Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury.

abstract：RATIONALE:The peptide ligand apelin and its receptor APJ constitute a signaling pathway with numerous effects on the cardiovascular system, including cardiovascular development in model organisms such as xenopus and zebrafish. OBJECTIVE:This study aimed to characterize the embryonic lethal phenotype of the Apj-/- mice...

journal_title：Circulation research

authors： Kang Y,Kim J,Anderson JP,Wu J,Gleim SR,Kundu RK,McLean DL,Kim JD,Park H,Jin SW,Hwa J,Quertermous T,Chun HJ

更新日期：2013-06-21 00:00:00

abstract：:Confocal imaging was used to study the influence of cytosolic ATP on the properties of spontaneous Ca(2+) sparks in permeabilized ventricular myocytes. Cells were perfused with mock intracellular solutions containing fluo 3. Reducing [ATP] to <0.5 mmol/L decreased the frequency but increased the amplitude of spontaneo...

journal_title：Circulation research

authors： Yang Z,Steele DS

更新日期：2001-09-14 00:00:00

abstract：:Angiotensin (Ang) II is present inside vascular smooth muscle cells (VSMCs); however, its intracellular functions, if any, are unknown. We tested the hypothesis that intracellular Ang II exerts effects on cytosolic Ca2+ ([Ca2+]i) in VSMCs. Ang II was administered via microinjection. Intracellular Ang II localization w...

journal_title：Circulation research

authors： Haller H,Lindschau C,Erdmann B,Quass P,Luft FC

更新日期：1996-10-01 00:00:00

abstract：:Recent advances in cardiac physiology identify the integrin-linked kinase (ILK) as an essential molecule regulating cardiac growth, contractility, and repair. A key transducer of biochemical signals initiated at the plasma membrane by cell-matrix interactions, ILK now emerges as a crucial player in mechanotransduction...

journal_title：Circulation research

authors： Hannigan GE,Coles JG,Dedhar S

更新日期：2007-05-25 00:00:00

abstract：:The isolated rat heart perfused with washed platelets was used as a model to examine platelet-vessel wall interactions. Release of prostacyclin and thromboxane A2 was measured, using a cascade of smooth muscle bioassay tissues or radioimmunoassays of the stable hydration products. In hearts perfused with rabbit or hum...

journal_title：Circulation research

authors： Purchase M,Dusting GJ,Li DM,Read MA

更新日期：1986-01-01 00:00:00

abstract：:We describe a straightforward gene-targeting technique to achieve uniform, stable, and genetically invariant expression of a transgene in the vascular endothelium of mice. To demonstrate the feasibility of this approach, the reporter gene bacterial beta-galactosidase was inserted via homologous recombination into the ...

journal_title：Circulation research

authors： Weiler-Guettler H,Aird WC,Husain M,Rayburn H,Rosenberg RD

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)γ agonists attenuate atherosclerosis and abdominal aortic aneurysms (AAAs). PPARγ, a nuclear receptor, is expressed on many cell types including smooth muscle cells (SMCs). OBJECTIVE:To determine whether a PPARγ agonist reduces angiotensin II (Ang II)-induced ...

journal_title：Circulation research

authors： Subramanian V,Golledge J,Ijaz T,Bruemmer D,Daugherty A

更新日期：2010-10-15 00:00:00

abstract：:Atherosclerotic lesion development seems to be inflammatory in nature and involves the recruitment of monocytes to the vessel wall. In this study, we investigated the role of vascular cell adhesion molecule-1 (VCAM-1) and fibronectin (FN) connecting segment-1 containing the amino acid sequence ILDV as functional ligan...

journal_title：Circulation research

authors： Huo Y,Hafezi-Moghadam A,Ley K

更新日期：2000-07-21 00:00:00

abstract：:Electrical field stimulation (EFS) of phenylephrine-contracted bovine mesenteric arteries pretreated with guanethidine elicited a relaxation that amounted to roughly 40%. This relaxation was sensitive to tetrodotoxin pretreatment, suggesting a neurogenic origin. The EFS-induced relaxation was correlated to an increase...

journal_title：Circulation research

authors： Ahlner J,Ljusegren ME,Grundström N,Axelsson KL

更新日期：1991-03-01 00:00:00

abstract：RATIONALE:Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation. OBJECTIV...

journal_title：Circulation research

authors： Drews O,Tsukamoto O,Liem D,Streicher J,Wang Y,Ping P

更新日期：2010-10-29 00:00:00

abstract：:The introduction of statins ≈ 30 years ago ushered in the era of lipid lowering as the most effective way to reduce risk of atherosclerotic cardiovascular disease. Nonetheless, residual risk remains high, and statin intolerance is frequently encountered in clinical practice. After a long dry period, the field of thera...

journal_title：Circulation research

authors： Shapiro MD,Fazio S

更新日期：2016-02-19 00:00:00

abstract：:This study investigated the possible roles of strongly binding myosin crossbridges in determining loaded shortening and power output in cardiac myocytes. Single skinned cardiac myocytes were attached between a force transducer and position motor, and shortening velocities were measured over a range of loads during var...

journal_title：Circulation research

authors： McDonald KS,Moss RL

更新日期：2000-10-27 00:00:00

abstract：:Peroxisome proliferator-activated receptor (PPAR) gamma is activated by thiazolidinediones (TZDs), widely used as insulin-sensitizing agents for the treatment of type 2 diabetes. TZDs have been shown to induce apoptosis in a variety of mammalian cells. In vascular smooth muscle cells (VSMCs), proliferation and apoptos...

journal_title：Circulation research

authors： Bruemmer D,Yin F,Liu J,Berger JP,Sakai T,Blaschke F,Fleck E,Van Herle AJ,Forman BM,Law RE

更新日期：2003-08-22 00:00:00

abstract：BACKGROUND:Myocyte contractile dysfunction occurs in pathological remodeling in association with abnormalities in calcium regulation. Mice with cardiac myocyte-specific overexpression of Galphaq develop progressive left ventricular failure associated with myocyte contractile dysfunction and calcium dysregulation. OBJE...

journal_title：Circulation research

authors： Lancel S,Qin F,Lennon SL,Zhang J,Tong X,Mazzini MJ,Kang YJ,Siwik DA,Cohen RA,Colucci WS

更新日期：2010-07-23 00:00:00

abstract：RATIONALE:Molecular imaging is useful for longitudinal assessment of engraftment. However, it is not known which factors, other than cell number, can influence the molecular imaging signal obtained from reporter genes. OBJECTIVE:The effects of cell dissociation/suspension on cellular bioenergetics and the signal obtai...

journal_title：Circulation research

authors： Chang C,Chan A,Lin X,Higuchi T,Terrovitis J,Afzal JM,Rittenbach A,Sun D,Vakrou S,Woldemichael K,O'Rourke B,Wahl R,Pomper M,Tsui B,Abraham MR

更新日期：2013-02-01 00:00:00

abstract：:The global prevalence of overweight and obesity has risen substantially over the past 4 decades and is accompanied by an increasing burden of cardiovascular risk factors such as hypertension. Metabolic surgery is the most effective method to treat obesity and may further improve associated conditions. Although most re...

journal_title：Circulation research

authors： Pareek M,Bhatt DL,Schiavon CA,Schauer PR

更新日期：2019-03-29 00:00:00

abstract：:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studi...

journal_title：Circulation research

authors： McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CB

更新日期：2018-04-27 00:00:00

abstract：:Cardiovascular aging is associated with decreased endothelial vasoreactivity and prolonged diastolic relaxation. As diminished NO signaling contributes to age-associated endothelial dysfunction, we tested the hypothesis that impaired NO signaling or bioactivity also contributes to slowed ventricular relaxation with ag...

journal_title：Circulation research

authors： Zieman SJ,Gerstenblith G,Lakatta EG,Rosas GO,Vandegaer K,Ricker KM,Hare JM

更新日期：2001-01-19 00:00:00

abstract：:We sought to determine the ejection variables that are principally responsible for increases in isovolumic ventricular relaxation rate observed with increases in stroke volume. In nine isolated canine hearts, left ventricular ejection was controlled by patterns specially designed to isolate the ejection parameters mos...

journal_title：Circulation research

authors： Hori M,Kitakaze M,Ishida Y,Fukunami M,Kitabatake A,Inoue M,Kamada T,Yue DT

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions. Because microRNAs are products of ...

journal_title：Circulation research

authors： Matkovich SJ,Hu Y,Dorn GW 2nd

更新日期：2013-06-21 00:00:00

abstract：:The sinoatrial node, which resides at the junction of the right atrium and the superior caval vein, contains specialized myocardial cells that initiate the heart beat. Despite this fundamental role in heart function, the embryonic origin and mechanisms of localized formation of the sinoatrial node have not been define...

journal_title：Circulation research

authors： Mommersteeg MT,Hoogaars WM,Prall OW,de Gier-de Vries C,Wiese C,Clout DE,Papaioannou VE,Brown NA,Harvey RP,Moorman AF,Christoffels VM

更新日期：2007-02-16 00:00:00

abstract：:The mechanism of propranolol-inhibited sarcolemmal membrane lipid peroxidation was investigated by electron spin resonance spin-trapping technique using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 2-methyl-2-nitrosopropane (MNP). Highly purified canine myocytic sarcolemma were peroxidized by a superoxide-driven (from ...

journal_title：Circulation research

authors： Mak IT,Arroyo CM,Weglicki WB

更新日期：1989-10-01 00:00:00

abstract：:Inflammatory processes underlie a broad spectrum of conditions that injure the heart muscle and cause both structural and functional deficits. In this article, we address current knowledge regarding 4 common forms of myocardial inflammation: myocardial ischemia and reperfusion, sepsis, viral myocarditis, and immune re...

journal_title：Circulation research

authors： Marchant DJ,Boyd JH,Lin DC,Granville DJ,Garmaroudi FS,McManus BM

更新日期：2012-01-06 00:00:00

abstract：:E1A can evoke G1 exit in cardiac myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket" proteins and by a less well-characterized p300-dependent pathway. Bypassing pocket proteins (through overexpression of E2F-1) reproduces the effect of inactivating pocket proteins (thro...

journal_title：Circulation research

authors： Akli S,Zhan S,Abdellatif M,Schneider MD

更新日期：1999-08-20 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：RATIONALE:Remodeling of the vessel wall and the formation of vascular networks are dynamic processes that occur during mammalian embryonic development and in adulthood. Plaque development and excessive neointima formation are hallmarks of atherosclerosis and vascular injury. As our understanding of these complex proces...

journal_title：Circulation research

authors： Becher T,Riascos-Bernal DF,Kramer DJ,Almonte VM,Chi J,Tong T,Oliveira-Paula GH,Koleilat I,Chen W,Cohen P,Sibinga NES

更新日期：2020-02-28 00:00:00

abstract：:To determine whether nifedipine, a calcium antagonist, protects ischemic myocardium, conscious dogs were subjected to coronary occlusion and given nifedipine by intravenous infusion beginning 30 minutes after the onset of ischemia and lasting for 24 hours while systemic arterial pressure, left atrial pressure, and car...

journal_title：Circulation research

authors： Henry PD,Shuchleib R,Borda LJ,Roberts R,Williamson JR,Sobel BE

更新日期：1978-09-01 00:00:00

abstract：RATIONALE:Mechanisms of angiogenesis in skeletal muscle remain poorly understood. Efforts to induce physiological angiogenesis hold promise for the treatment of diabetic microvascular disease and peripheral artery disease but are hindered by the complexity of physiological angiogenesis and by the poor angiogenic respon...

journal_title：Circulation research

authors： Rowe GC,Raghuram S,Jang C,Nagy JA,Patten IS,Goyal A,Chan MC,Liu LX,Jiang A,Spokes KC,Beeler D,Dvorak H,Aird WC,Arany Z

更新日期：2014-08-15 00:00:00

abstract：:The kinetic attributes of the afferent arteriole myogenic response were investigated using the in vitro perfused hydronephrotic rat kidney. Equations describing the time course for pressure-dependent vasoconstriction and vasodilation, and steady-state changes in diameter were combined to develop a mathematical model o...

journal_title：Circulation research

authors： Loutzenhiser R,Bidani A,Chilton L

更新日期：2002-06-28 00:00:00

abstract：:Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Cardiac malformations have been produced in multiple experimental animal models, by perturbing selected molecules that function in the developmental pathways involved in myocyte specification, differentiation, or cardiac morphogene...

journal_title：Circulation research

authors： Fahed AC,Gelb BD,Seidman JG,Seidman CE

更新日期：2013-02-15 00:00:00