Abstract:
:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studies have contributed to better understanding of the metabolic changes that occur in heart failure and ischemic heart disease and have identified new cardiovascular disease biomarkers. As technologies advance, the metabolomics field continues to evolve rapidly. In this review, we will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolomics to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field.
journal_name
Circ Resjournal_title
Circulation researchauthors
McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CBdoi
10.1161/CIRCRESAHA.117.311002subject
Has Abstractpub_date
2018-04-27 00:00:00pages
1238-1258issue
9eissn
0009-7330issn
1524-4571pii
CIRCRESAHA.117.311002journal_volume
122pub_type
杂志文章,评审abstract::Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B). We determined whether UT-A proteins could be detected in heart and whether their abundance was altered by uremia or hypertension or in human heart failure. In normal rat heart, bands were detected at 56, 51, and 39 kDa. In uremic ra...
journal_title:Circulation research
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doi:10.1161/hh1401.093293
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journal_title:Circulation research
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journal_title:Circulation research
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pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.116.309637
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journal_title:Circulation research
pub_type: 杂志文章,评审
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journal_title:Circulation research
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更新日期:1977-04-01 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章,评审
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更新日期:2011-01-21 00:00:00
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pub_type: 杂志文章
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.307647
更新日期:2016-04-01 00:00:00
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journal_title:Circulation research
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doi:10.1161/CIRCRESAHA.111.260943
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.116.304899
更新日期:2015-02-13 00:00:00
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journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/CIRCRESAHA.115.304457
更新日期:2015-01-02 00:00:00
abstract::We evaluated the contribution of intramural electrical events in initiation and maintenance of ventricular tachycardia in 15 dogs 3-8 days after either permanent (n = 2) or transient (n = 13) coronary artery occlusion. Seven of the dogs (47%) demonstrated eight distinct monomorphic ventricular tachycardia patterns whi...
journal_title:Circulation research
pub_type: 杂志文章
doi:10.1161/01.res.56.5.736
更新日期:1985-05-01 00:00:00
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更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Circulation research
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
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pub_type: 杂志文章,评审
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