Inhibition of sarcolemmal carbon-centered free radical formation by propranolol.

abstract：:The consequences of endothelin receptor activation were examined in atrial tumor myocytes derived from transgenic mice (AT-1 cells). Endothelin-1 (endothelin) stimulates phosphoinositide hydrolysis in a dose-dependent manner. Endothelin also induces the rapid and transient translocation of protein kinase C (PKC)-epsil...

journal_title：Circulation research

authors： Jiang T,Pak E,Zhang HL,Kline RP,Steinberg SF

更新日期：1996-04-01 00:00:00

abstract：RATIONALE:Individuals with naturally occurring loss-of-function proprotein convertase subtilisin/kexin type 9 (PCSK9) mutations experience reduced low-density lipoprotein cholesterol levels and protection against cardiovascular disease. OBJECTIVE:The goal of this study was to assess whether genome editing using a clus...

journal_title：Circulation research

authors： Ding Q,Strong A,Patel KM,Ng SL,Gosis BS,Regan SN,Cowan CA,Rader DJ,Musunuru K

更新日期：2014-08-15 00:00:00

abstract：:The effects of Bay K 8644 on the high-threshold calcium channel was investigated by means of the whole-cell patch-clamp technique in single guinea pig ventricular myocytes. The goal of the experiments was to characterize the inhibitory effects of Bay K 8644 on the calcium channel, and identify the factors that influen...

journal_title：Circulation research

authors： Hadley RW,Hume JR

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Although tyrosine kinases (TKs) are important for cardiac function, their relevant downstream targets in the adult heart are unknown. The ShcA docking protein binds specific phosphotyrosine (pTyr) sites on activated TKs through its N-terminal pTyr-binding (PTB) and C-terminal SH2 domains and stimulates downst...

journal_title：Circulation research

authors： Vanderlaan RD,Hardy WR,Kabir MG,Pasculescu A,Jones N,deTombe PP,Backx PH,Pawson T

更新日期：2011-01-21 00:00:00

abstract：:Among the factors that might influence collateral arterial growth after arterial occlusion, the capacity to deliver blood flow in relation to metabolic need and work performance are obvious candidates. In this study in rats after superficial femoral artery ligation, we assessed collateral arterial growth (by arteriogr...

journal_title：Circulation research

authors： Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1992-03-01 00:00:00

abstract：:The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden o...

journal_title：Circulation research

authors： Chan NC,Eikelboom JW,Weitz JI

更新日期：2016-04-29 00:00:00

abstract：:As described in earlier reviews in this series on the molecular basis of hypertrophic cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders to be understood at the molecular level. Twenty years after the discovery of the first HCM disease gene, genetic studies still confirm that HCM is ...

journal_title：Circulation research

authors： Ashrafian H,McKenna WJ,Watkins H

更新日期：2011-06-24 00:00:00

abstract：:The use of risk markers has transformed cardiovascular medicine, exemplified by the routine assessment of troponin, for both diagnosis and assessment of prognosis in patients with chest pain. Clinical risk factors form the basis for risk assessment of cardiovascular disease and the addition of biochemical, cellular, a...

journal_title：Circulation research

authors： Thomas MR,Lip GY

更新日期：2017-01-06 00:00:00

abstract：RATIONALE:Oxidative stress is an important contributing factor in several human pathologies ranging from atherosclerosis to cancer progression; however, the mechanisms underlying tissue protection from oxidation products are poorly understood. Oxidation of membrane phospholipids, containing the polyunsaturated fatty ac...

journal_title：Circulation research

authors： Kim YW,Yakubenko VP,West XZ,Gugiu GB,Renganathan K,Biswas S,Gao D,Crabb JW,Salomon RG,Podrez EA,Byzova TV

更新日期：2015-07-31 00:00:00

abstract：RATIONALE:Shear stress (SS) has an established role in atherosclerotic plaque localization, but how it exerts its protective effect is not fully understood. OBJECTIVE:To test the hypothesis that SS may downregulate angiotensin type 1 receptors (AT(1)Rs). Angiotensin II has been shown to be proinflammatory and to promo...

journal_title：Circulation research

authors： Ramkhelawon B,Vilar J,Rivas D,Mees B,de Crom R,Tedgui A,Lehoux S

更新日期：2009-10-23 00:00:00

abstract：:Connexin40 (Cx40) is a major gap junction protein that is expressed in the His-Purkinje system and thought to be a critical determinant of cell-to-cell communication and conduction of electrical impulses. Video maps of the ventricular epicardium and the proximal segment of the right bundle branch (RBB) were obtained u...

journal_title：Circulation research

authors： Tamaddon HS,Vaidya D,Simon AM,Paul DL,Jalife J,Morley GE

更新日期：2000-11-10 00:00:00

abstract：:Reperfusion of globally ischemic rat hearts causes the generation of inositol(1,4,5)trisphosphate [Ins(1,4,5)P3] and the initiation of arrhythmias. These responses are mediated by alpha1-adrenergic receptors (ARs), but the subtype of receptor involved has not been identified. Under normoxic conditions, hearts from tra...

journal_title：Circulation research

authors： Harrison SN,Autelitano DJ,Wang BH,Milano C,Du XJ,Woodcock EA

更新日期：1998-12-14 00:00:00

abstract：:Whole-cell voltage-clamp experiments and single-channel current recordings in cell-attached patch mode were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to compare the characteristics of inward rectifier K+ curre...

journal_title：Circulation research

authors： Furukawa T,Kimura S,Furukawa N,Bassett AL,Myerburg RJ

更新日期：1992-01-01 00:00:00

abstract：:Mechanoreceptors and chemoreceptors have been identified inside the kidney, but their functional role is still largely unclear. The aim of this study was to investigate whether changes in urine output could modify the discharge rate of renal afferent fibers. Experiments were performed in anesthetized cats in which aff...

journal_title：Circulation research

authors： Genovesi S,Pieruzzi F,Wijnmaalen P,Centonza L,Golin R,Zanchetti A,Stella A

更新日期：1993-11-01 00:00:00

abstract：:To investigate the effect of lactate, pyruvate, and glucose on the endogenous levels of lipids in the normoxic, ischemic, and reperfused myocardium, isolated working rat hearts were exposed to various grades of ischemic insult (15, 30, or 45 minutes). Glucose was present as the basal substrate in the perfusion medium,...

journal_title：Circulation research

authors： de Groot MJ,Coumans WA,Willemsen PH,van der Vusse GJ

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:The peptide ligand apelin and its receptor APJ constitute a signaling pathway with numerous effects on the cardiovascular system, including cardiovascular development in model organisms such as xenopus and zebrafish. OBJECTIVE:This study aimed to characterize the embryonic lethal phenotype of the Apj-/- mice...

journal_title：Circulation research

authors： Kang Y,Kim J,Anderson JP,Wu J,Gleim SR,Kundu RK,McLean DL,Kim JD,Park H,Jin SW,Hwa J,Quertermous T,Chun HJ

更新日期：2013-06-21 00:00:00

abstract：:We studied the mechanisms underlying the increase in automaticity induced by alpha 1-adrenergic stimulation of normal and "ischemic" canine Purkinje fibers. Fibers were superfused with a control Tyrode's solution, followed by an ischemic superfusate that included 10 mM KCl, 5 mM NaHCO3, Po2 of 10-25 mm Hg, and pH 6.7....

journal_title：Circulation research

authors： Anyukhovsky EP,Rybin VO,Nikashin AV,Budanova OP,Rosen MR

更新日期：1992-09-01 00:00:00

abstract：:The transcription factor signal transducer and activator of transcription 3 (STAT3) participates in a wide variety of physiological processes and directs seemingly contradictory responses such as proliferation and apoptosis. To elucidate its role in the heart, we generated mice harboring a cardiomyocyte-restricted kno...

journal_title：Circulation research

authors： Hilfiker-Kleiner D,Hilfiker A,Fuchs M,Kaminski K,Schaefer A,Schieffer B,Hillmer A,Schmiedl A,Ding Z,Podewski E,Podewski E,Poli V,Schneider MD,Schulz R,Park JK,Wollert KC,Drexler H

更新日期：2004-07-23 00:00:00

abstract：:Previous studies have demonstrated that low shear rates promote leukocyte adherence to microvascular endothelium in postcapillary venules. The objective of this study was to determine whether an accumulation of inflammatory mediators such as platelet activating factor and leukotriene B4 is responsible for shear rate-d...

journal_title：Circulation research

authors： Bienvenu K,Russell J,Granger DN

更新日期：1992-10-01 00:00:00

abstract：:In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to dete...

journal_title：Circulation research

authors： Lindner V,Fingerle J,Reidy MA

更新日期：1993-11-01 00:00:00

abstract：:Abstract: Macrophages, a key component of the innate defense against pathogens, participate in the initiation and resolution of inflammation, and in the maintenance of tissues. These diverse and at times antithetical functions of macrophages are executed via distinct activation states, ranging from classical to altern...

journal_title：Circulation research

authors： Chawla A

更新日期：2010-05-28 00:00:00

abstract：RATIONALE:Deep vein thrombosis (DVT) and its complication pulmonary embolism have high morbidity reducing quality of life and leading to death. Cellular mechanisms of DVT initiation remain poorly understood. OBJECTIVE:We sought to determine the role of mast cells (MCs) in DVT initiation and validate MCs as a potential...

journal_title：Circulation research

authors： Ponomaryov T,Payne H,Fabritz L,Wagner DD,Brill A

更新日期：2017-09-29 00:00:00

abstract：:Computer simulations and nonlinear dynamics have provided invaluable tools for illuminating the underlying mechanisms of cardiac arrhythmias. Here, we review how this approach has led to major insights into the mechanisms of spatially discordant alternans, a key arrhythmogenic factor predisposing the heart to re-entry...

journal_title：Circulation research

authors： Weiss JN,Karma A,Shiferaw Y,Chen PS,Garfinkel A,Qu Z

更新日期：2006-05-26 00:00:00

abstract：:The functional disturbance of microvasculature is recognized as an initiating mechanism that underlies the development of various diabetic complications. Although a causal relationship between microvascular leakage and tissue damage has been well documented in diabetic kidneys and eyes, there is a lack of information ...

journal_title：Circulation research

authors： Yuan SY,Ustinova EE,Wu MH,Tinsley JH,Xu W,Korompai FL,Taulman AC

更新日期：2000-09-01 00:00:00

abstract：:Nuclear factor kappa B (NF-kappaB) participates in hypertension-induced vascular and target-organ damage. We tested whether or not endothelial cell-specific NF-kappaB suppression would be ameliorative. We generated Cre/lox transgenic mice with endothelial cell-restricted NF-kappaB super-repressor IkappaBalphaDeltaN (T...

journal_title：Circulation research

authors： Henke N,Schmidt-Ullrich R,Dechend R,Park JK,Qadri F,Wellner M,Obst M,Gross V,Dietz R,Luft FC,Scheidereit C,Muller DN

更新日期：2007-08-03 00:00:00

abstract：:The aims of the current study were to examine the efficacy of acetylcholine (ACh) to mimic ischemic preconditioning in dogs and to determine the role of nitric oxide (NO), muscarinic receptors, and ATP-sensitive K+ (KATP) channels in mediating its effects. Barbital-anesthetized open-chest dogs were subjected to 60 min...

journal_title：Circulation research

authors： Yao Z,Gross GJ

更新日期：1993-12-01 00:00:00

abstract：RATIONALE:Histone deacetylase (HDAC)7 is expressed in the early stages of embryonic development and may play a role in endothelial function. OBJECTIVE:This study aimed to investigate the role of HDAC7 in endothelial cell (EC) proliferation and growth and the underlying mechanism. METHODS AND RESULTS:Overexpression of...

journal_title：Circulation research

authors： Margariti A,Zampetaki A,Xiao Q,Zhou B,Karamariti E,Martin D,Yin X,Mayr M,Li H,Zhang Z,De Falco E,Hu Y,Cockerill G,Xu Q,Zeng L

更新日期：2010-04-16 00:00:00

abstract：RATIONALE:Cryptogenic strokes, those of unknown cause, have been estimated as high as 30% to 40% of strokes. Inflammation has been suggested as a critical etiologic factor. However, there is lack of experimental evidence. OBJECTIVE:In this study, we investigated inflammation-associated stroke using a mouse model that ...

journal_title：Circulation research

authors： Hollander MC,Latour LL,Yang D,Ishii H,Xiao Z,Min Y,Ray-Choudhury A,Munasinghe J,Merchant AS,Lin PC,Hallenbeck J,Boehm M,Yang L

更新日期：2017-12-08 00:00:00

abstract：:Voltage-gated L-type Ca(2+) channels (LCCs) provide Ca(2+) ingress into cardiac myocytes and play a key role in intracellular Ca(2+) homeostasis and excitation-contraction coupling. We investigated the effects of a constitutive increase of LCC density on Ca(2+) signaling in ventricular myocytes from 4-month-old transg...

journal_title：Circulation research

authors： Song LS,Guia A,Muth JN,Rubio M,Wang SQ,Xiao RP,Josephson IR,Lakatta EG,Schwartz A,Cheng H

更新日期：2002-02-08 00:00:00

abstract：:The impact of vanadate on the Na,K-ATPase system in the vascular smooth muscle cell is poorly understood. The present study describes the kinetics of the effect of vanadate on Na,K-ATPase and the Na-K pump in in vitro grown rat VSMC's. Vanadate interaction with the Na,K-ATPase system in vascular smooth muscle cells wa...

journal_title：Circulation research

authors： Searle BM,Higashino H,Khalil F,Bogden JD,Tokushige A,Tamura H,Kino M,Aviv A

更新日期：1983-08-01 00:00:00