Evidence for isoproterenol-induced phosphorylation of phosphatase inhibitor-1 in the intact heart.

abstract：RATIONALE:Slow nonuniform electric propagation in the border zone (BZ) of a healed myocardial infarct (MI) can give rise to reentrant arrhythmia. The extent to which this is influenced by structural rather than cellular electric remodeling is unclear. OBJECTIVE:To determine whether structural remodeling alone in the i...

journal_title：Circulation research

authors： Rutherford SL,Trew ML,Sands GB,LeGrice IJ,Smaill BH

更新日期：2012-07-20 00:00:00

abstract：:Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss of endothelial and smooth muscle cells (SMC) is evident in remod...

journal_title：Circulation research

authors： Keogh RJ,Harris LK,Freeman A,Baker PN,Aplin JD,Whitley GS,Cartwright JE

更新日期：2007-03-30 00:00:00

abstract：:We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis. TRPV1 channels in 3T3-L1-preadipocytes and visceral adipose tissue from mice and humans were detected by immunoblotting and quantitative real-time RT-PCR. The effect of TRPV1 on cytosol...

journal_title：Circulation research

authors： Zhang LL,Yan Liu D,Ma LQ,Luo ZD,Cao TB,Zhong J,Yan ZC,Wang LJ,Zhao ZG,Zhu SJ,Schrader M,Thilo F,Zhu ZM,Tepel M

更新日期：2007-04-13 00:00:00

abstract：:Glibenclamide, one of the antidiabetic sulfonylureas, is known to block ATP-dependent K+ channels. We used this drug to determine to what extent K+ loss from acutely ischemic myocardium is mediated via these channels. We also investigated whether glibenclamide would influence ischemic arrhythmias. Isolated rat hearts ...

journal_title：Circulation research

authors： Kantor PF,Coetzee WA,Carmeliet EE,Dennis SC,Opie LH

更新日期：1990-02-01 00:00:00

abstract：:The paraoxonase (PON) gene cluster consists of the PON1, PON2, and PON3 genes, each of which can individually inhibit atherogenesis. To analyze the functions of the PON gene cluster (PC) in atherogenesis and plaque stability, human PC transgenic (Tg) mice were generated using bacterial artificial chromosome. The high-...

journal_title：Circulation research

authors： She ZG,Zheng W,Wei YS,Chen HZ,Wang AB,Li HL,Liu G,Zhang R,Liu JJ,Stallcup WB,Zhou Z,Liu DP,Liang CC

更新日期：2009-05-22 00:00:00

abstract：:The daily rate of cell replication in the aortic endothelium of the normal rat falls from a maximum of 13% at birth to 0.1-0.3% at age 5-6 months. This residual rate of replication largely represents the turnover rate of the endothelium in normal animals. After renal hypertension of 2-3 weeks duration, however, the ra...

journal_title：Circulation research

authors： Schwartz SM,Benditt EP

更新日期：1977-08-01 00:00:00

abstract：:To evaluate the degree and lateral extent of dysfunction in nonischemic myocardium adjacent to ischemic muscle, we measured systolic wall thickening with sonomicrometers during circumflex coronary occlusion in 12 anesthetized, open-chest dogs. The locations of the wall thickness measurements relative to the perfusion ...

journal_title：Circulation research

authors： Gallagher KP,Gerren RA,Stirling MC,Choy M,Dysko RC,McManimon SP,Dunham WR

更新日期：1986-04-01 00:00:00

abstract：:We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased atherosclerosis and decreased plasma high-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient (CBS(-/-)/apoE(-/-)) mice. We o...

journal_title：Circulation research

authors： Liao D,Tan H,Hui R,Li Z,Jiang X,Gaubatz J,Yang F,Durante W,Chan L,Schafer AI,Pownall HJ,Yang X,Wang H

更新日期：2006-09-15 00:00:00

abstract：:A series of new phenylethanolamines with 2-methoxy and/or 4-methyl, 4-chloro, or 4-bromo ring substituents and either N-isopropyl or N-tert butyl substituents have been synthesized and tested for beta 1- and beta 2-adrenoceptor blocking activity using isolated guinea pig atrial and tracheal preparations. Each of the d...

journal_title：Circulation research

authors： Letts LG,Temple DM,Williams LR

更新日期：1980-06-01 00:00:00

abstract：:After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable st...

journal_title：Circulation research

authors： Ito CS,Scher AM

更新日期：1979-07-01 00:00:00

abstract：:RNA splicing represents a post-transcriptional mechanism to generate multiple functional RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example of the Darwinian function follows form concept. A mutation that leads to a new mRNA (form) that encodes for a new functional protein (func...

journal_title：Circulation research

authors： van den Hoogenhof MM,Pinto YM,Creemers EE

更新日期：2016-02-05 00:00:00

abstract：:This report evaluates pulse wave propagation with respect to contributions by vascular wall elastic and geometric properties, vessel wall and blood viscosity, and nonlinearities in system parameters and in the equations of motion. Discrepancies in results obtained with different experimental methods and theory are dis...

journal_title：Circulation research

authors： Li JK,Melbin J,Riffle RA,Noordergraaf A

更新日期：1981-08-01 00:00:00

abstract：:Increased levels of C-peptide, a cleavage product of proinsulin, circulate in patients with insulin resistance and early type 2 diabetes mellitus. Recent data suggest a potential causal role of C-peptide in atherogenesis by promoting monocyte and T-lymphocyte recruitment into the vessel wall. The present study examine...

journal_title：Circulation research

authors： Walcher D,Babiak C,Poletek P,Rosenkranz S,Bach H,Betz S,Durst R,Grüb M,Hombach V,Strong J,Marx N

更新日期：2006-11-24 00:00:00

abstract：:Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We have developed a rabbit model in which an atherosclerotic plaque can be ruptured at will after an inflatable balloon becomes embedded into the plaque. Furthermor...

journal_title：Circulation research

authors： Rekhter MD,Hicks GW,Brammer DW,Work CW,Kim JS,Gordon D,Keiser JA,Ryan MJ

更新日期：1998-10-05 00:00:00

abstract：:Cardiac alpha-adrenergic receptors mediate cellular responses to norepinephrine through an undefined series of molecular events. We examined the possibility that phosphoinositide hydrolysis was stimulated through alpha-adrenergic receptors in cardiomyocytes purified from adult rat ventricle. Phosphoinositide stores we...

journal_title：Circulation research

authors： Brown JH,Buxton IL,Brunton LL

更新日期：1985-10-01 00:00:00

abstract：:We have used tryptic digestion to determine whether Ca(2+) can regulate cardiac ryanodine receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or whether Ca(2+) must first flow through the channel and act via cytosolically located binding sites. Cardiac RyRs were incorporated into bil...

journal_title：Circulation research

authors： Ching LL,Williams AJ,Sitsapesan R

更新日期：2000-08-04 00:00:00

abstract：:Purkinje cells contain sarcoplasmic reticulum (SR) directly under the surface membrane, are devoid of t-tubuli, and are packed with myofibrils surrounded by central SR. Several studies have reported that electrical excitation induces a biphasic Ca(2+) transient in Purkinje fiber bundles. We determined the nature of th...

journal_title：Circulation research

authors： Boyden PA,Pu J,Pinto J,Keurs HE

更新日期：2000-03-03 00:00:00

abstract：:We hypothesized that a redox-sensitive transcription factor, redox factor-1 (Ref-1) (HAP1, APE, and APEX), was critical in the regulation of endothelial cell survival in response to hypoxia and cytokines, including tumor necrosis factor (TNF)-alpha. Hypoxia resulted in a significant decrease in Ref-1 protein expressio...

journal_title：Circulation research

authors： Hall JL,Wang X,Van Adamson,Zhao Y,Gibbons GH

更新日期：2001-06-22 00:00:00

abstract：RATIONALE:Disruption of endothelial barrier function and neutrophil-mediated injury are two major mechanisms underlying the pathophysiology of sepsis-induced acute lung injury (ALI). Recently we reported that endotoxin induced activation of RhoA in mice lungs that led to the disruption of endothelial barrier and lung e...

journal_title：Circulation research

authors： Gorovoy M,Han J,Pan H,Welch E,Neamu R,Jia Z,Predescu D,Vogel S,Minshall RD,Ye RD,Malik AB,Voyno-Yasenetskaya T

更新日期：2009-09-11 00:00:00

abstract：:Power ratios were derived from the principle of ultrasonic Doppler velocimetry to determine a ratio of the volume of vortices to the total vessel volume under the ultrasonic beam. This ratio also equals the ratio of the cross-sectional area of vortices to the vessel lumen. In vitro pulsatile flow experiments were perf...

journal_title：Circulation research

authors： Tamura T,Fronek A

更新日期：1990-07-01 00:00:00

abstract：:A method was developed for recording isometric tension from isolated small arteries (mean internal diameter, 169 microns) and veins (mean internal diameter, 273 microns) of the term fetal lung and was then applied to the study of the mechanisms controlling perinatal pulmonary hemodynamics. The specific purpose was to ...

journal_title：Circulation research

authors： Wang Y,Coceani F

更新日期：1992-08-01 00:00:00

abstract：:The structure-function relationships of the sarcomeric proteins in the mammalian cardiac compartment remain ill-defined because of the lack of a suitable model in which they can be readily manipulated or exchanged in vivo. To establish the validity of the transgenic paradigm for remodeling the mammalian heart, the mur...

journal_title：Circulation research

authors： Palermo J,Gulick J,Colbert M,Fewell J,Robbins J

更新日期：1996-03-01 00:00:00

abstract：:Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF possesses a binding site for ECM components that maintain i...

journal_title：Circulation research

authors： Ehrbar M,Djonov VG,Schnell C,Tschanz SA,Martiny-Baron G,Schenk U,Wood J,Burri PH,Hubbell JA,Zisch AH

更新日期：2004-04-30 00:00:00

abstract：:The E-cadherin/beta-catenin/T-cell factor (Tcf) signaling pathway plays a crucial role in embryogenesis and carcinogenesis and has recently emerged in atherosclerosis. The aim of this work was to investigate whether this signaling pathway is involved in smooth muscle cell proliferation induced by oxidized low-density ...

journal_title：Circulation research

authors： Bedel A,Nègre-Salvayre A,Heeneman S,Grazide MH,Thiers JC,Salvayre R,Maupas-Schwalm F

更新日期：2008-09-26 00:00:00

abstract：:Oxidative stress through the production of oxygen metabolites such as hydrogen peroxide (H2O2) increases vascular endothelial permeability. H2O2 stimulates ADP-ribose formation, which in turn opens transient receptor potential melastatin (TRPM)2 channels. Here, in endothelial cells, we demonstrate transcript and prote...

journal_title：Circulation research

authors： Hecquet CM,Ahmmed GU,Vogel SM,Malik AB

更新日期：2008-02-15 00:00:00

abstract：:Mitochondria are an important source of reactive oxygen species (ROS), implicated in ischemia/reperfusion injury. When isolated from ischemic myocardium, mitochondria demonstrate increased ROS production as a result of damage to electron transport complexes. To investigate the mechanisms, we studied effects of hypoxia...

journal_title：Circulation research

authors： Korge P,Ping P,Weiss JN

更新日期：2008-10-10 00:00:00

abstract：:High sodium intake (HNa) increases brain ouabainlike activity (OLA) in rats. In spontaneously hypertensive rats (SHR), HNa exaggerates development of hypertension and pressor and sympathoexcitatory responses to stress. To investigate whether dietary sodium-induced changes in brain OLA play a functional role, responses...

journal_title：Circulation research

authors： Huang BS,Leenen FH

更新日期：1992-02-01 00:00:00

abstract：:Whole-cell voltage-clamp experiments and single-channel current recordings in cell-attached patch mode were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to compare the characteristics of inward rectifier K+ curre...

journal_title：Circulation research

authors： Furukawa T,Kimura S,Furukawa N,Bassett AL,Myerburg RJ

更新日期：1992-01-01 00:00:00

abstract：:We examined the function of the interventricular septum in six open-chest dogs by inserting piezoelectric crystals into the interventricular septum. Continuous ultrasonic recordings showed that the changes in myocardial chord length (MCL) in the septum and free walls of the right and left ventricle were similar during...

journal_title：Circulation research

authors： Molaug M,Stokland O,Ilebekk A,Lekven J,Kiil F

更新日期：1981-07-01 00:00:00

abstract：:Heart failure (HF) has been singled out as an epidemic and is a staggering clinical and public health problem, associated with significant mortality, morbidity, and healthcare expenditures, particularly among those aged ≥ 65 years. The case mix of HF is changing over time with a growing proportion of cases presenting ...

journal_title：Circulation research

authors： Roger VL

更新日期：2013-08-30 00:00:00