Cardiovascular Metabolomics.

Abstract:

:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studies have contributed to better understanding of the metabolic changes that occur in heart failure and ischemic heart disease and have identified new cardiovascular disease biomarkers. As technologies advance, the metabolomics field continues to evolve rapidly. In this review, we will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolomics to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field.

journal_name

Circ Res

journal_title

Circulation research

authors

McGarrah RW,Crown SB,Zhang GF,Shah SH,Newgard CB

doi

10.1161/CIRCRESAHA.117.311002

subject

Has Abstract

pub_date

2018-04-27 00:00:00

pages

1238-1258

issue

9

eissn

0009-7330

issn

1524-4571

pii

CIRCRESAHA.117.311002

journal_volume

122

pub_type

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