：:The beta-adrenergic agonist isoproterenol stimulates immunoreactive atrial natriuretic peptide (IR-ANP) secretion by superfused rat atria in vitro. beta-Adrenergic agonists alter the cellular handling of calcium, which culminates in a rise in the systolic calcium concentration. This is achieved by increasing calcium i...

journal_title：Circulation research

authors： Schiebinger RJ

更新日期：1989-09-01 00:00:00

abstract：RATIONALE:ATP-binding cassette transporter A1 (ABCA1) plays a critical role in eliminating excess free cholesterol from tissues by effluxing cellular free cholesterol and phospholipids to lipid-poor apolipoprotein AI. Macrophage ABCA1 also dampens proinflammatory myeloid differentiation primary-response protein 88-depe...

journal_title：Circulation research

authors： Zhu X,Westcott MM,Bi X,Liu M,Gowdy KM,Seo J,Cao Q,Gebre AK,Fessler MB,Hiltbold EM,Parks JS

更新日期：2012-11-09 00:00:00

abstract：RATIONALE:Remote ischemic preconditioning (rIPC) with short episodes of ischemia/reperfusion (I/R) of an organ remote from the heart is a powerful approach to protect against myocardial I/R injury. The signal transduction pathways for the cross talk between the remote site and the heart remain unclear in detail. OBJEC...

journal_title：Circulation research

authors： Rassaf T,Totzeck M,Hendgen-Cotta UB,Shiva S,Heusch G,Kelm M

更新日期：2014-05-09 00:00:00

abstract：RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts. In culture, fibroblasts maintain a similar activated phenotype. The mechanisms responsible for generation/maintenance of this phenotype remain unknown. OBJECTIV...

journal_title：Circulation research

authors： Wang D,Zhang H,Li M,Frid MG,Flockton AR,McKeon BA,Yeager ME,Fini MA,Morrell NW,Pullamsetti SS,Velegala S,Seeger W,McKinsey TA,Sucharov CC,Stenmark KR

更新日期：2014-01-03 00:00:00

abstract：RATIONALE:Cardiac myocyte-specific deletion of either glycogen synthase kinase (GSK)-3α and GSK-3β leads to cardiac protection after myocardial infarction, suggesting that deletion of both isoforms may provide synergistic protection. This is an important consideration because of the fact that all GSK-3-targeted drugs, ...

journal_title：Circulation research

authors： Zhou J,Ahmad F,Parikh S,Hoffman NE,Rajan S,Verma VK,Song J,Yuan A,Shanmughapriya S,Guo Y,Gao E,Koch W,Woodgett JR,Madesh M,Kishore R,Lal H,Force T

更新日期：2016-04-15 00:00:00

abstract：:Transmural heterogeneity of myocardial metabolism and function are present in the left ventricle under normal and ischemic conditions. To determine if endocardial versus epicardial differences of [Ca2+]i are also present, perfused rat heart studies using indo-1 fluorescence as an index of [Ca2+]i were performed in the...

journal_title：Circulation research

authors： Figueredo VM,Brandes R,Weiner MW,Massie BM,Camacho SA

更新日期：1993-05-01 00:00:00

abstract：:The vasoactive mechanisms of the serine protease alpha-thrombin were examined in isolated coronary arteries from dogs. In resting coronary arteries with endothelium, alpha-thrombin caused concentration-dependent contractions that were characterized by an initial transient relaxation followed by slowly developing susta...

journal_title：Circulation research

authors： Tesfamariam B

更新日期：1994-05-01 00:00:00

abstract：:The deposition of platelets at the site of balloon angioplasty is thought to play a major role in the pathogenesis of restenosis. The antibody AZ-1, which binds to the rabbit platelet glycoprotein IIb/IIIa receptor and inhibits platelet function both in vitro and in vivo, was produced and tested in an experimental mod...

journal_title：Circulation research

authors： Azrin MA,Ling FS,Chen Q,Pawashe A,Migliaccio F,Homer R,Todd M,Ezekowitz MD

更新日期：1994-08-01 00:00:00

abstract：:During ischemia and reperfusion, with an increase in intracellular Na+ and a depolarized membrane potential, Ca2+ may enter the myocyte in exchange for intracellular Na+ via reverse-mode Na+-Ca2+ exchange (NCX). To test the role of Ca2+ entry via NCX during ischemia and reperfusion, we studied mice with cardiac-specif...

journal_title：Circulation research

authors： Imahashi K,Pott C,Goldhaber JI,Steenbergen C,Philipson KD,Murphy E

更新日期：2005-10-28 00:00:00

abstract：:The role of the central nervous system in the mechanism(s) involved in acute carotid baroreflex resetting was studied in six conscious, chronically instrumented, aortic-denervated dogs. Dogs were prepared for reversible vascular isolation of the carotid sinuses. Acute baroreflex resetting was induced by holding the le...

journal_title：Circulation research

authors： Tan W,Panzenbeck MJ,Hajdu MA,Zucker IH

更新日期：1989-07-01 00:00:00

abstract：:To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implication...

journal_title：Circulation research

authors： Simari RD,Pepine CJ,Traverse JH,Henry TD,Bolli R,Spoon DB,Yeh E,Hare JM,Schulman IH,Anderson RD,Lambert C,Sayre SL,Taylor DA,Ebert RF,Moyé LA

更新日期：2014-05-09 00:00:00

abstract：:Angiotensin-converting enzyme inhibitor was used in dogs with uranyl nitrate-induced acute renal failure to evaluate (1) a possible protective effect of angiotensin blockade and (2)the role of angiotensin II in the generation of renal failure in this model. Angiotensin-converting enzyme inhibitor treatment attenuated ...

journal_title：Circulation research

authors： Lindner A,Cutler RE,Bell AJ

更新日期：1982-08-01 00:00:00

abstract：:We created knock-in mice in which a deletion of 3 base pairs coding for K210 in cardiac troponin (cTn)T found in familial dilated cardiomyopathy patients was introduced into endogenous genes. Membrane-permeabilized cardiac muscle fibers from mutant mice showed significantly lower Ca(2+) sensitivity in force generation...

journal_title：Circulation research

authors： Du CK,Morimoto S,Nishii K,Minakami R,Ohta M,Tadano N,Lu QW,Wang YY,Zhan DY,Mochizuki M,Kita S,Miwa Y,Takahashi-Yanaga F,Iwamoto T,Ohtsuki I,Sasaguri T

更新日期：2007-07-20 00:00:00

abstract：:We have observed that acute medial cell loss is an initial event in the response to vascular injury induced by balloon-catheter distention of the rabbit carotid artery. Numerous apoptotic medial cells were observed as early as 30 minutes after balloon inflation, and a 70% loss of cellularity was evident by 90 minutes....

journal_title：Circulation research

authors： Pollman MJ,Hall JL,Gibbons GH

更新日期：1999-01-08 00:00:00

abstract：:The mechanisms underlying the blunted contractile response to beta-adrenergic receptor (beta-AR) stimulation in heart failure (HF) are incompletely understood, especially with regard to beta-AR subtype-specific regulation of L-type Ca2+ channels. We evaluated the impact of HF induced by pacing tachycardia on beta-AR r...

journal_title：Circulation research

authors： He JQ,Balijepalli RC,Haworth RA,Kamp TJ

更新日期：2005-09-16 00:00:00

abstract：RATIONALE:We previously reported that type VI collagen deposition increases in the infarcted myocardium in vivo. To date, a specific role for this nonfibrillar collagen has not been explored in the setting of myocardial infarction (MI). OBJECTIVE:To determine whether deletion of type VI collagen in an in vivo model of...

journal_title：Circulation research

authors： Luther DJ,Thodeti CK,Shamhart PE,Adapala RK,Hodnichak C,Weihrauch D,Bonaldo P,Chilian WM,Meszaros JG

更新日期：2012-03-16 00:00:00

abstract：RATIONALE:It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function. OBJECTIVE:The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. METHODS AND RESULTS:In 110 patients with systolic heart failu...

journal_title：Circulation research

authors： Parisi V,Rengo G,Perrone-Filardi P,Pagano G,Femminella GD,Paolillo S,Petraglia L,Gambino G,Caruso A,Grimaldi MG,Baldascino F,Nolano M,Elia A,Cannavo A,De Bellis A,Coscioni E,Pellegrino T,Cuocolo A,Ferrara N,Leosco D

更新日期：2016-04-15 00:00:00

abstract：:Epidermal fatty acid-binding protein (E-FABP), previously characterized in human keratinocytes, is a cytoplasmic protein of 15 kD that specifically binds fatty acids (FAs). Previous PAGE-immunoblotting studies indicated that several human tissues display an immunoreactive band with an electrophoretic mobility identica...

journal_title：Circulation research

authors： Masouyé I,Hagens G,Van Kuppevelt TH,Madsen P,Saurat JH,Veerkamp JH,Pepper MS,Siegenthaler G

更新日期：1997-09-01 00:00:00

abstract：:The positive inotropic effect of the beta-adrenoceptor agonist isoproterenol is accompanied by inhibition of phosphatase type 1 activity in myocardium. Indirect assays suggest that this effect is due to activation of protein phosphatase inhibitor-1, which inhibits phosphatase activity only when phosphorylated. To test...

journal_title：Circulation research

authors： Neumann J,Gupta RC,Schmitz W,Scholz H,Nairn AC,Watanabe AM

更新日期：1991-12-01 00:00:00

abstract：:Proteases of the plasminogen activator (PA) and matrix metalloproteinase (MMP) system play an important role in smooth muscle cell (SMC) migration and neointima formation after vascular injury. Inhibition of either PAs or MMPs has previously been shown to result in decreased neointima formation in vivo. To inhibit bot...

journal_title：Circulation research

authors： Lamfers ML,Grimbergen JM,Aalders MC,Havenga MJ,de Vries MR,Huisman LG,van Hinsbergh VW,Quax PH

更新日期：2002-11-15 00:00:00

abstract：:Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in response to extracellular stimulants. The strength of signal transduction is controlled by intracellular cyclic nucleot...

journal_title：Circulation research

authors： Omori K,Kotera J

更新日期：2007-02-16 00:00:00